Tamio Yamaguchi

(山口太美雄)

Profile Information

Affiliation: Visiting Professor, Fujita Health University

Degree: Ph.D.(Fujita Health University)

Researcher number: 70536292
J-GLOBAL ID: 201901012659725723
researchmap Member ID: B000362979

Research Interests

Polycystic Kidney Disease (PKD), Diabetic Kidney Disease (DKD) in vivo and in vitro model/platform

Research Areas

Life sciences / Experimental pathology / Utilizing extrapolation models of human diseases: Nephrology (Polycystic Kidney Disease, Diabetic Kidney Disease), Molecular and cellular biology, Pharmacology, Organoid

Research History

Committee Memberships

2022 - Present

Board Member, Polycystic Kidney Disease Association of Japan
2020 - Present

Member, Certified Functional Food Consultant Recertification Examination Committee, Japanese Association of Food Science and Risk Analysis
2019 - Present

Committee Member, Chubu Branch, Japanese Association of Food Science and Risk Analysis
2003 - Present

Academic Advisor, PKD Foundation Chapter of Japan
2017 - 2026

Organizer, Tokai Renal Function Assessment Study Group

Awards

Jul, 2021

Outstanding Paper Award, The Research Society for Science of Dietary Habits

Chizuko Hotta, Tamio Yamaguchi
Jun, 2011

Best Presentation Award, The 54th Annual Meeting of the Japanese Society of Nephrology

Atsushi Hoshihara, Hiroki Kurahashi, Miwa Morita, Masanori Kugita, Yoshiyuki Hiki, Harold Aukema, Tamio Yamaguchi, James Calve, Darren Wallace, Shizuko Nagao (Fujita Health University, JAPAN, University of Manitoba, CANADA, University of Kansas Medical Center, U.S,A,)
Feb, 2007

PKD Investigator Award (for Outstanding Contribution of Research and Service), Kansas Interdisciplinary PKD Research Center, Kansas City, KS, U.S.A.

Tamio Yamaguchi, Ph.D., Research Assistant Professor, University of Kansas Medical Center, U.S.A.
Jul, 1999

Biomedical Research Scholar Award, University of Kansas Medical Center Training Program in Biomedical Research, Kansas City, KS, U.S.A.

Tamio Yamaguchi, Ph.D., Post-Doctoral Fellow, University of Kansas Medical Center, U.S.A.
Jul, 1998

Kansas Health Foundation Scholar Award, Kansas Health Foundation Cancer Research and Training Program, State of Kansas, U.S.A.

Tamio Yamaguchi, Ph.D., Post-Doctoral Fellow, University of Kansas Medical Center, U.S.A.

Papers

Intracellular signaling cascades and cell proliferation in polycystic kidney disease

Tamio Yamaguchi, Aya Yoshimura, Masanori Kugita, Shizuko Nagao

Kidney and Dialysis, 100(3) 346-350, Mar, 2026 InvitedLead authorCorresponding author
Current advance in animal models underpinning PKD research

Shizuko Nagao, Masanori Kugita, Aya Yoshimura, Tamio Yamaguchi

Kidney and Dialysis, 100(3) 334-338, Mar, 2026 InvitedLast author
セリノール核酸から合成した抗miR-21オリゴヌクレオチドのヒト,マウス嚢胞性腎疾患モデルに対する改善効果

野田悠平, 加藤規利, 山口太美雄, 長尾静子, 神谷由紀子, 浅沼浩之, 丸山彰一

日本腎臓学会誌, 67(4) 511-511, Jun, 2025
ETA受容体選択的拮抗薬を投与した食塩負荷SDT fattyラットの病理および遺伝子発現解析

福井渓実, 白水貴大, 釘田雅則, 熊本海生航, 山口太美雄, 高橋和男, 吉村文, 長尾静子

日本腎臓学会誌, 67(4) 543-543, Jun, 2025
食塩負荷SDT fattyにおけるMR拮抗薬とETAR拮抗薬の併用による降圧および腎保護作用

白水貴大, 吉村文, 福井渓実, 釘田雅則, 熊本海生航, 八代百合子, 白倉美雨, 大畑敬一, 秋江靖樹, 山口太美雄, 高橋和男, 長尾静子

日本腎臓学会誌, 67(4) 543-543, Jun, 2025

Misc.

109

Salt-sensitive genetic background strongly supresses medullary cyst formation in ARPKD rat model

Aya Yoshimura, Takahiro Shirozu, Masanori Kugita, Kanako Kumamoto, Akiko Takizawa, Melinda R. Dwinell, Masumi Hirabayashi, Kazuo Takahashi, Tamio Yamaguchi, Shizuko Nagao

World Congress of Nephrology 2026 (WCN '26), Yokohama, Japan, P520, Mar 30, 2026 Peer-reviewed
Improvement of hypertension, albuminuria, dyslipidemia, and renal impairment in salt-loaded SDT fatty rats by a mineralcorticoid receptor antagonist.

Takahiro Shirozu, Aya Yoshimura, Masanori Kugita, Kanako Kumamoto, Yuriko Yatsushiro, Miu Shirakura, Keiichi Ohata, Yasuki Akie, Tamio Yamaguchi, Kazuo Takahashi, Shizuko Nagao

World Congress of Nephrology 2026 (WCN '26), Yokohama, Japan, P323, Mar 28, 2026 Peer-reviewed
Antihypertensive and renoprotective effects of mineralocorticoid receptor antagonist on salt-loaded SDT fatty rat with diabetic nephropathy

Takahiro Shirozu, Aya Yoshimura, Masanori Kugita, Kanako Kumamoto, Yuriko Yatsushiro, Miu Shirakura, Keiichi Ohata, Yasuki Akie, Tamio Yamaguchi, Kazuo Takahashi, Shizuko Nagao

2025 Asian Pacific Congress of Nephrology (APCN), Taipei, Taiwan, Dec 5, 2025
Additive Antihypertensive and Renoprotective Effects of a Mineralocorticoid Receptor Antagonist Combined with an Endothelin Receptor Type A-Selective Antagonist in Salt-Loaded Spontaneously Diabetic Torii Rats

Takahiro Shirozu, Aya Yoshimura, Masanori Kugita, Kanako Kumamoto, Yuriko Yatsushiro, Miu Shirakura, Keiichi Ohata, Yasuki Akie, Tamio Yamaguchi, Kazuo Takahashi, Shizuko Nagao

American Society of Nephrology (ASN) KIDNEY WEEK 2025, Houston, U.S.A., Nov 8, 2025
ETA受容体選択的拮抗薬を投与した食塩負荷SDT fattyラットの病理および遺伝子発現解析

福井渓実, 白水貴大, 釘田雅則, 熊本海生航, 山口太美雄, 高橋和男, 吉村文, 長尾静子

日本腎臓学会誌(Web), 67(4), 2025

Presentations

Polycystic Kidney Disease Association Basic Research Session (Chair)

Chair, Tamio Yamaguchi, Speaker: Toshimi Hidaka

Polycystic Kidney Disease Association 3rd PKD Conference (Naha-city, Okinawa), Dec 7, 2025
Polycystic Kidney Disease Association Young Investigator Award– Award Lecture (Chair)

Chairs: Tamio Yamaguchi, Junichi Hoshino, Awardees: Shin-Ichi Mae, Yusuke Ushio

Polycystic Kidney Disease Association 2nd PKD Conference (Juntendo University, Tokyo), Dec 1, 2024 Invited
Symposium: Approaching PKD from the Mechanistic Perspective (Chair)

Chairs: Tamio Yamaguchi, Sumi Hidaka, Invited Speakers: Yoshikatsu Kaneko, Shizuko Nagao, Keiji Shimazu, Koichi Nakanishi

Polycystic Kidney Disease Association 1st PKD Conference (Juntendo University, Tokyo), Nov 12, 2023 Invited
International Exchange and Mutual Lecture on Healthcare Professional Education between Suzuka University of Medical Science and the University of Manitoba

Tamio Yamaguchi, Harold Aukema

International Exchange and Mutual Lecture on Healthcare Professional Education, Nov 1, 2023 Invited
Exploring progression factors of nephropathy in an obesity-associated type 2 diabetes rat model

Shizuko Nagao, Tamio Yamaguchi

University of Manitoba, Canadian Centre for Agri-Food Research in Health and Medicine Seminar, Nov 1, 2023 Invited

Research Projects

Effect of equivalent caloric intake/different PFC balance diets on diabetic nephropathy and cognitive impairment

Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2024

Tamio YAMAGUCHI, Aya YOSHIMURA, Shizuko NAGAO
Research on the key factors and signal transduction cascades of the onset of chronic kidney disease (CKD): Application of global omics technologies.

Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

Shizuko NAGAO, Masanori KUGITA, Tamio YAMAGUCHI
Effects of diet on progression of polycystic kidney disease in animal models with the same genetic mutation as the human disease

CIHR grant, Canadian Institutes of Health Research (CIHR), May, 2011 - Apr, 2014

Harold M Aukenma, Ph.D., Tamio Yamaguchi, Ph.D. (University of Manitoba, Canada)
A novel therapeutic approach for cystic disease:Inhibition of intracellular signal transduction pathways by a nuclear receptor cascade

Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, 2010 - 2012

Shizuko NAGAO, Masanori KUGITA, Daisuke YOSHIHARA, Miwa MORITA, Shigeru YAGYU, Tamio YAMAGUCHI, Yoshiyuki HIKI, Hiroki KURAHASHI

Industrial Property Rights

特開特表2022-506800 特表2022-506800 身体器官または腫瘤を包むためのカプセル器具およびその使用

ベイキョンテ, ベイジュヌ, ベイソヌ, 長尾静子, 熊本海生航, 吉村文, 山口太美雄

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