研究者業績
基本情報
- 所属
- 藤田医科大学 医療科学部 放射線学科 講師
- 学位
- 博士（工学）(広島大学)修士（工学）(広島大学)学士（工学）(広島大学)
- J-GLOBAL ID
- 201501008446166529
- researchmap会員ID
- 7000011532
- 外部リンク
経歴
4-
2022年4月 - 現在
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2015年4月 - 2022年3月
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2016年4月 - 2019年3月
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2013年4月 - 2015年3月
委員歴
6-
2021年10月 - 2022年3月
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2021年4月 - 2022年3月
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2021年1月 - 2022年3月
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2019年12月 - 2021年3月
受賞
8論文
58-
Scientific reports 14(1) 3383-3383 2024年2月9日 査読有りAnticipation of pain engenders anxiety and fear, potentially shaping pain perception and governing bodily responses such as peripheral vasomotion through the sympathetic nervous system (SNS). Sympathetic innervation of vascular tone during pain perception has been quantified using a peripheral arterial stiffness index; however, its innervation role during pain anticipation remains unclear. This paper reports on a neuroimaging-based study designed to investigate the responsivity and attribution of the index at different levels of anticipatory anxiety and pain perception. The index was measured in a functional magnetic resonance imaging experiment that randomly combined three visual anticipation cues and painful stimuli of two intensities. The peripheral and cerebral responses to pain anticipation and perception were quantified to corroborate bodily responsivity, and their temporal correlation was also assessed to identify the response attribution of the index. Contrasting with the high responsivity across levels of pain sensation, a low responsivity of the index across levels of anticipatory anxiety revealed its specificity across pain experiences. Discrepancies between the effects of perception and anticipation were validated across regions and levels of brain activity, providing a brain basis for peripheral response specificity. The index was also characterized by a 1-s lag in both anticipation and perception of pain, implying top-down innervation of the periphery. Our findings suggest that the SNS responds to pain in an emotion-specific and sensation-unbiased manner, thus enabling an early assessment of individual pain perception using this index. This study integrates peripheral and cerebral hemodynamic responses toward a comprehensive understanding of bodily responses to pain.
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Journal of neuroengineering and rehabilitation 20(1) 139-139 2023年10月18日 査読有りBACKGROUND: People who were previously hospitalised with stroke may have difficulty operating a motor vehicle, and their driving aptitude needs to be evaluated to prevent traffic accidents in today's car-based society. Although the association between motor-cognitive functions and driving aptitude has been extensively studied, motor-cognitive functions required for driving have not been elucidated. METHODS: In this paper, we propose a machine-learning algorithm that introduces sparse regularization to automatically select driving aptitude-related indices from 65 input indices obtained from 10 tests of motor-cognitive function conducted on 55 participants with stroke. Indices related to driving aptitude and their required tests can be identified based on the output probability of the presence or absence of driving aptitude to provide evidence for identifying subjects who must undergo the on-road driving test. We also analyzed the importance of the indices of motor-cognitive function tests in evaluating driving aptitude to further clarify the relationship between motor-cognitive function and driving aptitude. RESULTS: The experimental results showed that the proposed method achieved predictive evaluation of the presence or absence of driving aptitude with high accuracy (area under curve 0.946) and identified a group of indices of motor-cognitive function tests that are strongly related to driving aptitude. CONCLUSIONS: The proposed method is able to effectively and accurately unravel driving-related motor-cognitive functions from a panoply of test results, allowing for autonomous evaluation of driving aptitude in post-stroke individuals. This has the potential to reduce the number of screening tests required and the corresponding clinical workload, further improving personal and public safety and the quality of life of individuals with stroke.
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IEEE Transactions on Magnetics 58(8) 1-5 2022年8月 査読有り
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Sensors 22(9) 3509-3509 2022年5月5日 査読有りThis study was conducted with the aim of developing a circuit system that enables the measurement of the moisture content and ion concentration with a simple circuit configuration. Our previous studies have shown that soil can be represented by an equivalent circuit of a parallel circuit of resistors and capacitors. We designed a circuit that can convert the voltage transient characteristics of the soil when a current is applied to it into a square wave and output frequency information and developed an algorithm to analyze the two types of square waves and calculate R and C. Normal operation was confirmed in the range of 10 kΩ–1 MΩ for the designed circuit, and the calculation algorithm matched within a maximum error of 5%, thus confirming the validity of the program. These successfully confirmed the changes in the water content and ionic concentration. The soil moisture content measurement succeeded in measuring a maximum error of about 10%, except at one point, and the soil ion concentration measurement succeeded in measuring a maximum error of 6.6%. A new, simple, noise-resistant moisture content and ion concentration measurement circuit system with square wave output has been realized.
MISC
27-
Hiroshima Journal of Medical Sciences 67(3) 55-61 2018年9月 査読有り
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日本高血圧学会総会プログラム・抄録集 40th 385 2017年10月20日
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電気学会研究会資料. CHS = The papers of technical meeting on "chemical sensor", IEE Japan 2017(1) 9-12 2017年6月29日
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電気学会研究会資料. CHS = The papers of technical meeting on "chemical sensor", IEE Japan 2016(37) 33-36 2016年11月30日
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「センサ・マイクロマシンと応用システム」シンポジウム論文集 電気学会センサ・マイクロマシン部門 [編] 33 1-5 2016年10月2日
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ロボティクス・メカトロニクス講演会講演概要集 2016 1A2-02b6 2016年<p>This paper proposes an estimation algorithm of the arterial viscosity using cuff pressures and cuff pulse waves measured from an automatic oscillometric sphygmomanometer. A change in the arterial viscosity %η during the enclosed zone flow-mediated dilation (ezFMD) test is calculated as an index for vascular endothelial function.The index %η was measured and the receiver operating characteristic (ROC) analysis for the arterial viscosity change %η was performed in the experiment. The mean arterial viscosity change for the healthy subjects and that for the subjects at high-risk of arteriosclerosis were 13.4 ± 55.1 ％ and -32.7 ± 34.0 ％ (mean ± S.D., p < 0.05), respectively, and the area under the curve calculated from the ROC analysis was 0.77. It was thus concluded that the proposed method may evaluate vascular endothelial function.</p>
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ロボティクス・メカトロニクス講演会講演概要集 2016 1P1-13a2 2016年<p>This paper examines a relationship between an arterial stiffness parameter β and nociceptive mechanical stimuli. The stiffness parameter β which reacts according to peripheral sympathetic nerve activity is calculated from continuous arterial pressures and photoplethysmograms based on the log-linearized peripheral arterial viscoelastic model, while mechanical stimuli were applied to the subjects in the experiments. The results showed a significant correlation between the stimulus velocity and the stiffness parameter β when stimulus amplitude was constant (r = 0.63 (p < 0.05)) and that between the stimulus amplitude and the normalized stiffness parameter βn when stimulus velocity was constant (r = 0.54 (p < 0.01)). It was therefore concluded that the arterial stiffness parameter β may react to amplitude and velocity of mechanical stimuli.</p>
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計測自動制御学会システムインテグレーション部門講演会(CD-ROM) 16th 2015年
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ロボティクス・メカトロニクス講演会講演概要集 2015 _2P1-S07_1-_2P1-S07_4 2015年This study proposes a novel system that evaluates human higher brain functions with a tablet device based on cognitive information processing models. The system consists of three parts. The first part is to measure touch events on the tablet associated with visual cognition, reaching motion control, rhythmic motion control, and working memory retrieval; the second part to calculate indices from the measured touch events based on the cognitive information processing models; and the third part to assess a risk score calculated from the indices normalized to a control group, hi this paper, the validity of the proposed system was discussed with the calculated indices from adult healthy subjects. The results showed that the risk score increased linearly by age (r = 0.64, p < 0.01). This suggests that the proposed system has the potential to evaluate higher brain functions objectively and quantitatively.
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Transactions of Japanese Society for Medical and Biological Engineering 52 O-47 2014年8月17日© 2014, Japan Soc. of Med. Electronics and Biol. Engineering. All rights reserved. This study proposes a novel method to assess the sympathetic activity based on the log-linearized peripheral arterial viscoelastic model. The arterial stiffness included in the model was calculated from the measured electrocardiogram, continuous left radial arterial pressure, and left second finger photo-plethysmogram while applying the triangular pulse current to the right forearm. Additionally, the self-reported numeric rating scale (NRS) was compared with the estimated stiffness. As results of four subjects, the relation between the stiffness and the NRS was approximated by the sigmoid function. The result thus showed the proposed method has a potential to assess a pain objectively.
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生体医工学 52 O-387-O-388 2014年This study proposes a novel noninvasive arterial stiffness estimation technique based on the oscillometric method and applies it to assess the vascular endothelial function. Change of the arterial stiffness during the enclosed zone flow-mediated dilation test was calculated from the measured blood pressure, the cuff oscillation, and the applied pressure to the cuff. As results, the arterial stiffness change for the four healthy subjects was -42±17% and that for the four patients with high-risk of arteriosclerosis was -2.9±11%. The mean changes had significantly different between the two groups (p<0.01). The result thus indicated proposed method could assess the vascular endothelial function.
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生体医工学 52 O-47-O-48 2014年This study proposes a novel method to assess the sympathetic activity based on the log-linearized peripheral arterial viscoelastic model. The arterial stiffness included in the model was calculated from the measured electrocardiogram, continuous left radial arterial pressure, and left second finger photo-plethysmogram while applying the triangular pulse current to the right forearm. Additionally, the self-reported numeric rating scale (NRS) was compared with the estimated stiffness. As results of four subjects, the relation between the stiffness and the NRS was approximated by the sigmoid function. The result thus showed the proposed method has a potential to assess a pain objectively.
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ロボティクス・メカトロニクス講演会講演概要集 2012 _1P1-N03_1-_1P1-N03_4 2012年This paper proposes a novel non-invasive palpable sensor to measure carotid pulse pressure. The unit consists of a pair of coil printed circuit boards, a pair of springs, and a sensing plastic chip. The distance between the boards is monitored from the displacement of the springs, and the information is converted into a voltage signal based on electromagnetic induction. In this study, carotid pulse pressures of seven healthy males were measured using the proposed sensor and a commercial pulse pressure transducer. The results showed that the correlation coefficient between the two waveforms was 0.90 or more and the carotid pulse pressure was palpable throughout with the proposed sensor. Thus we conclude that the proposed sensor enables non-invasive measurement of carotid pulse waves.
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ロボティクス・メカトロニクス講演会講演概要集 2012 _1P1-M02_1-_1P1-M02_4 2012年This paper proposes a circulatory condition-monitoring system with an air-pack sensor for ongoing measurement of pressure signals in supine patients with cervical spinal cord injuries. The system can be used to determine pulse pressure waves, pulse beats, respiratory waves and the augmentation index (AI). In this study, the physiological significance of signals obtained via the sensor was elucidated by comparing them with signals actually measured using commercial devices. The results showed a close correspondence between the signals obtained using the proposed system and the pulse pressure waves, breathing waveforms and RR-intervals. The AI values estimated using the air-pack sensor also displayed a high level correlation with those determined from radial artery pressure waveforms. To verify the performance of the proposed system, a patient with an injury was tested while asleep. The results confirmed that the system can be used to assess circulatory states of arteriosclerosis using the estimated AI values.
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ロボティクス・メカトロニクス講演会講演概要集 2011 "2P1-B06(1)"-"2P1-B06(4)" 2011年5月26日This paper proposes a new model for estimating dynamic viscoelasticity of peripheral arterial wall using arterial pressure and photoplethysmogram. The proposed model is able to suppress the well-known pressure dependency of arterial stiffness using a log-linearization technique and estimate the changes of viscosity as well as stiffness of peripheral arterial wall induced by autonomic nervous activity. The validity of the proposal model is discussed by estimating the change of stiffness values during arm position tests and during endoscopic thoracic sympathectomies (ETSs). As results of the arm position tests, the position-dependent change of the stiffness was very little between arm positions during at rest and during loading (Up: 3.8 [%], Down: 5.6 [%]). Then, as results of the ETSs, the variation of the stiffness was significantly changed between before and during the ETS procedure (p<0.005), and between during and after the ETS procedure (p<0.025). Thus we concluded that the proposed method enabled to assess changes in the autonomic nervous activity.
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ロボティクス・メカトロニクス講演会講演概要集 2011 _2P2-O09_1-_2P2-O09_4 2011年This paper proposes a noninvasive method for estimating the dynamic characteristics of arterial walls using pulse waves measured in various parts of the body by a foil-type pressure sensor. The sensor was employed to measure pulse waves based on the tonometry approach, and a method of estimating changes in arterial viscoelastic indices was proposed based on the measured pulse waves and photoplethysmograms. In order to accurately measure blood pressure, we examined suitable mechanical forces externally applied to the sensor, and found that values of 5-25 [N] yielded the best performance. We then estimated the arterial viscoelastic indices of a radial artery and a dorsal pedis artery when mechanical pain stimuli were applied to the subjects. The results suggested the estimated indices can be used to quantitatively assess vascular response caused by sympathicotonia. We thus concluded the proposed method enabled noninvasive measurement of pulse waves and estimation of viscoelastic indices.
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IIP情報・知能・精密機器部門講演会講演論文集 2010 159-163 2010年3月16日Implantable medical devices need to transmit information between the inside and the outside of a human body. Therefore, sufficient information needs to traverse a long communication distance but at low power. However, electromagnetic waves attenuate when information is transmitted through tissues such as muscle, skin, and various organs. In this paper, we propose a new method for wireless information transmission that uses whole-body resonance. First, we constructed a cylindrical human body model (170 mm high). Electromagnetic simulation was provided by a small implanted dipole antenna. We then examined the maximum frequency values, taking the electric and magnetic fields surrounding the human body model and dividing by the transmitting power of the antenna. The maximum frequency value was 43 MHz, which was essentially the same frequency as the theoretical value of whole-body resonance (44.1 MHz). Therefore, information may possibly transmit more efficiently using whole-body resonance.
書籍等出版物
1講演・口頭発表等
96担当経験のある科目(授業)
15共同研究・競争的資金等の研究課題
4-
若手研究 2020年4月 - 2023年3月
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公益財団法人浜松科学技術研究振興会 2019年8月 - 2020年3月
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若手研究(B) 2016年4月 - 2019年3月
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特別研究員奨励費 2013年4月 - 2015年3月