研究者業績

岡村 拓哉

okamura takuya

基本情報

所属
藤田医科大学 医学部 医学科 呼吸器内科学Ⅰ 助教
学位
博士(医学)

J-GLOBAL ID
201501002126212037
researchmap会員ID
7000012739

MISC

 3
  • Sumito Isogai, Masamichi Hayashi, Naoki Yamamoto, Mariko Morishita, Tomoyuki Minezawa, Takuya Okamura, Tami Hoshino, Mitsushi Okazawa, Kazuyoshi Imaizumi
    Allergology international : official journal of the Japanese Society of Allergology 62(3) 367-73 2013年9月  
    BACKGROUND: Although a challenge test using non-steroidal anti-inflammatory drugs (NSAIDs) is crucial for diagnosis of aspirin-induced asthma (AIA), it also has drawbacks in terms of possible side effects. Therefore, alternative in-vitro diagnostic methods for AIA are awaited. METHODS: Nineteen stable non-AIA patients (9 males and 10 females; mean age, 49.4 ± 4.8 years), and 20 AIA patients (9 males and 11 females; mean age, 51.1 ± 4.8 years) were enrolled in this study. CD11b and CD16 expressions on the peripheral-blood granulocytes after administration of aspirin and different concentrations of PGE2 in vitro were examined using flowcytometry. RESULTS: Aspirin induced a significant increase in CD11b expression on eosinophils (CD16 negative granulocytes) in 19 AIA patients and one non-AIA patient. Increase in CD11b expression on eosinophils by aspirin administration was suppressed by PGE2 in a dose-dependent manner. CONCLUSIONS: The measurement of CD11b expression on peripheral-blood eosinophils showed very high sensitivity and specificity of (-95%) in diagnosing AIA. Although this method requires laboratory facilities for flowcytometry, it may be very useful in diagnosis of AIA without side effects. In addition, PGE2 may be involved in regulation of CD11b expression on eosinophils by aspirin administration.
  • 岡村拓哉
    学位論文集 263-284 2013年  
  • 磯谷澄都, 今泉和良, 岡澤光芝, 林 正道, 岡村拓哉, 峯澤智之
    平成23年度総括・分担研究報告書、厚生労働科学研究・免疫アレルギー疾患等予防・治療研究事業 23-26 2012年  

書籍等出版物

 1

講演・口頭発表等

 70

その他教育活動上特記すべき事項

 1
  • 件名
    第39回医学教育ワークショップ
    終了年月日
    2011/05/21
    概要
    「PBLテューター・トレーニング」に参加した。