医学部 呼吸器内科学

堀口 智也

ホリグチ トモヤ  (tomoya horiguchi)

基本情報

所属
藤田医科大学 医学部 医学科 呼吸器内科学 講師
学位
医学博士(2018年3月 藤田保健衛生大学)

J-GLOBAL ID
201501007574511845
researchmap会員ID
7000012741

論文

 18
  • Tomoki Takahashi, Yoshiyuki Ozawa, Hidekazu Hattori, Masahiko Nomura, Takahiro Ueda, Tomoya Horiguchi, Kazuyoshi Imaizumi, Yasushi Matsuda, Yasushi Hoshikawa, Yuka Kondo-Kawabe, Tetsuya Tsukamoto, Hiroyuki Nagata, Yoshiharu Ohno
    Journal of thoracic imaging 2024年9月16日  
  • Hirofumi Kamata, Kazufumi Takamatsu, Koichi Fukunaga, Shotaro Chubachi, Kensuke Nakagawara, Ho Namkoong, Hideki Terai, Katsushi Tanaka, Susumu Sato, Eri Hagiwara, Reoto Takei, Yasuhiro Kondoh, Takahiro Takazono, Midori Hashimoto, Sadatomo Tasaka, Takashi Ohrui, Yoshinori Tanino, Masamichi Mineshita, Yuko Komase, Kazuhito Miyazaki, Masanori Nishikawa, Akira Ando, Hideo Kita, Eiki Ichihara, Shinichiro Ohshimo, Yoriyuki Murata, Masayuki Ishida, Seiichi Kobayashi, Takahiro Uchida, Hiroki Tateno, Jun Ikari, Takeshi Terashima, Yutaka Kozu, Tomoya Tateishi, Masaharu Shinkai, Hironori Sagara, Yasuo To, Yoko Ito, Masaki Yamamoto, Yoshihiro Yamamoto, Toshiyuki Kita, Yutaka Ito, Keisuke Tomii, Yukio Fujita, Yoshihiro Funaki, Kazuhiro Yatera, Mari Yamasue, Kosaku Komiya, Satoko Kozawa, Hideaki Manabe, Hironao Hozumi, Tomoya Horiguchi, Takamasa Kitajima, Yasushi Nakano, Tetsutaro Nagaoka, Masayuki Hojo, Akinori Ebihara, Masayoshi Kobayashi, Koji Takayama, Torahiko Jinta, Toyomitsu Sawai, Yuichi Fukuda, Takeshi Kaneko, Kazuo Chin, Takashi Ogura, Hiroshi Mukae, Makoto Ishii, Akihito Yokoyama
    Respiratory investigation 62(4) 572-579 2024年4月25日  
    BACKGROUND: No comprehensive analysis of the pulmonary sequelae of coronavirus disease 2019 (COVID-19) in Japan based on respiratory function tests and chest computed tomography (CT) has been reported. We evaluated post-COVID-19 conditions, especially focusing on pulmonary sequelae assessed by pulmonary function tests and chest CT. METHODS: For this prospective cohort study, we enrolled 1069 patients who presented pneumonia at the time of admission in 55 hospitals from February 2020 to September 2021. Disease severity was classified as moderateⅠ, moderate II, and severe, defined primarily according to the degree of respiratory failure. The data on post-COVID-19 conditions over 12 months, pulmonary function, and chest CT findings at 3 months were evaluated in this study. Additionally, the impact of COVID-19 severity on pulmonary sequelae, such as impaired diffusion capacity, restrictive pattern, and CT abnormalities, was also evaluated. RESULTS: The most frequently reported post-COVID-19 conditions at 3 months after COVID-19 were muscle weakness, dyspnea, and fatigue (48.4%, 29.0%, and 24.7%, respectively). The frequency of symptoms gradually decreased over subsequent months. In pulmonary function tests at 3 months, the incidence of impaired diffusion capacity and restrictive pattern increased depending on disease severity. There also were differences in the presence of chest CT abnormalities at the 3 months, which was markedly correlated with the severity. CONCLUSION: We reported a comprehensive analysis of post-COVID-19 condition, pulmonary function, and chest CT abnormalities in Japanese patients with COVID-19. The findings of this study will serve as valuable reference data for future post-COVID-19 condition research in Japan.
  • Takuya Okamura, Sayako Morikawa, Tomoya Horiguchi, Kumiko Yamatsuta, Toshikazu Watanabe, Aki Ikeda, Yuri Maeda, Takuma Ina, Hideaki Takahashi, Ryoma Moriya, Yasuhiro Goto, Sumito Isogai, Naoki Yamamoto, Shotaro Okachi, Naozumi Hashimoto, Kazuyoshi Imaizumi
    Respiration; international review of thoracic diseases 2024年2月22日  
    INTRODUCTION: Increasing numbers of cases of mild asymptomatic pulmonary alveolar proteinosis (PAP) are being reported with the recent increase in chest computed tomography (CT). Bronchoscopic diagnosis of mild PAP is challenging because of the patchy distribution of lesions, which makes it difficult to obtain sufficient biopsy samples. Additionally, the pathological findings of mild PAP, particularly those that differ from severe PAP, have not been fully elucidated. This study aimed to clarify the pathological findings of mild PAP and the usefulness of optical biopsy using probe-based confocal laser endomicroscopy (pCLE). METHODS: We performed bronchoscopic optical biopsy using pCLE and tissue biopsy in five consecutive patients with PAP (three with mild PAP and two with severe PAP). We compared the pCLE images of mild PAP with those of severe PAP by integrating clinical findings, tissue pathology, and chest computed tomography images. RESULTS: pCLE images of PAP showed giant cells with strong fluorescence, amorphous substances, and thin alveolar walls. Images of affected lesions in mild PAP were equivalent to those obtained in arbitrary lung lesions in severe cases. All three patients with mild PAP spontaneously improved or remained stable after ≥3 years of follow-up. Serum autoantibodies to granulocyte-macrophage colony-stimulating factor were detected in all five cases. CONCLUSION: Optical biopsy using pCLE can yield specific diagnostic findings, even in patients with mild PAP. pCLE images of affected areas in mild and severe PAP showed similar findings, indicating that the dysfunction level of pathogenic alveolar macrophages in affected areas is similar between both disease intensities.
  • Ken Akao, Yuko Oya, Takaya Sato, Aki Ikeda, Tomoya Horiguchi, Yasuhiro Goto, Naozumi Hashimoto, Masashi Kondo, Kazuyoshi Imaizumi
    Exploration of targeted anti-tumor therapy 5(4) 826-840 2024年  
    Despite innovative advances in molecular targeted therapy, treatment strategies using immune checkpoint inhibitors (ICIs) for epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) have not progressed significantly. Accumulating evidence suggests that ICI chemotherapy is inadequate in this population. Biomarkers of ICI therapy, such as programmed cell death ligand 1 (PD-L1) and tumor-infiltrating lymphocytes (TILs), are not biomarkers in patients with EGFR mutations, and the specificity of the tumor microenvironment has been suggested as the reason for this. Combination therapy with PD-L1 and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) inhibitors is a concern because of its severe toxicity and limited efficacy. However, early-stage NSCLC may differ from advanced-stage NSCLC. In this review, we comprehensively review the current evidence and summarize the potential of ICI therapy in patients with EGFR mutations after acquiring resistance to treatment with EGFR-tyrosine kinase inhibitors (TKIs) with no T790M mutation or whose disease has progressed on osimertinib.
  • Takahiro Inoue, Sumito Isogai, Naoki Yamamoto, Noriko Hiramatsu, Yoshikazu Niwa, Hideaki Takahashi, Yutaro Kimura, Tomoya Horiguchi, Yasuhiro Goto, Naozumi Hashimoto, Kazuyoshi Imaizumi
    Therapeutic advances in respiratory disease 18 17534666241254980-17534666241254980 2024年  
    BACKGROUND: Bronchial thermoplasty (BT) is a recently developed non-pharmacological therapy for refractory bronchial asthma. Although increasing evidence has suggested that BT is effective for various phenotypes of severe asthma, its safety and efficacy in patients with severe irreversible impaired lung function are unclear. OBJECTIVES: To assess the efficacy and safety of BT in patients with refractory asthma, including patients with a severely impaired forced expiratory volume in 1 second (FEV1). DESIGN: This was a single-center, retrospective, observational cohort study. METHODS: We retrospectively reviewed the medical records of 15 patients with refractory asthma (Global Initiative for Asthma step 4 or 5), including patients with severely impaired airflow limitation (% predicted pre-bronchodilator FEV1 <60%), who had undergone BT between June 2016 and January 2022. We analyzed the efficacy (change in asthma symptoms, exacerbation rate, pulmonary function, asthma medication, and serum inflammatory chemokine/cytokines before and after BT) and complications in all patients. We compared these data between patients with severe obstructive lung dysfunction [group 1(G1)] and patients with FEV1 ⩾ 60% [group 2 (G2)]. RESULTS: Six patients were in G1 and nine were in G2. Clinical characteristics, T2 inflammation, and concurrent treatment were equivalent in both groups. BT significantly improved asthma-related symptoms (measured using the Asthma Control Test and Asthma Quality of Life Questionnaire scores) in both groups. FEV1 was significantly improved in G1 but not in G2. Four patients in G2, but none in G1, experienced asthma exacerbation requiring additional systemic corticosteroids (including two requiring prolonged hospitalization) after BT. Long-term responders (patients who reduced systemic or inhaled corticosteroid without newly adding biologics in a follow-up > 2 years) of BT were identified in G1 and G2 (n = 2, 33.3% and n = 4, 44.4%, respectively). CONCLUSION: BT in patients with refractory asthma and severe airflow limitation is equally safe and efficacious as that in patients with moderate airflow limitation.

MISC

 5

講演・口頭発表等

 148