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  2. 柴田 知行

柴田 知行

シバタ トモユキ  (tomoyuki shibata)

基本情報

所属
藤田医科大学 医学部 医学科 消化器内科学I 教授
学位
博士(医学）
J-GLOBAL ID
201501015372049859
researchmap会員ID
7000012747

研究キーワード

 11

研究分野

 1

経歴

 3

学歴

 2

委員歴

 7
もっとみる

受賞

 1

論文

 289
  • Tomomitsu Tahara, Noriyuki Horiguchi, Hyuga Yamada, Tsuyoshi Terada, Dai Yoshida, Masaaki Okubo, Kohei Funasaka, Yoshihito Nakagawa, Tomoyuki Shibata, Naoki Ohmiya
    Journal of gastrointestinal and liver diseases : JGLD 33(2) 164-169 2024年6月29日  
    BACKGROUND AND AIMS: Early gastric cancers (EGCs) after Helicobacter pylori (H. pylori) eradication often appear as reddish depressed lesions (RDLs); the same features are also appeared in benign stomachs after eradication. We compared clinic-pathological and endoscopic features of benign and neoplastic RDLs after H. pylori eradication. METHODS: 228 neoplastic RDLs after H. pylori eradication were studied. All lesions were divided into neoplastic RDLs (differentiated carcinoma or adenoma, n=114) and benign RDLs (n=114) according to the histology. Clinical and pathological characteristics were compared in neoplastic and benign groups. Endoscopic diagnostic yields using the white light (WL) endoscopy, chromoendoscopy (CE) using indigo carmine dye and the magnifying endoscopy with narrow-band imaging (ME-NBI) were also evaluated in relation to the pathological diagnosis. RESULTS: Size of neoplastic RDLs was larger than that of benign RDLs (p<0.01). Sensitivity, specificity and accuracy for predicting pathological types of RDLs was 70.1%, 52.6% and 61.4% for the WL, 65.8%, 63.1% and 65.4% for the CE, while the ME-NBI scored better with the 88.6%, 88.6%, 99.1% and 93.9% of sensitivity, specificity and accuracy. The accuracy of the ME-NBI was 99.9% (113/114) in the benign RDLs and 89.4% (101/114) for the neoplastic RDLs. Undiagnosed neoplastic RDLs using the ME-NBI were associated with more differentiated tumors such as adenoma and well-differentiated adenocarcinoma (tub1) and the presence of an unclear demarcation line. CONCLUSIONS: ME-NBI is useful to diagnose RDLs after H. pylori eradiation, while some of neoplastic lesions are difficult to diagnose using the ME-NBI.
  • 高原 頌子, 舩坂 好平, 小山 恵司, 山田 日向, 堀口 徳之, 柴田 知行, 長坂 光夫, 葛谷 貞二, 宮原 良二, 廣岡 芳樹
    日本消化器病学会東海支部例会プログラム抄録集 140回 52-52 2024年6月  
  • 村島 健太郎, 平山 裕, 中川 義仁, 長坂 光夫, 鎌野 俊彰, 舩坂 好平, 宮原 良二, 柴田 知行, 川部 直人, 大野 栄三郎, 葛谷 貞二, 廣岡 芳樹
    日本消化器がん検診学会雑誌 62(Suppl総会) 349-349 2024年5月  
  • 河村 岳史, 堀口 徳之, 萩原 聖也, 小山 恵司, 山田 日向, 舩坂 好平, 長坂 光夫, 大野 栄三郎, 葛谷 貞二, 宮原 良二, 柴田 知行, 廣岡 芳樹
    日本消化器がん検診学会雑誌 62(Suppl総会) 357-357 2024年5月  
  • 村島 健太郎, 平山 裕, 中川 義仁, 長坂 光夫, 鎌野 俊彰, 舩坂 好平, 宮原 良二, 柴田 知行, 川部 直人, 大野 栄三郎, 葛谷 貞二, 廣岡 芳樹
    日本消化器がん検診学会雑誌 62(Suppl総会) 349-349 2024年5月  
もっとみる

MISC

 384
  • 大久保 正明, 柴田 知行, 田原 智満, 吉田 大, 河村 知彦, 堀口 徳之, 石塚 隆充, 大森 崇史, 城代 康貴, 生野 浩和, 宮田 雅弘, 小村 成臣, 中野 尚子, 鎌野 俊彰, 長坂 光夫, 中川 義仁, 大宮 直木, 平田 一郎
    Gastroenterological Endoscopy 57(Suppl.1) 759-759 2015年4月  
  • 堀口 徳之, 田原 智満, 吉田 大, 河村 知彦, 大久保 正明, 石塚 隆充, 柴田 知行, 平田 一郎
    Gastroenterological Endoscopy 57(Suppl.1) 836-836 2015年4月  
  • 大森 崇史, 柴田 知行, 平田 一郎
    日本消化器病学会雑誌 112(臨増総会) A512-A512 2015年3月  
  • 田原 智満, 長坂 光夫, 中川 義仁, 柴田 知行, 大宮 直木, 平田 一郎
    日本内科学会雑誌 104(Suppl.) 197-197 2015年2月  
  • 大宮 直木, 堀口 徳之, 大森 崇史, 城代 康貴, 生野 浩和, 小村 成臣, 宮田 雅弘, 中野 尚子, 鎌野 俊彰, 田原 智満, 長坂 光夫, 中川 義仁, 柴田 知行, 平田 一郎
    消化と吸収 37(1) 39-39 2014年10月  
  • 柴田 知行
    消化器内科 59(4) 309-313 2014年10月  
  • Kazuya Sumi, Tomomitsu Tahara, Tomoyuki Shibata, Tomohiko Kawamura, Masaaki Okubo, Takamitsu Ishizuka, Masakatsu Nakamura, Tomiyasu Arisawa, Ichiro Hirata
    DIGESTIVE DISEASES AND SCIENCES 59(9) 2017-2017 2014年9月  
  • 角 一弥, 柴田 知行, 田原 智満, 吉田 大, 河村 知彦, 大久保 正明, 石塚 隆充, 高川 友花, 中川 義仁, 鎌野 俊彰, 中野 尚子, 小村 成臣, 宮田 雅弘, 生野 浩和, 城代 康貴, 大森 崇史, 長坂 光夫, 大宮 直木, 平田 一郎
    Gastroenterological Endoscopy 56(Suppl.2) 3060-3060 2014年9月  
  • 石塚 隆充, 柴田 知行, 田原 智満, 大久保 正明, 角 一弥, 長坂 光夫, 中川 義仁, 鎌野 俊彰, 中野 尚子, 小村 成臣, 生野 浩和, 宮田 雅弘, 城代 康貴, 大森 崇史, 河村 知彦, 吉田 大, 大宮 直木, 平田 一郎
    Gastroenterological Endoscopy 56(Suppl.2) 3065-3065 2014年9月  
  • 河村 知彦, 柴田 知行, 大久保 正明, 田原 智満, 石塚 隆充, 市川 裕一朗, 角 一弥, 吉田 大, 大森 崇史, 城代 康貴, 宮田 雅弘, 生野 浩和, 小村 成臣, 中野 尚子, 鎌野 俊彰, 中川 義仁, 長坂 光夫, 大宮 直木, 中村 正克, 平田 一郎
    Gastroenterological Endoscopy 56(Suppl.2) 3076-3076 2014年9月  
  • 大久保 正明, 柴田 知行, 吉田 大, 河村 知彦, 大森 崇史, 城代 康貴, 角 一弥, 生野 浩和, 市川 裕一朗, 宮田 雅弘, 小村 成臣, 中野 尚子, 鎌野 俊彰, 石塚 隆充, 田原 智満, 中川 義仁, 長坂 光夫, 大宮 直木, 平田 一郎
    Gastroenterological Endoscopy 56(Suppl.2) 3121-3121 2014年9月  
  • Tahara T, Shibata T, Okubo M, Ishizuka T, Kawamura T, Yamashita H, Nakamura M, Nakagawa Y, Nagasaka M, Arisawa T, Ohmiya N, Hirata I
    Biomed Rep 2(4) 555-558 2014年7月  
    Previous studies have demonstrated the protective role of inducible heat-shock protein (HSP) 70 in intestinal cells. The HSP70-2 gene has a PstI site due to an A-G transition at the 1,267 position and different genotypes are associated with various levels of mRNA expression. The present study aimed to clarify the effect of the HSP70-2 polymorphism on the risk of ulcerative colitis (UC), including its clinical phenotypes. A total of 121 patients with UC and 500 healthy control (HC) subjects participated in the study. To assess the polymorphisms at the 1,267 position of the HSP70-2 gene, restriction fragment length polymorphism analysis was performed. The subjects in the study were classified by disease behavior, severity and extent of disease. Although no significant difference of the HSP70-2 genotype distribution was identified between the HC and UC groups, the BB genotype exhibited a lower risk of the steroid-dependent phenotype [odds ratio (OR), 0.12; 95% confidence interval (CI), 0.02-0.95; P=0.02]. The same genotype was also associated with a lower risk of the refractory phenotype (OR, 0.16; 95% CI, 0.04-0.73; P=0.01). There was no direct correlation between the polymorphism of the HSP70-2 gene and UC susceptibility. However, there was an association between a reduced risk of the steroid-dependent and refractory phenotypes of UC and the BB genotype.
  • Tahara T, Shibata T, Okubo M, Ishizuka T, Kawamura T, Yamashita H, Nakamura M, Nakagawa Y, Nagasaka M, Arisawa T, Ohmiya N, Hirata I
    Biomed Rep 2(4) 602-606 2014年7月  
    A complex interaction of genetic and environmental factors is closely associated with the development of inflammatory bowel disease. Previous studies reported that the expression of the regulated upon activation, normal T-cell expressed and secreted (RANTES) gene is enhanced in the colonic mucosa of ulcerative colitis (UC). Quantitative differences in RANTES gene expression among numerous promoter genotypes have also been reported. The aim of the present study was to clarify the effect of RANTES promoter polymorphism on the risk of UC, including its clinical phenotypes. A total of 150 UC patients and 372 healthy control (HC) subjects participated in the study. The UC patients were classified by disease behavior, severity and extent of disease. Restriction fragment length polymorphism analysis was performed for polymorphisms at -28 C/G in the RANTES gene promoter region. Although no significant difference of the RANTES promoter genotype distribution was observed between the HC and UC groups, the G/G genotype was significantly higher among female (OR=3.95, 95% CI=1.22-12.82, P=0.03), non-steroid dependent (OR=3.37, 95% CI=1.16-9.85, P=0.03) and non-refractory (OR=3.76, 95% CI=1.29-10.98, P=0.02) UC patients. The G carrier was also found to be associated with an increased risk of rectal colitis (OR=2.21, 95% CI=1.12-4.39, P=0.03). The data indicate that the polymorphism of the RANTES promoter is not directly associated with the susceptibility to UC, but the -28 G allele is associated with female UC patients and mild clinical phenotypes of UC, including non-steroid dependency, non-refractory and rectal colitis.
  • 藤田 浩史, 長坂 光夫, 鎌野 俊彰, 小村 成臣, 生野 浩和, 大橋 儒郁, 遠藤 茂夫, 柴田 知行, 小池 光正, 平田 一郎
    Intestine 18(4) 365-372 2014年7月  
    潰瘍性大腸炎(UC)は2008年に10万人を超え,年々増加傾向にある.このうち初回発作型UCが2割弱程度認められるが,一部にUCとの鑑別に難渋するカンピロバクター腸炎(CC)が含まれている可能性が示唆される.今回われわれは初発UCとカンピロバクター腸炎の臨床症状と内視鏡像を比較しその鑑別点について検討し,初発UCと誤診される可能性のあるカンピロバクター腸炎の特徴を検討した.頻回の下痢,発熱があり浅いバウヒン弁上の潰瘍のあるびまん性腸炎で直腸に浮腫が主体の症例はカンピロバクター腸炎を強く疑う必要があると考えられた.またバウヒン弁上に潰瘍を認めない全大腸にびまん性連続性に炎症を認める症例がUCと誤診される可能性があるカンピロバクター腸炎と考えられた.(著者抄録)
  • 安藤 洋介, 太田 秀基, 中西 亨, 岡田 達佳, 柴田 知行, 佐藤 誠二, 船橋 依理子, 加藤 久乃, 今泉 和良, 櫻井 一生, 内藤 健晴, 平田 一郎, 宇山 一朗, 河田 健司, 山田 成樹
    日本癌治療学会誌 49(3) 2313-2313 2014年6月  
  • Tomiyasu Arisawa, Tomoki Fukuyama, Tomomitsu Tahara, Kaho Yamada, Hideto Yamada, Tomoe Nomura, Ranji Hayashi, Kazuhiro Matsunaga, Natsuko Kawada, Toshimi Otsuka, Masakatsu Nakamura, Takeo Shimasaki, Nobuyuki Toshikuni, Hisakazu Shiroeda, Tomoyuki Shibata
    GASTROENTEROLOGY 146(5) S318-S318 2014年5月  
  • Tomomitsu Tahara, Masaaki Okubo, Tomoyuki Shibata, Kazuya Sumi, Takamitsu Ishizuka, Yuichiro Ichikawa, Tomohiko Kawamura, Masakatsu Nakamura, Mitsuo Nagasaka, Yoshihito Nakagawa, Naoki Ohmiya, Tomiyasu Arisawa, Ichiro Hirata
    GASTROENTEROLOGY 146(5) S332-S332 2014年5月  
  • Tomomitsu Tahara, Tomoyuki Shibata, Masaaki Okubo, Kazuya Sumi, Takamitsu Ishizuka, Yuichiro Ichikawa, Tomohiko Kawamura, Masakatsu Nakamura, Mitsuo Nagasaka, Yoshihito Nakagawa, Naoki Ohmiya, Tomiyasu Arisawa, Ichiro Hirata
    GASTROENTEROLOGY 146(5) S513-S513 2014年5月  
  • Tomiyasu Arisawa, Toshimi Otsuka, Tomomitsu Tahara, Kaho Yamada, Hideto Yamada, Tomoe Nomura, Ranji Hayashi, Kazuhiro Matsunaga, Natsuko Kawada, Tomoki Fukuyama, Masakatsu Nakamura, Takeo Shimasaki, Nobuyuki Toshikuni, Hisakazu Shiroeda, Tomoyuki Shibata
    GASTROENTEROLOGY 146(5) S514-S514 2014年5月  
  • Tomiyasu Arisawa, Hisakazu Shiroeda, Tomomitsu Tahara, Kaho Yamada, Hideto Yamada, Tomoe Nomura, Ranji Hayashi, Kazuhiro Matsunaga, Natsuko Kawada, Tomoki Fukuyama, Toshimi Otsuka, Masakatsu Nakamura, Nobuyuki Toshikuni, Hisakazu Shiroeda, Tomoyuki Shibata
    GASTROENTEROLOGY 146(5) S515-S515 2014年5月  
  • Tomomitsu Tahara, Tomoyuki Shibata, Masaaki Okubo, Kazuya Sumi, Takamitsu Ishizuka, Yuichiro Ichikawa, Tomohiko Kawamura, Masakatsu Nakamura, Mitsuo Nagasaka, Yoshihito Nakagawa, Naoki Ohmiya, Tomiyasu Arisawa, Ichiro Hirata
    GASTROENTEROLOGY 146(5) S853-S853 2014年5月  
  • Tomomitsu Tahara, Tomoyuki Shibata, Masaaki Okubo, Daisuke Yoshioka, Takamitsu Ishizuka, Kazuya Sumi, Tomohiko Kawamura, Mitsuo Nagasaka, Yoshihito Nakagawa, Masakatsu Nakamura, Tomiyasu Arisawa, Naoki Ohmiya, Ichiro Hirata
    Case Reports in Gastroenterology 8(2) 211-215 2014年4月16日  
    Plummer-Vinson syndrome (PVS) is a rare entity characterized by upper esophageal webs and iron deficiency anemia. We report a case of PVS whose esophageal web was rapidly improved by iron therapy. A 77-year-old woman was admitted to our hospital with complaints of dysphagia, vomiting, shortness of breath and weight loss for 1 month. Physical examination revealed conjunctival pallor, koilonychia, angular cheilitis and smooth tongue, and laboratory findings were consistent with microcytic hypochromic anemia with iron deficiency. Gastrointestinal endoscopy and barium-swallow esophagography detected a web that prevented passage of the endoscope into the upper portion of the esophagus. The patient received oral iron therapy daily the hemoglobin concentration rose to 8.9 g/dl and the complaints of dysphagia were dramatically improved after 2 weeks, with improvement of luminal stenosis confirmed by gastrointestinal endoscopy and barium-swallow esophagography. The PVS described in this report had a distinct clinical course, showing very rapid improvement of dysphagia and esophageal web after 2 weeks of oral iron therapy.
  • 中川 義仁, 大宮 直木, 平田 一郎, 長坂 光夫, 鎌野 俊彰, 中野 尚子, 小村 成臣, 生野 浩和, 大森 崇史, 城代 康貴, 柴田 知行, 田原 智満, 石塚 隆充, 大久保 正明, 市川 裕一朗, 宮田 雅弘, 角 一弥, 釜谷 明美, 河村 知彦, 吉田 大
    Gastroenterological Endoscopy 56(Suppl.1) 1121-1121 2014年4月  
  • 大森 崇史, 柴田 知行, 平田 一郎, 河村 知彦, 中井 遥, 吉田 大, 城代 康貴, 市川 裕一朗, 生野 浩和, 角 一弥, 小村 成臣, 大久保 正明, 鎌野 俊彰, 中野 尚子, 中川 義仁, 長坂 光夫, 大宮 直木
    Gastroenterological Endoscopy 56(Suppl.1) 1143-1143 2014年4月  
  • 柴田 知行, 吉田 大, 河村 知彦, 大森 崇史, 城代 康貴, 角 一弥, 生野 浩和, 市川 裕一朗, 大久保 正明, 小村 成臣, 宮田 雅弘, 中野 尚子, 鎌野 俊彰, 石塚 隆充, 田原 智満, 中川 義仁, 長坂 光夫, 大宮 直木, 中村 正克, 有沢 富康, 平田 一郎
    Gastroenterological Endoscopy 56(Suppl.1) 1287-1287 2014年4月  
  • 宮田 雅弘, 柴田 知行, 高川 友花, 吉田 大, 河村 知彦, 大森 崇史, 城代 康貴, 角 一弥, 市川 裕一朗, 生野 浩和, 小村 成臣, 大久保 正明, 中野 尚子, 鎌野 俊彰, 石塚 隆充, 田原 智満, 中川 義仁, 長坂 光夫, 大宮 直木, 平田 一郎
    Gastroenterological Endoscopy 56(Suppl.1) 1340-1340 2014年4月  
  • Masaaki Okubo, Tomomitsu Tahara, Tomoyuki Shibata, Joh Yonemura, Daisuke Yoshioka, Yoshio Kamiya, Masakatsu Nakamura, Tomiyasu Arisawa, Naoki Ohmiya, Ichiro Hirata
    HEPATO-GASTROENTEROLOGY 61(130) 525-528 2014年3月  
    Background/Aims: Combining the magnifying endoscopy and the narrow-band imaging (NBI) system is an endoscopic imaging technique for the enhanced visualization of mucosal microscopic structure and capillaries of the superficial mucosal layer. Light blue crest (LBC) and, ridge/villous pattern have been thought to be suggestive signs for gastric intestinal metaplasia (IM) of magnifying NBI endoscopy. Since the IM is related to gastric cancer risk (GC), the prevalence of LBC and ridge/villous pattern in the nonneoplastic gastric antrum was examined in relation to gastric cancer (GC) risk and serological severity of gastritis. Methodology: In 100 subjects including 13 GC patients, gastric mucosal pattern were examined using magnifying NBI. The mucosal patterns in the antrum were classified according to the presence of LBC or ridge/villous pattern. Serum pepsinogen (PG) levels were also examined. Results: The sensitivity and specificity for predicting IM was the best when LBC and ridge/villous patterns were combined (sensitivity 95.2%, specificity 98.7%). Both LBC and ridge/villous pattern showed lower serum PGI and PGI/II ratio than those without (P = 0.046, 0.0005, respectively.) In particular, PGI/II ratio was lowest in ridge/villous pattern. The LBC and ridge/villous pattern showed higher incidence of all GC and diffuse GC compared to those without (P = 0.002, 0.002, respectively). Conclusions: LBC and ridge/villous pattern in uninvolved gastric antrum by magnifying NBI endoscopy are useful signs for predicting gastric atrophy in the entire Stomach and GC risk.
  • 鎌野 俊彰, 平田 一郎, 大宮 直木, 中野 尚子, 長坂 光夫, 中川 義仁, 柴田 知行, 溝口 良順, 黒田 誠, 大林 光念, 安東 由喜雄
    胃と腸 49(3) 366-375 2014年3月  
    患者は60歳代,女性.全身倦怠感を主訴に来院し,鉄欠乏性貧血を認め入院となった.上部消化管内視鏡下の生検で,野生型トランスサイレチン(transthyretin;TTR)由来のアミロイド沈着を認め,老人性全身性アミロイドーシス(senile systemic amyloidosis;SSA)と診断した.内視鏡像では,十二指腸に多発するびらん・小潰瘍と粘膜と襞の腫脹・断裂を認めた.また,S状結腸にも不整形の多発する浅い小潰瘍を認めた.小腸X線造影検査では,十二指腸から上部空腸にかけて多発する小顆粒状または粘膜下腫瘍様の結節状の小隆起,Kerckring皺襞の腫大を認めた.十二指腸病変からの生検で,粘膜固有層から粘膜下層にかけてのアミロイド沈着がみられ,抗TTR抗体による免疫染色で陽性像を呈した.本症例でTTR遺伝子の解析を行ったが,変異を認めなかったことから,SSAと診断した.SSAで広範囲な消化管病変を呈することは珍しく,本稿では詳細を解説する.(著者抄録)
  • 鎌野 俊彰, 平田 一郎, 大宮 直木, 中野 尚子, 長坂 光夫, 中川 義仁, 柴田 知行, 黒田 誠
    胃と腸 49(3) 385-393 2014年3月  
    患者は62歳,女性.20歳時に関節リウマチ(RA)を発症しており,最近5年間は無治療で放置していた.慢性下痢,食欲不振,体重減少を主訴に来院した.消化管内視鏡検査で上行結腸から直腸に連続性,びまん性に浮腫状,発赤調,微細顆粒状を呈する粘膜と厚い白苔を有する多発性・大小不同の不整型潰瘍が認められた.また,十二指腸には微細顆粒状の粘膜と多発するびらんが認められた.生検にてアミロイド蛋白の沈着を認め,RAに合併したAAアミロイドーシスと診断した.抗IL-6受容体抗体(トシリズマブ)の投与により,臨床症状とともに,内視鏡・病理所見の改善が認められた.トシリズマブはRAに合併したAAアミロイドーシスの有効な治療法であると考えられた.(著者抄録)
  • 市川 裕一朗, 柴田 知行, 吉田 大, 河村 知彦, 大森 崇史, 城代 康貴, 角 一弥, 生野 浩和, 宮田 雅弘, 小村 成臣, 大久保 正明, 中野 尚子, 鎌野 俊彰, 石塚 隆充, 田原 智満, 中川 義仁, 長坂 光夫, 大宮 直木, 平田 一郎
    日本消化器病学会雑誌 111(臨増総会) A347-A347 2014年3月  
  • 塚本 徹哉, 桐山 諭和, 柴田 知行
    臨床消化器内科 29(3) 337-344 2014年2月  
    Helicobacter pylori(H.pylori)除菌前の胃粘膜の萎縮や腸上皮化生の程度は胃癌の予防効果に重要な要因である.H.pylori感染によって,ヒトでは表層腺窩上皮の過形成と増殖帯の拡大がみられ,スナネズミでは粘膜過形成と異所性増殖性腺管の増生が起こるが,除菌によってそれらは正常化する.一方,生検組織による除菌前後の固有腺の萎縮や腸上皮化生の定量的判定は困難であり,それが除菌の効果判定の障害となっている.疫学的にも動物実験的にも早期除菌によるある程度の胃発癌抑制効果が得られており,適切な除菌治療と的確な効果判定が今後ますます必要になってくると考えられる.(著者抄録)
  • 藤田 浩史, 長坂 光夫, 大森 崇史, 城代 康貴, 生野 浩和, 小村 成臣, 中野 尚子, 鎌野 俊彰, 田原 智満, 中川 義仁, 黒田 誠, 大橋 儒郁, 遠藤 茂夫, 小池 光正, 大宮 直木, 柴田 知行, 平田 一郎
    栄養-評価と治療 31(1) 76-77 2014年2月  
  • 吉田 大, 中野 尚子, 中川 義仁, 内堀 遥, 河村 知彦, 城代 康貴, 大森 崇史, 角 一弥, 市川 裕一朗, 生野 浩和, 宮田 雅弘, 大久保 正明, 小村 成臣, 鎌野 俊彰, 石塚 隆充, 田原 智満, 長坂 光夫, 大宮 直木, 柴田 知行, 平田 一郎
    栄養-評価と治療 31(1) 79-79 2014年2月  
  • Kazuhiro Matsunaga, Tomomitsu Tahara, Hisakazu Shiroeda, Toshimi Otsuka, Masakatsu Nakamura, Takeo Shimasaki, Nobuyuki Toshikuni, Natsuko Kawada, Tomoyuki Shibata, Tomiyasu Arisawa
    MOLECULAR MEDICINE REPORTS 9(1) 28-32 2014年1月  
    Toll-like receptor activation intitially recruits the myeloid differentiation primary response gene (88) (MyD88) protein. A polymorphism *1244 A&gt;G (rs7744) in the 3-untranslated region of MyD88 has been identified. In the present study, the association of this polymorphism with ulcerative colitis (UC) was investigated. The population studied comprised 922 individuals, including patients with UC (UC cases) and without (controls). Genotyping of rs7744 was performed by PCR single-strand conformation polymorphism and the rs7744 G allele frequencies in the controls and UC cases were 32.8 and 43.5%, respectively (P&lt;0.0001). The results showed that the genotype frequency of the AA homozygote was significantly lower and that of the GG homozygote was significantly higher in the UC cases compared with those in the controls (P=0.0012 for both groups). The rs7744 minor allele variants were significantly associated with susceptibility to UC as indicated by dominant and recessive genetic models. The minor allele variants were associated with an increased risk for UC in the male individuals but not the female individuals. The rs7744 was also associated with a non-continuous phenotype of UC and steroid unused/independent UC. This minor allele homozygote was associated with the disease severity of UC, hospitalization and response to steroid treatment. The results of the present study provided evidence that MyD88 polymorphism rs7744 was significantly associated with the development of UC and that this polymorphism may be associated with the response to treatment therapies for UC.
  • Masakatsu Nakamura, Hisakazu Shiroeda, Tomomitsu Tahara, Tomoyuki Shibata, Tomiyasu Arisawa
    ENDOSCOPY 46(1) E115-E116 2014年1月  
  • Masakatsu Nakamura, Hisakazu Shiroeda, Tomomitsu Tahara, Tomoyuki Shibata, Tomiyasu Arisawa
    ENDOSCOPY 46(1) E176-E177 2014年  
  • Tomiyasu Arisawa, Tomomitsu Tahara, Hisakazu Shiroeda, Kaho Yamada, Tomoe Nomura, Hideto Yamada, Ranji Hayashi, Kazuhiro Matsunaga, Toshimi Otsuka, Masakatsu Nakamura, Takeo Shimasaki, Nobuyuki Toshikuni, Natsuko Kawada, Tomoyuki Shibata
    ONCOLOGY REPORTS 30(6) 3013-3019 2013年12月  
    In the present study, we report an association between gastric cancer and polymorphisms in NFKB1 (rs28362941 and rs78696119). We employed the PCR-SSCP method to detect gene polymorphisms in 479 gastric cancer cases and 880 controls. The rs28362941 del/del homozygote was significantly associated with gastric cancer development; in particular it was closely associated with diffuse type gastric cancer. The rs78696119 GG homozygote was also associated with the diffuse type of gastric cancer. In young subjects, both polymorphisms were significantly associated with the development of gastric cancer. In addition, both polymorphisms were related to tumor progression such as tumor invasion and lymph node metastasis. The inflammatory cell infiltration into non-cancerous gastric mucosa was greater in the subjects with the rs28362491 del/del or rs78696119 GG genotype when compared to those with the other genotypes. In conclusion, functional polymorphisms of NFKB1 are associated with an increased risk of gastric cancer; in particular they are closely associated with the development of diffuse type of gastric cancer via severe gastric inflammation. These polymorphisms also appear to be associated with gastric cancer progression.
  • Masakatsu Nakamura, Hisakazu Shiroeda, Tomomitsu Tahara, Tomoyuki Shibata, Tomiyasu Arisawa
    ENDOSCOPY 45(2) E387-E388 2013年12月  
  • Ranji Hayashi, Tomomitsu Tahara, Hisakazu Shiroeda, Takashi Saito, Masakatsu Nakamura, Mikihiro Tsutsumi, Tomoyuki Shibata, Tomiyasu Arisawa
    Clinical and Experimental Medicine 13(4) 239-244 2013年11月  
    Interleukin-17A plays a role in tissue inflammation by inducing release of proinflammatory and neutrophil-mobilizing cytokines. We investigated the association between ulcerative colitis (UC) and polymorphisms of IL17A, rs2275913 (-197 G &gt A), and rs3748067 (*1249 C &gt T). The study was performed in 475 healthy subjects (controls) and 202 with UC (UC cases), including 113 controls and 64 UC cases from previous study. We employed the multiplex PCR-SSCP method to detect gene polymorphisms. The minor allele frequency of rs2275913 was significantly higher but that of rs3748067 was significantly lower in UC cases than controls. The rs2275913 minor homozygote (AA) had an increased risk of the development of UC, whereas rs3748067 minor carrier (CT + TT) had decreased risks for the development of UC. When compared with LR group (rs2275913 GG + GA with rs3748067 CT + TT), HR group (rs2275913 AA with rs3748067 CC) had a more increased risk of the development of UC (OR, 3.38 p = 0.0007). The polymorphisms of IL17A were associated with the noncontinuous and pancolitis phenotypes of UC. Our results suggest that IL17A polymorphisms (both rs2275913 and rs3748067) influence the susceptibility to and pathophysiological features of UC, coordinately. © 2012 Springer-Verlag.
  • Tomomitsu Tahara, Shinji Maegawa, Woonbok Chung, Judith Garriga, Jaroslav Jelinek, Marcos R. H. Estécio, Tomoyuki Shibata, Ichiro Hirata, Tomiyasu Arisawa, Jean-Pierre J. Issa
    Cancer Prevention Research 6(10) 1093-1100 2013年10月  
    Whole blood DNA methylation analysis has been proposed to be a risk marker for cancer that can be used to target patients for preventive interventions. To test this, we examined whole blood DNA methylation of 16 CpG island promoters and LINE1 repetitive element in patients with gastric cancer and control subjects. Bisulfite pyrosequencing was used to quantify the methylation of 14 CpG island promoters (MINT25, RORA, GDNF, CDH1, RARAB2, ER, CDH13, MYOD1, SFRP1, P2RX7, SLC16A12, IGF2, DPYS, and N33) and LINE1 from 72 patients with gastric cancer, 67 control, and 52 healthy young individuals. Quantitative methylation-specific real-time PCR was also conducted for 3 CpG island promoters (MINT25, MYO3A, and SOX11). Among all sites tested, only a marginal increase in the methylation of the SFRP1 promoter was observed in the blood of patients with gastric cancer when compared with the control group (11.3% vs 10.5% age-adjusted P value: P = 0.009), and this association was also seen in a validation set of 91 patients with gastric cancer (11.5% vs 10.5% age-adjusted P value: P = 0.001). The methylation of 9 sites (GDNF, CDH1, RARAB2, CDH13, MYOD1, SFRP1, SLC16A12, DPYS, N33, and LINE1) and their mean Z score was correlated with higher age (R = 0.41, P &lt 0.0001) and marginally with telomere shortening (R = -0.18, P = 0.01) but not with gastric cancer risk (other than SFRP1 methylation). Variability in whole blood DNA methylation of cancer markers is primarily associated with aging, reflecting turnover of white blood cells, and has no direct link to gastric cancer predisposition. SFRP1 methylation in whole blood may be associated with gastric cancer risk. ©2013 AACR.
  • Yuichiro Ichikawa, Tomomitsu Tahara, Tomoyuki Shibata, Masaaki Okubo, Takamitsu Ishizuka, Joe Yonemura, Tomohiko Kawamura, Mitsuo Nagasaka, Ichiro Hirata, Yoshihito Nakagawa, Toshiaki Kamano, Naoko Maruyama, Naruomi Komura, Hirokazu Ikuno, Haruka Nakai, Masashi Ooki, Yasutaka Jodai, Takashi Omori, Akemi Kamatani
    DIGESTIVE DISEASES AND SCIENCES 58(9) 2436-2436 2013年9月  
  • Tomomitsu Tahara, Tomoyuki Shibata, Tomiyasu Arisawa, Jean-Pierre J. Issa, Ichiro Hirata
    DIGESTIVE DISEASES AND SCIENCES 58(9) 2435-2435 2013年9月  
  • Akemi Kamatani, Yoshihito Nakagawa, Yukihiro Akao, Naoko Maruyama, Mitsuo Nagasaka, Tomoyuki Shibata, Tomomitsu Tahara, Ichiro Hirata
    Medical Molecular Morphology 46(3) 166-171 2013年9月  
    Accumulating data indicate that some microRNAs (miRNAs or miRs) can function as tumor suppressors or oncogenes and as such are important in cancer development. We previously reported that miR-143 and -145 are frequently downregulated in colon adenomas and cancers, acting as tumor suppressors. In this present study, we investigated the relationship between the downregulation of the miR-143/145 cluster and genetic aberrations of adenomatous polyposis coli (APC), which are early genetic events in the development of colorectal tumors. The expression levels of both miRs were determined by performing real-time PCR on tissue samples of familial adenomatous polyposis (FAP), colorectal adenoma, colorectal cancer, and paired non-tumorous tissues. Also, the expression of C- or N-terminus of the APC protein and that of the p53 protein in these tissues were examined immunohistochemically. Our data clearly indicated that the decreased expression of miR-143 and -145 frequently occurred before APC gene aberrations. The downregulation of miR-143 and -145 is thus an important genetic event for the initiation step in colorectal tumor development. © 2013 The Japanese Society for Clinical Molecular Morphology.
  • 大久保 正明, 柴田 知行, 田原 智満, 河村 知彦, 中井 遥, 大森 崇史, 城代 康貴, 生野 浩和, 市川 裕一朗, 小村 成臣, 米村 穣, 釜谷 明美, 丸山 尚子, 鎌野 俊彰, 石塚 隆充, 中川 義仁, 長坂 光夫, 中村 正克, 有沢 富康, 平田 一郎
    Gastroenterological Endoscopy 55(Suppl.2) 2760-2760 2013年9月  
  • 柴田 知行, 石塚 隆充, 米村 穣, 田原 智満, 大久保 正明, 市川 裕一朗, 平田 一郎
    Gastroenterological Endoscopy 55(Suppl.2) 2770-2770 2013年9月  
  • 柴田 知行, 石塚 隆充, 平田 一郎
    日本消化器病学会雑誌 110(臨増大会) A621-A621 2013年9月  
  • 田原 智満, 柴田 知行, 平田 一郎
    日本消化器病学会雑誌 110(臨増大会) A771-A771 2013年9月  
  • 田原 智満, 柴田 知行, 大久保 正明, 河村 知彦, 市川 裕一朗, 石塚 隆充, 長坂 光夫, 中川 義仁, 平田 一郎
    日本消化器病学会雑誌 110(臨増大会) A889-A889 2013年9月  
  • 田原 智満, 柴田 知行, 大久保 正明, 河村 知彦, 市川 裕一朗, 石塚 隆充, 長坂 光夫, 中川 義仁, 平田 一郎
    日本消化器病学会雑誌 110(臨増大会) A899-A899 2013年9月  
  • 田原 智満, 柴田 知行, 平田 一郎, 有沢 富康, Issa J.-P
    日本消化器病学会雑誌 110(臨増大会) A902-A902 2013年9月  

書籍等出版物

 1

講演・口頭発表等

 36
もっとみる

所属学協会

 7
もっとみる

共同研究・競争的資金等の研究課題

 1

教育内容・方法の工夫（授業評価等を含む）

 1
  • 件名
    動画を取り入れた学生講義
    開始年月日
    2009
    概要
    M3「症候別診療手順」講義で実際の診療動画を複数取り入れ変化を持たせた講義を行った。

作成した教科書、教材、参考書

 1
  • 件名
    救急診療マニュアル
    開始年月日
    2011
    概要
    消化器について分担執筆

教育方法・教育実践に関する発表、講演等

 1
  • 件名
    内視鏡学会東海地方会
    終了年月日
    2011/11
    概要
    新しい内視鏡トレーニングモデルの発表
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