研究者業績

宮田 雅弘

miyata masahiro

基本情報

所属
藤田保健衛生大学 医学部 医学科 消化管内科学 助教

J-GLOBAL ID
201501014980513553
researchmap会員ID
7000012757

MISC

 2
  • Tomomitsu Tahara, Tomoyuki Shibata, Tomohiko Kawamura, Masaaki Okubo, Yuichiro Ichikawa, Kazuya Sumi, Masahiro Miyata, Takamitsu Ishizuka, Masakatsu Nakamura, Mitsuo Nagasaka, Yoshihito Nakagawa, Naoki Ohmiya, Tomiyasu Arisawa, Ichiro Hirata
    DIGESTIVE DISEASES AND SCIENCES 60(1) 205-210 2015年1月  
    Background and Aims Fusobacterium species are part of the gut microbiome in humans, but some species have been recognized as opportunistic pathogens implicated in inflammatory diseases including inflammatory bowel diseases. Here, we performed prevalence screening of Fusobacterium in ulcerative colitis (UC) in Japanese patients. Methods We examined Fusobacterium nucleatum (F. nucleatum) and whole Fusobacterium species (Panfusobacterium) by quantitative real-time PCR in 163 inflamed mucosae from 152 UC patients. Data were correlated with clinical subtypes of UC. Results In an initial prevalence screen, F. nucleatum and Pan-fusobacterium were detected in 6.3 % (4/64) and 53.1 % (34/64). For all 163 mucosae, the prevalence of Pan-fusobacterium was 54.6 % (89/163). Pan-fusobacterium status was concordant in inflamed and normal adjacent samples, and the matched cases during 1-year followup colonoscopy. The higher amount of Pan-fusobacterium was observed in chronic continuous type compared to one attack and relapse/remitting type (p = 0.039). The higher amount of Pan-fusobacterium was also associated with rather mild clinical course of disease, such as non-steroid dependency (p = 0.015), non-refractory phenotype (p = 0.013), and non-severe phenotype (p = 0.04). Based on the distribution of Pan-fusobacterium measurable cases, we identified 10 cases as having a high amount of Panfusobacterium (FB-high). The clinicopathological features of FB-high UC cases were also highlighted by chronic continuous type and mild phenotypes of disease. Conclusion Whole Fusobacterium species, but not F. nucleatum, are common in UC patients and have a role in persistence of colonic inflammation in UC. However, Fusobacterium infection is associated with rather mild clinical phenotypes of UC.
  • 馬場 泰輔, 山口 竜三, 笹本 彰紀, 渡邊 真哉, 會津 恵司, 栗田 賢二, 宮田 雅弘, 渡辺 伸元, 籾田 葵, 野田 尚未, 金井 道夫, 片野 敬仁
    胆と膵(0388-9408) 32(7) 655-659 2011年7月  

講演・口頭発表等

 8