Curriculum Vitaes

kizawa madoka

  (木澤 真努香)

Profile Information

Affiliation
School of Medicine, Faculty of Medicine, Fujita Health University
Degree
博士(医学)

J-GLOBAL ID
201501003453240520
researchmap Member ID
7000012807

Misc.

 10
  • Seiko Hirota, Shinji Ito, Takao Fukui, Kenichiro Murate, Sayuri Shima, Madoka Kizawa, Akihiro Ueda, Kunihiko Asakura, Tatsuro Mutoh
    INTERNAL MEDICINE, 54(2) 215-218, 2015  Peer-reviewed
    A 74-year-old woman was hospitalized due to dysuria, weakness and dysesthesia of the lower extremities. She was in an immunosuppressed state following the administration of methylprednisolone therapy for idiopathic interstitial pneumonia. Cerebrospinal fluid and blood cultures were negative, and no infectious biomarkers were found. A gadolinium (Gd)-enhanced T1-weighted image of magnetic resonance imaging (MRI) revealed disseminated nodular lesions along the spinal cord. We suspected a diagnosis of seronegative deep mycosis and initiated anti-fungal therapy with voriconazole, which subsequently alleviated all of the patient's symptoms and MRI findings. Therefore, the presence of Gd-enhanced disseminated nodules on spinal MRI may be a good marker of deep meningeal mycosis.
  • Naoki Kawamura, Madoka Kizawa, Akihiro Ueda, Yoshiki Niimi, Tatsuro Mutoh
    FUTURE VIROLOGY, 7(9) 901-909, Sep, 2012  Peer-reviewed
    Viral encephalitis is still a life-threatening disease occurring at any age. It is critical to make a rapid and correct diagnosis for a better outcome of the disease. Accumulating evidence has suggested that MRI is a powerful tool for the detection of any lesion of the CNS caused by viral infections and helps to initiate the timely treatment. In this review, we summarize the current understanding of MRI findings of viral encephalitis, especially related to HSV, HIV, varicella zoster, Japanese encephalitis, John Cunningham, and influenza viruses. With these considerations, we learnt that the inclusion of diffusion-weighted image sequences on routine MRI examination would have a significant value in detecting the pathologic changes that occur following viral invasion of the CNS.
  • 植田晃広, 上田真努香, 三原貴照, 伊藤信二, 朝倉邦彦, 武藤多津郎
    臨床神経学, 51(4) 243-247, 2011  Peer-reviewed
  • Madoka Kizawa-Ued, Akihiro Ueda, Naoki Kawamura, Tomomasa Ishikawa, Eri Mutoh, Yu Fukuda, Ryouichi Shiroki, Kiyotaka Hoshinaga, Shinji Ito, Kunihiko Asakura, Tatsuro Mutoh
    EUROPEAN NEUROLOGY, 65(3) 138-143, 2011  Peer-reviewed
    Background: The data on cerebrospinal fluid (CSF) levels of neurotrophins (NTs) in patients with meningoencephalitis are scarce, especially in adult patients. Methods: We measured CSF levels of NTs such as nerve growth factor (NGF), brain-derived neurotrophic factor, and neurotrophin-3 (NT-3) in adult patients with various meningitis (n = 10) and encephalitis (n = 10) in both acute phase and recovery phase and adult control subjects (n = 21) by the enzyme-linked immunosorbent assay for NTs. Results: Data show that NGF and NT-3 CSF levels were markedly elevated in the patient group in the acute phase compared with non-neurological controls (p < 0.001 and p < 0.05, respectively) and later returned to the levels of controls. Most intriguingly, we only recognized a significant correlation between NGF and NT-3 CSF levels in the patients in the acute phase. Conclusion: Such strong correlation of NGF and NT-3 CSF levels strongly suggests that in adult patients, some common regulatory mechanism(s) might be present among various kinds of NTs to cope with central nervous system infection. Copyright (C) 2011 S. Karger AG, Basel
  • Akihiro Ueda, Sayuri Shima, Tadayuki Miyashita, Shinji Ito, Masami Ueda, Susumu Kusunoki, Kunihiko Asakura, Tatsuro Mutoh
    MOLECULAR AND CELLULAR NEUROSCIENCE, 45(4) 355-362, Dec, 2010  Peer-reviewed
    Previous studies have shown that patients with the axonal form of Guillain-Barre syndrome (CBS) develop autoantibodies against GM1 ganglioside (GM1) Nerve growth factor (NGF) is essential for neuronal survival in vivo and its functional receptor is Trk-tyrosine kinase Here we examined the biological effects of sera from patients with the axonal form of GBS on the morphology and the phosphorylation state of Trk-tyrosine kinase in PC12 cells Furthermore we examined the effect of the sera on the integrity of membrane lipid rafts biochemically The data show that anti GM1 antibodies found in patients sera but not control sera inhibit NGF-induced Trk autophosphorylation Most intriguingly the autoantibodies alter the distribution of Trk in lipid rafts without shifting the distribution of a rafts marker protein These data strongly suggest that anti GM1 antibodies directly influence the integrity of the signaling platform lipid rafts implicating the importance of lipid rafts in the development of this disorder (C) 2010 Elsevier Inc All rights reserved

Presentations

 35