医学部
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  2. ueda akihiro

ueda akihiro

  (植田 晃広)

Profile Information

Affiliation
Associate Professor, Department of Internal Medicine, Neurology, Fujita Health University Okazaki Medical Center
Degree
博士(医学）(藤田保健衛生大学)
J-GLOBAL ID
201501008162133427
researchmap Member ID
7000012808

Research Areas

 1

Papers

 144
  • Sayuri Shima, Yasuaki Mizutani, Junichiro Yoshimoto, Yasuhiro Maeda, Reiko Ohdake, Ryunosuke Nagao, Toshiki Maeda, Atsuhiro Higashi, Akihiro Ueda, Mizuki Ito, Tatsuro Mutoh, Hirohisa Watanabe
    NPJ Parkinson's disease, 10(1) 170-170, Sep 9, 2024  
    The relationship between reduced serum uric acid (UA) levels and Parkinson's disease (PD), particularly purine metabolic pathways, is not fully understood. Our study compared serum and cerebrospinal fluid (CSF) levels of inosine, hypoxanthine, xanthine, and UA in PD patients and healthy controls. We analyzed 132 samples (serum, 45 PD, and 29 age- and sex-matched healthy controls; CSF, 39 PD, and 19 age- and sex-matched healthy controls) using liquid chromatography-tandem mass spectrometry. Results showed significantly lower serum and CSF UA levels in PD patients than in controls (p < 0.0001; effect size r = 0.5007 in serum, p = 0.0046; r = 0.3720 in CSF). Decreased serum hypoxanthine levels were observed (p = 0.0002; r = 0.4338) in PD patients compared to controls with decreased CSF inosine and hypoxanthine levels (p < 0.0001, r = 0.5396: p = 0.0276, r = 0.2893). A general linear model analysis indicated that the reduced UA levels were mainly due to external factors such as sex and weight in serum and age and weight in CSF unrelated to the purine metabolic pathway. Our findings highlight that decreased UA levels in PD are influenced by factors beyond purine metabolism, including external factors such as sex, weight, and age, emphasizing the need for further research into the underlying mechanisms and potential therapeutic approaches.
  • Mao Asakura, Yasuaki Mizutani, Sayuri Shima, Yoshiki Kawamura, Akihiro Ueda, Mizuki Ito, Tatsuro Mutoh, Tetsushi Yoshikawa, Hirohisa Watanabe
    Journal of medical virology, 96(8) e29850, Aug, 2024  
    Herpes simplex encephalitis (HSE) is an acute form of encephalitis that can lead to poor neurological outcomes. Although the exact pathogenesis of HSE remains elusive, recent reports suggest a significant role for postinfectious immune-inflammatory processes in the central nervous system (CNS). This study aimed to clarify the association between CNS autoimmune responses and clinical presentation in patients with HSE, focusing on cerebrospinal fluid (CSF) characteristics, particularly the IgG index. We retrospectively analyzed 176 consecutive patients suspected of having aseptic meningitis /encephalitis for chronological changes in CSF findings and clinical presentations. These patients underwent PCR screening for herpesviruses (HV) in their CSF. We identified seven patients positive for herpes simplex virus type 1 (HSV-1), 20 patients positive for varicella-zoster virus, and 17 patients who met the criteria for aseptic meningitis but were PCR-negative for HV. Patients in the HSV-1-positive group exhibited a significant increase in the IgG index at the time of PCR-negative conversion compared with on admission (p = 0.0156), while such a change was not observed in the other two groups. Additionally, all patients in the HSV-1-positive group tested negative for anti-neural autoantibodies in CSF and serum samples collected approximately 3 weeks after onset. This study, therefore, highlights that CSF IgG index elevation occurs even after PCR-confirmed HSV-1 clearance, which might indicate immunopathogenesis that is independent of antibody-mediated mechanisms.
  • 東 篤宏, 大嶽 れい子, 前田 康博, 長尾 龍之介, 前田 利樹, 島 さゆり, 水谷 泰彰, 植田 晃広, 伊藤 瑞規, 渡辺 宏久
    パーキンソン病・運動障害疾患コングレスプログラム・抄録集, 18回 73-73, Jul, 2024  
  • 前田 利樹, Zhu Xi-Chen, 水谷 泰彰, 東 篤宏, 長尾 龍之介, 廣田 政古, 島 さゆり, 植田 晃広, 伊藤 瑞規, 伊藤 信二, 武藤 多津郎, 渡辺 宏久
    パーキンソン病・運動障害疾患コングレスプログラム・抄録集, 18回 85-85, Jul, 2024  
  • 水谷 泰彰, 大嶽 れい子, 東 篤宏, 前田 利樹, 長尾 龍之介, 島 さゆり, 植田 晃広, 伊藤 瑞規, 伊藤 信二, 武藤 多津郎, 渡辺 宏久
    パーキンソン病・運動障害疾患コングレスプログラム・抄録集, 18回 86-86, Jul, 2024  
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Misc.

 27
  • Hirohisa Watanabe, Sayuri Shima, Yasuaki Mizutani, Akihiro Ueda, Mizuki Ito
    Brain and nerve = Shinkei kenkyu no shinpo, 74(7) 879-884, Jul, 2022  
    A group of patients with coronavirus disease 2019 (COVID-19) exhibited various persistent or new systemic symptoms, including psychiatric symptoms, sleep disturbances, exercise intolerance, arthralgia, headache, cognitive decline, brain fog, and autonomic symptoms, all of which persisted long after the resolution of infectious symptoms. Several imaging studies have shown that long COVID cases present with decreased glucose metabolism and progressive brain atrophy. Although no single pathological hypothesis thoroughly explains the varied clinical presentations and timings, the following have attracted attention: 1) persistent viral infection, 2) persistent inflammation, 3) involvement of the autoimmune system, and 4) mitochondrial dysfunction. In all these hypotheses, inflammatory cytokines may be involved in orthostatic dysregulation by decreasing the expression and activity of ACE2, consequently changing the blood pressure through vagus nerve hyperactivation. Myopathy and peripheral neuropathy may also be caused by direct infection of the muscles and nerves, hypoxia, mitochondrial damage, and cytokine storm. Furthermore, multiple theories regarding the mechanisms by which systemic inflammatory findings affect the central nervous system have been postulated, including neuroinflammation caused by inflammatory cells crossing the blood-brain barrier via choroid plexus cells and the involvement of various autoantibodies. Despite these findings, no definitive consensus has been reached due to the complexity and diversity of COVID-19 pathophysiology. Thus, it is essential to understand the neurological symptoms and pathophysiology involved in long COVID.
  • 渡辺 宏久, 大嶽 れい子, 水谷 泰彰, 島 さゆり, 伊藤 瑞規, 植田 晃広, 桝田 道人
    画像診断, 42(2) 145-155, Jan 25, 2022  
    ＜文献概要＞TDP-43は主に核内に存在し,RNAの生合成をはじめ様々なプロセスに関与する.TDP-43の核内局在の喪失と異常な翻訳後修飾を受けた不溶化TDP-43の存在を特徴とする一群は,TDP-43proteinopathyと呼ばれ,筋萎縮性側索硬化症と前頭側頭葉変性症が代表的な疾患である.
  • 伊藤 瑞規, 水谷 泰彰, 植田 晃広, 渡辺 宏久
    難病と在宅ケア, 27(10) 51-55, Jan, 2022  
  • 渡辺 宏久, 大嶽 れい子, 水谷 泰彰, 島 さゆり, 伊藤 瑞規, 植田 晃広
    画像診断, 41(14) 1470-1481, Nov 25, 2021  
    ＜文献概要＞認知症の診断は,適切な病歴聴取,神経学的診察,高次脳機能評価,脳画像を評価することで行われる.最近は,血液や髄液のバイオマーカー開発も目覚ましい.脳画像を解釈する上で,認知症の臨床像の特徴,診断基準,臨床病型の多様性,高次脳機能検査結果の解釈方法などを整理することは有益である.
  • 坂野 文彦, 水谷 泰彰, 前田 利樹, 長尾 龍之介, 島 さゆり, 伊藤 瑞規, 植田 晃広, 村山 和宏, 外山 宏, 渡辺 宏久
    パーキンソン病・運動障害疾患コングレスプログラム・抄録集, 15回 76-76, Jul, 2021  
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Presentations

 164
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Research Projects

 4
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