研究者業績

河田 健司

kawada kenji

基本情報

所属
藤田医科大学 医学部 医学科 臨床腫瘍科 教授
学位
医学博士

J-GLOBAL ID
201501011257698120
researchmap会員ID
7000012828

MISC

 11
  • Megumi Inada-Inoue, Yuichi Ando, Kenji Kawada, Ayako Mitsuma, Masataka Sawaki, Taro Yokoyama, Yu Sunakawa, Hiroo Ishida, Kazuhiro Araki, Keishi Yamashita, Keiko Mizuno, Fumio Nagashima, Akiko Takekura, Kazuo Nagamatsu, Yasutsuna Sasaki
    CANCER CHEMOTHERAPY AND PHARMACOLOGY 73(4) 673-683 2014年4月  
    Purpose A phase 1 study of pazopanib alone or in combination with lapatinib was conducted to assess the safety, tolerability, and pharmacokinetics of these oral tyrosine kinase inhibitors in Japanese patients with solid tumors. Methods In part A (monotherapy), 7 patients initially received pazopanib 800 mg/day, the recommended dose for non-Japanese patients. Then, 3 patients received pazopanib 400 mg/day on day 1 followed by 800 mg/day from day 2 onward. Three other patients received pazopanib 1,000 mg/day. In part B (combination therapy), 17 patients received pazopanib plus lapatinib (pazopanib/lapatinib) at once-daily doses of 400/1,000 mg (4 patients), 800/1,000 mg (3 patients), 400/1,500 mg (3 patients), and then 600/1,250 mg (7 patients). Results T here was no dose-limiting toxicity during the study. In part A, most drug-related adverse events were grade 2 or lower, including neutropenia/neutrophil count decreased, thrombocytopenia/platelet count decreased, diarrhea, hypertension, aspartate aminotransferase increased, and lipase increased. In part B, rash, decreased appetite, and serum thyroid-stimulating hormone increased also occurred. In all dose groups, the plasma concentrations after multiple doses of pazopanib exceeded the target trough concentration for inhibition of vascular endothelial growth factor receptor-2 activity (20 mu g/mL). Conclusions T he pharmacokinetic profiles of pazopanib and lapatinib in Japanese patients were not apparently different from those reported in non-Japanese patients. There were no consistent trends in pharmacokinetic drug interactions between pazopanib and lapatinib. Pazopanib monotherapy at 800 and 1,000 mg once daily and pazopanib plus lapatinib once daily at any doses studied were well tolerated in Japanese patients.
  • Toru Murata, Masahiro Fujii, Kazuhisa Akahane, Koji Oda, Toshihiro Ohama, Yasushi Yatabe, Kenji Kawada
    NAGOYA JOURNAL OF MEDICAL SCIENCE 76(1-2) 173-180 2014年2月  
    We report a case of primary small cell carcinoma (SCC) of the breast in a 59-year-old female. To the best of our knowledge, there are only 44 cases of this disease reported in the English literature. The patient also had regional nodal metastases, but no distant metastases. She underwent neoadjuvant chemotherapy according to a regimen of pulmonary SCC, and combination of cisplatin and etoposide (CDDP+VP16). The tumor partially responded to neoadjuvant chemotherapy. The treatment was followed by modified radical mastectomy and adjuvant chemotherapy, i.e., EC therapy (epirubicin and cyclophosphamide). She was also administered in total 50 Gy of radiation treatment to the chest wall. At this writing, the patient has evidenced no recurrence 36 months after her diagnosis.
  • 船橋依理子, 加藤久乃, 河田健司, 櫻井一生
    JOHNS(耳鼻咽喉科・頭頸部外科) 30 1003-1006 2014年  
  • K. Kitagawa, K. Kawada, S. Morita, M. Inada, A. Mitsuma, M. Sawaki, S. Iino, Y. Inden, T. Murohara, T. Imai, Y. Ando
    ANNALS OF ONCOLOGY 23(3) 743-747 2012年3月  
    Background: Corrected QT (QTc) interval prolongation can induce fatal arrhythmias such as torsade de pointes. Patients and methods: To assess the characteristics of QTc intervals and arrhythmias in women with early breast cancer who received FEC100 adjuvant chemotherapy, electrocardiograms (ECGs) were recorded before and after each chemotherapy. Associations between QTc interval prolongation and single nucleotide polymorphisms (SNPs) of potassium channel genes were also investigated. Results: A total of 131 ECG records were obtained in 34 patients who received 153 cycles of FEC100. QTc intervals could be measured in 127 records. There was a significant trend toward QTc interval prolongation after each treatment, persisting through four cycles of chemotherapy (P < 0.001). Median QTc interval prolongations were 13, 11, 18, and 14 ms in the first through fourth cycles of chemotherapy, respectively. QTc intervals differed significantly between cycles 1 and 4 before treatment as well as after treatment (P < 0.05). A single supraventricular premature contraction was noted in 3 (2.3%) of the 131 cycles in 2 (5.9%) of the 34 patients. There was no significant association between QTc interval prolongation and SNPs of potassium channel genes. Conclusion: This prospective study confirmed that FEC100 is associated with significant QTc interval prolongation in women with early breast cancer.
  • Yuichi Ando, Kenji Kawada, Megumi Inada, Sachi Morita, Ayako Mitsuma, Yoshinari Yasuda, Mariko Hiramatsu, Yasushi Fujimoto, Ken-ichi Fujita
    ONCOLOGY 83(1) 38-44 2012年  
    Objective: This pharmacokinetic study of S-1 was conducted in patients in whom glomerular filtration rate (GFR) was directly measured to explore the possibility of adjusting the S-1 dose on the basis of GFR in patients with normal or nearly normal renal function. Methods: S-1 was given to 12 patients twice daily for 28 consecutive days followed by 14 days of rest, repeated every 6 weeks. GFR was measured on the basis of inulin clearance (CLin) before the first day of treatment. Results: The area under the time-concentration curve (AUC) of 5-fluorouracil (5-FU) correlated with that of 5-chloro-2,4-dihydroxypyridine (CDHP, r = 0.750, p = 0.005). The AUC of CDHP correlated with the measured 24-hour creatinine clearance (CLcr) per subject (r = -0.620, p = 0.032), but not with the CLin (r = -0.356, p = 0.257). The AUC of 5-FU did not correlate with either the 24-hour CLcr per subject (r = -0.401, p = 0.187) or with the CLin (r = -0.300, p = 0.351). Conclusion: Dosage adjustment based on the GFR does not reduce individual variations in 5-FU concentrations among patients with normal or nearly normal renal function who receive S-1. Copyright (C) 2012 S. Karger AG, Basel

書籍等出版物

 4

講演・口頭発表等

 8

作成した教科書、教材、参考書

 1
  • 件名
    抗悪性腫瘍薬コンサルトブック
    概要
    分担執筆 ; 41-43ページ, 110-114ページ, 115-118ページ, 編者 南博信, 医学書院, 2010年

その他教育活動上特記すべき事項

 2
  • 件名
    東海がんプロ講師
    概要
    2012年度,2014年度
  • 件名
    愛知県立看護大学看護実践センター認定看護師教育課程講師
    概要
    2010年度〜2014年度