研究者業績
基本情報
研究分野
1論文
61-
International archives of allergy and immunology 1-6 2023年10月18日BACKGROUND: Allergen-specific immunotherapy (AIT), an established treatment for allergic diseases, prevents the development of other allergic manifestations. Although the mechanisms remain unclear, AIT has been shown to reduce basophil activation (BA) against nontarget allergens. OBJECTIVES: The aim of this study was to assess immunological changes in Dermatophagoides farinae (Der f) after Japanese cedar pollen (JCP)-based subcutaneous immunotherapy (SCIT) monotherapy. METHOD: The data of 16 patients (age: 6-37 years) with JCP-induced allergic rhinitis who were sensitive to Der f (serum Der f-specific immunoglobulin E [IgE] level >0.34 kUA/L) and received JCP-based SCIT for 5 years were reviewed retrospectively. BA by Der f and JCP extracts and serum-specific IgE and immunoglobulin G4 (IgG4) levels against these allergens were evaluated before and after completing 5 years of JCP-based SCIT monotherapy. RESULTS: The areas under the dose-response curves of BA by Der f and JCP extracts were significantly reduced (p = 0.02 and p = 0.002, respectively). JCP-specific IgE levels decreased and JCP-specific IgG4 levels increased significantly (p < 0.001 for both), whereas Der f-specific IgE and IgG4 levels did not change significantly. CONCLUSIONS: JCP-based SCIT monotherapy reduced Der f-specific BA. These findings suggest that JCP-based SCIT has the potential to modulate immune response toward nontarget allergens.
MISC
216-
Visual Dermatology 21(1) 50-52 2021年12月
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食物アレルギー研究会会誌 21(2) 101-102 2021年9月
書籍等出版物
1講演・口頭発表等
8-
67th American Academy of Allergy Asthma and Immunology 2011年
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Asia Pacific Association of Pediatric Allergy, Respirology & Immunology 2011年
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66th American Academy of Allergy Asthma and Immunology 2010年
共同研究・競争的資金等の研究課題
2-
日本学術振興会 科学研究費助成事業 2020年4月 - 2025年3月
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日本学術振興会 科学研究費助成事業 2021年4月 - 2024年3月