医学部 小児外科学
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  2. 渡邉 俊介

渡邉 俊介

watanabe shunsuke

基本情報

所属
藤田医科大学 医学部 医学科 小児外科学 講師
学位
博士（医学）(藤田医科大学)
J-GLOBAL ID
201501009281932970
researchmap会員ID
7000012895

研究キーワード

 3

研究分野

 1

経歴

 1

主要な論文

 94
  • 渡邉 俊介, 土屋 智寛, 近藤 靖浩, 直江 篤樹, 宇賀 菜緒子, 安井 稔博, 原 普二夫, 鈴木 達也
    日本小児血液・がん学会雑誌 57(1) 24-27 2020年  査読有り筆頭著者
    我々は稀な肝未分化肉腫を2例経験したので報告する.症例1は11歳女児.発熱,腹痛で発症し,CTで肝右葉に巨大腫瘍,PET-CTでは腫瘍辺縁に強く集積を認めた.血液検査所見ではLDHとCA125が高値を示し,生検にて肝未分化肉腫と診断した.VAC療法(ビンクリスチン,アクチノマイシンD,シクロフォスファミド)(5クール)後に腫瘍核出術を施行した.術後VAC療法(8クール)を行い治療終了後5年2ヶ月経過し再発なく生存中である.症例2は12歳男児.右上腹部膨隆と腹痛で発症し,CTで肝右葉に腫瘍,PET-CTで腫瘍辺縁に集積を認めた.血液検査所見ではLDHとCA125が高値を示し,肝未分化肉腫と術前診断し右3区域切除術を行った.摘出腫瘍は肝未分化肉腫の病理診断であった.術後VAC療法(5クール)行い治療終了後1年4ヶ月経過し無病生存中である.年長児で特異的腫瘍マーカーの上昇が伴わない肝腫瘍においては,本疾患を想起することが肝要である.(著者抄録)
  • Shunsuke Watanabe, Yasuhiro Kondo, Atuki Naoe, Toshihiro Yasui, Tatsuya Suzuki, Fujio Ha-ra, Naoko Uga, Masafumi Miyata, Hiroko Boda
    J Neonatal Perinatal Med, 11 379-385 2018年  査読有り筆頭著者
  • Shunsuke Watanabe, Tatsuya Suzuki, Yasuhiro Kondo, Atuki Naoe, Naoko Uga, Toshihiro Yasui, Fujio Hara, Masafumi Miyata, Hiroko Boda, Tetsushi Yoshikawa
    Journal of Neonatal Surgery 7(2) 2018年  査読有り筆頭著者
  • Shunsuke Watanabe, Fujio Hara, Yasuhiro Kondo, Tatsuya Suzuki, Toshihiro Yasui, Naoko Uga, Atuki Naoe
    Journal of Tumor Research & Reports 3(1) 2018年  査読有り筆頭著者
  • Shunsuke Watanabe, Tatuya Suzuki, Fujio Hara, Toshihiro Yasui, Naoko Uga, Atuki Naoe
    PEDIATRIC SURGERY INTERNATIONAL 33(6) 713-719 2017年6月  査読有り
    Purpose Neuroblastoma is a refractory pediatric malignant solid tumor. The previous studies demonstrated that Polyphyllin D, the main constituent of Paris polyphylla, a traditional Chinese medicine, exerts an anti-tumor effect on many tumors. However, its effects against neuroblastomas are unclear. Methods We examined the anti-tumor effect of polyphyllin D in human neuroblastoma using IMR-32 and LA-N-2 cells, which exhibit MYCN gene amplification, and NB-69 cells, which do not exhibit MYCN gene amplification. Results All cell lines showed reduced cell viability in response to polyphyllin D treatment. No caspase-3/-7, -8, and -9 activity was observed in IMR-32 and LA-N-2 cells treated with polyphyllin D. In contrast, activation of caspase-3/-7, and -8 activity was observed in NB-69 cells. When polyphyllin D and specific inhibitors of RIPK3 involved in necroptosis were added to IMR-32 and LA-N-2 cell lines, polyphyllin D-induced cell death was inhibited. Conclusion Together, this indicates that the underlying mechanism of polyphyllin D-induced cell death in NB-69 cells is apoptosis, whereas the cell death of IMR-32 and LA-N-2 cells occurs by necroptosis. We continue research on this topic and look forward the discovery of a new therapeutic agent for neuroblastoma.
  • Shunsuke Watanabe, Tatuya Suzuki, Fujio Hara, Toshihiro Yasui, Naoko Uga, Atuki Naoe
    Journal of Pediatric Surgery Case Reports 17 42-45 2017年2月1日  査読有り
    We experienced the case of an eight-month-old male with intralobar pulmonary sequestration complicated by gastric duplication. The chief complaint was an abnormal shadow on the chest radiograph the patient was diagnosed with pulmonary sequestration via chest computed tomography (CT). Intraoperative findings and postoperative histopathological examination revealed intralobar pulmonary sequestration with associated gastric duplication. Pulmonary sequestration is relatively rare although there are reports of extralobar pulmonary sequestration with gastric duplication, the present case of intralobar pulmonary sequestration with gastric duplication is extremely rare. This case is considered to be an embryologic bronchopulmonary foregut malformation, and is considered important in understanding the aetiology.
  • Shunsuke Watanabe, Tatuya Suzuki, Fujio Hara, Toshihiro Yasui, Naoko Uga, Atuki Naoe
    Journal of Neonatal Surgery 6(2) 2017年  査読有り筆頭著者
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主要なMISC

 6
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講演・口頭発表等

 9
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担当経験のある科目(授業)

 2

所属学協会

 7
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共同研究・競争的資金等の研究課題

 2
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