研究者業績
基本情報
- 所属
- 藤田医科大学 医学部 医学科 脳神経外科学 講師
- 学位
- 医学博士(藤田医科大学)Master of Science(San Diego State University)
- J-GLOBAL ID
- 201501021123484677
- researchmap会員ID
- 7000012929
研究分野
1経歴
11-
2023年5月 - 現在
-
2023年4月 - 2023年5月
-
2019年8月 - 2023年4月
-
2018年12月 - 2019年7月
受賞
2論文
35-
Scientific reports 15(1) 1750-1750 2025年1月11日Karnofsky Performance Status (KPS) is a widely used scale to assess performance status. KPS ≥ 50% implies that patients can live at home. Therefore, maintaining KPS ≥ 50% is important to improve the quality of life of patients with glioblastoma, whose median survival is less than 2 years. This study aimed to identify the factors associated with survival time with maintenance of KPS ≥ 50% (survival with KPS ≥ 50%) in patients with glioblastoma, IDH-wildtype. Ninety-eight patients with glioblastomas, IDH-wildtype, who were treated with concomitant radiotherapy (RT) and temozolomide (TMZ) followed by maintenance TMZ therapy, and whose KPS at the start of RT was ≥ 50%, were included. The median survival with KPS ≥ 50% was 13.3 months. In univariate analysis, preoperative KPS (≥ 80%), KPS at the start of RT (≥ 80%), residual tumor size (< 2 cm3), methylated MGMT promotor, and implantation of BCNU wafer were associated with survival with KPS ≥ 50%. In multivariate analysis, KPS at the start of RT (≥ 80%), methylated MGMT promotor, and residual tumor size (< 2 cm3) were significantly associated with increased survival with KPS ≥ 50%. A strategy of maximum possible tumor resection without compromising KPS is desirable to prolong the survival time with KPS ≥ 50%.
-
Brain Sciences 13(3) 482-482 2023年3月13日 査読有り筆頭著者責任著者Fence-post catheter techniques are used to use tumor margins when resecting gliomas. In the present study, deep electrodes instead of catheters were used as fence-posts. The case of a 25-year-old female patient whose magnetic resonance images (MRI) revealed a tumor in the left cingulate gyrus is presented in this study. She underwent daily seizures without loss of consciousness under the administration of anti-seizure medications. Despite video electroencephalography (EEG) monitoring, the scalp inter-ictal EEG did not show obvious epileptiform discharges. We were consequently uncertain whether such frequent seizures were epileptic seizures or not. As a result, deep electrodes were used as fence-posts: three deep electrodes were inserted into the tumor’s anterior, lateral, and posterior margins using a navigation-guided method. The highest epileptic discharge was detected from the anterior deep electrode. As a result, ahead of the tumor was extendedly resected, and epileptic discharges were eliminated using EEG. The postoperative MRI revealed that the tumor was resected. The patient has never experienced seizures after the surgery. In conclusion, when supratentorial gliomas complicated by frequent seizures are resected, intraoperative EEG monitoring using deep electrodes as fence-posts is useful for estimating epileptogenic areas.
-
Brain Sciences 13(3) 396-396 2023年2月25日 査読有り筆頭著者責任著者Vagus nerve stimulation (VNS) is an effective surgical option for intractable epilepsy. Although the surgical procedure is not so complicated, vagus nerve detection is sometimes difficult due to its anatomical variations, which may lead to surgical manipulation-associated complications. Thus, this study aimed to visualize the vagus nerve location preoperatively by fused images of three-dimensional computed tomography angiography (3D-CTA) and magnetic resonance imaging (MRI). This technique was applied to two cases. The neck 3D-CTA and MRI were performed, and the fused images were generated using the software. The vagus nerve and its anatomical relationship with the internal jugular vein (IJV) and common carotid artery were clearly visualized. The authors predicted that the vagus nerve was detected by laterally pulling the IJV according to the images. Intraoperatively, the vagus nerve was located as the authors predicted. The time of the surgery until the vagus nerve detection was <60 min in both cases. This novel radiological technique for visualizing the vagus nerve is effective to quickly detect the vagus nerve, which has anatomical variations, during the VNS.
-
Cancers 15(3) 952-952 2023年2月2日Distinguishing primary central nervous system lymphoma (PCNSL) from glioblastoma, isocitrate dehydrogenase (IDH)-wildtype is sometimes hard. Because the role of operation on them varies, accurate preoperative diagnosis is crucial. In this study, we evaluated whether a specific kind of chemical exchange saturation transfer imaging, i.e., amide proton transfer-weighted (APTw) imaging, was useful to distinguish PCNSL from glioblastoma, IDH-wildtype. A total of 14 PCNSL and 27 glioblastoma, IDH-wildtype cases were evaluated. There was no significant difference in the mean APTw signal values between the two groups. However, the percentile values from the 1st percentile to the 20th percentile APTw signals and the width1–100 APTw signals significantly differed. The highest area under the curve was 0.796, which was obtained from the width1–100 APTw signal values. The sensitivity and specificity values were 64.3% and 88.9%, respectively. APTw imaging was useful to distinguish PCNSL from glioblastoma, IDH-wildtype. To avoid unnecessary aggressive surgical resection, APTw imaging is recommended for cases in which PCNSL is one of the differential diagnoses.
講演・口頭発表等
79-
Hoi Thao Khua Hoc Nhung Tien Bo Tong Chan Doan Va Dieu Tri Dong Kinh, Ho Chi Minh City 2025年6月9日 招待有り
-
the 4th ACNS Interim meeting,Dhaka 2025年5月5日 招待有り
-
Meeting at National Institute for Neurosciences, Dhaka 2025年5月4日 招待有り
-
Two-day practical training of the use of the orbeye 4k3D exoscope in neurosurgery (Ukraine, online) 2025年4月10日 招待有り
-
The 8th Fujita Bantane Winter Seminar 2025年2月9日 招待有り
-
The 23th Vietnam Neurosurgery Conference Lunch Symposium 2024年12月7日 招待有り
-
The 23th Vietnam Neurosurgery Conference 2024年12月7日 招待有り
-
Viet Duc University Hospital conference 2024年7月2日 招待有り
-
2nd ACNS-BSNS Hybrid Conference 2024年5月2日 招待有り
-
6th ACNS - Bosnia and Herzegovina Web Seminar 2024年1月13日 招待有り
-
The ACNS Red River Bootcamp, Hanoi 2023年12月9日 招待有り
共同研究・競争的資金等の研究課題
4-
日本学術振興会 科学研究費助成事業 2020年4月 - 2023年3月
-
科学研究費助成事業 若手研究 2021年4月 - 2023年3月
-
科学研究費助成事業 若手研究B 2016年4月 - 2018年3月
-
第28回公益財団法人市原国際奨学財団研究助成