murashima tomoaki

A few studies about laryngeal symptoms and sleep disorder in perennial allergic rhinitis patients have been demonstrated. In this paper, we investigated about postnasal drip, cough, foreign body sensation of the larynx (FBSL) and sleep disorder including the efficacy of bepotastine besilate in perennial allergic rhinitis patients. In 28 perennial allergic rhinitis patients visited Fujita Health University Hospital and the associated facilities, peroral ingestion of bepotasitine besilate were given for 4 weeks. The scores of the paroxysmal sneeze, nasal discharge, nasal obstruction, cough and nasal findings were significantly improved 2 weeks and 4 weeks after bepotastine besilate ingestion. FBSL was significantly improved 4 weeks later. The findings of postnasal drip and arytenoidal edema showed the tendency to be diminished but not significant. There were no significant relationships between postnasal drip and cough or FBSL, while cough and FBSL had a significant relationship. According to this study, cough and FBSL in perennial allergic rhinitis patients were similar to the indulgent diagnostic criteria of perennial laryngeal allergy proposed in 2005. Sleep disorder was significantly improved 4 weeks after bepotastine besilate ingestion.<br>