研究者業績

栗山 直英

kuriyama naohide

基本情報

所属
藤田医科大学 医学部 医学科 麻酔・侵襲制御医学 助教
学位
学士(医学)

J-GLOBAL ID
201501005949783241
researchmap会員ID
7000012992

MISC

 17
  • 栗山 直英, 西田 修
    ICU・CCU看護の超重要ポイント マスターブック 177-180 2013年  
  • 西田 修, 湯本美穂, 森山和広, 加藤由布, 下村泰代, 中村智之, 栗山直英, 原 嘉孝, 伊藤 舞, 野田昌宏, 秋山正慶, 早川聖子, 小松聖史, 山田晋吾, 宮庄 拓
    日本アフェレイシス学会雑誌 31(2) 148-15 2012年  
  • 山下千鶴, 西田 修, 伊藤 舞, 中村智之, 栗山直英, 原 嘉孝, 柴田純平, 下村泰代, 安岡なつみ, 河田耕太郎, 内山壮太, 栃井都紀子, 湯本美穂, 山田晋吾, 宮庄 拓
    エンドトキシン血症救命治療研究会誌. 16(1) 172-177 2012年  
  • Miho Yumoto, Osamu Nishida, Kazuhiro Moriyama, Yasuyo Shimomura, Tomoyuki Nakamura, Naohide Kuriyama, Yoshitaka Hara, Shingo Yamada
    THERAPEUTIC APHERESIS AND DIALYSIS 15(4) 385-393 2011年8月  
    The high mobility group box 1 protein (HMGB1) is an alarmin that plays an important role in sepsis and has been recognized as a promising target with a wide therapeutic window; however, no drugs and devices are currently in practical use. We hypothesized that hemofilters composed of porous membranes or cytokine-adsorbing membranes could remove HMGB1 from the blood. We performed experimental hemofiltration in vitro using four types of hemofilters composed of different membranes specifically designed for continuous hemofiltration. The test solution was a 1000-mL substitution fluid containing 100 mu g of HMGB1 and 35 g of bovine serum albumin. Experimental hemofiltration was conducted for 360 min in a closed loop circulation system. Among the four membranes, surface-treated polyacrylonitrile (AN69ST) showed the highest capacity to adsorb HMGB1; it adsorbed nearly 100 mu g of HMGB1 in the initial 60 min and showed a markedly high clearance rate (60.8 +/- 5.0 mL/min) at 15 min. The polymethylmethacrylate membrane had half of the adsorption capacity of the AN69ST membrane. Although the highest sieving coefficient for HMGB1 was obtained with the high cut-off polyarylethersulfone membrane, which correlated with a constant filtrate clearance rate, albumin loss was observed. However, no such removal of both HMGB1 and albumin was observed with the polysulfone membrane and tubing. We conclude that continuous hemofiltration using the AN69ST membrane is a promising approach for HMGB1-related sepsis.

書籍等出版物

 14

講演・口頭発表等

 166

その他教育活動上特記すべき事項

 1
  • 件名
    第43回参加型臨床実習における病棟での具体的な指導方法
    終了年月日
    2012/08/04