Faculty of Medical Technology

雪竹 潤

yukitake jun

基本情報

所属
藤田医科大学 医療科学部 臨床検査学科 臨床病態解析学 准教授
学位
博士(医学)

J-GLOBAL ID
201501003877566000
researchmap会員ID
7000013017

論文

 3
  • Jun Yukitake
    Int J Anal Bio-Sci 4(1) 1-5 2015年11月  査読有り
  • Kan Shimpo, Takeshi Chihara, Takaaki Kaneko, Hidehiko Beppu, Kazumasa Wakamatsu, Masanori Shinzato, Jun Yukitake, Shigeru Sonoda
    ASIAN PACIFIC JOURNAL OF CANCER PREVENTION 15(14) 5587-5592 2014年  査読有り
    Aloe-emodin (AE), a natural anthraquinone compound, has been reported to exhibit anticancer activity in various cancer cell lines and anti-inflammatory effects in murine macrophages. In the present study, we investigated the cancer chemopreventive effects of AE in an Apc-deficient Min mouse model. In the first experiment, male Min mice were fed a basal diet or diets containing 5 ppm AE and 10 ppm AE for 12 weeks. The dietary administration of 5 ppm AE significantly reduced the number of colorectal tumors. In a second experiment, we investigated the effects of AE on colitis-related colon carcinogenesis in Min mouse treated with dextran sodium sulfate (DSS). Female Min mice were administered 1% DSS in their drinking water for 7 days. AE was given to mice in their diet at a dose of 5 or 50 ppm for 5 weeks. Feeding with AE significantly reduced the number of colorectal tumors. When proliferation of cells in normal-appearing colonic mucosa was assessed by monoclonal anti-rat Ki-67 antibody (MIB-5) immunohistochemistry in experiments 1 and 2, the AE treatment significantly decreased the mean MIB-5-labeling index. These results suggest that the dietary administration of low-dose AE may have chemopreventive effects against development of colorectal tumors in Min mice, possibly in part by reducing cell proliferation in colorectal mucosa.

MISC

 1

書籍等出版物

 1
  • 東隆親, 磯部光章, 井上茂樹, 岡村和彦, 小野川傑, 小幡文弥, 窪田哲朗, 小松博義, 笹原武志, 佐藤孝三郎, 中川武正, 畑中道代, 藤田禎三, 松下祥, 森尾友宏, 山本恵申, 雪竹潤, 浅川英男, 大戸斉, 烏山一, 宮坂信之, 山田俊幸
    講談社サイエンティフィク 2009年

講演・口頭発表等

 5

作成した教科書、教材、参考書

 3
  • 件名
    医学領域における臨床検査学入門第2版
    終了年月日
    2009/07/24
  • 件名
    臨床免疫学実習書
    終了年月日
    2010/05/25
  • 件名
    医学領域における臨床検査学入門第3版
    終了年月日
    2013/07/25