研究者業績

井上 孝

inoue takashi

基本情報

所属
藤田保健衛生大学 医療科学部 臨床検査学科 予防医療情報解析学 教授
学位
博士(医学)

J-GLOBAL ID
201501004232684269
researchmap会員ID
7000013018

論文

 3
  • 井上孝
    Fujita Medical Journal 2(1) 1-5 2016年1月  査読有り
    Objectives: Circulating micro (mi)RNA profiles are influenced by various medical conditions, and miRNAs have been examined as potential biomarkers for cancer, cardiovascular disease, and diabetes. However, few studieshave investigated whether circulating miRNAs and cigarette smoking are correlated. Our aim was to determine theassociation between smoking status and expression of various miRNAs in a Japanese population sample.Methods: We conducted a cross-sectional analysis of 526 subjects (219 men and 307 women) aged 39 years and older who had undergone a health examination at a clinic in Yakumo, Hokkaido in August 2012. We used quantitative real-time polymerase chain reaction to determine serum miRNA expression. We then calculated the odds ratios for elevated serum miRNA levels according to smoking status using never-smokers as the reference group.Results: Expression of lethal (let)-7d, miRNA(miR)-150, miR-192, miR-197 and miR320 was significantly higher in current smokers than in never-smokers. Multivariate logistic regression analyses showed that while current smokers were significantly more likely to have elevated serum levels of miRNA let-7d, miR-21, miR-122, miR-146, miR-150, miR-192, miR-197, and miR320 than never-smokers, former smokers had significantly higher odds of having elevated miR-1, miR-146, miR-150, miR-195, and miR-320 levels in their sera.Conclusions: We found that cigarette smoking is associated with elevated expression of various serum miRNAs. Our results suggest that it is necessary to consider the confounding effect caused by smoking when evaluating expression of serum miRNAs for diagnosing pathological conditions.
  • Rika Watarai, Koji Suzuki, Naohiro Ichino, Keisuke Osakabe, Keiko Sugimoto, Hiroya Yamada, Takeshi Hamajima, Nobuyuki Hamajima, Takashi Inoue
    JOURNAL OF EPIDEMIOLOGY 24(3) 250-257 2014年5月  査読有り
    Background: Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of endothelium nitric oxide synthase (NOS). ADMA binds to a substrate-binding site of NOS and then inhibits nitric oxide production from vascular endothelial cells. Elevated ADMA levels are a risk factor for cardiovascular disease. Recently, it was reported that plasma ADMA levels were negatively correlated with vegetable and fruit consumption. The purpose of this study was to examine the association between serum levels of carotenoids and serum ADMA levels in Japanese subjects. Methods: We conducted a cross-sectional study of 470 subjects (203 men and 267 women) who attended a health examination in August 2011. Serum levels of several carotenoids were separately measured by high-performance liquid chromatography. Serum ADMA levels were determined by using an enzyme-linked immunosorbent assay kit. Results: In women, the multivariate-adjusted odds ratios (ORs) of elevated serum ADMA levels were significantly decreased in the highest tertile for beta-cryptoxanthin (OR 0.47, 95% CI 0.23-0.95), alpha-carotene (OR 0.39, 95% CI 0.18-0.79), and beta-carotene (OR 0.36, 95% CI 0.17-0.73) compared to the lowest tertile. In men, significantly decreased ORs were observed in the highest tertiles of serum zeaxanthin/lutein (OR 0.23, 95% CI 0.06-0.69) and acarotene (OR 0.26, 95% CI 0.07-0.82), and in the middle and the highest tertiles of serum beta-carotene (OR 0.27, 95% CI 0.09-0.74 and OR 0.20, 95% CI 0.03-0.88, respectively) when the tertile cutoff points of women were extrapolated to men. Conclusions: Higher serum levels of carotenoids, such as alpha-carotene and beta- carotene, may help to prevent elevated serum ADMA levels in Japanese subjects.

MISC

 94
  • Inoue T, Suzuki K, Hamajima T, Watarai R, Kimura A, Ichino N, Kusuhara Y, Osakabe K, Sugimoto K, Yamada H, Hamajima N
    Int. J. Anal.Bio-Sci. 2(2) 72-76 2014年5月  査読有り
  • Rika Watarai, Koji Suzuki, Naohiro Ichino, Keisuke Osakabe, Keiko Sugimoto, Hiroya Yamada, Takeshi Hamajima, Nobuyuki Hamajima, Takashi Inoue
    JOURNAL OF EPIDEMIOLOGY 24(3) 250-257 2014年5月  査読有り
    Background: Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of endothelium nitric oxide synthase (NOS). ADMA binds to a substrate-binding site of NOS and then inhibits nitric oxide production from vascular endothelial cells. Elevated ADMA levels are a risk factor for cardiovascular disease. Recently, it was reported that plasma ADMA levels were negatively correlated with vegetable and fruit consumption. The purpose of this study was to examine the association between serum levels of carotenoids and serum ADMA levels in Japanese subjects. Methods: We conducted a cross-sectional study of 470 subjects (203 men and 267 women) who attended a health examination in August 2011. Serum levels of several carotenoids were separately measured by high-performance liquid chromatography. Serum ADMA levels were determined by using an enzyme-linked immunosorbent assay kit. Results: In women, the multivariate-adjusted odds ratios (ORs) of elevated serum ADMA levels were significantly decreased in the highest tertile for beta-cryptoxanthin (OR 0.47, 95% CI 0.23-0.95), alpha-carotene (OR 0.39, 95% CI 0.18-0.79), and beta-carotene (OR 0.36, 95% CI 0.17-0.73) compared to the lowest tertile. In men, significantly decreased ORs were observed in the highest tertiles of serum zeaxanthin/lutein (OR 0.23, 95% CI 0.06-0.69) and acarotene (OR 0.26, 95% CI 0.07-0.82), and in the middle and the highest tertiles of serum beta-carotene (OR 0.27, 95% CI 0.09-0.74 and OR 0.20, 95% CI 0.03-0.88, respectively) when the tertile cutoff points of women were extrapolated to men. Conclusions: Higher serum levels of carotenoids, such as alpha-carotene and beta- carotene, may help to prevent elevated serum ADMA levels in Japanese subjects.
  • 伊藤哲也, 岸野恵理子, 別府秀彦, 井上 孝, 川井薫, 鈴木康司, 小塚諭, 足立俊雄, 新里俊子, 土井直子, 三國克彦, 新保寛, 多田伸
    応用糖質科学 4(1) 39-48 2014年2月  査読有り
  • Hiroya Yamada, Koji Suzuki, Naohiro Ichino, Yoshitaka Ando, Akira Sawada, Keisuke Osakabe, Keiko Sugimoto, Koji Ohashi, Ryouji Teradaira, Takashi Inoue, Nobuyuki Hamajima, Shuji Hashimoto
    Clinica Chimica Acta 424 99-103 2013年9月3日  査読有り
    Background: In many industrialized countries, non-alcoholic fatty liver disease (NAFLD) is recognized as an important disease that increases the risk of cardiovascular disease, type-2 diabetes, and metabolic syndrome. Most people with NAFLD are asymptomatic, and the disease is discovered incidentally during clinical laboratory tests. Present screening methods for NAFLD use ultrasound, and CT scans that are time-consuming, and a simple screening method for NAFLD is needed. In this study, we investigated whether serum miRNAs are associated with NAFLD and assessed the potential of serum miRNAs as a biomarker for NAFLD. Methods: We assessed intrahepatic fat by ultrasound scan, and the serum levels of five miRNAs (miR-21, miR-34a, miR-122, miR-145, and miR-451), which help regulate cholesterol and fatty acid homeostasis in liver tissue, by real-time PCR in a cross-sectional sample of 403 participants who attended health examinations. Results: Serum levels of miRNAs, miR-21, miR-34a, miR-122, and miR-451 were higher in participants with NAFLD. The serum level of miR-122 was correlated with the severity of liver steatosis. Conclusion: Serum levels of miRNAs, particularly miR-122, may be a useful biomarker for NAFLD. © 2013 Elsevier B.V.
  • Koji Suzuki, Hisashi Honjo, Naohiro Ichino, Keisuke Osakabe, Keiko Sugimoto, Hiroya Yamada, Yasuhiro Kusuhara, Rika Watarai, Takeshi Hamajima, Nobuyuki Hamajima, Takashi Inoue
    Journal of Epidemiology 23(6) 451-456 2013年8月31日  査読有り
    Background: Albuminuria is a risk factor for not only nephropathy progression but also cardiovascular disease. Oxidative stress may have a role in the positive association between albuminuria and cardiovascular disease. Methods: This cross-sectional study investigated the associations of serum levels of carotenoids, which are dietary antioxidants, with albuminuria among 501 Japanese adults (198 men, mean age ± SD: 66.4 ± 10.0 years 303 women, mean age ± SD: 65.4 ± 9.8 years) who attended a health examination. Serum levels of carotenoids were determined by high-performance liquid chromatography. Logistic regression analysis was used to estimate odds ratios (ORs) with 95% CIs for albuminuria after adjustment for age, body mass index, smoking habits, drinking habits, hypertension, diabetes mellitus, and dyslipidemia. Results: Prevalence of albuminuria was 15.4% among men and 18.1% among women. Among women with albuminuria, geometric mean serum levels of canthaxanthin, lycopene, ß-carotene, total carotenes, and provitamin A were significantly lower than those of normoalbuminuric women. Adjusted ORs for albuminuria among women in the highest tertiles of serum ß-carotene (OR, 0.45 95% CI, 0.20-0.98) and provitamin A (OR, 0.45 95% CI, 0.20-0.97) were significantly lower as compared with those for women in the lowest tertile. There were no associations between serum carotenoids and albuminuria in men. Conclusions: An increased level of serum provitamin A, especially serum ß-carotene, was independently associated with lower risk of albuminuria among Japanese women. © 2013 Koji Suzuki et al.
  • Koji Suzuki, Junichi Ishii, Fumihiko Kitagawa, Atsuhiro Kuno, Yasuhiro Kusuhara, Junichi Ochiai, Naohiro Ichino, Keisuke Osakabe, Keiko Sugimoto, Hiroya Yamada, Yoshinori Ito, Nobuyuki Hamajima, Takashi Inoue
    Journal of Epidemiology 23(3) 163-168 2013年  査読有り
    Background: Several epidemiologic studies have reported an inverse association between serum levels of carotenoids and cardiovascular disease risk. However, no studies have reported an association between serum carotenoids and N-terminal pro-brain-type natriuretic peptide (NT-proBNP) in the general population. Methods: In this cross-sectional study,we investigated whether serum carotenoids were associated with serum NTproBNP in 1056 Japanese subjects (390 men, 666 women) who attended a health examination. Serum levels of carotenoids were separately determined by high-performance liquid chromatography. Serum NT-proBNP level was measured by electrochemiluminescence immunoassay. Results: Serum NT-proBNP was elevated (≥55 pg/ml) in 31.8% of men and 48.2% of women. Multivariate logistic regression analyses adjusted for confounding factors showed a significant association between the highest quartile of serum a-carotene and elevated NT-proBNP in men (odds ratio [OR]= 0.40, 95% CI = 0.19-0.82, P for trend = 0.005) and women (OR = 0.62, 95% CI = 0.39-0.99, P for trend = 0.047). In women, moreover, elevated serum NTproBNP was significantly associated with serum canthaxanthin (OR = 0.57, 95% CI = 0.36-0.90 for highest quartile, P for trend = 0.026) and ß-cryptoxanthin (OR = 0.53, 95% CI = 0.32-0.85 for highest quartile, P for trend = 0.026), after adjusting for potential confounders. Conclusions: Higher levels of serum carotenoids were associated with lower risk of elevated serum NT-proBNP levels after adjusting for possible confounders, which suggests that a diet rich in carotenoids could help prevent cardiac overload in the Japanese population. © 2013 Japan Epidemiological Association.
  • Naohiro Ichino, Keisuke Osakabe, Keiko Sugimoto, Akira Yokoi, Takashi Inoue, Koji Suzuki, Yasuhiro Kusuhara, Nobuyuki Hamajima, Hiroji Takai, Tadayoshi Hata
    JOURNAL OF MEDICAL ULTRASONICS 39(1) 3-9 2012年1月  査読有り
    Assessment of plaque formation in the common carotid artery (CCA) is important for stratification of the risk of subsequent stroke. The stiffness parameter beta, which can be assessed using an ultrasonic phase-locked echo-tracking system, was developed to evaluate arterial stiffness. The purpose this study was to examine the relationship of the stiffness parameter beta to intima-media thickness (IMT) and plaque formation. The stiffness parameter beta and mean IMT were measured using an ultrasonic phase-locked echo-tracking system and an automatic IMT measurement system, respectively, and the presence of plaque was assessed by ultrasonography in 347 subjects who took part in a health check-up program for community-dwelling people in Hokkaido. Values of the stiffness parameter beta were significantly higher in subjects with plaque formation than in those without plaque (10.60 +/- A 0.45 vs. 8.88 +/- A 0.23, P < 0.005) in whom IMT was not thickened; however, it was not different in subjects with increased IMT (> 1.0 mm). The percentage of plaque formation was significantly correlated with the value of the stiffness parameter beta. Furthermore, the stiffness parameter beta was significantly correlated with plaque formation after adjustment for several clinical variables (odds ratio 1.113-1.178, P < 0.001). The stiffness parameter beta is associated with plaque formation in the CCA, especially in subjects with a normal IMT. This could potentially be used as a predictor for plaque formation.
  • 井上 孝
    暮らしの百科9月号 2011年9月  
  • Koji Suzuki, Yoshinori Ito, Takashi Inoue, Nobuyuki Hamajima
    CLINICAL NUTRITION 30(3) 369-375 2011年6月  査読有り
    Background & aims: Several epidemiological studies have shown that circulating antioxidant levels are inversely associated with metabolic syndrome status. The purpose of this study was to examine the association of serum carotenoid levels, which have potent antioxidant effects, with metabolic syndrome and metabolic syndrome components in Japanese subjects. Methods: We conducted a cross-sectional study of 931 subjects (318 men and 613 women), aged 39-70 years, who attended a health examination. Metabolic syndrome was defined according to the diagnostic definition from the Japanese Examination Committee of Criteria for Metabolic Syndrome, which was released in 2005. Serum carotenoids were measured by high-performance liquid chromatography. Results: A significantly lower odds ratio (OR) for metabolic syndrome was observed in the highest tertile of serum beta-cryptoxanthin (OR:0.45; 95% CI:0.22-0.93 in men and 0.41; 0.17-0.93 in women) and beta-carotene (OR:0.45; 95% CI:0.21-0.95 in men and 0.37; 0.15-0.83 in women) compared to the lowest tertiles, in both sexes, but no significant association was found in male smokers. In women, moreover, OR for metabolic syndrome in the highest tertile of serum zeaxanthin/lutein (OR:0.37; 95% CI:0.16-0.84) was significantly lower than in the lowest tertile. Serum levels of beta-cryptoxanthin, alpha-carotene, and beta-carotene were significantly decreased with an increasing number of metabolic syndrome components in both sexes. Conclusions: These findings indicate that carotenoids may be important factors in the prevention of metabolic syndrome in nonsmokers, but further studies are required in smokers. (C) 2010 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
  • Koji Suzuki, Takashi Inoue, Shuji Hashimoto, Junichi Ochiai, Yasuhiro Kusuhara, Yoshinori Ito, Nobuyuki Hamajima
    CLINICA CHIMICA ACTA 411(17-18) 1330-1334 2010年9月  査読有り
    Background: Several studies have reported that serum concentrations of carotenoids and adiponectin are inversely associated with the risk for cardiovascular disease (CVD). However, no studies have investigated the association between serum concentrations of adiponectin and carotenoids in the general population. Methods: We investigated cross-sectionally whether serum carotenoids are associated with serum high molecular weight (HMW) adiponectin and some inflammatory markers in 437 Japanese subjects (116 men and 321 women) who attended a health examination. Results: In multiple linear regression analysis adjusted for confounding factors, serum beta-carotene concentrations were significantly associated with serum HMW adiponectin concentrations in both sexes (standardized beta coefficient = 0.197, p = 0.036 for men; standardized beta coefficient = 0.146, p = 0.012 for women). Serum alpha-carotene and beta-carotene concentrations were significantly associated with serum C-reactive protein (CRP) concentrations in men. In women, there were significant negative associations between serum carotenoids concentrations and serum interleukin-6 (IL-6) concentrations. Additional adjustment for serum concentrations of IL-6 or CRP did not significantly affect the association between carotenoids and HMW adiponectin in non-smoking men as well as in women. Conclusion: Serum beta-carotene concentrations were positively associated with serum HMW adiponectin concentrations even after adjustment for possible confounding factors including inflammatory markers. (C) 2010 Elsevier B.V. All rights reserved.
  • 井上 孝, 鈴木康司
    広報やくも 40(8月) 2010年8月  
  • 森田えみ, 鈴木康司, 井上 孝, 栗木砂家加, 冨田耕太郎, 伊藤宜則, 浜島信之
    日本森林学会誌 92(5) 273-277 2010年7月  査読有り
    農漁業がおもな産業である北海道南部の八雲町の住民健診受診者を対象に, 自記式質問紙にて森林散策頻度の実態調査を行った。解析対象者は578人 (男性215人, 女性363人: 平均年齢 (標準偏差) 64.4 (10.2) 歳, 年齢範囲39∼89歳) であった。月1回以上, 森林散策をしている人は83人 (14.4%), 年1回以上の人は180人 (31.1%) であった。70歳代でも9.8%, 80歳代でも14.3%の人が, 週1回以上, 森林散策をしていた。都市部である静岡県中西部地区と比較した結果, 年齢, 性別, 職業, 森林散策の好き嫌いの分布を調整した後でも, 八雲町の方が森林散策頻度は有意に低く, 地域差が認められた。一方で, 森林散策と関連がある要因は静岡県中西部地区の結果と同様であり, 年齢が高く, 男性で, 森林散策が好きな人が森林散策の頻度が高い傾向が認められた。
  • 別府秀彦, 井上 孝, 金児孝晃, 川井薫, 田口義浩, 藤田孝輝, 鈴木康司, 木村麻美, 柳澤昌実, 山口久美子, 土井直子, 三木潤子, 石井嘉時, 園田茂, 新保寛
    機能性食品と薬理栄養 6(2) 147-156 2010年2月  査読有り
  • Akiko Kimata, Takaaki Kondo, Jun Ueyama, Kanami Yamamoto, Junko Yoshitake, Kenji Takagi, Koji Suzuki, Takashi Inoue, Yoshinori Ito, Nobuyuki Hamajima, Michiro Kamijima, Masahiro Gotoh, Eiji Shibata
    INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH 82(10) 1173-1178 2009年11月  査読有り
    Objectives The purpose of this study is to determine the levels of urinary 3-phenoxybenzoic acid (3-PBA) among general populations in rural and suburban areas and employees of pest control firms to evaluate the differences in the level of environmental or occupational pyrethroid (PYR) pesticides to which those populations are exposed. Methods Spot urine specimens were collected from male residents in a rural area (n = 143) and male residents in a suburban area (n = 66) in August of 2005 and 2007, respectively. Male employees of pest control firms, who also provided their urine specimens at the time of a health-checkup in August 2007, were classified either as sprayers (n = 14) or as non-sprayers ( n = 16) according to the presence of spraying during the pre-checkup week. Urinary concentrations of 3-PBA were determined using gas chromatography-mass spectrometry and corrected for the urinary creatinine concentrations. An analysis of covariance was used to examine the statistical difference in 3-PBA concentrations between these four groups after adjustment for age, body mass index, and current smoking/drinking habits. Results Multiple comparisons indicated no differences in adjusted 3-PBA concentrations between the groups of general residents from the rural areas (0.33 mu g/g cre in geometric mean) and suburban area (0.51 mu g/g cre). The group of sprayers showed a much higher level of 3-PBA concentrations (25.0 mu g/g cre) than the other three groups. A statistically significant difference, though to a lesser extent, was also exhibited in 3-PBA concentrations between the group of non-sprayers (5.6 mu g/g cre) and that of general residents. Conclusions The results indicated that the levels of background low-dose exposure to PYRs are not likely to differ evidently among general populations according to the area of residence. Moreover, employees of pest control firms, who have been away from PYR spraying operations for a week or more, still retain much higher urinary 3-PBA concentrations than general populations.
  • Koji Suzuki, Takashi Inoue, Atsumi Yanagisawa, Asami Kimura, Yoshinori Ito, Nobuyuki Hamajima
    JOURNAL OF EPIDEMIOLOGY 19(3) 131-135 2009年5月  査読有り
    Background: Recent studies have revealed a close relationship between obesity and polymorphism in the inflammation gene. However, the association between interleukin-1beta (IL-1 beta) and obesity remains controversial. We therefore investigated the association between IL-1B C-31T polymorphism and obesity in Japanese. Methods: The participants were 802 inhabitants (281 men and 521 women) of Japan, aged 39 to 88 years, who attended a health examination in 2003. Body height, weight, waist and hip circumferences, and body fat percentage were measured. The IL-1B C-31T polymorphism was genotyped by polymerase chain reaction with confronting 2-pair primers. The association between IL-1B C-31T genotypes and various indices of obesity was then investigated. The confounding factor-adjusted odds ratios (OR) and 95% confidence intervals (CI) for obesity were calculated for each IL-1B C-31T genotype by using unconditional logistic regression analysis. Results: Among male carriers of the CT and TT genotypes, the ORs for high body fat percentage were 2.58 (95% CI, 1.17-6.34) and 2.81 (1.17-7.33), respectively, as compared to carriers of the CC genotype (P for trend = 0.037). Among women, carriers of the TT genotype had significantly higher ORs for high BMI (OR, 2.13; 95% CI, 1.25-3.67) and large waist circumference (2.49; 1.37-4.66), as compared to women with the CC genotype (P for trend = 0.005 and 0.004, respectively). Conclusions: The IL-1B C-31T polymorphism is associated with obesity in Japanese. Men and women with the TT genotype of IL-1B C-31T had a higher risk for obesity than those with the CC genotype.
  • Akiko Kimata, Takaaki Kondo, Jun Ueyama, Kanami Yamamoto, Michihiro Kamijima, Koji Suzuki, Takashi Inoue, Yoshinori Ito, Nobuyuki Hamajima
    Environmental Health and Preventive Medicine 14(3) 173-179 2009年5月  
    Objectives The ingestion of pesticides in the daily diet is assumed to be the main modality of pesticide exposure for most people. A widely used class of pesticides in agricultural or residential settings is pyrethroid. We have examined the relationship between the intake frequency of selected items of vegetables and fruits and urinary metabolites of pyrethroid pesticides in a healthy general population. Methods A total of 535 residents (184 men and 351 women) who attended a healthcare checkup program conducted in a rural area of Hokkaido, Japan, in August 2005 provided informed consent for their spot urine samples to be used for the determination of 3-phenoxybenzoic acid (3-PBA) levels. They also completed a self-administered questionnaire regarding the intake frequency of 12 food items. The concentrations of creatinine-corrected 3-PBA were predicted by the intake frequency of each item, using analysis-of-covariance models to adjust for age, sex, body mass index, and drinking and smoking status. Results Both a significant association between the 3-PBA concentration and the frequency of tomato consumption and a significant positive linear trend was found in female subjects. In contrast, no such association was found in the male subjects. Conclusions The frequency of tomato consumption was confirmed to strongly predict the urinary pyrethroid metabolite levels in the general population\\-presumably because tomatoes are most often consumed raw and unpeeled (more so than all other vegetables and fruits analyzed in the current study). However, it should be noted that the 3-PBA levels, even among those subjects with the highest consumption of tomatoes, were far below the levels of toxicological significance, although the health consequences from long-term low-level exposure to pyrethroid requires further exploration. © 2009 The Japanese Society for Hygiene.
  • Atsurni Yanagisawa, Koji Suzuki, Asami Kimura, Yoshinori Ito, Nobuyuki Hamajima, Takashi Inoue
    CLINICAL NUTRITION 28(2) 198-202 2009年4月  査読有り
    Background & aims: Recent studies have indicated a close relationship between hypertension and inflammation. Antioxidant substances, including beta-carotene, are known to be preventive factors for hypertension. We investigated the effect of serum P-carotene levels on the association between the interleukin-1 beta (IL-1B) C-31T polymorphism and hypertension. Methods: Subjects were 625 inhabitants (200 males and 425 females) of Japan, aged 39-70 years, who attended a health check-up examination in 2003. The IL-1B C-31T polymorphism was genotyped by polymerase chain reaction with confronting two-pair primers. Serum beta-carotene levels were measured using high-performance liquid chromatography. Results: The TT genotype of IL-1B C-31T was associated with an increased risk of hypertension in all subjects (Odds Ratio [OR] = 1.82, 95% Confidence Interval [95% CI] = 1.09-3.06, compared with CC genotype). Among male CC carriers, those with high serum P-carotene levels had a significantly lower OR (OR = 0.25, 95% CI = 0.06-0.95) for hypertension relative to those with low serum beta-carotene levels. The TT carriers had a significantly higher OR compared with the CC carriers among males with high serum beta-carotene levels (OR = 5.03, 95% CI = 1.34-21.58) and among females with low serum beta-carotene levels (OR = 2.47, 95% CI = 1.04-6.00). Conclusion: This study suggests that the IL-1B C-31T polymorphism is associated with hypertension, and that this association is modulated by serum beta-carotene levels. (C) 2009 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
  • Jun Ueyama, Akiko Kimata, Michihiro Kamijima, Nobuyuki Hamajima, Yoshinori Ito, Koji Suzuki, Takashi Inoue, Kanami Yamamoto, Kenji Takagi, Isao Saito, Ken-ichi Miyamoto, Takaaki Hasegawa, Takaaki Kondo
    ENVIRONMENTAL RESEARCH 109(2) 175-180 2009年2月  査読有り
    Limited data are available on the background levels of exposure to synthetic pyrethroid (PYR) in Japan, despite their frequent application for agriculture and indoor extermination and possible effects of chronic and/or low-dose PYR exposure on human health. This study was conducted to describe the level and distribution of one of the major PYR metabolites, 3-phenoxybenzoic acid (3-PBA), in urine samples collected from a general population in Japan. The subjects were 535 individuals (184 men and 351 women; 61.5 +/- 9.8 years of age. mean +/- S.D.) residing in a town in Hokkaido, a dairy and agricultural area. Urinary 3-PBA was found detectable in 98% of samples above the limit of detection of 0.02 mu g/l. The geometric mean values of urinary 3-PBA in occupationally exposed farmers (n = 87) and the remaining general group without occupational exposure (n = 448) were 0.38 and 0.29 mu g/l, respectively, ranging from <LOD to 17.09 mu g/l. No significant differences in urinary 3-PBA concentrations were shown between these two groups. Moreover, 3-PBA concentrations were found comparable to those reported in some countries. The present study is, to our knowledge, the first report of a biological monitoring study of urinary 3-PBA, which elucidated the background environmental exposure level of PYR in the Japanese general population without occupational exposure. Further nationwide studies covering different seasons and age distribution are needed to monitor the urinary 3-PBA levels in Japan. (C) 2008 Elsevier Inc. All rights reserved.
  • 井上 孝
    日本液学会ニュースレター 32(5) 2008年10月  
  • 井上 孝
    広報やくも 16(8月) 2008年8月  
  • Ueyama J, Kondo T, Imai R, Kimata A, Yamamoto K, Suzuki K, Inoue T, Ito Y, Miyamoto K, Hasegawa T, Hamajima N
    Environ. Health Prev. Med. 13 36-42 2008年1月  査読有り
  • 多田 伸, 井上 孝
    医学と薬学 58(1) 55-59 2007年7月  査読有り
  • 井上 孝
    健康食品管理士認定協会第3版 440-446 2007年3月  
  • 尾崎清香, 別府秀彦, 井上 孝, 川井薫, 田口義浩, 石井嘉時, 藤田孝輝, 新保寛, 園田茂
    機能性食品と薬理栄養 4(1) 15-22 2006年11月  査読有り
  • Koji Suzuki, Takashi Inoue, Risa Hioki, Junichi Ochiai, Yasuhiro Kusuhara, Naohiro Ichino, Keisuke Osakabe, Nobuyuki Hamajima, Yoshinori Ito
    CLINICAL NUTRITION 25(5) 780-789 2006年10月  査読有り
    Background Et aims: Few epidemiological studies have investigated the relationship between abdominal adiposity and serum levels of carotenoids. This study investigated the relationship between total and abdominal obesity and serum Levels of carotenoids. Methods: Study population consisted of healthy Japanese males (n = 192) and females (n = 398) who attended a health examination screening (age: 49-86 years). Serum carotenoids were measured by high-performance liquid chromatography. Multiple logistic regression analysis was used to provide the muttivariate-adjusted odds ratio (OR) and 95% confidence interval (CI) of obesity indices for low levels of serum carotenoids. Results: In females, High waist circumference was associated with tow levels of serum canthaxanthin (OR = 2.00, 95% CI = 1.26-3.19) and beta-carotene (BC) (OR = 2.01, 95% CI = 1.23-3.28). High waist hip ratio was also associated with low levels of serum alpha-carotene and BC (OR = 2.44, 95% CI = 1.49-4.03, and OR = 1.97, 95% CI = 1.20-3.28, respectively). Similar results were obtained when body mass index was added to confounding factors. In mates, however, there were no significant associations between obesity indices and serum levels of carotenoids. Conclusions: Our results suggest that abdominal fat accumulation is associated with oxidative stress as determined by low levels of serum carotenoids in females. In mates, further study excluding the effect of strong confounding factors, including smoking, is needed. (c) 2006 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
  • Koji Suzuki, Yoshinori Ito, Kenji Wakai, Miyuki Kawado, Shuji Hashimoto, Nao Seki, Masahiko Ando, Yoshikazu Nishino, Takaaki Kondo, Yoshiyuki Watanabe, Kotaro Ozasa, Takashi Inoue, Akiko Tamakoshi
    CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION 15(9) 1733-1737 2006年9月  査読有り
    Chronic inflammation contributes to the process of carcinogenesis, but few epidemiologic studies have examined associations with risk of lung cancer. Relationships between lung cancer risk and serum levels of both heat shock protein 70 (Hsp70) and high-sensitivity C-reactive protein (hsCRP) were investigated in a case-control study nested in the Japan Collaborative Cohort Study for Evaluation of Cancer Risk. Serum samples and lifestyle information were collected at baseline from 39,242 men and women between 1988 and 1990. Of these, 240 deaths from lung cancer were identified through 1999, and 569 controls were matched for sex, age, and study area. Serum levels were measured in 189 cases and 377 controls for Hsp70 and in 209 cases and 425 controls for hsCRP. Odds ratios (95% confidence intervals) across quartiles, adjusted for confounding factors, including smoking habits, were 0.83 (0.44-1.58), 1.41 (0.77-2.60), and 1.84 (0.92-3.71) for Hsp70 (P-trend = 0.042) and 1.13 (0.67-1.91), 0.66 (0.38-1.16), and 1.19 (0.70-2.02) for hsCRP (P-trend = 0.941). In males, odds ratios (95% confidence intervals) across quartiles were 1.30 (0.59-2.84), 1.74 (0.83-3.67), and 2.49 (1.06-5.85) for Hsp70 (P-trend = 0.029). High levels of serum Hsp70 might thus be associated with increased risk of lung cancer among Japanese males, although further studies are needed to clarify associations between chronic inflammation and lung cancer.
  • 尾崎清香, 伊藤哲也, 別府秀彦, 井上 孝, 川井 薫, 井谷功典, 上野隆嗣, 川田道子, 横山次郎, 藤田孝輝, 新保寛, 中野浩, 園田茂
    機能性食品と薬理栄養 3(4) 275-284 2006年6月  査読有り
  • 別府秀彦, 井上 孝, 川井薫, 尾崎清香, 田口義浩, 藤田孝輝, 石井嘉時, 新保寛, 岩瀬正嗣, 中野浩, 園田茂
    機能性食品と薬理栄養 3(4) 261-273 2006年6月  査読有り
  • 北川文彦, 石井潤一, 久野貴弘, 鈴木康司, 井上 孝, 斉藤翠, 伊藤直美, 近藤文子, 藤田孝, 長谷川勝俊
    藤田学園医学会誌 30(1) 7-10 2006年1月  査読有り
  • Inoue T, Suzuki K, Beppu H, Kawai K, Shimpo K, Sonoda S, Nakano H
    J. Analytical Bio-Science 28(5) 428-432 2005年10月  査読有り
  • 井上 孝, 伊藤哲也, 別府秀彦, 川井薫, 尾崎清香, 岸野恵理子, 藤田孝輝, 山下亜希子, 橋本博之, 新保寛, 中野浩, 園田茂
    日本食品新素材研究会誌 8(2) 145-154 2005年9月  査読有り
  • Inoue T, Nakano H, Beppu H, Kawai K, Suzuki K, Shimpo K, Sonoda S
    Current topics in Peptide and Protein Reseach 7 35-40 2005年7月  査読有り
  • Suzuki K, Ito Y, Inoue T, Hioki R, Ochiai J, Kusuhara Y, Ichino N, Osakabe K, Hamajima N
    Health Evaluation and Promotion(HEP) 32(4) 364-369 2005年4月  査読有り
  • 山本恵申, 井上 孝, 濵子二治
    生物試料分析 27(5) 409-412 2004年12月  査読有り
  • 鍵小野美和, 大西文子, 井上 孝
    医学と生物 148(11) 18-23 2004年12月  査読有り
  • 井上 孝
    健康創造研究 3(2) 1-7 2004年10月  
  • Inoue T, Takasaki A, Hamako J, Yamamoto Y, Nagamura Y
    J. Analytical Bio-Science 27(4) 303-308 2004年8月  査読有り
  • 別府秀彦, 井上 孝, 川井薫, 沖村謙一, 三上寿枝, 尾崎清香, 藤田孝輝, 新保寛, 荒井哲也, 藤井侃, 中野浩, 葛谷博磁
    日本食品新素材研究 7(1) 69-81 2004年1月  査読有り
  • 別府秀彦, 井上 孝, 川井薫, 小島みどり, 佐藤紘子, 谷口治, 藤田孝輝, 新保寛, 中野浩, 葛谷博磁
    健康・創造研究会誌 2(1) 44-56 2003年1月  査読有り
  • 高崎昭彦, 伊藤美武, 北川章, 井上 孝, 秋山秀彦, 長村洋一
    健康・創造研究会誌 1(2) 116-121 2002年3月  査読有り
  • 伊藤保博, 山本直樹, 早川敏, 西村朋美, 江崎幸治, 井上 孝, 原 進
    医学検査 50(1) 8-12 2001年1月  査読有り
  • 森 清, 加藤育男, 小川浩司, 別府秀彦, 井上 孝, 川井薫, 今村誠司, 新保寛, 玉井育子, 中野浩, 葛谷博磁
    健康・栄養食品研究 4(1) 45-48 2001年1月  査読有り
  • 上田浩二, 別府秀彦, 丸山昌樹, 榊剛弘, 白砂史行, 井上 孝, 川井薫, 玉井育子, 池田宏, 藤田孝輝, 葛谷博磁
    日本食品科学工学 47(11) 836-843 2000年8月  査読有り
  • 小川浩司, 森 清, 加藤育男, 別府秀彦, 井上 孝, 川井薫, 新保寛, 玉井育子, 中野浩, 葛谷博磁
    健康・栄養食品研究 3(1) 73-81 2000年5月  査読有り
  • 山本直樹, 馬嶋清如, 井上 孝, 神戸俊夫, 日比野勤, 原田信広, 堀口正之, 馬嶋慶直
    臨床と微生物 27(1) 103-108 2000年1月  査読有り
  • 丸山昌樹, 別府秀彦, 井上 孝, 川井薫, 新保寛, 玉井育子, 中野浩, 葛谷博磁
    健康・栄養食品研究 2(4) 33-46 1999年4月  査読有り
  • 山本直樹, 高坂昌志, 井上 孝, 日比野勤, 長村洋一, 堀口正之, 馬嶋慶直
    生物試料分析 22(2) 157-162 1999年1月  査読有り
  • 野村知沙, 三沢美帆, 伊藤隆雄, 長坂光夫, 松浦良徳, 外間政希, 宇野浩之, 神谷雅人, 保原怜子, 西井雅俊, 大橋秀徳, 高浜和也, 渡邊真, 中野浩, 黒田誠, 深山昭雄, 井上 孝, 早川敏, 杉浦緑
    藤田学園医会誌 22(2) 67-70 1998年10月  査読有り

書籍等出版物

 11

講演・口頭発表等

 50

作成した教科書、教材、参考書

 2
  • 件名
    医学領域における臨床検査学入門第3版
    終了年月日
    2013/07/25
    概要
    臨床検査技師国家試験問題の傾向と解説をまとめたもの(公衆衛生学担当)
  • 件名
    公衆衛生学実習書
    終了年月日
    2013/04/01
    概要
    平成25年度公衆衛生学実習に関わる機器操作法や検査方法など内容を記載した実習書