Curriculum Vitaes
Profile Information
- Affiliation
- School of Medicine, Faculty of Medicine, Fujita Health University
- Degree
- 博士(医学)
- J-GLOBAL ID
- 201501000566558030
- researchmap Member ID
- 7000013208
Misc.
20-
Critical Care, 17(6), Nov 13, 2013 Peer-reviewedIntroduction: Abnormal body temperatures (Tb) are frequently seen in patients with severe sepsis. However, the relationship between Tb abnormalities and the severity of disease is not clear. This study investigated the impact of Tb on disease severity and outcomes in patients with severe sepsis. Methods: We enrolled 624 patients with severe sepsis and grouped them into 6 categories according to their Tb at the time of enrollment. The temperature categories (≤35.5°C, 35.6-36.5°C, 36.6-37.5°C, 37.6-38.5°C, 38.6-39.5°C, ≥39.6°C) were based on the temperature data of the Acute Physiology and Chronic Health Evaluation II (APACHE II) scoring. We compared patient characteristics, physiological data, and mortality between groups. Results: Patients with Tb of ≤36.5°C had significantly worse sequential organ failure assessment (SOFA) scores when compared with patients with Tb > 37.5°C on the day of enrollment. Scores for APACHE II were also higher in patients with Tb ≤35.5°C when compared with patients with Tb > 36.5°C. The 28-day and hospital mortality was significantly higher in patients with Tb ≤36.5°C. The difference in mortality rate was especially noticeable when patients with Tb ≤35.5°C were compared with patients who had Tb of > 36.5°C. Although mortality did not relate to Tb ranges of ≥37.6°C as compared to reference range of 36.6-37.5°C, relative risk for 28-day mortality was significantly greater in patients with 35.6-36.5°C and ≤35.5°C (odds ratio 2.032, 3.096, respectively). When patients were divided into groups based on the presence (≤36.5°C, n = 160) or absence (> 36.5°C, n = 464) of hypothermia, disseminated intravascular coagulation (DIC) as well as SOFA and APACHE II scores were significantly higher in patients with hypothermia. Patients with hypothermia had significantly higher 28-day and hospital mortality rates than those without hypothermia (38.1% vs. 17.9% and 49.4% vs. 22.6%, respectively). The presence of hypothermia was an independent predictor of 28-day mortality, and the differences between patients with and without hypothermia were observed irrespective of the presence of septic shock. Conclusions: In patients with severe sepsis, hypothermia (Tb ≤36.5°C) was associated with increased mortality and organ failure, irrespective of the presence of septic shock.Trial registration: UMIN-CTR ID UMIN000008195. © 2013 Kushimoto et al. licensee BioMed Central Ltd.
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Jpn J Clin Toxicol, 26 44-48, 2013 Peer-reviewed
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J Clin Lab Invest Updates, 1 3-4, 2013 Peer-reviewed
Books and Other Publications
4Presentations
92-
31st International symposium on Intensive Care and Emergency medicine, Mar, 2014
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The 7th Asian conference on emergency medicine, Oct, 2013
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Seventh Mediterranean Emergency Medicine Congress, Sep, 2013
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The 7th Asian conference on emergency medicine, Jan, 2013