akita hirotaka

We carried out a four-week study of female patients with acne vulgaris in order to assess the safety of make-up cosmetics for sensitive skin, consisting of powder foundation, liquid foundation, and loose powder in the "d Program^®" series developed by Shiseido Co., Ltd. Eighty-five subjects completed the study. We found adverse skin reactions in 2.1% of the subjects who used the powder foundation. On the basis of these findings, it was concluded that these make-up cosmetics for sensitive skin can be used safely by the great majority of female patients with acne vulgaris.Skin Research, 10: 170-182, 2011

We report two cases of anaphylaxis due to ingestion of mite-contaminated Okonomi-yaki (Japanese pancake) mix. Case 1: A 50-year-old female developed anaphylaxis after eating Okonomi-yaki prepared from Okonomi-yaki mix that had been stored at room temperature after opening. She demonstrated serum specific IgE against Dermatophagoides farinae (Der. f.), but did not demonstrate any wheat- or gluten-specific IgE antibodies. Prick tests showed positive reactions to Der. f. antigen (Torii) but not to previously unopened Okonomi-yaki mix or wheat flour that had been stored in a freezer. Case 2: A 28-year-old female developed anaphylaxis after eating Monja-yaki prepared from Okonomi-yaki mix that had been stored at room temperature after opening. She demonstrated serum specific IgE antibodies against Der. f. but no wheat- or gluten-specific IgE antibodies. Prick tests showed positive reactions to the responsible Okonomi-yaki mix and Der. f. antigen (Torii), but not to wheat flour that had been stored in a freezer. The responsible Okonomi-yaki mix contained 50 heads/g of Der. f., and a high level (64.1 μg/g) of Der f1 antigen was detected by specific ELISA. Immunoblotting revealed a specific 25 kDa band in patient sera against the responsible Okonomi-yaki mix, which was absorbed by Der. f. crude antigen.

We reported three cases of papular tuberculid after receiving Bacille Calmette-Guerin (BCG) vaccination. Case 1 was a 5-month-old girl who developed eruptions on her extremities five weeks after the BCG vaccination. Case 2 was a 6-month-old boy who developed eruptions on his extremities one month after the BCG vaccination. Case 3 was a 5-month-old boy who developed eruptions all over his body 6 weeks after BCG vaccination. Histopathologically, dermal perivascular lymphocytic inflammatory infiltrate and non-caseous epithelioid cell granulomas were observed in all cases. We diagnosed these cases as papular tuberculid resulting from BCG vaccination. All lesions resolved in three months without treatment. To establish the diagnosis when discrete eruptions are observed in a child under one year old, it is important to ask the guardians about the time of BCG vaccination.