Curriculum Vitaes

ito keisuke

  (伊藤 圭介)

Profile Information

Affiliation
School of Medicine Faculty of Medicine, Fujita Health University

J-GLOBAL ID
201501012233533267
researchmap Member ID
7000013289

Misc.

 7
  • Joji Inamasu, Keisuke Ito, Keiko Sugimoto, Eiichi Watanabe, Yoko Kato, Yuichi Hirose
    International journal of cardiology, 168(2) 1667-9, Sep 30, 2013  
  • Joji Inamasu, Takeya Watabe, Tsukasa Ganaha, Yasuhiro Yamada, Shunsuke Nakae, Tatsuo Ohmi, Shuei Imizu, Takafumi Kaito, Keisuke Ito, Yuya Nishiyama, Takuro Hayashi, Hirotoshi Sano, Yoko Kato, Yuichi Hirose
    JOURNAL OF CLINICAL NEUROSCIENCE, 20(8) 1095-1098, Aug, 2013  
    Chronic subdural haematoma (CSDH) is an uncommon but potentially serious complication of clipping unruptured cerebral aneurysms. We conducted a study to identify the patients who are at risk of developing postoperative CSDH. The data from 713 consecutive patients who underwent clipping of unruptured anterior circulation aneurysms were reviewed, and risk factors correlated with CSDH were identified by multivariate regression analysis of demographic variables. Fifteen patients (2.1%) developed CSDH after the surgery. Advanced age (odds ratio [OR] 1.151, 95% confidence interval [CI] 1.051-1.261) and male gender (OR 3.167, 95% CI 1.028-9.751) were correlated with CSDH. Subsequently, all 713 patients were quadrichotomized on the basis of gender and age, with 70 years as the cut-off value for age. The frequency of CSDH in men <70 years of age was 1.3% and that in men 70 years of age was 15.1%, with risk of CSDH was significantly higher in the older men (OR 13.39; 95% CI: 3.42-52.44). The frequency of CSDH in women <70 years of age was 0.6% and that in women >= 70 years of age was 3.7%. As in men, the risk of CSDH was significantly higher in the older women (OR 6.69, 95% CI 1.10-40.73). The interval between the aneurysm clipping and CSDH development was 0.5-6 months, suggesting that clinical observation should be continued up to 6 months after surgery. Although prognosis for patients with a. postoperative CSDH complication is generally favourable, the risk of CSDH should be taken into account when considering elective clipping of unruptured aneurysms in patients >= 70 years of age. (C) 2012 Elsevier Ltd. All rights reserved.
  • Joji Inamasu, Shunsuke Tanoue, Takeya Watabe, Shuei Imizu, Takafumi Kaito, Keisuke Ito, Natsuki Hattori, Yuya Nishiyama, Takuro Hayashi, Yoko Kato, Yuichi Hirose
    Neurosurgical Review, 36(3) 447-453, Jul, 2013  
    Seizures occurring after clipping of unruptured cerebral aneurysms have rarely been documented in the literature. The objective of this retrospective study is to clarify whether the frequency of early seizures, i.e., seizures occurring within 14 days of surgery, is influenced by patient- or aneurysm-specific characteristics. Data on 1,000 consecutive patients who underwent clipping of unruptured anterior circulation aneurysms were reviewed. They consisted of 387 men and 613 women with mean age of 59.8 ± 9.7 years. Fifty-one patients (5.1 %) developed early seizures. Interestingly, the frequency was similar to that occurring after clipping of unruptured posterior circulation aneurysms (n = 20, 5.0 %). Multivariate regression analysis revealed that younger age was correlated with early seizures (odds ratio (OR) 0.902 95 % confidence interval (CI) 0.891-0.989). However, other variables, including aneurysm size and operation length, were not correlated. Although patients with history of epilepsy exhibited relatively high frequency of early seizures, the difference was not statistically significant. The frequency was unaffected by location or multiplicity of aneurysms. Thirty-one patients (61 %) developed seizures within 24 h of clipping. Regarding seizure types, 34 (67 %) developed generalized seizures and the other 17 (33 %) experienced partial seizures. Patients with generalized seizures were significantly more likely to harbor an iatrogenic brain lesion than those with partial seizures (47 vs. 18 % OR 4.148 95 % CI 1.005-17.113). Among 40 patients with follow-up period &gt 12 months, seizures were temporary without recurrence in 38 (95 %). Although early seizures are mostly benign, a small possibility of them becoming a permanent morbidity needs to be explained to patients undergoing elective clipping. © 2013 Springer-Verlag Berlin Heidelberg.
  • 定藤章代, 早川基治, 田中鉄兵, 安達一英, 伊藤圭介, 稲桝丈司, 加藤庸子, 廣瀬雄一
    脳血管攣縮, 29 62-65, 2013  
  • Joji Inamasu, Keiko Sugimoto, Yasuhiro Yamada, Tsukasa Ganaha, Keisuke Ito, Takeya Watabe, Takuro Hayashi, Yoko Kato, Yukio Ozaki, Yuichi Hirose
    ACTA NEUROCHIRURGICA, 154(12) 2179-2185, Dec, 2012  
    Neurogenic pulmonary edema (NPE) occurs frequently after aneurysmal subarachnoid hemorrhage (SAH), and excessive release of catecholamines (epinephrine/norepinephrine) has been suggested as its principal cause. The objective of this retrospective study is to evaluate the relative contribution of each catecholamine in the pathogenesis of NPE associated with SAH. Records of 63 SAH patients (20 men/43 women) whose plasma catecholamine levels were measured within 48 h of SAH onset were reviewed, and the clinical characteristics and laboratory data of those who developed early-onset NPE were analyzed thoroughly. Seven patients (11 %) were diagnosed with NPE on admission. Demographic comparison revealed that the NPE+ group sustained more severe SAH than the NPE- group. Cardiac dysfunction was also significantly more profound in the former, and the great majority of the NPE+ group sustained concomitant cardiac wall motion abnormality. There was no significant difference in the plasma epinephrine levels between NPE+ and NPE- group (324.6 +/- 172.8 vs 163.1 +/- 257.2 pg/ml, p = 0.11). By contrast, plasma norepinephrine levels were significantly higher in the NPE+ group (2977.6 +/- 2034.5 vs 847.9 +/- 535.6 pg/ml, p < 0.001). Multivariate regression analysis revealed that increased norepinephrine levels were associated with NPE (OR, 1.003; 95 % CI, 1.002-1.007). Plasma epinephrine and norepinephrine levels were positively correlated (R = 0.48, p < 0.001). According to receiver operating characteristic curve analysis, the threshold value for plasma norepinephrine predictive of NPE was 2,000 pg/ml, with an area under the curve value of 0.85. Elevated plasma norepinephrine may have more active role in the pathogenesis of SAH-induced NPE compared with epinephrine, although both catecholamines may be involved via multiple signaling pathways.

Presentations

 16