研究者業績

戸松 瑛介

トマツ エイスケ  (Tomatsu Eisuke)

基本情報

所属
藤田医科大学 医学科 内科学 講師
学位
博士(医学)(2018年3月 藤田医科大学)

J-GLOBAL ID
201501016739258588
researchmap会員ID
7000012789

研究キーワード

 3

論文

 25
  • Yasumasa Yoshino, Tomoka Hasegawa, Shukei Sugita, Eisuke Tomatsu, Naoya Murao, Izumi Hiratsuka, Sahoko Sekiguchi-Ueda, Megumi Shibata, Takeo Matsumoto, Norio Amizuka, Yusuke Seino, Takeshi Takayanagi, Yoshihisa Sugimura, Atsushi Suzuki
    Fujita medical journal 10(4) 87-93 2024年11月  
    OBJECTIVES: Phosphate (Pi) induces differentiation of arterial smooth muscle cells to the osteoblastic phenotype by inducing the type III Na-dependent Pi transporter Pit-1/solute carrier family member 1. This induction can contribute to arterial calcification, but precisely how Pi stress acts on the vascular wall remains unclear. We investigated the role of extracellular Pi in inducing microstructural changes in the arterial wall. METHODS: Aortae of Pit-1-overexpressing transgenic (TG) rats and their wild-type (WT) littermates were obtained at 8 weeks after birth. The thoracic descending aorta from WT and TG rats was used for the measurement of wall thickness and uniaxial tensile testing. Structural and ultrastructural analyses were performed using light microscopy and transmission electron microscopy. Gene expression of connective tissue components in the aorta was quantified by quantitative real-time polymerase chain reaction. RESULTS: Aortic wall thickness in TG rats was the same as that in WT rats. Uniaxial tensile testing showed that the circumferential breaking stress in TG rats was significantly lower than that in WT rats (p<0.05), although the longitudinal breaking stress, breaking strain, and elastic moduli in both directions in TG rats were unchanged. Transmission electron microscopy analysis of the aorta from TG rats showed damaged formation of elastic fibers in the aortic wall. Fibrillin-1 gene expression levels in the aorta were significantly lower in TG rats than in WT rats (p<0.05). CONCLUSIONS: Pi overload acting via the arterial wall Pit-1 transporter weakens circumferential strength by causing elastic fiber malformation, probably via decreased fibrillin-1 expression.
  • 九鬼 伴樹, 吉岡 哲志, 戸松 瑛介, 鈴木 敦詞, 楯谷 一郎
    耳鼻咽喉科臨床 115(6) 491-496 2022年6月  
    38歳男性。全身の骨痛、歩行・起立障害を主訴に前医を受診した。腫瘍性骨軟化症(TIO)が疑われ、精査加療目的に当院へ紹介となった。FGF23の全身静脈サンプリングと68Ga-DOTATOC-PET/CTにより右鼻腔内の腫瘤がTIOの原因腫瘍であると診断し、内視鏡下に右鼻腔腫瘍摘出術が施行された。その結果、病理組織学的に鼻腔原発リン酸塩尿性間葉系腫瘍と診断され、術後5日で全身の骨痛は完全消失し、立位保持・歩行ともに可能となった。術後1年経過現在、腫瘍の再発や骨痛の再燃はなく、FGF23も正常範囲内である。
  • 中島 優華, 川上 司, 戸松 瑛介, 牧野 真樹, 淺田 陽平, 清野 祐介, 鈴木 敦詞
    糖尿病 65(4) 202-202 2022年4月  
  • Takeshi Takayanagi, Hiroyuki Hirai, Yohei Asada, Takaaki Yamada, Seiji Hasegawa, Eisuke Tomatsu, Yoshiteru Maeda, Yasumasa Yoshino, Izumi Hiratsuka, Sahoko Sekiguchi-Ueda, Megumi Shibata, Yusuke Seino, Yoshihisa Sugimura, Hirohiko Akamatsu, Mitsuyasu Itoh, Atsushi Suzuki
    Molecular biology reports 49(7) 5875-5882 2022年3月26日  
    AIMS: Although skin manifestations are common in diabetic patients, its characteristics are poorly identified. This study explored the differentiation process of keratinocytes in type 2 diabetes mellitus (T2DM) in vivo. METHODS: Back skin of T2DM model KKAy/TaJcl mice (KKAy) and C57BL/6JJcl mice (control) aged 8 and 12 weeks was used. The mRNA expression of differentiation markers of keratinocytes was measured by quantitative real-time polymerase chain reaction (qRT-PCR). The expression of each marker in situ was examined immunohistochemically. RESULTS: KKAy mice showed hyperglycemia versus control mice. The histological findings showed increased thickness and structural impairment of epidermal tissue in KKAy mice. The qRT-PCR revealed that the expression of integrin beta 1 and keratin 14 in KKAy and control mice was identical. However, the expression of involucrin at 8 weeks, keratin 10 at 12 weeks, and filaggrin and loricrin at 8 and 12 weeks was decreased in KKAy mice. Immunohistochemical findings showed that filaggrin was markedly decreased in KKAy mice, though Ki-67 remained unchanged. CONCLUSION: The terminal differentiation process was impaired in the diabetic skin, while keratinocyte proliferation was preserved. Damaged terminal differentiation of keratinocytes may contribute to impairment of the skin barrier function in diabetic dermatoses.
  • 植田 佐保子, 中島 優華, 松尾 悠志, 九鬼 伴樹, 淺田 陽平, 戸松 瑛介, 吉野 寧維, 平塚 いづみ, 藤沢 治樹, 垣田 彩子, 四馬田 恵, 清野 祐介, 高柳 武志, 牧野 真樹, 楯谷 一郎, 鈴木 敦詞
    日本内分泌学会雑誌 97(5) 1162-1162 2022年3月  
  • 植田 佐保子, 中島 優華, 松尾 悠志, 九鬼 伴樹, 淺田 陽平, 戸松 瑛介, 吉野 寧維, 平塚 いづみ, 藤沢 治樹, 垣田 彩子, 四馬田 恵, 清野 祐介, 高柳 武志, 牧野 真樹, 楯谷 一郎, 鈴木 敦詞
    日本内分泌学会雑誌 97(5) 1162-1162 2022年3月  
  • 垣田 彩子, 西田 康貴, 根木 可奈, 公文 尚子, 淺田 陽平, 松尾 悠志, 戸松 瑛介, 平塚 いづみ, 植田 佐保子, 四馬田 恵, 牧野 真樹, 清野 祐介, 高柳 武志, 鈴木 敦詞
    日本内分泌学会雑誌 97(2) 519-519 2021年10月  
  • 公文 尚子, 垣田 彩子, 川上 司, 長尾 龍之介, 戸松 瑛介, 平塚 いづみ, 高柳 武志, 清野 祐介, 渡辺 宏久, 鈴木 敦詞
    糖尿病 64(Suppl.1) P-3 2021年5月  
  • 藤沢 治樹, 中山 将吾, 川上 司, 上野 慎士, 淺田 陽平, 戸松 瑛介, 吉野 寧維, 平塚 いづみ, 清野 祐介, 四馬田 恵, 高柳 武志, 椙村 益久, 鈴木 敦詞
    日本内分泌学会雑誌 97(1) 261-261 2021年4月  
  • 高柳 武志, 公文 尚子, 森川 理佐, 轟木 秀親, 淺田 陽平, 松尾 悠志, 岡本 慧子, 戸松 瑛介, 吉野 寧維, 植田 佐保子, 垣田 彩子, 平塚 いづみ, 藤沢 治樹, 四馬田 恵, 清野 祐介, 浦野 誠, 楯谷 一郎, 日比 八束, 鈴木 敦詞
    日本内分泌学会雑誌 96(4) 968-968 2021年4月  
  • 中島 優華, 生田 麻美, 戸松 瑛介, 上野 慎士, 吉野 寧維, 平塚 いづみ, 藤沢 治樹, 植田 佐保子, 清野 祐介, 高柳 武志, 鈴木 敦詞
    日本内分泌学会雑誌 96(3) 719-719 2021年1月  
  • 戸松 瑛介, 川嶋 明香, 根木 加奈, 平塚 いづみ, 藤沢 治樹, 植田 佐保子, 垣田 彩子, 清野 祐介, 四馬田 恵, 高柳 武志, 牧野 真樹, 鏡 雅代, 深見 真紀, 鈴木 敦詞
    日本内分泌学会雑誌 96(1) 333-333 2020年8月  
  • 川上 司, 藤沢 治樹, 中山 将吾, 淺田 陽平, 増田 富, 戸松 瑛介, 吉野 寧維, 平塚 いづみ, 清野 祐介, 四馬田 恵, 高柳 武志, 椙村 益久, 鈴木 敦詞
    日本内分泌学会雑誌 96(1) 271-271 2020年8月  
  • 戸松 瑛介, 川嶋 明香, 根木 加奈, 平塚 いづみ, 藤沢 治樹, 植田 佐保子, 垣田 彩子, 清野 祐介, 四馬田 恵, 高柳 武志, 牧野 真樹, 鏡 雅代, 深見 真紀, 鈴木 敦詞
    日本内分泌学会雑誌 96(1) 333-333 2020年8月  
  • 川上 司, 藤沢 治樹, 中山 将吾, 淺田 陽平, 増田 富, 戸松 瑛介, 吉野 寧維, 平塚 いづみ, 清野 祐介, 四馬田 恵, 高柳 武志, 椙村 益久, 鈴木 敦詞
    日本内分泌学会雑誌 96(1) 271-271 2020年8月  
  • 四馬田 恵, 奈倉 裕子, 淺田 洋平, 戸松 瑛介, 安藤 瑞穂, 吉野 寧維, 高柳 武志, 関谷 隆夫, 上西 一弘, 藤井 多久磨, 鈴木 敦詞
    日本内分泌学会雑誌 95(2) 793-793 2019年10月  査読有り
  • Kondo-Ando M, Seino Y, Morikawa R, Negi K, Todoroki H, Kawakami T, Asada Y, Yoshimoto R, Tanaka C, Okamoto K, Masuda A, Tomatsu E, Hiratsuka I, Yoshino Y, Maki W, Kakita A, Shibata M, Takayanagi T, Makino M, Sugimura Y, Asai S, Ito A, Ueno S, Fujiwara Y, Kuwata H, Yabe D, Suzuki A
    Journal of Diabetes and Its Complications 33(11) 107415 2019年8月  査読有り
  • 藤沢 治樹, 椙村 益久, 中山 将吾, 川上 司, 淺田 陽平, 増田 富, 戸松 瑛介, 吉野 寧維, 平塚 いづみ, 清野 祐介, 四馬田 恵, 高柳 武志, 鈴木 敦詞
    日本内分泌学会雑誌 95(1) 387-387 2019年4月  
  • 戸松 瑛介, 稲垣 秀人, 川上 司, 淺田 陽平, 増田 富, 中山 将吾, 平塚 いづみ, 藤沢 治樹, 植田 佐保子, 四馬田 恵, 高柳 武志, 椙村 益久, 倉橋 浩樹, 鈴木 敦詞
    日本内分泌学会雑誌 95(1) 422-422 2019年4月  
  • Yohei Asada, Takeshi Takayanagi, Tsukasa Kawakami, Eisuke Tomatsu, Atsushi Masuda, Yasumasa Yoshino, Sahoko Sekiguchi-Ueda, Megumi Shibata, Tomihiko Ide, Hajime Niimi, Eishin Yaoita, Yusuke Seino, Yoshihisa Sugimura, Atsushi Suzuki
    International journal of endocrinology 2019 4194853-4194853 2019年  査読有り
    Osteoporosis patients with chronic kidney disease (CKD) are becoming common in our superaging society. Renal dysfunction causes phosphorus accumulation in the circulating plasma and leads to the development of CKD-mineral bone disorder (MBD). We have previously reported that type III Pi transporter-overexpressing transgenic (Pit-1 TG) rats manifest phosphate (Pi)-dependent podocyte injury. In the present study, we explored the effect of risedronate on Pi-induced podocyte injury in vivo. Pit-1 TG rats and wild-type rats at 5 weeks old were divided into a risedronate-treated group and an untreated group. We subcutaneously administered 5 μg/kg body weight of risedronate or saline twice a week during the experimental period. Risedronate did not alter serum creatinine levels at 5, 8, and 12 weeks of age. However, electron microscopy images showed that thickening of the glomerular basement membrane was improved in the risedronate treatment group. Furthermore, immunostaining for podocyte injury markers revealed that both desmin- and connexin43-positive areas were smaller in the risedronate-treated group than in the untreated group, suggesting that bisphosphonates could rescue Pi-induced podocyte injury. In conclusion, our findings suggest that risedronate could maintain glomerular barrier function by rescuing Pi-induced podocyte injury.
  • Tomatsu Eisuke
    Fujita Medical Journal, 藤田医科大学 4(1) 1-5 2018年  査読有り筆頭著者
  • 吉野 寧維, 戸松 瑛介, 平塚 いづみ, 植田 佐保子, 四馬田 恵, 伊藤 泰平, 佐々木 ひとみ, 長谷川 みどり, 日下 守, 白木 良一, 剣持 敬, 湯澤 由紀夫, 星長 清隆, 鈴木 敦詞
    移植 51(総会臨時) 357-357 2016年9月  
  • Eisuke Tomastu, Eri Ninomiya, Mizuho Ando, Izumi Hiratsuka, Yasumasa Yoshino, Sahoko Sekiguchi-Ueda, Megumi Shibata, Akemi Ito, Kazuhiro Uenishi, Atsushi Suzuki
    Osteoporosis and Sarcopenia 2(2) 94-98 2016年6月  査読有り筆頭著者
  • 四馬田 恵, 戸松 瑛介, 安藤 瑞穂, 平塚 いづみ, 吉野 寧維, 植田 佐保子, 垣田 彩子, 高柳 武志, 牧野 真樹, 早川 伸樹, 伊藤 泰平, 佐々木 ひと美, 日下 守, 白木 良一, 剣持 敬, 星長 清隆, 鈴木 敦詞
    Osteoporosis Japan 23(Suppl.1) 204-204 2015年8月  
  • Izumi Hiratsuka, Mitsuyasu Itoh, Hiroya Yamada, Keiko Yamamoto, Eisuke Tomatsu, Masaki Makino, Shuji Hashimoto, Atsushi Suzuki
    Endocrine journal 62(12) 1059-66 2015年  
    Autoimmune thyroid diseases (AITDs), including Graves' diseases (GD) and Hashimoto's thyroiditis (HT), are the most common autoimmune diseases, and are mainly mediated by T cells that produce cytokines and chemokines in abnormal amounts. Few reports have described the circulating chemokines active in AITDs. Recently, we used a new multiplex immunobead assay to simultaneously measure cytokines and chemokines in small volume serum samples from patients with AITDs. We measured 23 selected serum chemokines in patients with GD (n=45) or HT (n=26), and healthy controls (n=9). GD patients were further classified as either untreated, intractable, or in remission, while HT patients were classified as either hypothyroid or euthyroid. Of the 23 serum chemokines assayed, only the serum level of IP-10 (CXCL10/interferon-γ-inducible protein 10) was elevated, depending on disease activity, in GD or HT compared with healthy controls. However, the serum level of IP-10 was also increased in both untreated GD patients and hypothyroid HT patients, suggesting that levels of this cytokine may not be affected by disease specificity. In conclusion, autoimmune inflammation in patients with AITD is closely related to the level of the serum chemokine, IP-10. Therefore, IP-10 might be a good biomarker for tissue inflammation in the thyroid, but not a useful biomarker for predicting disease specific activity, the progression of AITDs, or responsiveness to treatment because of its independence from thyroid function or disease specificity.

MISC

 36

講演・口頭発表等

 16