Quinonoid dihydropteridine reductase, a tetrahydrobiopterin-recycling enzyme, contributes to 5-hydroxytryptamine-associated platelet aggregation in mice

Yui Suganuma, Chiho Sumi-Ichinose, Taiki Kano, Kazuhisa Ikemoto, Taei Matsui, Hiroshi Ichinose, Kazunao Kondo

Journal of Pharmacological Sciences, 150 173-179, Jun, 2022 Peer-reviewed
Perturbation of monoamine metabolism and enhanced fear responses in mice defective in the regeneration of tetrahydrobiopterin

Katsuya Miyajima, Yusuke Sudo, Sho Sanechika, Yoshitaka Hara, Mieko Horiguchi, Feng Xu, Minori Suzuki, Satoshi Hara, Koichi Tanda, Ken-ichi Inoue, Masahiko Takada, Nozomu Yoshioka, Hirohide Takebayashi, Masayo Mori-Kojima, Masahiro Sugimoto, Chiho Sumi-Ichinose, Kazunao Kondo, Keizo Takao, Tsuyoshi Miyakawa, Hiroshi Ichinose

Journal of Neurochemistry, 161(2) 129-145, Feb, 2022 Peer-reviewed
Priapism caused by partial deficiency of tetrahydrobiopterin through hypofunction of the sympathetic neurons in sepiapterin reductase gene-disrupted mice

Chiho Sumi-Ichinose, Yui Suganuma, Taiki Kano, Kazuhisa Ikemoto, Noriko Ihira, Hiroshi Ichinose, Kazunao Kondo

Journal of Inherited Metabolic Disease, 45(3) 621-634, Feb, 2022 Peer-reviewedLead authorCorresponding author
Salivary neopterin and related pterins: their comparison to those in plasma and changes in individuals

Kazuhisa Ikemoto, Chiho Sumi-Ichinose, Yui Suganuma, Taiki Kano, Noriko Ihira, Toshiharu Nagatsu, Kazunao Kondo

J Biochem ., 170(4) 559-567, Dec, 2021 Peer-reviewed
Tyrosine hydroxylase conditional KO mice reveal peripheral tissue-dependent differences in dopamine biosynthetic pathways

Katsuya Miyajima, Chiaki Kawamoto, Satoshi Hara, Masayo Mori-Kojima, Tamae Ohye, Chiho Sumi-Ichinose, Nae Saito, Toshikuni Sasaoka, Daniel Metzger, Hiroshi Ichinose

J Biol Chem ., 296 100544-100544, 2021 Peer-reviewed

Misc.

In vitroとin vivoにおける、Rho/MAL/SRF経路を介したV-1遺伝子による黒質線条体のドーパミン系の機能の調節(In vitro and in vivo regulation of the nigrostriatal dopaminergic function by V-1 gene via the Rho/MAL/SRF pathway)

川畑伊知郎, 来延新, 大宅史織, 森田淳一, 加藤茂樹, 田渕明子, 福地守, 津田正明, 大橋一正, 水野健作, 泉安彦, 久米利明, 赤池昭紀, 富岡佳久, 一瀬千穂, 一瀬宏, 小林和人, 山國徹

パーキンソン病・運動障害疾患コングレスプログラム・抄録集, 9回 66-66, Oct, 2015
Orally administered tetrahydrobiopterin (BH4) suppresses platelet aggregation via intraplatelet production of nitric oxide

Y. Suganuma, T. Kano, K. Ikemoto, C. Ichinose, T. Nomura, K. Kondo

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 13 908-909, Jun, 2015
Antiplatelet effect of tetrahydrobiopterin in mouse whole blood aggregation and its NO-independent mechanism

Yui Suganuma, Taiki Kano, Kazuhisa Ikemoto, Chiho Ichinose, Takahide Nomura, Kazunao Kondo

JOURNAL OF PHARMACOLOGICAL SCIENCES, 124 132P-132P, 2014
Anti-platelet effect of tetrahydrobiopterin on mouse whole blood

Yui Suganuma, Kazuhisa Ikemoto, Chiho Ichinose, Takahide Nomura, Kazunao Kondo

JOURNAL OF PHARMACOLOGICAL SCIENCES, 121 85P-85P, 2013
GTP Cyclohydrolase Regulation: Implications for Brain Development and Function

Ichinose H, Homma D, Sumi-Ichinose C, Nomura T, Kondo K

Advances in Pharmacology, 68 23-35, 2013

Books and Other Publications

GTP Cyclohydrolase Regulation: Implications for Brain Development and Function.

Hiroshi Ichinose, Daigo Homma, Chiho Sumi-Ichinose, Takahide Nomura, Kazunao Kondo (Role: Joint author, Advances in Pharmacology 68 : A New Era of Catecholamines in the Laboratory and Clinic (Lee E. Eiden Ed))

Academic Press, 2013
Dopa-responsive dystonia. ,

Ichinose H, Sumi-Ichinose C, Nagatsu T, Noumra T (Role: Joint author, Genetics of movement disorders (Stefan-M. Pulst Ed))

Elsevier Science (USA), 2003
Effects of acute and repeated Administration of Tetrahydrobiopterin to 6-Pyruvoyltetrahydropterin Synthase Knockout Mice.

C. Sumi-Ichinose, F. Urano, R. Kuroda, T. Ohye, M. Kojima, M. Tazawa, H. Shiraishi, K. Ikemoto, Y. Hagino, T. Nagatsu, T. Nomura, H. Ichinose (Role: Joint author, Pterins, Folates and Neurotransmitters in Molecular Medicine,(Blau N., and Thony B Eds))

SPS Verlagsgesellschaft (Germany), 2003,, 2003
Tetrahydrobiopterin differentially regulates the biosynthesis of catecholamines and serotonin, Implication in neuropsychiatric disorders.

Sumi-Ichinose C, Urano F, Kojima M, Kuroda R, Shiraishi H, Nomura T, Ichinose H (Role: Joint author, Catecholamine research: From molecular insights to clinical medicine (Advances in Behavioral Biology , 53)(Nagatsu T., Nabeshima T., McCarty R., Goldstein S. D. , Eds))

Kluwer Academic/Plenum Publishers, 2002
The gene for human aromatic L-amino avid decarboxylase, the enzyme for serotonin and catecholamine biosynthesis.

Nagatsu T, Ichinose H, Sumi-Ichinose C, Hagino Y (Role: Joint author, Serotonin in the central nervous system and periphery (Takata A. and Curzon G. Eds))

Elsevier Science B. V., 1995

Presentations

Effect of adrenalin alpha-2 agonists on thrombogenesis: risk in animal anesthesia with medetomidine, but safety in clinical sedation with dexmedetomidine.

Kazunao Kondo, Taiki Kano, Yui Suganuma, Kazuhisa Ikemoto, Chiho Sumi-Ichinose, Toshiaki Mochizuki

EPHAR2024 (The Federation of 9th European Pharmacological Societies), Athens, Greece
低酸素が炎症性サイトカイン刺激下のヒト血管内皮細胞内のテトラヒドロビオプテリン（BH4）量に及ぼす効果

池本和久, 狩野泰輝, 菅沼由唯, 一瀬千穂, 近藤一直

第36回日本プテリジン研究会, Feb 23, 2024
セピアプテリン還元酵素遺伝子ノックアウトマウスで観察されるチロシン水酸化酵素Ser40のリン酸化亢進

一瀬(鷲見)千穂, 菅沼由唯, 狩野泰輝, 井平典子, 池本和久, 一瀬宏, 近藤一直

第36回日本プテリジン研究会, Feb 23, 2024
Platelet aggregation enhancement by sedatives, not by clinical dexmedetomidine but by medetomidine for animal anesthesia.

Kondo K, Kano T, Suganuma Y, Ikemoto K, Sumi-Ichinose C, Mochizuki T

19th World Congress of Basic & Clinical Pharmacology 2023, Glasgow, Unatied Kingdom
Serotonin plays an essential role in platelet aggregation via BH4-requiring biosynthesis regulated by Quinonoid dihydropteridine reductase.

Kazunao Kondo, Yui Suganuma, Chiho Sumi-Ichinose, Hiroshi Ichinose

The 87th Annual Scientific Meeting of The Japanese Circulation Society, JCS2023 FUKUOKA

Teaching Experience

アセンブリ（弓道） (藤田保健衛生大学)
読書ゼミナール (藤田保健衛生大学医学部)
Human Biology (藤田保健衛生大学医学部)
臨床薬理学特論 (藤田保健衛生大学大学院医療科学研究科)
薬理学 (藤田保健衛生大学医学部、藤田保健衛生大学看護専門学校、名古屋大学医学部)

Professional Memberships

Research Projects

テトラヒドロビオプテリンによる神経・循環器系の機能調節と疾患治療への挑戦

科学研究費助成事業, 日本学術振興会, Apr, 2022 - Mar, 2025

一瀬千穂
Tetrahydrobiopterin-deficiency causes hypertension with fluctuation, bradycardia and priapism.

Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

SUMI-ICHINOSE Chiho, KONDO Kazunao, ICHINOSE Hiroshi, IHIRA Noriko
Study on the disease induced by imbalance of tetrahydrobiopterin-metabolism and research on the mechanisms for protection against the state.

Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

Sumi-Ichinose Chiho, Kondo Kazunao, Ichinose Hiroshi, Ihira Noriko
Development of tetrahydrobiopterin-based therapy for neurological and cardiovascular disease

Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, 2010 - 2012

SUMI-ICHINOSE Chiho, KONDO Kazunao
Developmental disturbance in model mice with abnormal pterin metabolism

Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, 2004 - 2005

SUMI-ICHINOSE Chiho, NOMURA Takahide, SHIRAISHI Hiroaki, IKEMOTO Kazuhisa

Other

医師免許取得

May, 1988 - Present
研究ニーズ

血液・尿・脳脊髄液等の臨床検体（精神・神経疾患、疼痛性疾患、アレルギー疾患、血管病変、代謝異常、産婦人科疾患、血液疾患、悪性腫瘍、骨疾患、臓器移植、腎・泌尿器疾患、睡眠障害、川崎病、敗血症、インフルエンザ脳症、原因不明な肢体不自由または知能障害をともなう疾患等）、これらの疾患のモデルマウス等に由来する検体、薬物投与・運動負荷前後で変化の期待される検体＊本研究ニーズに関する産学共同研究の問い合わせは藤田医科大学産学連携推進センター（fuji-san@fujita-hu.ac.jp）まで。
研究シーズ

①ポストカラム法を用いたテトラヒドロビオプテリン(BH4)、ジヒドロビオプテリン(BH2)の定量 ②テトラヒドロビオプテリン生合成酵素遺伝子欠損マウス（Pts-KO, Pts-KO/DPS) ③カテコラミン、セロトニンおよびその代謝物の分析 ④カテコラミン合成酵素の活性測定 ⑤アミノ酸分析＊本研究シーズに関する産学共同研究の問い合わせは藤田医科大学産学連携推進センター（fuji-san@fujita-hu.ac.jp）まで

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