研究者業績

法月 千尋

ノリヅキ チヒロ  (Chihiro Norizuki)

基本情報

所属
藤田医科大学 医療科学部 講師

研究者番号
20965280
J-GLOBAL ID
202201003006467652
researchmap会員ID
R000035123

研究キーワード

 1

論文

 11
  • 津田 裕介, 法月 千尋, 荒川 宜親
    日本細菌学雑誌 79(2) 149-149 2024年6月  
  • Jun-ichi Wachino, Wanchun Jin, Chihiro Norizuki, Kouji Kimura, Motonori Tsuji, Hiromasa Kurosaki, Yoshichika Arakawa
    Microbiology Spectrum 2024年2月5日  
    The number and type of metallo-β-lactamase (MΒL) are increasing over time. Carbapenem resistance conferred by MΒL is a significant threat to our antibiotic regimen, and the development of MΒL inhibitors is urgently required to restore carbapenem efficacy. Microbial natural products have served as important sources for developing antimicrobial agents targeting pathogenic bacteria since the discovery of antibiotics in the mid-20th century. MΒL inhibitors derived from microbial natural products are still rare compared to those derived from chemical compound libraries. Hydroxyhexylitaconic acids (HHIAs) produced by members of the genus Aspergillus have potent inhibitory activity against clinically relevant IMP-type MBL. HHIAs may be good lead compounds for the development of MBL inhibitors applicable for controlling carbapenem resistance in IMP-type MBL-producing Enterobacterales .
  • 和知野 純一, 法月 千尋, 荒川 宜親
    日本医学検査学会抄録集 72回 32-32 2023年5月  
  • Masahiro Suzuki, Chihiro Norizuki, Jun-Ichi Wachino, Kumiko Kawamura, Noriyuki Nagano, Yukiko Nagano, Wataru Hayashi, Kouji Kimura, Yohei Doi, Yoshichika Arakawa
    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 28(4) 473-479 2022年4月  
    OBJECTIVES: We aimed to elucidate the relationship among blaCTX-M-carrying plasmids and their transmission between humans and domestic animals. METHODS: Phylogenetic relationship of 90 I1 plasmids harboring blaCTX-M genes encoding extended-spectrum β-lactamase (ESBL) was analyzed using the ORF-based binarized structure network analysis of plasmids (OSNAp). RESULTS: The majority of plasmids carrying blaCTX-M-1 or blaCTX-M-8 belonged to a single lineage, respectively, and were primarily associated with domestic animals especially chickens. On the other hand, plasmids carrying blaCTX-M-14 or blaCTX-M-15, identified from both humans and domestic animals, were distributed in two or more lineages. CONCLUSION: OSNAp has revealed the phylogenetic relationships and diversity of plasmids carrying blaCTX-M more distinctly than pMLST. The findings suggest that circulation of I1 plasmids between humans and animals may contribute to their diversity.
  • 法月千尋, 石原誉志美, 位田陽史, 武藤義和, 須川真規子, 市原利彦
    陶生医報(CD-ROM) (36) 2022年  

MISC

 9

書籍等出版物

 1
  • 荒川宜親, 法月千尋 (担当:分担執筆, 範囲:ウイルス感染症(その他のウイルス感染症)、細菌感染症、真菌感染症)
    南江堂 2024年9月 (ISBN: 9784524234486)

担当経験のある科目(授業)

 3

所属学協会

 1

共同研究・競争的資金等の研究課題

 2