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  2. Sato Harunobu

Sato Harunobu

  (佐藤 美信)

Profile Information

Affiliation
Professor, Fujita Health University
Degree
Doctor(Mar, 1996, Fujita Health University)
Researcher number
50329736
ORCID ID
 https://orcid.org/0000-0003-4637-8853
J-GLOBAL ID
200901029590935073
researchmap Member ID
5000024804

Research Interests

 4

Research Areas

 3

Awards

 7
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Papers

 77
  • Hiroki Tani, Hiroyuki Kato, Yukio Asano, Masahiro Ito, Satoshi Arakawa, Masahiro Shimura, Daisuke Koike, Takayuki Ochi, Kenshiro Kamio, Toki Kawai, Hironobu Yasuoka, Takahiko Higashiguchi, Yoshiki Kunimura, Kazuma Horiguchi, Hidetoshi Nagata, Yuka Kondo, Yutaro Kato, Tsunekazu Hanai, Harunobu Sato, Akihiko Horiguchi
    Gan to kagaku ryoho. Cancer & chemotherapy, 50(8) 929-932, Aug, 2023  Peer-reviewed
    We report a case of a woman in her 70s who underwent conversion surgery after FOLFIRINOX, followed by radiation therapy for initially locally advanced unresectable pancreatic cancer. She visited her local doctor with a chief complaint of upper abdominal pain. Contrast-enhanced CT scan of the abdomen revealed an irregular mass invading the superior mesenteric artery, and the first and second jejunal arteries(>180°)in the pancreatic uncinate region. Based on imaging, she was diagnosed as UR-LA(sm), cT4N0M0, cStage Ⅲ pancreatic cancer, and underwent 5 courses of modified FOLFIRINOX. Radiation therapy of 50.4 Gy was added for local control, and CA19-9 decreased from 394.1 U/mL to 10.5 U/mL. The treatment effect was judged as RECIST: partial response. The tumor was considered to be potentially curative, and a subtotal stomach preserving pancreaticoduodenectomy was performed 8 months after the initial treatment. The tumor was found to be 3× 2 mm in size, pStage ⅠA, R0, and the response to preoperative chemotherapy: Evans Grade Ⅲ. The patient is alive at 5 months postoperatively without recurrence.
  • Eita Joki, Hiroyuki Kato, Hiroki Tani, Yukio Asano, Masahiro Ito, Satoshi Arakawa, Masahiro Shimura, Daisuke Koike, Takayuki Ochi, Kenshiro Kamio, Toki Kawai, Hironobu Yasuoka, Takahiko Higashiguchi, Yoshiki Kunimura, Kazuma Horiguchi, Hidetoshi Nagata, Yuka Kondo, Harunobu Sato, Yutaro Kato, Tsunekazu Hanai, Akihiko Horiguchi
    Gan to kagaku ryoho. Cancer & chemotherapy, 50(8) 933-936, Aug, 2023  Peer-reviewed
    We report a case of a patient with sigmoid colon cancer and multiple liver metastases who underwent hepatectomy after chemotherapy and pathological results showed complete remission. However, after chemotherapy was discontinued, the patient developed a local recurrence of the liver metastasis and underwent rehepatectomy. The patient came to our hospital with lower abdominal pain. Colonoscopy revealed a circumferential type Ⅱ, well-differentiated adenocarcinoma. Laparoscopic sigmoidectomy with lymph node dissection was performed. Postoperative CT scan showed multiple liver metastases at S5, S7, and S8. 11 cycles of bevacizumab plus modified FOLFOX(mFOLFOX)were subsequently performed. The liver metastases shrank at all sites, and the patient underwent right hepatectomy. The resected specimen was considered to be in complete remission, with no evidence of viable malignant cells. Postoperatively, bevacizumab plus mFOLFOX was resumed for 6 cycles and the patient remained in remission. However, 3 months after stopping chemotherapy and 1 year and 6 months after hepatectomy, a follow-up CT scan showed local recurrence of the liver edge, and a diagnosis of local recurrence of liver metastasis was made, and a partial hepatectomy was performed. The patient is recurrence-free and resuming modified FOLFOX 9 months after surgery.
  • Harunobu Sato, Koichi Suda, Yoshikazu Koide, Yukio Asano, Satoshi Arakawa, Hiroyuki Kato, Masahiro Shimura, Daisuke Koike, Kenshiro Kamiya, Eiki Kawai, Takahiko Higashiguchi, Akihiko Horiguchi
    Gan to kagaku ryoho. Cancer & chemotherapy, 49(13) 1423-1425, Dec, 2022  Peer-reviewedLead author
    The outcomes of 88 patients with lower rectal T2 cancer who underwent radical A surgery(T2)were compared with those of 340 patients with T3 or T4a cancer(T3/T4a)and 51 patients with T1 cancer(T1). The rates of all lymph node(LN) metastasis, paraintestinal LN metastasis, intermediate and main LN metastasis, and lateral LN metastasis in T2 were all significantly lower than in T3/T4a and not different from those in T1. The recurrence rate of T2 was 15.9%, significantly lower than that of T3/T4a and not different from that of T1. Fifty percent of T2 recurrences were observed after 30 months postoperatively, significantly higher than that of T3/T4a and not different from that of T1. The 5-year survival rate of T2 was significantly higher than that of T3/T4a and did not differ from that of T1. In lower rectal T2, cancer LN dissection similar to that in T1 is appropriate, and high preoperative serum CA19-9 level is a risk factor for recurrence, suggesting the need for follow-up after 30 months postoperatively to take recurrence into consideration.
  • Hiroyuki Kato, Yukio Asano, Masahiro Ito, Satoshi Arakawa, Masahiro Shimura, Daisuke Koike, Takayuki Ochi, Hironobu Yasuoka, Toki Kawai, Takahiko Higashiguchi, Hiroki Tani, Yoshiki Kunimura, Yuka Kondo, Hidetoshi Nagata, Harunobu Sato, Akihiko Horiguchi
    World journal of surgical oncology, 20(1) 278-278, Sep 3, 2022  Peer-reviewed
    In this report, we describe a case of highly advanced hepatocellular carcinoma with tumor thrombosis extending into the main portal vein of the pancreas that was successfully treated with adjuvant lenvatinib after right hepatic resection with thrombectomy. A 70-year-old woman was referred from the clinic because of elevated hepatobiliary enzymes. The patient was positive for the hepatitis B virus antigen at our hospital. The tumor markers were highly elevated with alpha-fetoprotein (14.5 U/mL) and protein induced by vitamin K absence (PIVKAII) (1545 ng/mL), suggesting hepatocellular carcinoma. Dynamic abdominal computed tomography showed an early enhanced tumor approximately 6 cm in size and portal vein tumor thrombosis filling the main portal vein, but not extending into the splenic or superior mesenteric vein (SMV). On magnetic resonance imaging 1 week after CT, portal vein tumor thrombosis had extended to the confluence of the splenic vein with the SMV, indicating rapid tumor growth. Thus, we performed emergent right hepatectomy with tumor thrombectomy. Postoperatively, we treated the patient with lenvatinib for a tumor reduction surgery. Fortunately, the patient was alive 2 years postoperatively without recurrence. This case report suggests that a favorable outcome may be achieved with multidisciplinary treatment including resection and postoperative treatment with lenvatinib.
  • Koji Masumori, Kotaro Maeda, Tsunekazu Hanai, Harunobu Sato, Yoshikazu Koide, Hiroshi Matsuoka, Hidetoshi Katsuno, Tomoyoshi Endo, Yeongcheol Cheong, Ichiro Uyama
    Fujita medical journal, 8(3) 67-72, Aug, 2022  Peer-reviewed
    OBJECTIVES: Surgical site infection (SSI) is a problematic complication after stoma closure. The purse string suture (PSS) technique eliminates this problem, but the area takes longer to heal. The present retrospective study was performed to evaluate the usefulness of a vacuum-assisted closure (VAC) system for the promotion of wound healing after stoma closure. METHODS: Consecutive patients undergoing stoma closure with the PSS technique were divided into two groups: those treated with and without use of the VAC system. The volume of dead space and the size of the wound were measured after stoma closure in both groups. The same measurements were performed on days 3 and 7 after closure. The time needed for wound closure was also examined in both groups. Outcomes were also evaluated according to age, body mass index, operative time, bleeding volume, wound consistency, patient satisfaction, perioperative inflammatory response, occurrence of SSI, and hospitalization days. RESULTS: The VAC group comprised 31 patients, and the non-VAC group comprised 34 patients. The volume of dead space on days 3 and 7 after closure was significantly smaller in the VAC group than in the non-VAC group (P=0.006 and P<0.001, respectively). The number of SSIs was significantly lower in the VAC group than in the non-VAC group (P=0.014). CONCLUSION: The dead space volume on days 3 and 7 after stoma closure with PSS significantly decreased by using the VAC system. The incidence of SSI after stoma closure also significantly decreased by using the VAC system.
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Misc.

 176
  • 丸田 守人, 佐藤 美信, 前田 耕太郎
    臨床外科, 62(11) 345-348, 2007  
  • 花井 恒一, 前田 耕太郎, 佐藤 美信
    臨床外科, 62(1) 41-46, Jan, 2007  
  • 前田 耕太郎, 花井 恒一, 佐藤 美信, 升森 宏次, 小出 欽和, 青山 浩幸, 勝野 秀稔, 船橋 益夫, 鎌野 俊彰, 野呂 智仁, 安形 俊久
    外科, 68(12) 1535-1539, Nov, 2006  
  • 前田 耕太郎, 花井 恒一, 佐藤 美信
    救急医学, 30(11) 1537-1541, Oct, 2006  
  • 小出 欣和, 前田 耕太郎, 花井 恒一, 佐藤 美信, 升森 宏次, 青山 浩幸, 船橋 益夫, 鎌野 俊彰, 安形 俊久, 野呂 智仁, 本多 克行, 遠藤 智美
    外科, 68(9) 1037-1042, Sep, 2006  
    直腸早期癌に対する局所切除術には,内視鏡的切除術,経肛門的アプローチによる局所切除術,後方アプローチによる局所切除術があげられる.治療を受ける患者に対して,より低侵襲な治療を提供することと,治療目的に応じた必要かつ十分な切除法を選択し,過小・過大手術を避けることが重要であり,そのためには,内科は内視鏡的手術,外科は外科的手術にこだわらず,それぞれの局所切除法の利点や欠点を十分に理解したうえで,目的に応じたより確実な切除法を選択し,患者に提供することが重要である(著者抄録)
  • 前田 耕太郎, 花井 恒一, 佐藤 美信
    手術, 60(10) 1469-1474, Sep, 2006  
  • 守瀬 善一, 杉岡 篤, 星本 相淳, 加藤 充純, 池田 匡宏, 須田 隆, 根木 浩路, 服部 良信, 佐藤 美信, 花井 恒一, 前田 耕太郎, 加藤 良一
    癌の臨床, 52(3) 187-195, Jul, 2006  
    当院で1974〜2005年に肝切除術を行った大腸癌肝転移196例の治療成績を単発転移群と多発転移群,同時性転移群と異時性転移群,大腸癌取扱い規約H分類別などに分けて比較検討した.全症例の初回肝切除後5年生存率は42.2%,10年生存率は33.4%であった.単発転移群は5年生存率54.7%,10年生存率46.9%,多発転移群はそれぞれ27.9%,18.8%で,多発転移群が有意に予後不良であった.同時性転移群は5年39.2%,10年28.2%,異時性群はそれぞれ44.9%,38.4%で,両群間に有意差は認められなかった.大腸癌取扱い規約(旧)H分類による比較ではH1群がH2・H3群に比べて有意に予後良好であった.残肝再発に対する再肝切除群,肺転移切除群,肝肺3回以上繰り返し切除群の再切除後5年生存率はそれぞれ31.1%,39.6%,22.5%であった.術前検査として血管造影下CTを施行された群と非施行群とで5年生存率を比較すると,それぞれ42.6%,43.2%で有意差は認められなかった
  • 勝野 秀稔, 前田 耕太郎, 花井 恒一, 佐藤 美信, 升森 宏次, 小出 欣和
    手術, 60(5) 577-581, May, 2006  
  • 前田 耕太郎, 花井 恒一, 佐藤 美信, 升森 宏次, 小出 欣和, 青山 浩幸, 勝野 秀稔
    消化器科, 42(5) 468-472, May, 2006  
  • 前田 耕太郎, 花井 恒一, 佐藤 美信, 升森 宏次, 小出 欣和, 青山 浩幸, 勝野 秀稔
    胃と腸, 41(4) 562-566, Apr, 2006  
  • OKAMOTO N, MAEDA K, SATO S, SENGA S, SATO H, HOSONO R, KATSUNO H
    The Japanese journal of proctology, 59(4) 198-202, Apr 1, 2006  
    A 53-year-old man was admitted to our hospital because of anal bleeding and thin feces. Digital examination revealed a protruding lesion 7 cm above the anal verge at the site of the anterior wall of the rectum. Colonoscopic examination revealed multiple map-like ulcers in the area extending from the anal canal to the upper rectum. Examination of a biopsy specimen failed to demonstrate Treponema pallidum, but syphilitic proctitis was suspected because of positive reaction in the serological tests (TPHA, SLIDE, FTA-ABS) for syphilis. After initiation of amoxicillin treatment, rapid healing of the rectal lesions was confirmed by colonoscopy. Overall, a definitive diagnosis of syphi-litic proctitis was made.
  • KATSUNO H, MAEDA K, MATSUMOTO M, HANAI T, SATO H, MASUMORI K, KOIDE Y, AOYAMA H, FUNABASHI M, INUKAI K
    The Japanese journal of proctology, 59(4) 208-209, Apr 1, 2006  
  • 青山 浩幸, 青山 敦子, 青木 秀, 加藤 勝也, 飯沼 雅朗, 前田 耕太郎, 花井 恒一, 佐藤 美信, 升森 宏次, 小出 欣和, 勝野 秀稔, 船橋 益夫, 犬飼 健太郎, 安形 俊久, 野呂 智仁, 鎌野 俊彰, 本多 克行, 近藤 智美
    東三医学会誌, (28) 79-81, Mar, 2006  
    89歳女性。患者は食道裂孔ヘルニアに対し内服薬にて経過観察中であったが、嘔吐回数が頻回となり、経口摂取困難となったため、緊急入院となった。精査の結果、通過障害を伴う混合型食道裂孔ヘルニアと診断し、内視鏡的に嵌頓した胃を整復、胃壁の固定と栄養補助目的に胃瘻を造設した。整復・固定後、経口摂取の回復とともにQOLの改善がみられた。
  • 前田 耕太郎, 花井 恒一, 佐藤 美信
    臨床外科, 61(11) 171-178, 2006  
  • OKAMOTO N, MAEDA K, HANAI T, SATO H, MASUMORI K, KOIDE Y, AOYAMA H, KATSUNO H, MARUTA M
    The Japanese journal of proctology, 59(1) 59-61, Jan 1, 2006  
  • 小出 欣和, 前田 耕太郎, 花井 恒一, 佐藤 美信, 升森 宏次, 青山 浩幸, 勝野 秀稔
    臨床外科, 60(10) 1285-1289, Oct, 2005  
  • 小出 欣和, 前田 耕太郎, 花井 恒一, 佐藤 美信, 升森 宏次, 青山 浩幸, 勝野 秀稔, 船橋 益夫, 鎌野 俊彰, 安形 俊久, 野呂 智仁
    癌と化学療法, 32(11) 1718-1720, Oct, 2005  
    根治術不能と診断された進行直腸癌および局所再発直腸癌に対して,経内腸骨動脈の動注化学療法を施行した5例について報告する.方法は,毎週1回左右のリザーバーよりそれぞれ5-FU 500mg,l-leucovorin 125mg/m2を動注した.治療施行回数および施行期間は,平均40(17〜74)回,平均12.8(5〜23)ヵ月であった.治療効果は,症状が消失または緩和した症例4例,画像評価(CT)で腫瘍の縮小を認めた症例2例,CEA値が低下した症例が3例であった.合併症は,皮膚障害が全例,下肢の感覚障害3例,感染2例,カテーテル閉塞が2例に認められた.治療継続状況では,全例が合併症の出現により投与量の減量や休薬・中止され他の治療法が施行されていた.臨床経過は原発直腸癌では1年後および3年後に,再発直腸癌では7ヵ月後および1年後に原癌死し,原発直腸癌1例は治療を継続しているが,肝・肺に多発転移を認め治療開始後2年生存中である(著者抄録)
  • 花井 恒一, 前田 耕太郎, 佐藤 美信, 升森 宏次, 小出 欣也, 青山 浩幸, 松岡 宏, 勝野 秀稔, 船橋 益夫, 鎌野 俊彰
    日本消化器外科学会雑誌, 38(7) 1110-1110, Jul 1, 2005  
  • 前田 耕太郎, 花井 恒一, 佐藤 美信
    手術, 59(8) 1107-1111, Jul, 2005  
  • 升森 宏次, 前田 耕太郎, 花井 恒一, 佐藤 美信, 小出 欣和, 松本 昌久, 青山 浩幸, 松岡 宏, 勝野 秀稔, 石川 太郎, 船橋 益夫, 鎌野 俊彰
    栄養-評価と治療, 22(3) 337-338, Jun, 2005  
  • 前田 耕太郎, 花井 恒一, 佐藤 美信
    手術, 59(6) 777-781, May, 2005  
  • 前田 耕太郎, 花井 恒一, 佐藤 美信, 升森 宏次, 松本 昌久, 小出 欣和, 青山 浩幸, 松岡 宏, 勝野 秀稔
    消化器外科, 28(5) 709-715, Apr, 2005  
  • 青山 浩幸, 加藤 勝也, 青木 秀, 青山 敦子, 飯沼 雅朗, 前田 耕太郎, 花井 恒一, 佐藤 美信, 升森 宏次, 松本 昌久, 小出 欣和, 松岡 宏, 勝野 秀稔, 石川 太郎, 船橋 益夫, 鎌野 俊彰, 渡邊 真
    東三医学会誌, (27) 38-41, Mar, 2005  
    50歳女.健診で便潜血反応陽性を指摘された.大腸内視鏡検査では肛門側より約6cmの直腸Rbに,約20mm大のIIc+IIa型早期直腸癌を認めた.注腸造影では直腸後壁側に腫瘍を認め,周囲の偽足様変形や中央にバリウムの溜まりのある透亮像を認めた.精査内視鏡では陥凹内隆起を認め,超音波内視鏡では概ねM癌で,陥凹内隆起部に一致してSM浸潤が疑われた.診断治療目的でminimally invasive transanal surgery(MITAS)を行い,病巣は完全に一括切除できた.病理組織学的には高分化腺癌で,粘膜筋板は保たれており,sm層への浸潤はみられなかった.壁深達度はm,ly0,v0,切除断端陰性であった.術後経過は良好であった.MITASは,早期直腸癌に対し正確な壁深達度診断と低侵襲治療を行うことのできる有用な術式であると思われた
  • Sato H, Maeda K, Hanai T, Masumori K, Koide Y, Aoyama H, Katsuno H, Kuroda M
    The Japanese journal of proctology, 58(8) 432-437, 2005  Peer-reviewedLead author
    Several researchers have reported the possible association between colorectal cancer and schistosomiasis japonica. However, it remains to be determined whether this association is significant. We report a case of sigmoid colon cancer associated with schistosomiasis japonica and discuss the relationship between schistosoma japonica and the development of colorectal cancer from a review of the Japanese literature. An 82-year-old man was referred to our hospital because of bloody stool. He had worked as a fisherman for 30 years in an endemic schistosomal area. A tumor was detected in the sigmoid colon without distant metastases. Sigmoidectomy with lymph node dissection was performed. A type-1 tumor measuring 2.5 × 2 × 1.5 cm was revealed in the resected specimen. Histological findings demonstrated well differentiated adenocarcinoma with muscular invasion, moderately lymphatic vessel invasion and lymph node metastases (n1). Many calci-fied eggs of schistosomiasis japonica were also seen in the colonic wall of both the tumor and normal tissue, mainly in the submucosal layer. The eggs were more often seen in the tumor than in the normal tissue. The patient also underwent transanal local excision for rectal adenoma 16 months later and survived for 50 months after the initial operation without recurrence.
  • SATO H, MAEDA K, HANAI T, MASUMORI K, MATSUMOTO M, KOIDE Y, AOYAMA H, MATSUOKA H, KATSUNO H
    The Japanese journal of proctology, 58(1) 19-24, Jan 1, 2005  Peer-reviewedLead author
    Twenty-seven patients with ischemic colitis who were referred to Fujita Health University between 1988 and 2002 were studied to clarify the clinical features of ischemic colitis after colorectal surgery. The patients were divided into two groups : the patients undergoing colorectal surgery (POIC, 10 cases) and the patients without previous colorectal surgery (NOIC, 17 cases). Gangrenous colitis was seen in 1 of POIC and transient colitis was seen in 26. Among 10 patients of POIC, low anterior resection was performed in 8 patients, sigmoidectomy and right hemicolectomy in 1 patient each. The main feeding artery was divided at its root in every operative case. Predisposing factors of ischemic colitis were seen in 5 (63.6%) of POIC. They were more frequently seen in NOIC than in POIC with a significant difference. Abdominal pain appeared in 3 (33.3%) of POIC as the first symptom and in 4 (44.4%) of POIC during the course. It more frequently ap-peared in NOIC than in POIC as the first symptom and the symptom during the course, although there were no significant differences. Ischemic change occupying more than a half the circumference of intestinal wall was found in 2 (22.2 %) of POIC. Although transient ischemic colitis after colorectal surgery tended to occur without an underlying disease or conditions, severe symptoms rarely occur. However, if ischemic colitis occurs in a patient with severe underlying disease, it is important to remember that severe colitis such as gangrenous colitis could occur.
  • 前田 耕太郎, 花井 恒一, 佐藤 美信
    臨床外科 = Journal of clinical surgery, 59(13) 1523-1527, Dec, 2004  
  • 勝野 秀稔, 前田 耕太郎, 内海 俊明, 花井 恒一, 佐藤 美信, 升森 宏次, 小出 欣和, 松本 昌久
    癌と化学療法, 31(11) 1652-1654, Oct, 2004  
    進行大腸癌患者における抗癌剤,免疫賦活剤投与による全身および局所での免疫状態の変動を,血漿中ならびに末梢血リンパ球および所属リンパ節細胞培養上清中の各種サイトカイン産生量を指標として検討した.対象は大腸癌患者51例で,各種サイトカイン産生量はELISA法にて測定した.血漿TGFβ産生量の全身での変動は抗癌剤投与例において増加した症例を多く認め,平均値も有意に増加した.PBMC培養上清中IFN-γ,IL-2,IL-12産生量は免疫賦活剤投与例において増加した症例を多く認め,PBMC培養上清中IL-4,IL-6産生量は抗癌剤投与例において増加した症例を多く認めた.局所では,IL-2産生量は免疫賦活剤投与例が非投与例に比して有意に高値を示し,逆にIL-10産生量は免疫賦活剤投与例が非投与例に比して低値を示した(著者抄録)
  • 丸田 守人, 岡本 規博, 前田 耕太郎, 花井 恒一, 佐藤 美信, 升森 宏次, 小出 欣和, 松本 昌久, 青山 浩幸, 松岡 宏, 勝野 秀稔, 石川 太郎, 船橋 益夫
    外科治療, 91(4) 444-447, Oct, 2004  
  • MATSUMOTO Masahisa, MARUTA Morito, MAEDA Koutarou, HANAI Tsunekazu, SATOU Harunobu, MASUMORI Kouji, KOIDE Yoshikazu, FUNAHASHI Masuo
    日本腹部救急医学会雑誌 = Journal of abdominal emergency medicine, 24(5) 915-918, Jul 31, 2004  
  • 丸田 守人, 前田 耕太郎, 内海 俊明, 花井 恒一, 佐藤 美信, 松本 昌久, 小出 欣和, 松岡 宏, 岡本 規博, 勝野 秀稔, 中村 悟, 古賀 崇
    消化器外科, 27(7) 1095-1104, Jun, 2004  
  • SATO H, SATO S, SENGA S, HOSONO R, MARUTA M, MAEDA K, KURODA M
    The Japanese journal of proctology, 57(3) 150-156, Mar 1, 2004  Peer-reviewedLead author
    Ulcerative colitis generally occurs in young people under 30 years old ; the occurrence of ulcerative colitis in patients more than 70 years old is uncommon. We report a case of ulcerative colitis induced by barium enema study and colonoscopy at the age of 75 with a review of 29 cases with ulcerative colitis that occurred among those more than 70 years old reported in Japan. A 75-year-old man with paralysis of his left hand due to poliomyelitis was referred to Rokuwa hospital to check the large bowel because of constipation. Barium enema study and colonoscopy did not show any findings. However, he had bloody stool, abdominal pain and diarrhea 10 days after the barium enema study and 6 days after the colonoscopy. Colonoscopy was performed to check the origin and the findings were compatible with ulcerative colitis, but histopathological findings with a biopsy specimen did not support clinical diagnosis. He was treated for colitis by intravenous hyperalimentation, but symptoms did not improve much. Biopsy specimens taken 20 days after the onset of the colitis confirmed that his illness was ulcerative colitis. Mesalazine was administered and clinical symp-toms improved together with endoscopic remission. The patient has remained asymptomatic for 1 month after his discharge.
  • MAEDA K, MARUTA M, HANAI T, SATO H, MASUMORI K, MATSUMOTO M, KOIDE Y, MATSUOKA H, OKAMOTO H, KATSUNO H, NAKAMURA S, KOGA T, ISHIKAWA T, FUNAHASHI M, KOISHI K, HIROTA Y
    The Japanese journal of proctology, 57(2) 81-85, Feb 1, 2004  
    We report herein surgical treatments for vaginal vault and complete genital prolapse with rectocele, peritoneocele, cystocele, and sphincter dysfunction.&lt;BR&gt;A 51-year-old woman, who had a 13-year history of vaginal vault and complete genital prolapse with urinary incontinence and dysfunction, constipation, and soiling of stool, was referred to our department for surgery. One-fourth of the anal sphincter was interrupted anteriorly by digital examination, and defecogra-phy revealed an enterocele. Anterior levatorplasty with sphincteroplasty was performed in addition to a transvaginal hysterectomy, anterior colporraphy. Partial excision and closure of the cul de sac of the perito-neum with pexy of the vaginal wall was added during surgery. The postoperative course was essentially uneventful without further recurrence or appearance of symptoms during a six-month follow-up.
  • 勝野 秀稔, 丸田 守人, 前田 耕太郎, 花井 恒一, 佐藤 美信, 升森 宏次, 松本 昌久, 小出 欣和, 松岡 宏, 岡本 規博
    藤田学園医学会誌, 27(2) 135-139, Dec, 2003  
    進行大腸癌手術症例を対照群と化学療法群に無作為に分け,対照群では術前の化学療法を施行せず,加療群ではUFTを手術前日迄の14日間経口投与した.術前に化学療法を施行することによって起こる免疫抑制状態の有無を,血漿中と所属リンパ節細胞の培養上清中のTGF-β発現量を指標として検討した.その結果,腫瘍最大径と深達度において血漿TGF-β発現量との関連性が認められ,より進行した癌で免疫抑制状態が引き起こされていることが示唆された.術直前の方が術前14日前に比し血漿TGF-β発現量は対照群及び加療群共に増加傾向にあり,加療群では有意に増加していた.担癌宿主の免疫抑制状態は化学療法を行うことによって,より助長されると考えられた.以上より,術前化学療法は全身及び局所リンパ節における免疫機構を抑制する働きを有する可能性が示唆された
  • 89(4) 374-379, Oct, 2003  Lead author
  • KATSUNO H, MARUTA M, MAEDA K, HANAI T, SATO H, MASUMORI K
    The Japanese journal of proctology, 56(8) 417-422, Aug 1, 2003  
    In order to clarify the significance of both chest X-ray and CT for postoperative lung metastasis from colorectal cancer, we studied 27 patients with lung metastasis detected by X-ray or CT among 543 patients after curative resection for colorectal cancer. Although there was no significant difference in the size of the lesions detected by X-ray or CT, only one of nine lesions (11.1%) detected by CT could be identified by X-ray when the lesions were 5 mm or smaller whereas five of six lesions (83.3%) could be detected when 6 mm or greater. The lesions could be identified by retrospective review of the chest X-ray in 12 of 27 patients (44.4%). The lesions overlapping on heart, aorta, pulmonary artery and bone shadow were often overlooked on chest X-ray. Detectable lesions on X-ray have been checked and overlooked by a single doctor in patients. Therefore, a double-checking system might help prevent delayed detection of metastatic lung lesions.
  • OKAMOTO N, MARUTA M, MAEDA K, SATO H, MASUMORI K, AOYAMA H, MATSUOKA H, KATO R
    The Japanese journal of proctology, 56(5) 251-256, May 1, 2003  
    We report a case of ASPS with special reference to the usefulness of multi planer reconstruction (MPR) and 3D-angio by MSCT for selecting an operation method and approach. A 31-year-old man with anal pain and bleeding during defecation was admitted to our hospital for further examination. Diagnostic imaging studies revealed a suspectable sarcoma. MPR and 3D-angio were used to select the approach to the tumor and operation method. Tumorectomy, combined with partial resection of the anal sphincter, and puborectal and external sphincter muscle plication, were successfully performed. Histological findings of the resected specimen showed the tumor grown like an alveolar origined from the striate muscle. Immunohistochemical testing was negative for HMB-45 and positive for myoglobin, and the tumor was diagnosed as ASPS. The postoperative course was uneventful.
  • KATSUNO H, MARUTA M, MAEDA K, UTSUMI T, HANAI T, SATO H, MASUMORI K
    The Japanese journal of proctology, 56(5) 262-265, May 1, 2003  
    A 58-year-old female with anal bleeding. soiling and defecating disturbance was admitted to our hospital. She was diagnosed as rectal prolapse (Tuttle II type) with rectocele on defecography. Manometry revealed an obscure high-pressure zone, low maximum resting pressure and maximum squeezing pressure. She underwent laparoscopic rectopexy and anterior levatorplasty with sphincter plication. She had no significant complications postoperatively, and preoperative symptoms disappeared after the surgery.
  • SATO Harunobu, FUJISAKI Masato, TAKAHASHI Takayuki, TIBA Youhei, MARUTA Morito, MAEDA Koutarou
    日本臨床外科学会雑誌 = The journal of the Japan Surgical Association, 64(4) 883-887, Apr 25, 2003  Peer-reviewedLead author
    We report a case of lipoma of the ileum with massive bleeding treated by laparoscopy-assisted partial resection of the ileum and review 49 cases of lipoma of the small intestine reported in Japan in the last 16 years. A 75-year-old woman with massive anal bleeding was admitted to the hospital. He had been examined for the same symptom 6 months earlier. Although colonoscopy suggested bleeding from the small intestine, we could not identify any lesions. We conducted laparoscopic surgery to identify the cause of the massive bloody stool. A tumor was detected in the ileum 90 cm proximal to Bauhin's valve, necessitating partial resection of the ileum. The resected specimen was a 2.5×2.1×3.5 cm submucosal tumor diagnosed histopathologically as lipoma. The patient has remained asymptomatic in the 4 years since surgery.
  • 岡本規博, 丸田守人, 前田耕太郎, 佐藤美信, 滝沢健次郎, 升森宏次, 青山浩幸, 加藤良一
    癌と化学療法, 30(4) 501-504, Apr, 2003  
  • MAEDA K, SATO H, MARUTA M, UTSUMI T, MASUMORI K, MATSUMOTO M
    The Japanese journal of proctology, 56(4) 170-173, Apr 1, 2003  
    A novel transanal local excision, named minimally invasive transanal surgery (MITAS ; 89 cases), was retrospectively compared with conventional transanal excision (27cases) in perioperative outcome. MITAS includes usage of a new anal retractor and a stapler with several modified surgical techniques. Age, gender, tumor size, and complication rate were equivalent in both methods. Tumors were located higher up in MITAS than in the conventional method (p&lt;0.01). Operative time, blood loss, and date of oral intake were less in MITAS (p&lt;0.04). MITAS was considered to be a minimally invasive transanal local excision procedure, which is accessible to proximal tumors less invasively than conventional method for rectal tumors.
  • KATSUNO H, MARUTA M, MAEDA K, UTSUMI T, SATO H, MASUMORI K
    The Japanese journal of proctology, 56(4) 166-169, Apr 1, 2003  
    We reported a case with necrosis of the colon proximal to the anastomosis 3.5 years after low anterior resection. A 69-year-old woman with nausea and abdominal pain was admitted to our hospital. She had undergone a low anterior resection, with division of the inferior mesenteric artery at its root, for rectal cancer, 3.5 years previously. Emergency surgery was performed for increasing abdominal symptoms after conservative therapy. A laparotomy revealed necrosis of the colon proximal to the anastomosis after the low anterior resection. A colectomy with a colostomy in the transverse colon, and closure of the remnant rectum, were performed for the condition. She died eight months following the surgery, due to multiple organ failure.
  • 前田 耕太郎, 丸田 守人, 佐藤 美信, 花井 恒一, 升森 宏次, 松本 昌久
    消化器外科, 26(3) 303-308, Mar, 2003  
    直腸早期癌に対する局所切除術の適応と手技について述べた.術前検査所見でSM3の所見がなく,分化型の癌,もしくは壁深達度の所見に検査間で一致がみられない腫瘍の場合には局所切除の適応となり,これにより過大手術を回避できる.局所切除の術式として,低位の腫瘍には従来法による経肛門的切除を行い,高位の腫瘍にTEMやMITASなどによる低侵襲な経肛門的切除を行う.局所切除では,癌の組織学的な評価と治癒度が確認でき,少なくとも筋層が一部含まれる標本を採取すべきであり,これが可能な術式を選択する必要がある
  • OKAMOTO N, MARUTA M, MAEDA K, HANAI T, SATO H, MASUMORI K, KOIDE K, MATUOKA H
    The Japanese journal of proctology, 56(3) 123-127, Mar 1, 2003  
    A 42-year-old woman with anal bleeding at menstruation consulted a nearby clinic. She was diagnosed as having endometriosis, by biopsy under colonoscopy, and had been treated by endocrine hormone therapy for six months, without success. Colonoscopy and a barium emena study showed a stenosis with a mass in the sigmoid colon. Bilateral oophorectomy and partial resection of the sigmoid colon were performed under laparoscopy. Histopathological findings revealed endometriosis affecting the sigmoid colon, with fibrosis causini obstruction. The nostonerative course was uneventful.
  • 岡本規博, 丸田守人, 前田耕太郎, 花井恒一, 佐藤美信, 升森宏次, 松本昌久, 小出欣和, 青山浩幸, 松岡 宏, 勝野秀稔, 加藤良一, 工藤 元, 井田義宏, 石黒雅伸
    藤田医会誌, 27(2) 205-208, Feb, 2003  Peer-reviewed
  • Masumori K, Maruta M, Maeda K, Hanai K, Sato H, Matumoto M, Koide Y, Matuoka H, Okamoto N, Katuno H, Nakamura S, Koga T, Ishikawa T, Funahashi M
    Japan Journal of Molecular Tumor Marker Research, 19 45-46, 2003  
  • Norihiro Okamoto, Morito Maruta, Koutarou Maeda, Harunobu Sato, Koji Masumori, Yoshikazu Koide, Masahisa Matsumoto, Hiroyuki Aoyama
    Japanese Journal of Gastroenterological Surgery, 36(8) 1237-1241, 2003  
    We report a case of gastrointestinal pacemaker cell tumor (GIPACT) with special reference to the usefulness of multiplaner reconstruction (MPR) and three-dimensional imaging (3D) by multislice computed tomography (MSCT) for selecting the surgical procedure and approach. A 36-year-old man with constipation was admitted for further examination was found in diagnostic imaging studies to have a submucosal tumor in the lower rectum. MPR and 3D were used to select the tumor approach and surgical procedure, resulting in a successful ultralow anterior resection with transanal anastmosis. Histological examination of the resected specimen showed the tumor consisted of spindle-shaped cells. Immunohistochemical testing was negative for s-100 and muscle-actin, and positive for CD34 and c-kit and the tumor was diagnosed as GIPACT. The postoperative course was uneventful except for temporary urinary dysfunction.
  • MASUMORI Koji, MARUTA Morito, MAEDA Koutaro, UTSUMI Toshiaki, SATO Harunobu, KOIDE Yoshikazu
    日本腹部救急医学会雑誌 = Journal of abdominal emergency medicine, 22(7) 1083-1086, Nov 30, 2002  
  • SATO Harunobu, MARUTA Morito, MAEDA Kotaro, MASUMORI Koji, KOIDE Yoshikazu, KATSUNO Hidetoshi
    日本腹部救急医学会雑誌 = Journal of abdominal emergency medicine, 22(5) 801-807, Jul 31, 2002  Peer-reviewedLead author
  • MATSUMOTO M, MARUTA M, MAEDA K, UTSUMI T, SATO Y, TAKIZAWA K, MASUMORI K, MATSUOKA H
    The Japanese journal of proctology, 54(7) 489-492, Jul 1, 2001  
    Radiation therapy is one choice for malignant disease of the lower abdomen. However, radiation sometimes induces radiation colitis as a severe side effect. Radiation colitis sometimes causes severe bleeding, and it is often difficult to treat, A 66-year-old man received radiation therapy (external radiation with 65.2 Gy) for carcinoma of the bladder. Bleeding in the rectum occurred approximately 15 months after irradiation. Severe bleeding and anemia could not be controlled by Salazosulfapyridine and steroid enemas, and frequent blood transfusion was needed. Therefore, we gave ecabet sodium enemas to this patient, twice every day, for four weeks. Bleeding and anemia could be controlled by this treatment. It is suggested that ecabet sodium enema can be an available treatment for radiation colitis.
  • MAEDA Koutarou, MARUTA Morito, UTSUMI Toshiaki, SATO Harunobu, MASUMORI Kohji
    The Japanese journal of proctology, 54(5) 343-344, May, 2001  

Books and Other Publications

 4
  • 日本消化器外科学会, 消化器外科専門医テキスト制作委員会 (Role: Contributor, 27. 肛門良性疾患)
    一般社団法人 日本消化器外科学会, Jul, 2023
  • (Role: Contributor)
    Apr, 2023 (ISBN: 9784830623455)
  • 日本消化器外科学会, 消化器外科専門医テキスト制作委員会 (Role: Contributor, 肛門良性疾患)
    一般社団法人 日本消化器外科学会, Feb, 2020 (ISBN: 9784991132100)
  • 武藤, 徹一郎, 渡辺, 英伸, 杉原, 健一, 多田, 正大 (Role: Contributor, StageⅡ大腸癌に対する補助化学療法-臨床試験からみたハイリスク因子)
    日本メディカルセンター, Jan, 2010 (ISBN: 4888751560)

Presentations

 803
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Professional Memberships

 17
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Research Projects

 1

Social Activities

 3
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