Curriculum Vitaes
Profile Information
- Affiliation
- Senior Assistant Professor, School of Medicine, Fujita Health University
- Degree
- D.Eng.
- J-GLOBAL ID
- 201101048913430092
- researchmap Member ID
- B000000634
I am developing databases of life sciences and medical information.
Research Interests
9Research Areas
1Research History
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Oct, 2012 - Mar, 2015
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Oct, 2007 - Sep, 2012
Papers
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Journal of the Endocrine Society, 9(1), Nov 26, 2024Abstract Context Oxytocin supplementation improves obstructive sleep apnea (OSA), and animal studies suggest involvement of oxytocin in respiratory control. However, the relationship between endogenous oxytocin signaling and human sleep status remains undetermined. Objective In this study, we approached the contribution of the intrinsic oxytocin-oxytocin receptor (OXTR) system to OSA by genetic association analysis. Methods We analyzed the relationship between OXTR gene polymorphisms and sleep parameters using questionnaire data and sleep measurements in 305 Japanese participants. OSA symptoms were assessed in 225 of these individuals. Results The OXTR rs2254298 A allele was more frequent in those with OSA symptoms than in those without (P = .0087). Although total scores on the Pittsburgh Sleep Quality Index questionnaire did not differ between the genotypes, breathlessness and snoring symptoms associated with OSA were significantly more frequent in individuals with rs2254298 A genotype (P = .00045 and P = .0089 for recessive models, respectively) than the G genotype. A multivariable analysis confirmed these genotype-phenotype associations even after adjusting for age, sex, and body mass index in a sensitivity analysis. Furthermore, objective sleep efficiency measured by actigraph was not significantly different between genotypes; however, subjective sleep efficiency was significantly lower in the rs2254298 A genotype (P = .013) compared with the G genotype. The frequency of the A allele is higher in East Asians, which may contribute to their lean OSA phenotype. Conclusion The OXTR gene may contribute to OSA symptoms via the respiratory control system, although it could be in linkage disequilibrium with a true causal gene.
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BioPsychoSocial medicine, 18(1) 20-20, Oct 2, 2024BACKGROUND: Low-grade systemic inflammation may be a key player in the immune activation that has been reported for mental health deterioration. We hypothesised that elevated serum levels of inflammatory cytokines increase neuroinflammation and exacerbate depressive symptoms. METHODS: The participants were part of a cohort study for whom data was available for both 2015 and 2019. In 2015, blood samples were collected from 232 participants. Their depressive symptoms were assessed both 2015 and 2019 using the Centre for Epidemiologic Studies Depression Scale (CES-D) (n = 33). The multiplex immunoassay system (Luminex® 200) was used to measure the serum concentrations of IL-6, IL-10, IL-12, IL-17A and TNFα. Data were analysed using linear models with the level of significance considered to be p < 0.05. RESULTS: After controlling for age, BMI, smoking and alcohol consumption, in 2015 the serum concentrations of IL-17A and TNFα in 2015 were significantly positively associated with the CES-D scores of women (standardised β (B) = .027, p < 0.01 and B = 0.26, p < 0.01, respectively). The serum concentrations of IL-17A and TNFα of men were significantly positively associated with the CES-D scores of 2019 (B = 0.62, p = 0.02 and B = 0.59, p = 0.02, respectively). CONCLUSIONS: In this cross-sectional study, we found a significant positive correlation between the depressive symptoms and serum TNFα and IL-17A levels of women. In addition, our longitudinal findings suggest the possibility that TNFα and IL-17A could elevate the depressive symptoms of men.
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Journal of Nutritional Science, 13 e45, Sep 23, 2024Abstract Although the relationship between dyslipidaemia (DL) and coronary artery disease (CAD) or between trace minerals intake and CAD is well known separately, the exact nature of this relationship remains unknown. We hypothesize that the relationship between trace mineral intake and CAD may differ depending on whether or not the individual has DL. The present study analysed the relationships among trace mineral intake, DL, and CAD in middle-aged and older adults living in Shika town, Ishikawa prefecture, Japan. This study included 895 residents following the exclusion of those with genetic risk carriers for familial hypercholesterolemia. Trace mineral intake was evaluated using the brief-type self-administered diet history questionnaire. Interactions were observed between DL and CAD with zinc (p = 0.004), copper (p = 0.010), and manganese intake (p < 0.001) in a two-way analysis of covariance adjusted for covariates such as sex, age, body mass index, and current smokers and drinkers. Multiple logistic regression analysis showed that zinc (odds ratio (OR): 0.752; 95% confidence interval (CI): 0.606, 0.934; p = 0.010), copper (OR: 0.175; 95% CI: 0.042, 0.726; p = 0.016), and manganese (OR: 0.494; 95% CI: 0.291, 0.839; p = 0.009) were significant independent variables for CAD in the dyslipidaemic group. The present results suggest that DL with a low trace mineral intake is associated with CAD. Further longitudinal studies are required to confirm this relationship.
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Frontiers in Molecular Neuroscience, 17 1379089-1379089, Apr 2, 2024Protein phosphorylation, a key regulator of cellular processes, plays a central role in brain function and is implicated in neurological disorders. Information on protein phosphorylation is expected to be a clue for understanding various neuropsychiatric disorders and developing therapeutic strategies. Nonetheless, existing databases lack a specific focus on phosphorylation events in the brain, which are crucial for investigating the downstream pathway regulated by neurotransmitters. To overcome the gap, we have developed a web-based database named “Kinase-Associated Neural PHOspho-Signaling (KANPHOS).” This paper presents the design concept, detailed features, and a series of improvements for KANPHOS. KANPHOS is designed to support data-driven research by fulfilling three key objectives: (1) enabling the search for protein kinases and their substrates related to extracellular signals or diseases; (2) facilitating a consolidated search for information encompassing phosphorylated substrate genes, proteins, mutant mice, diseases, and more; and (3) offering integrated functionalities to support pathway and network analysis. KANPHOS is also equipped with API functionality to interact with external databases and analysis tools, enhancing its utility in data-driven investigations. Those key features represent a critical step toward unraveling the complex landscape of protein phosphorylation in the brain, with implications for elucidating the molecular mechanisms underlying neurological disorders. KANPHOS is freely accessible to all researchers at https://kanphos.jp.
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BMJ Open, 14(2) e078129, Feb, 2024 Peer-reviewedOBJECTIVE: To investigate the relationship between oral frailty (OF), nutrient intake and calf circumference (CC) in middle-aged and older adults. DESIGN: Cross-sectional study. SETTING: Residents of four model districts of Shika town, Ishikawa Prefecture, Japan, using data from November 2017 to February 2018. PARTICIPANTS: One hundred and ninety-four residents aged ≥50 years in four model districts of Shika town. The OF total score ≥3 was defined as OF. Participants were divided into OF and non-OF groups and divided into the low-CC/kg and the high-CC/kg groups. OUTCOME MEASURES: The primary outcome is to use a two-way analysis of covariance to analyse the interaction between the two CC/kg groups and the two OF groups on nutrition intake. The secondary outcome is to use multiple regression analysis to investigate the nutrients significantly related to CC/kg when stratified by OF, with age, sex, body mass index, drinking status, smoking status and regular exercise as input covariates. RESULTS: A two-way analysis of covariance revealed a significant interaction between the two CC/kg groups and the two OF groups on animal protein intake (p=0.039). Multiple comparisons using the Bonferroni analysis revealed a significantly lower animal protein intake in the OF group than in the non-OF group with a low CC/kg (p=0.033) but not in the group with a high CC/kg. The multiple regression analysis stratified by OF revealed a positive correlation between animal protein intake and CC/kg (p=0.002). CONCLUSIONS: The present results revealed a significantly lower animal protein intake in the OF group than in the non-OF group in the low-CC/kg group, but no such difference was observed in the high-CC/kg group. Further longitudinal studies are needed to elucidate this relationship.
Misc.
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Proceedings for Annual Meeting of The Japanese Pharmacological Society, 92 1-P-132, 2019<p>Protein phosphorylation is a major and essential post-translational modification in eukaryotic cells that plays a critical role in various cellular processes. While recent advances in mass spectrometry based proteomics allowed us to identify approximately 200,000 phosphorylation sites, it is not fully understood which sites are phosphorylated by a specific kinase and which extracellular stimuli regulate the protein phosphorylation via intracellular signaling cascades. Recently, we have developed an in vitro approach termed the kinase-interacting substrate screening (KISS) method and an in vivo approach termed kinase-oriented substrate screening (KIOSS) method. Using KIOSS method, we analyzed the phosphorylation signals downstream of dopamine in mouse striatal slices, and found that about 100 proteins including ion channels and transcription factors were phosphorylated probably by PKA or MAPK. Here, we present an on-line database system which provides the phosphorylation signals identified by our KISS and KIOSS methods as well as those previously reported in the literature. The database system and its web portal, named KANPHOS (Kinase-Associated PHOspho-Signaling), were built based on the Next Generation XooNIps. We also demonstrate how to retrieve proteins and pathways in striatal medium-sized spiny neurons modulated by extracellular dopaminergic stimulation.</p>
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日本生化学会大会プログラム・講演要旨集, 91回 [2P-391], Sep, 2018
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Neuroinformatics 2017, D1, Aug, 2017
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日本細胞生物学会大会講演要旨集, 69回 83-83, May, 2017
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Trends Pharmacol. Sci., 37 858–871, Oct, 2016 Peer-reviewedInvited
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MOLECULAR BIOLOGY OF THE CELL, 27, 2016
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Front. Neurosci. Conference Abstract: Neuroinformatics 2015, Aug, 2015
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Transactions of Japanese Society for Medical and Biological Engineering, 53 S147_03-S147_03, 2015To develop a large scale model of brain or organs of living matter, collaboration of neuroscientists specialized in those fields and integration of multiple lines of evidence into a large scale model are necessary. To implement this strategy, we have been developed PLATO (latform for the collaborative brain system modeling) where the neuroscientists enable to collaboratively make a large scale model. The PLATO consists of data management tool to search and gather resources for model development from neuroinformatics platforms in the world, the data-oriented model integration library with a graphical user interface editor, and simulation agent. The PLATO enables users to integrate and to reuse newly developing and existing sub-system models by minimum changes in the program codes with plug-in/out way for development and simulation of a large scale model. Here we introduce the features of the PLATO, a use case in a large scale modeling of visual system, and its simulation results intended for the effect of miniature eye movement on retinal signal processing using the K computer. From those results, we discuss the state of a large scale modeling in near future in the symposium.
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Technical report of IEICE. HIP, 114(226) 61-65, Sep 25, 2014Fixation, holding one's eyes on an object, plays a key role in the perception of visual scenes. The miniature fluctuation, microsaccades, drifts and tremors, are involved in the fixation even the eyes seem still. Although the functional roles of the miniature eye movements have gradually been uncovered, the detail of those still remains mysteries. Here, we constructed a large scale visual system model to investigate contribution of the miniature eye movement on the visual functions -especially focusing on the processing in the retinal photoreceptors. The model consists of brainstem (eye movement control), eye optics, and photoreceptors; and those models are constructed based on the known anatomical and physiological evidence. We simulated fixation of the several scenes using the constructed model and evaluated photoreceptor responses by information rate. We confirmed that the information rate for the photoreceptor responses was increased with the miniature eye movement, while it was decreased without miniature eye movement. We also confirmed that increasing of the information rate resulted from increasing the responses for the edges of objects by the miniature eye movement. These results suggest that visual information is already enhanced at the retina level by miniature eye movement.
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Front. Neuroinform. Conference Abstract: 5th INCF Congress of Neuroinformatics, 2014
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研究報告バイオ情報学(BIO), 2012(2) 1-6, Jun 21, 2012脳全体をシステムとして理解するためには,特定の領域・機能だけを記述・再現するサブモデルではなく大規模脳数理モデルを構築する必要がある.我々は,大規模脳数理モデルをスクラッチから構築し直すのではなく,これまで蓄積されてきたサブモデル,および多くの研究者が構築している数理モデルをうまく統合することによって,大規模脳数理モデルを共同開発するプラットフォームを開発した.プラットフォームは,統一データ規約による大規模数理モデル開発支援ライブラリ PLATONIC と GUI によるモデル統合開発環境 PLATO IDEA によって構成される.In order to understand details of brain function, each sub-system model, which is focused on specific functional areas in the brain, needs to be integrated toward a large-scale brain system model. Our aim is to build a large-scale brain model not from scratch but by integrating sub-system models that have been built and accumulated so far by many researchers. Therefore we have developed a platform for integrating large-scale brain model from sub-system models. This platform includes a data-oriented model integration library named PLATO Network Interface Class Library (PLATONIC) and an integrated development environment based on graphical user interface (PLATO IDEA).
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IEICE technical report. Neurocomputing, 112(108) 7-12, Jun 21, 2012In order to understand details of brain function, each sub-system model, which is focused on specific functional areas in the brain, needs to be integrated toward a large-scale brain system model. Our aim is to build a large-scale brain model not from scratch but by integrating sub-system models that have been built and accumulated so far by many researchers. Therefore we have developed a platform for integrating large-scale brain model from sub-system models. This platform includes a data-oriented model integration library named PLATO Network Interface Class Library (PLATONIC) and an integrated development environment based on graphical user interface (PLATO IDEA).
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Front. Neuroinform. Conference Abstract: 4th INCF Congress of Neuroinformatics, 2011
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Front. Neuroinform. Conference Abstract: 4th INCF Congress of Neuroinformatics, 2011
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IEICE technical report, 108(480) 37-42, Mar 4, 2009Mathematical model of the brain developed so far have targeted specific brain areas such as, cells, networks and/or phenomena, including microscopic and macroscopic levels. However, in order to understand the whole brain system, integration of such specific models and large scale simulation studies are necessary. To tackle this issue, we are developing a collaborative platform implemented as an Eclipse plug-in. It consists of: the Concierge plug-in used to store, search and manage experimental data, paper PDFs, etc, which have being extended for the management of mathematical models as well; the netCDF-NI plug-in which allows users to easily implement input and output features to their models to make use of a common data format called netCDF.
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IEICE technical report, 107(542) 31-36, Mar 5, 2008Researchers access digital files everyday for experiments, presentations and writing articles. Consequently, they spend a lot of time and labor managing files that are produced from their daily activities. Concierge software significantly enhances file management efficiency by providing the functions to manage, search, and sort digitized research assets, and is developed in an open-source project based on the Eclipse Rich Client Platform. In addition, it realizes high expansibility and flexibility because all functions are implemented in the form of plug-in. In this presentation, function for data exchange with XooNIps, and a research note function are introduced as examples of Concierge plug-ins.
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The IEICE transactions on information and systems, 91(2) 497-503, Feb 1, 2008
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The IEICE transactions on information and systems, 90(7) 1812-1819, Jul, 2007
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IEICE technical report, 106(590) 7-10, Mar 9, 2007We investigated the effects of figure-ground segregation on the blur adaptation. The adaptation stimuli were a set of noise images filtered with a two-dimensional Gaussian filter and changed at 5Hz with different time phase from which a spot area with illusory contour was evoked. Even though the local spatio-temporal characteristics of the retinal image were same in all conditions, the improvement of Landolt visual acuity was significantly large in the spot compared with non-spot and control. However, this improvement disappeared when presentation duration of the spot stimulus was shortened. These results are suggesting that the blur adaptation to the place of figure was promoted compared with other places as ground.
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IEICE technical report. Neurocomputing, 104(760) 53-57, Mar 23, 2005We investigated the effects of blur adaptation on the transfer characteristics of a spatial vision. We measured and compared the percentage of correct answers for Snellen letter blurred by an ametropy-simulated filter in each adaptive state. As a result, it was found that the percent correct is significantly improved when the identical blur filter is applied to the stimuli for adaptation. This indicates that the inverse filter of eye optics which causes the retinal image blur is acquired by the blur adaptation in the visual system so as to decrease the perceived blur. Such compensation effect occurs also against the blur filter with non-linear phase characteristics. We therefore concluded that the classical local contrast adaptation is unlikely as a neuronal mechanism underlying the blur compensation effect.
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IEICE technical report. Neurocomputing, 103(490) 25-29, Dec 8, 2003Several lines of studies have suggested the existence of mechanisms that compensate the retinal image blur induced by a refractive error. In the current study we compared the visual acuities of blurred Snellen letters in various adaptation conditions in order to examine the hypothesis that the neural compensation mechanism can reduce the perceived blur due to spherical, cylindrical, and higher order aberration like coma. Our results demonstrated that the adaptation to noise blurred with a one-dimensional Gaussian filter improved the ability to recognize letters applied the same filter along the iso-orientation axis, but not along the orthogonal axis. Furthermore, in the case of adaptation to a phase shifted natural image, the visual acuity measured by the phase shifted letters was improved. These results suggest that the compensation mechanism is acqired in the visual system to reduce the retinal image blur due to myopia, astigmatism, and coma-like aberration, which supports our hypothesis.
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電子情報通信学会技術研究報告. NC, ニューロコンピューティング, 103(490) 25-29, Dec 1, 2003
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生体・生理工学シンポジウム論文集, 17 401-402, Sep 9, 2002
Research Projects
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Grants-in-Aid for Scientific Research Fund for the Promotion of Joint International Research (Fostering Joint International Research (B)), Japan Society for the Promotion of Science, Oct, 2019 - Mar, 2023
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Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Jun, 2019 - Mar, 2021
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Grants-in-Aid for Scientific Research Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2017 - Mar, 2019