Curriculum Vitaes
Profile Information
- Affiliation
- (Special Fellow), xFOREST Therapuetics Co., Ltd.Visitiing Professor (Professor Emeritus), Oncology Innovastion Center, Fujita Health University
- Degree
- Ph.D. (Doctor of Medical Science)
- Researcher number
- 50212204
- J-GLOBAL ID
- 201101037230271477
- researchmap Member ID
- B000004071
- External link
Believe or not, mRNAs encode all the designs of our bodies and all the plans of our living activity! However, nascent pre-mRNAs transcribed from human genes are terribly disrupted by intervening sequences, termed introns. The process to removed introns, termed pre-mRNA splicing, is therefore highly discriminatory and faithful. And thus, misregulation in this process causes disorders in cell functions, often with severe clinical consequences. We are studying to elucidate precise regulation system of splicing and challenges to understand the mechanism of aberrant splicing occurred in various serious diseases.
Research Interests
10Research Areas
6Research History
3-
May, 2024 - Present
Papers
84-
Biochemical and Biophysical Research Communications, 703 149682-149682, Apr, 2024 Peer-reviewed
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Nature Communications, 15(1), Jan 15, 2024 Peer-reviewedAbstract mRNA export is an essential pathway for the regulation of gene expression. In humans, closely related RNA helicases, UAP56 and URH49, shape selective mRNA export pathways through the formation of distinct complexes, known as apo-TREX and apo-AREX complexes, and their subsequent remodeling into similar ATP-bound complexes. Therefore, defining the unidentified components of the apo-AREX complex and elucidating the molecular mechanisms underlying the formation of distinct apo-complexes is key to understanding their functional divergence. In this study, we identify additional apo-AREX components physically and functionally associated with URH49. Furthermore, by comparing the structures of UAP56 and URH49 and performing an integrated analysis of their chimeric mutants, we exhibit unique structural features that would contribute to the formation of their respective complexes. This study provides insights into the specific structural and functional diversification of these two helicases that diverged from the common ancestral gene Sub2.
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Cell Reports, 42(12) 113534-113534, Dec, 2023 Peer-reviewedLast authorCorresponding author
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Anticancer Research, 43(10) 4663-4672, Sep 29, 2023 Peer-reviewed
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Mol. Cell. Oncol., ,in press., Dec, 2021 Peer-reviewed
Misc.
15-
Frontiers in molecular biosciences, 6 53-53, 2019 Peer-reviewed
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臨床血液, 59(9) 1642-1642, Sep, 2018
Books and Other Publications
4-
羊土社, Dec, 2016 (ISBN: 4758101582) -
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Presentations
191-
Eukaryotic mRNA Processing Meeting, Aug, 2009
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Eukaryotic mRNA Processing Meeting, Aug, 2009
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The 14th Annual Meeting of the RNA Society, May, 2009
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第31回 日本分子生物学会年会・第 81 回日本生化学会大会 合同大会, Dec, 2008
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第31回 日本分子生物学会年会・第81回日本生化学会大会 合同大会, Dec, 2008
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第 31 回 日本分子生物学会年会・第 81 回日本生化学会大会 合同大会, Dec, 2008
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The 13th Annual Meeting of the RNA Society, Jul, 2008
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Gordon Research Conference on the Biology of Post-Transcriptional Gene Regulation, Jul, 2008
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20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress, Jun, 2006
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The 11th Annual Meeting of the RNA Society, 2006
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Eukaryotic mRNA Processing Meeting, Aug, 2005
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The 10th Annual Meeting of the RNA Society, May, 2005
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The 9th Annual Meeting of the RNA Society, Jun, 2004
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International Symposium RNA 2003 Kyoto–The New Frontier of RNA Science, Nov, 2003
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Eukaryotic mRNA Processing Meeting, Aug, 2003
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The 8th Annual Meeting of the RNA Society, Jul, 2003
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The 7th Annual Meeting of the RNA Society, Jun, 2002
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Eukaryotic mRNA Processing Meeting, Aug, 2001
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Eukaryotic mRNA Processing Meeting, Aug, 2001
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Eukaryotic mRNA Processing Meeting, Aug, 2001
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Eukaryotic mRNA Processing Meeting, Aug, 2001
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Annual Meeting of the RNA Society of Japan, Aug, 2001
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The 6th Annual Meeting of the RNA Society, Jun, 2001
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The 6th Annual Meeting of the RNA Society, Jun, 2001
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The 5th Annual Meeting of the RNA Society, Jun, 2000
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Eukaryotic mRNA Processing Meeting, Aug, 1999
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Eukaryotic mRNA Processing Meeting, Aug, 1999
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Eukaryotic mRNA Processing Meeting, Aug, 1999
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The 4th Annual Meeting of the RNA Society, Jun, 1999
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The 4th Annual Meeting of the RNA Society, Jun, 1999
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The 3rd Annual Meeting of the RNA Society, May, 1998
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Eukaryotic mRNA Processing Meeting, Aug, 1997
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Eukaryotic mRNA Processing Meeting, Aug, 1997
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The 2nd Annual Meeting of the RNA Society, May, 1997
Teaching Experience
14-
May, 2020 - PresentSpecial Lecture for Biological Science I (Fujita Health University)
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Jun, 2014 - Present卒業論文研究 (藤田医科大学 医療科学部)
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2013 - Present大学院生のための分子生物学技術講座 (藤田医科大学)
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Sep, 2020健康栄養特論II（集中講義） (滋賀県立大学大学院人間文化学研究科)
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Sep, 2016生物環境特別講義（集中講義） (熊本大学大学院自然科学研究科)
Professional Memberships
4Research Projects
25-
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Apr, 2024 - Mar, 2027
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Research Grant, The Naito Foundation, Dec, 2023 - Nov, 2025
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Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2024
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科学研究費補助金(基盤研究(B)), 文部科学省, Apr, 2016 - Mar, 2020
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二国間交流事業共同研究経費支援（オーストリアとの共同研究）, 日本学術振興会, Apr, 2017 - Mar, 2019
Other
2-
① がん由来細胞を用いた、mRNA再スプライシングを含む異常スプライシングの分子機構の解析、 ② ヒトの新規スプライシング因子として再発見されたSPF45の、抗がん多剤耐性への関与機構の解析、 ＊本研究シーズに関する産学共同研究の問い合わせは藤田医科大学産学連携推進セン ター（fuji-san@fujita-hu.ac.jp）まで
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mRNA前駆体のスプライシングはイントロンを取り除いて蛋白質の設計図であるmRNAを作るが故に、遺伝子発現における必須の過程である。スプライシングは正確無比に制御され、ひとたび異常が起きると、しばしば重篤な疾患を引き起こす。プロテオームに多様性をもたらす選択的スプライシングが、様々な生命現象において重要な役割を果たしている事実は明らかである。講義では、ヒト遺伝子発現を制御するネットワークについて理解する。最近の画期的なアンチセンス核酸医薬の開発は記憶に新しい。疾患治療につながる低分子化合物によるスプライシング操作機構についても、学んでいきたい。アメリカでの１７年にわたる研究所/大学教育現場での貴重な体験を、本学の教育の現場で生かし、国際的に活躍出来る研究者の育成を目標としたい。