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  2. Hasegawa Midori

Hasegawa Midori

  (長谷川 みどり)

Profile Information

Affiliation
School of Medicine Faculty of Medicine, Fujita Health University
Degree
医学博士
J-GLOBAL ID
200901076209356036
researchmap Member ID
5000025129

Research Interests

 9

Research Areas

 1

Research History

 4

Education

 2

Committee Memberships

 2

Awards

 1

Papers

 117
  • Midori Hasegawa, Hiromichi Matsushita, Kensei Yahata, Akira Sugawara, Yoshitaka Ishibashi, Ryoko Kawahara, Yoshifumi Hamasaki, Hitoshi Kanno, Sachie Yamada, Norio Nii, Masao Kato, Atsushi Ohashi, Shigehisa Koide, Hiroki Hayashi, Yukio Yuzawa, Naotake Tsuboi
    Therapeutic Apheresis and Dialysis, 25(4) 407-414, Aug, 2021  
  • 多賀谷 知輝, 中島 颯之介, 中島 若菜, 堀内 雅人, 田中 友規, 成宮 利幸, 大山 翔也, 伊藤 辰将, 大谷内 樹那, 横江 優貴, 平野 恭子, 小出 滋久, 林 宏樹, 高橋 和男, 長谷川 みどり, 湯澤 由紀夫, 坪井 直毅
    日本透析医学会雑誌, 54(Suppl.1) 532-532, May, 2021  
  • 細江 眞生, 森 万佑子, 鈴木 むつみ, 山田 幸恵, 新 典雄, 加藤 政雄, 大高 洋平, 長谷川 みどり, 坪井 直毅, 中井 滋
    日本透析医学会雑誌, 54(Suppl.1) 557-557, May, 2021  
  • Midori Hasegawa, Jin Iwasaki, Satoshi Sugiyama, Takuma Ishihara, Yoshihiro Yamamoto, Hiroaki Asada, Shigehisa Koide, Hiroki Hayashi, Kazuo Takahashi, Daijo Inaguma, Yukio Yuzawa, Naotake Tsuboi
    PloS one, 16(1) e0245869, 2021  
    INTRODUCTION: Degenerative aortic valve stenosis (AS) is a chronic progressive disease that resembles atherosclerosis development. Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is reportedly associated with accelerated atherosclerosis. This study aimed to examine the development of AS in patients with myeloperoxidase-AAV (MPO-AAV) with renal involvement at more than 1 year after the onset of vasculitis. METHODS: We performed a retrospective review of clinical records of MPO-AAV patients with renal involvement without AS at the onset of vasculitis who were treated in three hospitals and three dialysis clinics. RESULTS: The study included 97 MPO-AAV patients with renal involvement and 230 control patients with chronic kidney disease (CKD). Among them, 64 patients had AS. The prevalence rates of AS were 28.9% and 15.7% in MPO-AAV and control patients, respectively (p = 0.006). The multivariable logistic regression analysis showed that MPO-AAV, dialysis dependence, and hypertension were independently associated factors for AS. In MPO-AAV patients, systolic blood pressure was positively significantly associated with AS, whereas glucocorticoid dose of induction therapy was negatively significantly associated. The use of cyclophosphamide tended to be negatively associated with AS. The survival rate was significantly lower for patients with AS than for those without AS. CONCLUSIONS: The AS prevalence rate was significantly higher in MPO-AAV patients at more than 1 year after the onset of vasculitis than in control CKD patients. Therefore, regular monitoring of echocardiography during MPO-AAV treatment is suggested.
  • Haruna Arai, Soshiro Ogata, Takaya Ozeki, Kazuo Takahashi, Naotake Tsuboi, Shoichi Maruyama, Daijo Inaguma, Midori Hasegawa, Yukio Yuzawa, Hiroki Hayashi
    Arthritis research & therapy, 22(1) 261-261, Nov 5, 2020  
    BACKGROUND: The present study aimed to investigate associations between long-term renal function, whether IgG4-related tubulointerstitial nephritis (TIN) was diagnosed by renal biopsy at initial examination, chronic kidney disease (CKD) stage, and histological stage in patients with IgG4-related TIN. METHODS: This study used a retrospective cohort design including almost all patients who underwent renal biopsy at Fujita Health University Hospital and Nagoya University or its affiliated hospitals in Aichi between April 2003 and March 2015 (n = 6977 renal biopsies). The primary outcome was longitudinal changes in eGFR. Main exposures were whether IgG4-related TIN was diagnosed by renal biopsy at the initial examination, CKD stage, and its histological stage. Linear mixed models were performed to examine associations. RESULTS: Of the 6977 samples, there were 24 patients (with 201 records due to repeated measures) with IgG4-related TIN (20 men, mean age, 68.7 ± 9.7 years). They were followed up 6.6 ± 2.8 years after the renal biopsy and underwent glucocorticoid treatment. We found significant increase in eGFR from the baseline to 2 and 6 months after treatment initiation, which was maintained until 60 months. Patients initially diagnosed with IgG4-related TIN had higher eGFR from the baseline (at the start of treatment) to 60 months than those who were not. Compared with patients with CKD stage 3, patients with CKD stages 4 and 5 had lower eGFR at the baseline and other time points. Patients with histological stage B had comparatively lower eGFR at each point than stage A patients. Those mean differences of eGFR were stable from the baseline to 60 months. CONCLUSIONS: After the treatment initiation, renal function rapidly improved and maintained for a long period, even with advanced CKD stage. We showed importance of early diagnosis of IgG4-related TIN in maintaining eGFR.
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Misc.

 165
  • Toshikazu Watanabe, Tomoyuki Minezawa, Midori Hasegawa, Yasuhiro Goto, Takuya Okamura, Yosuke Sakakibara, Yoshikazu Niwa, Atsushi Kato, Masamichi Hayashi, Sumito Isogai, Masashi Kondo, Naoki Yamamoto, Naozumi Hashimoto, Kazuyoshi Imaizumi
    BMC pulmonary medicine, 19(1) 194-194, Nov 1, 2019  
    BACKGROUND: Myeloperoxidase anti-neutrophil cytoplasmic antibody-related nephritis (MPO-ANCA nephritis) is occasionally accompanied by lung abnormalities such as pulmonary fibrosis. However, the clinical features of pulmonary fibrosis in patients with MPO-ANCA nephritis have not been well documented. This study was performed to compare the prognosis of a usual interstitial pneumonia (UIP) pattern of lung fibrosis in patients with MPO-ANCA nephritis with the prognosis of idiopathic pulmonary fibrosis (IPF). METHODS: We retrospectively reviewed the medical records of 126 patients with MPO-ANCA nephritis and identified 31 with a UIP pattern of lung fibrosis on high-resolution or thin-slice computed tomography (CT). We compared the characteristics and prognosis of these patients with those of 32 patients with IPF. In 18 patients from both groups, we assessed and compared the decline in lung volume over time using three-dimensional (3D) CT images reconstructed from thin-section CT data. RESULTS: The numbers of male and female patients were nearly equal among patients with MPO-ANCA nephritis exhibiting a UIP pattern; in contrast, significant male dominancy was observed among patients with IPF (p = 0.0021). Significantly fewer smokers were present among the patients with MPO-ANCA nephritis with a UIP pattern than among those with IPF (p = 0.0062). There was no significant difference in the median survival time between patients with MPO-ANCA nephritis with a UIP pattern (50.8 months) and IPF (55.8 months; p = 0.65). All patients with IPF in this cohort received antifibrotic therapy (pirfenidone or nintedanib). Almost half of the deaths that occurred in patients with MPO-ANCA nephritis with a UIP pattern were caused by non-respiratory-related events, whereas most deaths in patients with IPF were caused by respiratory failure such as acute exacerbation. In the 3D CT lung volume analyses, the rate of decline in lung volume was equivalent in both groups. CONCLUSIONS: MPO-ANCA nephritis with a UIP pattern on CT may have an unfavorable prognosis equivalent to that of IPF with a UIP pattern treated with antifibrotic agents.
  • 大山友香子, 高橋和男, 山口央輝, 松下祥子, 伊藤辰将, 中嶋和紀, 林宏樹, 小出滋久, 坪井直毅, 稲熊大城, 長谷川みどり, 湯澤由紀夫
    日本腎臓学会誌, 61(3) 287, May 15, 2019  
  • 大山友香子, 高橋和男, 山口央輝, 松下祥子, 伊藤辰将, 中嶋和紀, 林宏樹, 小出滋久, 坪井直毅, 稲熊大城, 長谷川みどり, 湯澤由紀夫
    日本腎臓学会誌, 61(3) 340, May 15, 2019  
  • 佐々木ひと美, 倉橋浩樹, 長谷川みどり, 剣持敬, 日下守, 市野学, 住友誠, 白木良一
    日本移植学会総会プログラム抄録集, 55th, 2019  
  • 佐々木ひと美, 長谷川みどり, 鈴木敦詞, 深見直彦, 市野学, 日下守, 剣持敬, 白木良一
    日本臨床腎移植学会プログラム・抄録集, 52nd, 2019  
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Books and Other Publications

 6
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Presentations

 268
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Teaching Experience

 1

Professional Memberships

 11
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Research Projects

 9
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