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  2. Naoki Yamamoto

Naoki Yamamoto

  (山本 直樹)

Profile Information

Affiliation
Professor, Center for Society-Academia Collaboration, Research Promotion Headquarters, Fujita Health University
(Concurrent)Professor, International Center for Cell and Gene Therapy, Research Promotion Headquarters
(Concurrent)Professor, Graduate School of Medical Sciences
Degree
医学博士(藤田保健衛生大学)
Contact information
naokiyfujita-hu.ac.jp
Researcher number
00267957
J-GLOBAL ID
200901054071171303
researchmap Member ID
6000005815
External link

Research Interests

 16

Research Areas

 6

Research History

 12
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Education

 1

Committee Memberships

 16
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Awards

 13

Papers

 203
  • Hiroko Otake, Tetsushi Yamamoto, Naoki YAMAMOTO, Yosuke Nakazawa, Yoshiki Miyata, Atsushi Taga, HIROSHI SASAKI, Noriaki Nagai
    Medicina, Feb, 2025  
  • Yu Kato, Takeshi Inaba, Koudai Shinke, Noriko Hiramatsu, Tetsuhiro Horie, Takuya Sakamoto, Yuko Hata, Eiji Sugihara, Tetsuya Takimoto, Noriaki Nagai, Yasuhito Ishigaki, Hajime Kojima, Osamu Nagano, Naoki YAMAMOTO, Hideyuki Saya
    Cells, Feb, 2025  
  • Kazuo Ichikawa, Kei Ichikawa, Seiji Tokiwa, Yuki Sato, Tomoyuki Miyazaki, Yoshiki Tanaka, Naoki YAMAMOTO
    Bioengineering, Nov, 2024  
  • Yosuke Nakazawa, Yumika Kuno, Hibiki Shimada, Noriaki Nagai, Noriko Hiramatsu, Shun Takeda, Naoki Yamamoto, Megumi Funakoshi-Tago, Hiroshi Sasaki
    Medical molecular morphology, Jul 9, 2024  
    The prevalence of presbyopia and nuclear cataracts (NUC) is reported to be higher in tropical areas than that in other regions, suggesting a potential influence of high temperatures on lens health. Transient receptor potential vanilloid (TRPV) channels play a crucial role in detecting ambient temperatures across various species, with TRPV1 and TRPV4 expressed in lens epithelial cells. In this study, we investigated whether ambient temperatures affect TRPV1 and TRPV4 activity in the lens, potentially contributing to the development of presbyopia and NUC. We conducted experiments using cultured human lens epithelial cell lines under different temperature conditions. Our results revealed that the mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) and p38 pathways, downstream molecules of TRPV1, were activated, while Src family kinase, a downstream molecule of TRPV4, was inhibited at 37.5 °C culture compared to 35.0 °C. Confocal microscope images demonstrated higher expression of TRPV1 in 3D-structured cells under high-temperature culture conditions. Additionally, in organ culture lenses, higher elasticity was observed at elevated temperatures compared to that at lower temperatures. These results suggest that high ambient temperatures may induce lens sclerosis via TRPV1 activation, potentially contributing to the development of presbyopia and NUC.
  • Koji Komatsu, Yoichiro Masuda, Ai Iwauchi, Hoshiho Kubota, Masanobu Iida, Kosuke Ichihara, Masami Iwamoto, Kenji Kawai, Naoki Yamamoto, Masayuki Shimoda, Tadashi Nakano
    Journal of Cataract & Refractive Surgery, 50(6) 611-617, Jun, 2024  Peer-reviewed
    Purpose: To explore lens capsule pathological characteristics in intraocular lens (IOL) dislocation after cataract surgery in patients with atopic dermatitis (AD). Setting: University hospital department of ophthalmology. Design: Case series with clinicopathological correlations. Methods: Lens capsules and surrounding tissues excised during surgery from eyes with AD (AD group) and eyes without AD (non-AD group) with IOL dislocation were histologically evaluated. Hematoxylin and eosin staining was used to assess abnormal changes in lens epithelial cells (LECs). Masson trichrome staining distinguished the fibrous metaplasia around the lens capsule into high-density and low-density fibrosis. Capsular splitting (thinning) was identified in both stained preparations. Results: The IOL dislocation morphology in the AD group (10 eyes of 10 patients) included 7 cases of capsular bag dislocation (CBD) and 3 cases of dead bag syndrome (DBS), with an average duration to IOL dislocation of 11.5 ± 5.6 years. All patients in the non-AD group (12 eyes of 12 patients) had CBD, averaging 10.2 ± 5.7 years to dislocation. Abnormal LECs, low-density fibrosis, and capsular splitting were observed in 9 (90), 9 (90), and 6 (60) of the patients in the AD group compared with 6 (50), 3 (25), and 2 (18), respectively, in the non-AD group (total n [%]). Conclusions: Compared with the non-AD group, the AD group exhibited higher frequencies of morphological changes in LECs, low-density fibrosis around the lens capsule, and capsular splitting characteristics of DBS. These results suggest LEC degeneration and increased lens capsule fragility occurred in patients with AD.
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Misc.

 56
  • 門脇玲太, 浅井拓己, 出口粧央里, 大竹裕子, 中澤洋介, 山本直樹, 長井紀章
    日本白内障学会総会・水晶体研究会プログラム・講演抄録集, 62nd-49th, 2023  
  • 山本直樹, 山本直樹, 平松範子, 佐々木洋, 近藤征史, 小島肇
    Journal of Toxicological Sciences, 46(Supplement), 2021  
  • 林 卓馬, 山本 直樹, 田島 香里, 長谷川 正樹, 谷口 巧, 藤田 順之, 石村 大輔
    日本整形外科学会雑誌, 94(8) S1859-S1859, Sep, 2020  
  • Tomohide Souma, Tomoyuki Minezawa, Hiroshi Yatsuya, Takuya Okamura, Kumiko Yamatsuta, Sayako Morikawa, Tomoya Horiguchi, Shingo Maeda, Yasuhiro Goto, Masamichi Hayashi, Sumito Isogai, Naoki Yamamoto, Masashi Kondo, Kazuyoshi Imaizumi
    Chest, 158(2) 797-807, Mar 4, 2020  
    BACKGROUND: Infectious complications after endobronchial ultrasound-guided transbronchial biopsy with a guide sheath (EBUS-GS-TBB) are serious in that they may delay or change scheduled subsequent therapy. The aim of this study was to identify risk factors for infection after EBUS-GS-TBB. RESEARCH QUESTION: What are the risk factors for infection after EBUS-GS-TBB? STUDY DESIGN AND METHODS: We retrospectively reviewed the medical records of 1,045 consecutive patients who had undergone EBUS-GS-TBB for peripheral lung lesions between January 2013 and December 2017 at Fujita Health University Hospital. We evaluated the following risk factors for infectious complications after EBUS-GS-TBB: relevant patient characteristics (age and comorbidities), lesion size, CT scan features of target lesion (intratumoral low-density areas [LDAs] and cavitation), stenosis of responsible bronchus observed by bronchoscopy, and laboratory data before EBUS-GS-TBB (WBC count and C-reactive protein concentration). RESULTS: Forty-seven of the study patients developed infectious complications (24 with pneumonia, 14 with intratumoral infection, three with lung abscess, three with pleuritis, and three with empyema), among whom the complication caused a delay in cancer treatment in 13 patients, cancellation of cancer treatment in seven patients, and death in three patients. Multivariate analysis showed that cavitation (P = .007), intratumoral LDAs (P < .001), and stenosis of responsible bronchus observed by bronchoscopy (P < .001) were significantly associated with infectious complications after EBUS-GS-TBB. Prophylactic antibiotics had been administered to 13 patients in the infection group. Propensity matched analysis could not show significant benefit of prophylactic antibiotics in preventing post-EBUS-GS-TBB infections. INTERPRETATION: Cavitation, LDAs for CT scan features of target lesions, and stenosis of responsible bronchus observed by bronchoscopy are risk factors of post-EBUS-GS-TBB infection. In the cohort, prophylactic antibiotics failed to prevent infectious complications.
  • 山本直樹, 平松範子, 久保江理, 佐々木洋
    日本白内障学会誌, 32(1), 2020  
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Books and Other Publications

 10
  • 山本 直樹 (Role: Contributor, 第2章 動物実験代替法における評価モデル 、第3節 不死化ヒト角膜上皮細胞株を用いた眼刺激性試験代替法)
    株式会社 技術情報協会, Jun, 2018
  • 山本 直樹 (Role: Joint author, 細胞培養基盤技術)
    株式会社 じほう, Jun, 2013
  • 山本 直樹 (Role: Contributor, フルオレセイン漏出試験法（Fluorescein leakage test method; FL試験法）)
    株式会社 シーエムシー出版, Jun, 2013
  • 山本 直樹 (Role: Contributor, アトピー白内障 －その発症に関与する要因とメカニズム－)
    学際企画株式会社, Jun, 2011
  • 山本 直樹 (Role: Contributor, 子どもに多い目の病気 “感染予防の必要性の有無と指導の実際")
    健学社, Oct, 2008
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Presentations

 51
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Teaching Experience

 7
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Professional Memberships

 8
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Works

 1

Research Projects

 19
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Industrial Property Rights

 4

Other

 3
  • 市販のリプログラミングベクターを用いて、ヒト末梢血単球由来iPS細胞を作製することに成功した。研究成果は、以下のジャーナルで報告している。Isogai S, Yamamoto N et al., Cell Reprogram 20(6), 347-355, 2018. Hiramatsu N, Yamamoto N et al., Med Mol Morphol 53(2), 63-72, 2020. ＊本研究シーズに関する産学共同研究の問い合わせは藤田医科大学産学連携推進センター（fuji-san@fujita-hu.ac.jp）まで
  • ヒト虹彩由来iPS細胞の作製に成功した。研究成果は、以下のジャーナルで報告している。Yamamoto N et al., Cells 10(4), 743, 2021. ＊本研究シーズに関する産学共同研究の問い合わせは藤田医科大学産学連携推進センター（fuji-san@fujita-hu.ac.jp）まで
  • 臓器・組織を迅速に固定できる固定液を発明。日本で特許を取得（特許3723204 難浸透性組織迅速固定液）。本特許の技術の一部を利用した商品（組織用迅速固定液 スーパーフィックス KY-500, クラボウ）が販売されている。他にも、本特許技術を用いた無ホルマリン固定液を開発中。 ＊本研究シーズに関する産学共同研究の問い合わせは藤田医科大学産学連携推進センター（fuji-san@fujita-hu.ac.jp）まで
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