研究者業績
基本情報
研究分野
1経歴
4-
2019年10月 - 現在
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2013年10月 - 2019年9月
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2010年5月 - 2012年3月
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2007年4月 - 2010年4月
学歴
1-
1994年4月 - 2000年3月
受賞
6論文
333-
The spine journal : official journal of the North American Spine Society 2026年4月28日BACKGROUND CONTEXT: The Oswestry Disability Index (ODI) is one of the most widely used instruments for assessing disability related to low back pain (LBP). However, population-based normative values are scarce, and the structural validity of Japanese version of the ODI (version 2.1a) has not been sufficiently evaluated. PURPOSE: To psychometrically validate the Japanese version of the ODI (version 2.1a) and to establish population-based normative values stratified by age and LBP duration. STUDY DESIGN/SETTING: Population-based cross-sectional study using a nationwide survey in Japan. PATIENT SAMPLE: A nationally representative sample of community-dwelling adults in Japan selected through a two-stage stratified random sampling design. A total of 5,000 individuals were invited to participate. OUTCOME MEASURES: Self-report measures: Disability related to low back pain assessed using the Japanese version of the ODI (version 2.1a). METHODS: Japan was stratified into 65 strata, from which 250 sampling points were randomly selected, and 20 residents were randomly sampled per point. Psychometric properties of the ODI version 2.1a were evaluated among respondents using factor analyses. Response-adjusted, survey-weighted normative values were estimated for the general population and for individuals with LBP, stratified by age group and pain duration subtype (acute, subacute, and chronic). RESULTS: Of the 5,000 individuals invited, 2,188 responded (response rate 43.8%). Among respondents, 1,270 had complete ODI data and were included in the psychometric analysis, including 173 individuals with LBP. The estimated population prevalence of LBP was 14.7% (95% confidence interval [CI] 13.1-16.4%), comprising acute 2.5% (95% CI 1.9-3.3%), subacute 1.1% (95% CI 0.7-1.7%), and chronic 11.1% (95% CI 9.8-12.5%). Factor analyses demonstrated a unidimensional structure of the ODI version 2.1a. Among individuals with LBP, the survey-weighted mean ODI score was 20.23 (95% CI 18.32-22.13). Normative values varied by pain duration (acute: 12.54 [95% CI 8.87-16.22]; subacute: 13.54 [95% CI 8.78-18.31]; chronic: 22.74 [95% CI 20.56-24.92]) and increased with advancing age. CONCLUSION: This study provides psychometric validation of the Japanese ODI version 2.1a and establishes age- and pain duration-specific normative values. These findings support the use of ODI version 2.1a as a single total score for profiling disability in everyday life and for evaluating the management of LBP in both clinical practice and research.
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Spine surgery and related research 10(2) 228-235 2026年3月27日BACKGROUND: The 25-item Geriatric Locomotive Function Scale (GLFS-25) is often used to assess locomotive syndrome stage in older adults with lumbar spinal stenosis (LSS). However, locomotive syndrome stage three encompasses a wide score range, potentially masking clinically meaningful improvements. This study aimed to establish the minimal clinically important difference (MCID) for the GLFS-25 and determine whether MCID-based assessment better reflects surgical outcomes than stage-based evaluation. METHODS: This study included 314 patients aged 65 years and older with LSS who were preoperatively classified as having locomotive syndrome stage three. Patient-reported outcome measures, including the GLFS-25, the Japanese Orthopaedic Association Back Pain Evaluation Questionnaire (JOABPEQ), and Zurich Claudication Questionnaire (ZCQ), were administered before and at six months and 1 year after surgery. The MCID for the GLFS-25 was calculated using an anchor-based method, with the satisfaction item from the ZCQ at 1 year after surgery serving as the anchor. Patients were then categorized into four groups based on whether they achieved improvements in locomotive syndrome stage and/or the GLFS-25 MCID. RESULTS: A 19-point improvement in the GLFS-25 was determined to be the MCID, with an area under the receiver operating characteristic curve, sensitivity, and specificity of 0.80, 65.8%, and 90.2%, respectively. Based on postoperative changes, 129, 49, 33, and 103 patients achieved both stage and MCID improvement (group C), improvement in MCID alone (group M), improvement in stage alone (group S), and no improvement, respectively. Group C showed significantly better surgical effectiveness across all JOABPEQ domains. Group M showed significant improvements in four domains, whereas group S showed significant improvement in only one domain. CONCLUSIONS: The newly established 19-point MCID for the GLFS-25 more accurately represented clinically meaningful improvement than stage-based evaluation. The combined use of MCID and stage classification may enhance outcome assessment after LSS surgery in older adults.
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Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 2026年3月25日BACKGROUND: Hip fractures in older adults require surgery and frequently result in prolonged hospital stays. Recently, the revision of Japan's medical reimbursement system introduced an acute care incentive to promote early surgery for hip fracture cases, highlighting the need for timely intervention and efficient inpatient management. In this context, the present study aimed to identify factors associated with prolonged hospital stay in older adults undergoing hip fracture surgery at two acute care hospitals in Japan. METHODS: A retrospective review was conducted on data from 1184 patients aged ≥65 years who underwent hip fracture surgery between April 2021 and March 2024. Patients were categorized into three groups based on their length of stay: ≤14 days (short group), 15-28 days (moderate group), and ≥29 days (long group). Multinomial logistic regression analysis was utilized to identify factors associated with prolonged hospital stays. Receiver operating characteristic curve analysis was conducted to determine the optimal cutoff for preoperative waiting time in predicting a prolonged hospital stay. RESULTS: The short group included 260 patients (22.0%), the moderate group 631 (53.3%), and the long group 293 (24.7%). Multivariable analysis revealed that extended preoperative waiting time and living with others were independently associated with prolonged hospital stay. The odds ratio for being in the long group was 3.62 (95% confidence interval: 2.40-5.46) for a preoperative waiting time of ≥3 days compared with ≤2 days. The optimal cutoff for preoperative waiting time to predict a hospital stay ≥29 days was 2.5 days (area under the curve: 0.68; sensitivity: 62.8%; specificity: 62.5%), highlighting a clear window for surgical intervention. CONCLUSION: The preoperative waiting time was crucial factor influencing the length of hospital stay after hip fracture surgery in older adults. Timely surgical intervention within 2 days of admission can enhance care efficiency and shorten the hospitalization period.
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Long-Term Outcomes of Total Knee Arthroplasty Without Patellar Resurfacing for Rheumatoid Arthritis.Modern rheumatology 2026年2月11日OBJECTIVES: Whether to resurface the patella in total knee arthroplasty for patients with rheumatoid arthritis remains controversial. This study evaluated long-term clinical and radiographic outcomes after total knee arthroplasty without patellar resurfacing. METHODS: Of 100 knees in 74 patients who underwent total knee arthroplasty without patellar resurfacing, 64 knees in 49 patients were available for follow-up (mean, 13.6 years). Clinical evaluations included the presence of anterior knee pain at final follow-up, Knee Society Score, Knee Society Functional Score and Kujala score. Plain radiographic evaluations assessed patellar thinning and its relationship with clinical outcomes. We also compared outcomes between remission and non-remission groups based on Disease Activity Score in 28 joints using C-reactive protein at final follow-up. RESULTS: The incidence of anterior knee pain was 9.3%. At follow-up, Knee Society Scores and Functional Scores had improved significantly (p < 0.05). Although patellar thinning progressed, it did not appear to affect clinical outcomes or incidence of anterior knee pain. Disease activity did not differ significantly between groups or by presence of anterior knee pain. CONCLUSIONS: Long-term outcomes of total knee arthroplasty without patellar resurfacing in rheumatoid arthritis were favourable, indicating that this approach is acceptable.
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Fujita medical journal 12(1) 12-19 2026年2月OBJECTIVES: Patients with lumbar spinal stenosis (LSS) exhibit significantly different scoring patterns on the visual analogue scale (VAS) chart for low back pain (LP), buttock and lower limb pain (PL), and buttock and lower limb numbness (NL). This study investigated the usefulness of these preoperative scoring patterns on the VAS chart in predicting surgical outcomes in older adults undergoing LSS surgery. METHODS: Time-course data from patients aged ≥65 years who underwent LSS surgery at two institutions were retrospectively assessed. All participants completed the Zurich Claudication Questionnaire and the Japanese Orthopaedic Association Back Pain Evaluation Questionnaire, which included the VAS chart, before surgery and at 6 months and 1 year postoperatively. RESULTS: In total, 334 participants were evaluated. Patients with equal preoperative scores across all three scales showed the highest average postoperative reduction in the three VAS scores. By contrast, those with the highest preoperative VAS scores for LP or NL had the lowest reductions. Based on the multivariable analysis, the highest preoperative VAS scores for LP (relative risk: 2.1) and NL (relative risk: 2.1) were significantly associated with poor surgical improvement in older adults with LSS. CONCLUSIONS: This study demonstrated the potential clinical utility of the preoperative VAS chart in predicting surgical improvement in older patients with LSS. Patients with equal preoperative VAS scores for LP, PL, and NL were more likely to have favorable surgical outcomes, while those with the highest preoperative scores for LP or NL were at higher risk for poor outcomes.
MISC
533-
日本結合組織学会学術大会・マトリックス研究会大会合同学術集会プログラム・抄録集 44回・59回 51-51 2012年6月
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臨床スポーツ医学 26(9) 1163-1167 2009年9月膝前十字靱帯(ACL)再建術後患者の装具使用状況を調査した。対象は97名97膝で、装具の使用状況は硬性装具使用者(K群):61名、軟性装具使用者(N群):21名、硬性・軟性装具使用者(KN群):15名であった。膝の「不安定感」はKN群:40%、K群:23%、N群:14%にみられた。装具の装着期間は、KN群:3.2ヵ月、K群:3.1ヵ月、N群:4.2ヵ月であった。また、装具を着用するのは、KN群はスポーツ時(S):56%、通勤・通学・仕事時(T):19%、1日中(I):25%、K群はS:35%、T:35%、I:30%、N群はS:31%、T:69%、I:0%であった。装具の利点として84%が「安心感」と答え、KN群:100%、K群:92%、N群:52%であった。装具使用を90%の患者が「必要である」と感じており、術後患者の不安感を軽減するためにも有効であると思われた。しかし、硬性装具の長期着用は後の膝「不安定感」を残す結果となる可能性もあり、留意するべきであると思われた。
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骨・関節・靱帯 20(3) 225-232 2007年3月椎間板変性のメカニズム解明を目的に髄核細胞と線維輪細胞に生理的条件下でどのような遺伝子が発現しているか、8週齢Wistar系ラットを用いて遺伝子発現を網羅的に解析した。その結果、Glycosylphosphatidylinositolアンカー型の細胞表面蛋白であるCD24が髄核細胞特異的に発現していることが見出され、CD24が髄核細胞に発現しているという報告はこれまでになく、本報告が初めてであった。今回のマイクロアレイ解析によってCD24以外にも髄核細胞と線維輪細胞の各々に高発現している遺伝子群が同定された。以上よりこれまで髄核細胞特異的なマーカーの報告がなかったことから、CD24は脊索由来の有用な分子マーカーとして椎間板変性の分子生物学的メカニズムの解明に有用なツールとなり得るものと考えられた。
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日本整形外科学会雑誌 80(8) S1049-S1049 2006年8月
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臨床整形外科 41(6) 701-704 2006年6月66歳女.患者は腰痛および左下肢痛を主訴とした.画像所見ではL4/5椎間からL5後方で脊柱管内に占拠病変を認め,椎体左後面と椎弓根にscallopingを認めた.神経鞘腫と椎間板ヘルニアの鑑別が問題となったが,脊柱管内腫瘤の診断で手術を施行した.左L5椎弓を片側椎弓切除した後,L5椎根弓,L5下関節突起の内側1/2も切除した.L5神経根は後下方に圧排されており,後縦靱帯下に存在していた腫瘤を切開すると硬いヘルニア塊が噴出したので,これを摘出した.病理所見では変性した髄核,軟骨終板を認め,腰椎椎間板ヘルニアと診断された.炎症性細胞の浸潤は著明ではなかった.術後1年の現在,左下肢痛は消失し,JOAスコアも改善した
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関東整形災害外科学会雑誌 34(5) 341-346 2003年10月62歳女.SLEに対してステロイド治療中であったが,両下肢の痺れ,脱力感が出現し歩行不能となり精査加療目的で受診した.入院時の神経学的検査,血液生化学検査,動脈血培養検査,単純X線・MRI画像所見より,Th5/6とTh11/12椎間板に発生したMRSA化膿性脊髄炎を疑い化学療法を行ったが,麻痺の改善が見られず手術を施行した.椎体及び椎間板の病巣を掻爬し,切除した血管柄付き肋骨を移植し,胸腔ドレーンを留置した.術後4日より創部とドレーンから膿が排出し,CTで膿胸を認めたため,ドレーンを抜去し,開胸下で連日洗浄した.しかし膿の排出がやまず,術後3週に内視鏡下にドレーンを再留置した.術後6週目には感染巣は鎮静化し,10週目より歩行訓練を開始し,20週目に退院した.術後1年2ヵ月移植骨は癒合し,感染の再発はない
共同研究・競争的資金等の研究課題
5-
日本学術振興会 科学研究費助成事業 2026年4月 - 2029年3月
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日本学術振興会 科学研究費助成事業 2023年4月 - 2026年3月
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日本学術振興会 科学研究費助成事業 2019年4月 - 2022年3月
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日本学術振興会 科学研究費助成事業 2015年4月 - 2018年3月
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日本学術振興会 科学研究費助成事業 2013年4月 - 2015年3月