研究者業績

稲田健一

イナダケンイチ (Ken'ichi Inada)

基本情報

所属: 藤田医科大学医学部医学科教授

学位: 医学博士(東海大学)

J-GLOBAL ID: 200901082865010243
researchmap会員ID: 0000002032

研究キーワード

2

研究分野

2

経歴

1

藤田保健衛生大学医学部医学科第1病理助教授

MISC

129

N-Methyl-N-nitrosourea Concentration-dependent, Rather than Total Intake-dependent, Induction of Adenocarcinomas in the Glandular Stomach of BALB/C Mice.

Jpn. J. Cancer Res. 89, 385-391 1998年

1998
Increased Expression of Sucrase and Intestinal-type Alkaline Phosphatase in Human Gastric Carcinomas with Progression.

Jpn. J. Cancer Res. 89, 186-191 1998年
A New Prognostic Factor for Colorectal Carcinoma, Thymidylate Synthase, and Its Therapeutic Significance.

Cancer 82 (1), 70-77, 1998年
Stable expression of glutathione S-transferase P-form mRNA and TGF-α immunohistochemical expression are useful markers for identification of persistent nodules from an early stage in rat hepatocarcinogenesis

Toshio Imai, Toshifumi Tashiro, Kazuhiro Hayakawa, Junichi Nakanowatari, Taneo Fukuta, Satoru Hosokawa, Tetsuya Tsukamoto, Ken-Ichi Inada, Masae Tatematsu

Journal of Toxicologic Pathology 11(4) 249-255 1998年
Phenotypic shift in human differentiated gastric cancers from gastric to intestinal epithelial cell type during disease progression.

Gastric Cancer 1, 134-141 1998年
N-Methyl-N-nitrosourea Concentration-dependent, Rather than Total Intake-dependent, Induction of Adenocarcinomas in the Glandular Stomach of BALB/c Mice.

Jpn. J. Cancer Res. 89, 385-391 1998年
Increased Expression of Sucrase and Intestinal-type Alkaline Phosphatase in Human Gastric Carcinomas with Progression.

Jpn. J. Cancer Res. 89, 186-191, 1998年
A New Prognostic Factor for Colorectal Carcinoma, Thymidylate Synthase, and Its Therapeutic Significance.

Cancer 82 (1), 70-77 1998年
治療成績からみた胃筋原性腫瘍の手術適応と術式

小寺泰弘, 山村義孝, 稲田健一, 清水泰博, 鳥井彰人, 平井孝, 安井健三, 森本剛史, 加藤知行, 紀藤毅

日本臨床外科医学会雑誌 58(8), 1712-1716(8) 1712-1716 1997年

過去30年間に切除した胃筋原性腫瘍41例を対象とし,その治療方針,術式について検討した.今回検討した範囲でリンパ節転移例は1例も認めず,術式の違いによる生存曲線の差もないことから,良悪性を問わず,胃の切除範囲は適切な局所切除で充分と思われた.ただし,腫瘍の取り残し,損傷は確実に再発につながることを念頭において切除を行うべきである.一方,切除標本をもってしてもHE染色による検討のみでは良悪性の鑑別すら困難であり, 10例において切除当時と今回検索時の病理組織学的診断が食い違った.よって,良悪性の術前診断に基づく治療方針の選択にこだわるよりも,術前には悪性のリスクのある症例を洩れなく拾い出す基準を確立すること,術後は予後因子として有用な分子生物学的パラメーターを求めることを今後の課題とすべきと考える.
Reciprocal Control of Colon-specific Sulfomucin and Sialosyl-Tn Antigen Expression in Human Colorectal Neoplasia.

Virchows Arch. 431, 25-30 1997年
Intestinalization of Gastric Signet Ring Cell Carcinomas with Progression.

Virchows Arch. 431, 103-110 1997年
Induction of Invasive Squamous Cell Carcinomas in the Forestomach of (C3H X MSM)F1, MSM, and C3H Mice by N-methyl-N-nitrosourea and Mutational Analysis of the H-ras and p53 genes.

Cancer Letters 111, 97-104 1997年
Immunoelectron Microscopic Demonstration of Regulated Pathway for Calcitonin and Constitutive Pathway for Carcinoembryonic Antigen in the Same Cells of Human Medullary Carcinomas of Tyroid Glands.

Modern Pathology 10 (1), 7-11 1997年
Highly Metastatic Hepatocellular Carcinomas Induced in Male F344 Rats Treated with N-nitrosomorpholine in Combination with Other Hepatocarcinogens Show a High Incidence of p53 Gene Mutations Along with Altered mRNA Expression of Tumor-related Genes.

Cancer Letters. 112, 33-45 1997年
Gastric and Intestinal Mixed and Solely Intestinal Types of Intestinal Metaplasia in the Human Stomach.

Pathology international 47, 831-841 1997年
Effects of Carbon Tetrachloride Administration on Initiation of Liver Cell Foci by the Non-hepatocarcinogens N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)and Benzo(a)pyrene (B(a)P).

Cancer Letters 118, 55-60 1997年
Dose-dependent Promoting Effects of Catechol on Glandular Stomach Carcinogenesis in BALB/C Mice initiated with N-Methyl-N-nitrosourea.

Jpn. J. Cancer Res. 88, 1143-1148 1997年
Dose-dependent Induction of both Pepsinogen-altered Pyloric Glands and Adenocarcinomas in the Glandular Stomach of C3H Treated with N-Methyl-N-nitrosourea.

Jpn. J. Cancer Res. 88, 238-244 1997年
Denervation Promotes the Development of Cancer-Related Lesions in the Gastric Remnant.

J. Clin. Gastroenterol. 25, 129-134, 1997年
Reciprocal Control of Colon-specific Sulfomucin and Sialosyl-Tn Antigen Expression in Human Colorectal Neoplasia.

Virchows Arch. 431, 25-30 1997年
Intestinalization of Gastric Signet Ring Cell Carcinomas with Progression.

Virchows Arch. 431, 103-110 1997年
Induction of Invasive Squamous Cell Carcinomas in the Forestomach of (C3HXMSM)F1, MSM, and C3H Mice by N-methyl-N-nitrosourea and Mutational Analysis of the H-ras and p53 genes.

Cancer Letters 111, 97-104 1997年
Immunoelectron Microscopic Demonstration of Regulated Pathway for Calcitonin and Constitutive Pathway for Carcinoembryonic Antigen in the Same Cells of Human Medullary Carcinomas of Tyroid Glands.

Modern Pathology 10 (1), 7-11, 1997年
Highly Metastatic Hepatocellular Carcinomas Induced in Male F344 Rats Treated with N-nitrosomorpholine in Combination with Other Hepatocarcinogens Show a High Incidence of p53 Gene Mutations Along with Altered mRNA Expression of Tumor-related Genes.

Cancer Letters. 112, 33-45 1997年
Gastric and Intestinal Mixed and Solely Intestinal Types of Intestinal Metaplasia in the Human Stomach.

Pathology international 47, 831-841 1997年
Effects of Carbon Tetrachloride Administration on Initiation of Liver Cell Foci by the Non-hepatocarcinogens N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)and Benzo(a)pyrene (B(a)P).

Cancer Letters 118, 55-60 1997年
Dose-dependent Promoting Effects of Catechol on Glandular Stomach Carcinogenesis in BALB/C Mice initiated with N-Methyl-N-nitrosourea.

Jpn. J. Cancer Res. 88, 1143-1148 1997年
Dose-dependent Induction of both Pepsinogen-altered Pyloric Glands and Adenocarcinomas in the Glandular Stomach of C3H Treated with N-Methyl-N-nitrosourea.

Jpn. J. Cancer Res. 88, 238-244 1997年
Denervation Promotes the Development of Cancer-Related Lesions in the Gastric Remnant.

J. Clin. Gastroenterol. 25, 129-134 1997年
胃・大腸癌の単クローン増殖と細胞分化

消化器癌 6(1), 31-35 1996年
p53 mutations in Transitional Cell Carcinomas of the Urinary Bladder in Rats Treated with N-buty1-N-(4-hydroxyhbuty1)-nitrosamine.

Cancer Letters 105, 105-112 1996年
The Coexistence of Systemic Sclerosis and Rheumatoid Arthritis in Five Patients. Clinical and Immunogenetic Feature Suggest a Distinct Entity.

Arthritis & Rheumatism 39 (1), 152-156 1996年
T-cell Lymphomas Diffusely Involving the Intestine: Report of Two Rare Cases:

Jpn. J. Clin. Oncol. 26, 264-272 1996年

1996
Primary Monoclonal and Secondary Polyclonal Growth of Colon Neoplastic Lesions in C3H/HeN<->BALB/c Chimeric Mice Treated with l, 2-Dimethylhydrazine: Immunohistochemical Detection of C3H Strain-specific Antigen and Simple Sequence Length Polymorphism A・・・

Int. J.Cancer 66, 234-238 1996年

Primary Monoclonal and Secondary Polyclonal Growth of Colon<br /> Neoplastic Lesions in C3H/HeN<->BALB/c Chimeric Mice<br /> Treated with l, 2-Dimethylhydrazine: Immunohistochemical<br /> Detection of C3H Strain-specific Antigen and Simple<br /> Sequence Length Polymorphism Analysis of DNA.
Monoclonal Development of Squamous Cell Carcinomas from Polyclonal Papillary or Nodular Hyperplasias in the Forestomach of C3H/HeN<->BALB/c Chimeric Mice Treated with N-methyl-N-nitrosourea or Diethylnitrosamine.

Carcinogenesis 17 (6), 1365-1371 1996年
Growth Characteristics in the Initial Stage of Micrometastasis Formation by Bacterial LacZ Gene-tagged Rat Prostatic Adenocarcinoma Cells.

Jpn. J. Cancer Res. 87, 1227-1234 1996年
Expression of Hepatocyte Growth Factor and c-met mRNAs during Rat Chemically Induced Hepatocarcinogenesis.

Carcinogenesis 17 (1), 19-24 1996年
Development of Aberrant Crypt Foci Involves a Fission Mechanism as Revealed by Isolation of Aberrant Crypts.

Jpn. J. Cancer Res. 87, 1199-1203 1996年
Cellular Differentiation and Development of Pyloric Mucosal Metaplasia in the Human Gall-bladder.

Pathology International. 46, 261-266, 1996年
p53 mutations in Transitional Cell Carcinomas of the Urinary Bladder in Rats Treated with N-buty1-N-(4-hydroxyhbuty1)-nitrosamine.

Cancer Letters 105, 105-112 1996年
The Coexistence of Systemic Sclerosis and Rheumatoid Arthritis in Five Patients. Clinical and Immunogenetic Feature Suggest a Distinct Entity.

Arthritis & Rheumatism 39 (1), 152-156 1996年
T-cell Lymphomas Diffusely Involving the Intestine: Report of Two Rare Cases:

Jpn. J. Clin. Oncol. 26, 264-272 1996年
Primary Monoclonal and Secondary Polyclonal Growth of Colon Neoplastic Lesions in C3H/HeN<->BALB/c Chimeric Mice Treated with l, 2-Dimethylhydrazine: Immunohistochemical Detection of C3H Strain-specific Antigen and Simple Sequence Length Polymorphism A・・・

Int. J.Cancer 66, 234-238 1996年

Primary Monoclonal and Secondary Polyclonal Growth of Colon<br /> Neoplastic Lesions in C3H/HeN<->BALB/c Chimeric Mice<br /> Treated with l, 2-Dimethylhydrazine: Immunohistochemical<br /> Detection of C3H Strain-specific Antigen and Simple<br /> Sequence Length Polymorphism Analysis of DNA.
Monoclonal Development of Squamous Cell Carcinomas from Polyclonal Papillary or Nodular Hyperplasias in the Forestomach of C3H/HeN<->BALB/c Chimeric Mice Treated with N-methyl-N-nitrosourea or Diethylnitrosamine.

Carcinogenesis 17 (6), 1365-1371 1996年
Growth Characteristics in the Initial Stage of Micrometastasis Formation by Bacterial LacZ Gene-tagged Rat Prostatic Adenocarcinoma Cells.

Jpn. J. Cancer Res. 87, 1227-1234 1996年
Expression of Hepatocyte Growth Factor and c-met mRNAs during Rat Chemically Induced Hepatocarcinogenesis.

Carcinogenesis 17 (1), 19-24 1996年
Development of Aberrant Crypt Foci Involves a Fission Mechanism as Revealed by Isolation of Aberrant Cypts.

Jpn. J. Cancer Res. 87, 1199-1203 1996年
Cellular Differentiation and Development of Pyloric Mucosal Metaplasia in the Human Gall-bladder.

Pathology International. 46, 261-266 1996年
Mixed Connective Tissue Disease Complicated by Pneumatosis Cystoides Intestinalis and Malabsorption Syndrome: Case Report and Literature Review.

Pathology International 45, 875-878 1995年
CD68+ Reactive Histiocytosis Complicating Early Gastric Cancer.

Pathology international 45, 698-701, 1995年

書籍等出版物

39

器官培養法を用いたヒト胃粘膜腸上皮化生腺管の細胞動態 -腺管分離法による解析-

消化器癌発生学会編、消化器癌の発生と進展10、靖文社、東京、 1998年
p53 knockoutマウスにおけるN-methyl-N-nitrosourea誘発胃癌

消化器癌発生学会編、消化器癌の発生と進展10、靖文社、東京 1998年
MNU誘発キメラマウス腺胃腫瘍の組織発生と発育進展形式の検討

消化器癌発生学会編、消化器癌の発生と進展10、靖文社、東京、 1998年
Helicobacter pylori感染の胃癌発生増強作用 -スナネズミモデルの検討-

消化器癌発生学会編、消化器癌の発生と進展10、靖文社、東京、 1998年
Helicobacter pylori infection enhances glandular stomach carcinogenesis in Mongolian gerbils treated with chemical carcinogens.

J. Jpn. Society Gastroenterol. Carcinogenesis (in Japanese) 1998年

もっとみる

所属学協会

7

もっとみる

共同研究・競争的資金等の研究課題

4

消化管粘膜における細胞分化

共同研究 1999年
Celluler differentiation of gastrointestinal mucosa

Cooperative Research 1999年
腸上皮化生

科学研究費補助金 1995年
Intestinal metaplasia

Grant-in-Aid for Scientific Research 1995年

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