Pharmacology

Kazuhisa Ikemoto

  (池本 和久)

Profile Information

Affiliation
School of Medicine Faculty of Medicine, Fujita Health University
Degree
PhD(Mar, 2002, Nagoya University)

Contact information
ikeikefujita-hu.ac.jp
Researcher number
40351019
J-GLOBAL ID
200901070779328798
researchmap Member ID
5000024590

Papers

 24
  • 狩野 泰輝, 管沼 由唯, 池本 和久, 一瀬 千穂, 望月 利昭, 近藤 一直
    日本血栓止血学会誌, 34(2) 276-276, May, 2023  
  • Yui Suganuma, Chiho Sumi-Ichinose, Taiki Kano, Kazuhisa Ikemoto, Taei Matsui, Hiroshi Ichinose, Kazunao Kondo
    Journal of Pharmacological Sciences, 150 173-179, Jun, 2022  Peer-reviewed
  • Chiho Sumi-Ichinose, Yui Suganuma, Taiki Kano, Kazuhisa Ikemoto, Noriko Ihira, Hiroshi Ichinose, Kazunao Kondo
    Journal of Inherited Metabolic Disease, 45(3) 621-634, Feb, 2022  Peer-reviewed
  • Kazuhisa Ikemoto, Chiho Sumi-Ichinose, Yui Suganuma, Taiki Kano, Noriko Ihira, Toshiharu Nagatsu, Kazunao Kondo
    The Journal of Biochemistry, Jun 28, 2021  Peer-reviewedLead authorCorresponding author
    <title>Abstract</title> Neopterin (NP), biopterin (BP) and monapterin (MP) exist in saliva. The physiological role of salivary NP as well as the pathophysiological role of increased NP in the immune-activated state has been unclear. Saliva is a characteristic specimen different from other body fluids. In this study, we analysed salivary NP and related pterin compounds, BP and MP and revealed some of its feature. High-performance liquid chromatography (HPLC) analysis of saliva and plasma obtained from 26 volunteers revealed that salivary NP existed mostly in its fully oxidized form. The results suggested that salivary NP as well as BP would mostly originate from the oral cavity, perhaps the salivary glands, and that salivary NP levels might not reflect those in the plasma. We also found that a gender difference existed in correlations between concentrations of salivary total concentrations of NP (tNP) and BP (tBP). HPLC analysis of saliva obtained from 5 volunteers revealed that the concentrations of salivary tNP as well as tBP fluctuated in an irregular fashion in various individuals. MP, a diastereomer of NP, might have come from oral cavity NP itself or its precursor. These results indicated that the nature of salivary NP might be different from that of NP in the blood or urine.
  • 狩野 泰輝, 菅沼 由唯, 池本 和久, 一瀬 千穂, 松井 太衛, 近藤 一直
    日本血栓止血学会誌, 31(2) 262-262, May, 2020  

Misc.

 10

Presentations

 33

Research Projects

 2

教育内容・方法の工夫(授業評価等を含む)

 1
  • 件名(英語)
    薬物の作用機序を理解できるよう授業を行っている
    概要(英語)
    病態生理と関連付けた薬物の理解に力点を置いている。

作成した教科書、教材、参考書

 1
  • 件名(英語)
    講義資料集、問題集
    概要(英語)
    学生の授業内容の理解に役立てている。

その他教育活動上特記すべき事項

 1
  • 件名(英語)
    学生間の国際交流
    概要(英語)
    交換留学生の受け入れ時の世話