tsuruta kyoko

A 42-year-old male noticed a subcutaneous small nodule in the abdomen 7 years ago. On the initial consultation in our department, a red, elastic-hard, cauliflower-like giant tumor measuring 17×16×9 cm was detected in the abdomen. The tumor surface was destroyed and hemorrhagic. Resection and mesh skin grafting were performed at an area horizontally 5 cm from the tumor peduncle margin. Since the border between the deep tumor area and rectus abdominis was partially unclear on magnetic resonance imaging, the anterior sheath of the rectus abdominis was also resected. In the totally extirpated specimen, CD34-negative, spindle tumor cells comprised approximately 70% of the tumor, showing a herringbone pattern, while CD34-positive, spindle tumor cells comprised the remaining 30%, showing a storiform pattern. COL1A1-PDGFB fusion gene was detected in the tumor tissue, and a diagnosis of dermatofibrosarcoma protuberans with fibrosarcomatous change was made. There has been no relapse or metastasis during the 1-year-and-2-month postoperative follow-up.[Skin Cancer (Japan) 2012 ; 27 : 339-344]