研究者業績

井澤 英夫

イザワ ヒデオ  (Hideo Izawa)

基本情報

所属
藤田医科大学 医学部 医学科 教授
学位
医学博士(名古屋大学)

J-GLOBAL ID
200901029584552340
researchmap会員ID
6000001679

学歴

 2

論文

 200
  • Reina Ozaki, Sadako Motoyama, Yukio Ozaki, Masayoshi Sarai, Hideki Kawai, Tevfik F. Ismail, Wakaya Fujiwara, Keiichi Miyajima, Yasuomi Nagahara, Noriya Uchida, Scot Garg, Naoyuki Kawashima, Yudai Niwa, Hidemaro Takatsu, Yu Yoshiki, Masaya Ohta, Takashi Muramatsu, Masahide Harada, Hiroyuki Naruse, Ayaka Matsui, Haruo Kamiya, Akihiko Tobe, Tsai Tsung-Ying, Yasuko Bando, Yoshinobu Onuma, Hiroshi Takahashi, Hideo Izawa, Patrick W. Serruys, Toyoaki Murohara
    International Journal of Cardiology 421 132895-132895 2025年2月  
  • Yu Yoshiki, Yukio Ozaki, Mitsuru Abe, Tevfik F Ismail, Hiroshi Takahashi, Masaharu Akao, Hideki Kawai, Takashi Muramatsu, Masahide Harada, Masaya Ohta, Yosuke Hashimoto, Yuichiro Shiki, Masayuki Koshikawa, Keiichi Miyajima, Hidemaro Takatsu, Yudai Niwa, Naoyuki Kawashima, Reina Ozaki, Naotake Tsuboi, Satoshi Iimuro, Hiroshi Iwata, Ichiro Sakuma, Yoshihisa Nakagawa, Kiyoshi Hibi, Takafumi Hiro, Yoshihiro Fukumoto, Seiji Hokimoto, Katsumi Miyauchi, Hisao Ogawa, Hiroyuki Daida, Hiroaki Shimokawa, Hideo Izawa, Takeshi Kimura, Ryozo Nagai
    Journal of the American Heart Association 14(2) e034627 2025年1月21日  
    BACKGROUND: The effect of worsening renal function and baseline chronic kidney disease (CKD) on outcomes in patients with chronic coronary syndrome in the setting of optimal medical therapy remains unknown. METHODS AND RESULTS: The REAL-CAD (Randomized Evaluation of Aggressive or Moderate Lipid Lowering Therapy With Pitavastatin in Coronary Artery Disease) study is a prospective, multicenter, randomized trial of high-dose (pitavastatin 4 mg/day) or low-dose (pitavastatin 1 mg/day) statin therapy in 12 118 patients with chronic coronary syndrome. The primary end point was a composite of cardiovascular death, nonfatal myocardial infarction, stroke, or unstable angina requiring hospitalization (major adverse cardiac and cerebral events [MACCE]). CKD was defined as an estimated glomerular filtration rate [eGFR] <60 mL/min per 1.73 m2. WRF was defined as a decrease in eGFR ≥20% in the initial year; borderline renal function was an annual decrease of 0%<eGFR<20%, and stable renal function was no decrease. Of 12 118 patients, 4340 had baseline CKD and 7778 did not. The rate of MACCE at 5 years was significantly lower in those without (5.5%) versus with CKD (9.5%) (P<0.0001). After excluding 1247 patients who had MACCE, were censored, or missing eGFR within 1 year, 10 871 patients were included. Of these, 3885 were baseline CKD and the remaining 6986 did not have baseline CKD. Of the 10 871 patients, 577 patients had WRF, 6014 patients showed borderline renal function, and the remaining 4280 patients maintained stable renal function. In patients with CKD, WRF was an independent predictor for MACCE at 4 years as compared with stable renal function (hazard ratio [HR]: 1.67; [95% CI, 1.03-2.73; P=0.039]). In patients without CKD, borderline renal function was a significant predictor for MACCE at 4 years compared with stable renal function (HR: 1.40 [95% CI, 1.03-1.91; P=0.032]). CONCLUSIONS: Baseline CKD was an independent predictor for MACCE in patients with CCS. WRF was a significant predictor for MACCE in patients with CKD. Because borderline renal function was an independent predictor for MACCE even in patients without CKD, mild-to-moderate annual declines of eGFR should be carefully monitored (NCT01042730). REGISTRATION: URL: https://www.clinicaltrials.gov; Unique Identifier: NCT01042730.
  • Yuji Kono, Masahiko Mukaino, Yushi Ozawa, Koji Mizutani, Yuki Senju, Takayuki Ogasawara, Masumi Yamaguchi, Takashi Muramatu, Hideo Izawa, Yohei Otaka
    Heart and vessels 39(10) 918-919 2024年10月  
  • Taro Makino, Yuya Ishihara, Masahide Harada, Yoshihiro Sobue, Eiichi Watanabe, Yukio Ozaki, Hideo Izawa
    International Heart Journal 65(5) 841-848 2024年9月30日  
  • Masataka Yoshinaga, Takashi Muramatsu, Masato Ishikawa, Takuo Toriya, Takashi Uwatoko, Yuji Matsuwaki, Yuko Ukai, Yohei Kobayashi, Katsuyoshi Ito, Hideaki Ota, Hideo Izawa
    Cardiovascular intervention and therapeutics 2024年8月13日  
    Slow-flow or no-reflow phenomenon is a common procedural complication during percutaneous coronary intervention (PCI). Given the presence of fragile plaque or thrombotic materials, we hypothesized that long-time predilatation using a perfusion balloon in conjunction with intracoronary nicorandil administration reduces the risk of slow-flow or no-reflow in patients presenting with acute coronary syndrome (ACS). Subjects were patients presenting with ACS who underwent PCI between April 2020 and April 2022. We retrospectively investigated the incidence of slow-flow or no-reflow during the procedure as well as in-hospital outcomes in comparison between the cases undergoing 3-min predilatation using a perfusion balloon in conjunction with intracoronary nicorandil administration followed by DES implantation (PB group) and those with direct stenting (DS group). Among 439 ACS patients, 36 patients in the PB group and 51 patients in the DS group were examined. Mean age was 70 years and 78.2% was male. Distal protection devices were more frequently used in the DS group than in the PB group (31.3% vs. 11.1%, p = 0.02). The incidence rate of slow-flow or no-reflow was significantly lower in the PB group than in the DS group (2.8% vs. 23.5%; p < 0.01). Six cases (11.7%) in the DS group required intra-aortic balloon pumping (IABP), while none in the PB group required (p < 0.01). In-hospital clinical outcomes did not differ between the two groups. Prolonged perfusion balloon predilatation in conjunction with intracoronary nicorandil administration was safe and feasible. This novel strategy could be an attractive alternative to conventional direct stenting for ACS patients.

MISC

 273
  • Yuko Shimizu, Sumio Yamada, Makoto Suzuki, Kotaro Iwatsu, Hiroko Miyoshi, Hideo Izawa, Toyoaki Murohara
    JOURNAL OF CARDIAC FAILURE 12(8) S182-S182 2006年10月  
  • Sumio Yamada, Kotaro Iwatsu, Yuko Shimizu, Hiroko Miyoshi, Hideo Izawa, Mitsuyoshi Oono, Rinya Kao, Toyoaki Murohara
    JOURNAL OF CARDIAC FAILURE 12(8) S156-S156 2006年10月  
  • 平敷 安希博, 井澤 英夫, 山田 高資, 村瀬 洋介, 小林 正和, 大島 覚, 浅野 展行, 西澤 孝夫, 磯部 智, 小川 恭弘, 近藤 隆久, 飯野 重夫, 因田 恭也, 奥村 健二, 室原 豊明
    Circulation Journal 70(Suppl.III) 1199-1199 2006年10月  
  • 宮田 聖子, 野田 明子, 浅野 展行, 平敷 安希博, 小林 正和, 山田 高資, 大島 覚, 片岡 浩樹, 西澤 孝夫, 村瀬 洋介, 海野 一雅, 磯部 智, 飯野 重夫, 井澤 英夫, 永田 浩三, 因田 恭也, 奥村 建二, 室原 豊明, 横田 充弘
    Journal of Cardiology 48(Suppl.I) 564-564 2006年9月  
  • K. Yamada, S. Iino, T. Tanaka, M. Yoshikane, N. Ikeda, T. Kondo, H. Izawa, T. Murohara
    JOURNAL OF HYPERTENSION 24 S78-S79 2006年6月  
  • 梶口 雅弘, 近藤 隆久, 山本 晃士, 井澤 英夫, 小林 昌義, 古森 公浩, 室原 豊明
    70 1041 2006年4月20日  
  • Kohzo Nagata, Koji Obata, Jinglan Xu, Sahoko Ichihara, Akiko Noda, Hirotaka Kimata, Tomoko Kato, Hideo Izawa, Toyoaki Murohara, Mitsuhiro Yokota
    Hypertension 47(4) 656-664 2006年4月  
    Chronic elevation of plasma aldosterone contributes to heart failure. Mineralocorticoid receptor (MR) antagonism is cardioprotective in such a setting, but whether such protection occurs in the presence of low-aldosterone concentrations remains unclear. We investigated whether MR blockade attenuates cardiac hypertrophy and failure in rats with salt-sensitive hypertension. Dahl salt-sensitive (DS) rats fed a high-salt diet from 7 weeks develop concentric left ventricular (LV) hypertrophy secondary to hypertension at 12 weeks followed by heart failure at 19 weeks (DS-CHF). DS rats on such a diet were treated with a non-antihypertensive dose of the selective MR antagonist eplerenone from 12 to 19 weeks. Renin activity and aldosterone concentration in plasma were decreased in DS-CHF rats compared with controls. LV hypertrophy and fibrosis, as well as macrophage infiltration around coronary vessels, were apparent in DS-CHF rats. The amounts of mRNAs for 11β-hydroxysteroid dehydrogenase type 1, MR, monocyte chemoattractant protein 1, and osteopontin were increased in these hearts. Treatment of DS-CHF rats with eplerenone inhibited these changes in gene expression, as well as coronary vascular inflammation and heart failure. Eplerenone attenuated both the decrease in the ratio of reduced to oxidized glutathione and the increase in NADPH oxidase activity apparent in DS-CHF rat hearts. MR blockade with eplerenone thus resulted in attenuation of LV hypertrophy and failure, without an antihypertensive effect, in rats with low-aldosterone hypertension. The beneficial cardiac effects of eplerenone are likely attributable, at least in part, to attenuation of myocardial oxidative stress and coronary vascular inflammation induced by glucocorticoid-activated MRs. © 2006 American Heart Association, Inc.
  • A Hirashiki, H Izawa, F Somura, K Obata, T Kato, T Nishizawa, A Yamada, H Asano, S Ohshima, A Noda, S Iino, K Nagata, K Okumura, T Murohara, M Yokota
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 47(7) 1382-1389 2006年4月  
    OBJECTIVES The relation between the occurrence of pacing-induced mechanical alternans and prognosis in patients with mild-to-moderate idiopathic dilated cardiomyopathy (IDCM) in sinus rhythm was investigated prospectively. The myocardial expression of genes for Ca2+-handling proteins in such patients was also examined. BACKGROUND Mechanical alternans occurs in some patients with severe heart failure, but the relation between the occurrence of mechanical alternans and prognosis in patients with IDCM has remained unknown. METHODS Left ventricular (LV) pressure was measured during atrial pacing, and LV endomyocardial biopsy specimens were collected in 36 IDCM patients and 8 controls. Idiopathic dilated cardiomyopathy patients were divided into two groups consisting of 22 individuals who did not develop mechanical alternans at heart rates up to 140 beats/min (group A) and of 14 individuals who did (group B). The patients were followed up for a mean of 3.7 years. RESULTS There was no significant difference in LV ejection fraction or the plasma concentration of brain natriuretic peptide between groups A and B. The myocardial abundance of ryanodine receptor 2 messenger ribonucleic acid (mRNA) was significantly lower in groups A and B than in controls, whereas that of sarcoplasmic reticulum Ca2+-ATPase mRNA was significantly lower in group B than in group A or controls. Stepwise multivariate analysis identified pacing-induced mechanical alternans as the strongest predictor of cardiac events. Event-free survival in group A was significantly greater than that in group B. CONCLUSIONS The occurrence of pacing-induced mechanical alternans is a potentially useful indicator of poor prognosis in patients with mild-to-moderate IDCM in sinus rhythm.
  • 近藤 隆久, 井澤 英夫, 小林 光一, 梶口 雅弘, 新谷 理, 室原 豊明
    日本病院薬剤師会雑誌 42(4) 461-465 2006年4月  
  • 吉田 幸彦, 臼井 真人, 田嶋 一喜, 平山 治雄, 坪井 直哉, 伊藤 昭男, 因田 恭也, 井澤 英夫, 近藤 隆久, 室原 豊明, 山田 純生, 平井 真理
    医工学治療 18(Suppl.) 91-91 2006年4月  
  • 平敷安 希博, 井澤 英夫, 曽村 富士, 村瀬 洋介, 山田 高資, 小林 正和, 山田 晶, 大島 覚, 浅野 展行, 加藤 倫子, 永田 浩三, 奥村 健二, 室原 豊明, 横田 充弘
    Circulation Journal 70(Suppl.II) 1041-1041 2006年4月  
  • T Amano, T Matsubara, H Izawa, M Torigoe, T Yoshida, Y Hamaguchi, H Ishii, M Miura, Y Hayashi, Y Ogawa, T Murohara
    AMERICAN JOURNAL OF CARDIOLOGY 97(6) 785-788 2006年3月  
    Aldosterone promotes vascular smooth muscle cell proliferation and endothelial dysfunction, suggesting the contribution to in-stent restenosis (ISR). This study evaluated any relation between plasma aldosterone levels and ISR 6 months after successful coronary stenting. We enrolled 156 consecutive patients with stable angina who underwent coronary bare metal stenting. Plasma aldosterone levels and other serum markers known to influence cardiovascular events were measured in all patients at baseline. Patients with restenosis were found to have significantly higher plasma aldosterone levels than their counterparts without restenosis (162 +/- 60 vs 122 +/- 60 pg/ml, p = 0.007). On logistic regression analysis, even after adjusting for clinical, angiographic, and other confounding variables, plasma aldosterone level per 10 pg/ml (odds ratio 1.34, 95% confidence interval 1.10 to 1.63, p = 0.006) proved to be the independent predictor of ISR. The area under the receiver-operating characteristic curve for plasma aldosterone level was 0.75, and the optimal cut-off value identified by receiver-operating characteristic analysis was 141.9 pg/ml, which had a predictive accuracy of 69%. In conclusion, the present findings indicate that plasma aldosterone levels at baseline are independent predictors of ISR and may constitute a potential therapeutic target. (c) 2006 Elsevier Inc. All rights reserved.
  • H Umeda, T Katoh, M Iwase, H Izawa, K Nagata, K Watanabe, T Okada, T Yamada, T Tani, T Matsushita, Y Murakami, M Okamoto, T Shimizu, T Murohara, M Yokota
    CIRCULATION JOURNAL 70(3) 232-238 2006年3月  
    Background The presence of intracoronary large thrombus burden (LTB) in the infarct-related artery increases the risk of distal embolization and no-reflow during percutancous coronary intervention (PCI). Evaluation of whether the distal protection (DP) during primary PCI reduces adverse effects of LTB on myocardial reperfusion and infarct size was investigated. Methods and Results A consecutive series of 88 patients with acute myocardial infarction undergoing primary PCI using DP were compared with 81 consecutive patients treated by primary PCI alone. The DP use showed similar post-procedural myocardial blush grade (MBG)-3 and infarct size, but improved corrected thrombolysis in myocardial infarction frame count (cTFC) (29 +/- 11 vs 35 +/- 20, p=0.011) and the incidence of ST-segment resolution (80.7% vs 66.7%, p=0.038). In patients with LTB present, however, the DP use reduced occurrences of no-reflow (0% vs 11.8%, p=0.036) and distal embolization (4.8% vs 17.6%, p=0.129), resulting in higher occurrences of MBG-3 (61.9% vs 35.3%, p=0.021) and ST-segment resolution (78.6% vs 50.0%, p=0.009), lower cTFC values (30 8 vs 40 22, p=0.012) and smaller infarct size (12.2 +/- 11.2 vs 18.7 +/- 11.1, p=0.015). Conclusions With an improved myocardial reperfusion and smaller infarct size in patients with LTB, the DP during primary PCI might be a better strategy in this particular setting compared with conventional strategy.
  • 加藤 倫子, 井澤 英夫, 天野 哲也, 室原 豊明, 真野 暁子, 橋村 一彦, 植田 初江, 中谷 武嗣
    今日の移植 19(2) 173-177 2006年3月  
  • 近藤 隆久, 新谷 理, 梶口 雅弘, 小林 光一, 井澤 英夫, 古森 公浩, 室原 豊明
    呼吸と循環 54(2) 169-176 2006年2月  
  • 近藤 隆久, 新谷 理, 梶口 雅弘, 小林 光一, 井澤 英夫, 古森 公浩, 室原 豊明
    呼吸と循環 54(2) 169-176 2006年2月1日  
  • J Xu, K Nagata, K Obata, S Ichihara, H Izawa, A Noda, T Nagasaka, M Iwase, T Naoe, T Murohara, M Yokota
    HYPERTENSION 47(2) E8-E8 2006年2月  
  • S Ichihara, Y Yamada, K Obata, K Negata, A Noda, G Ichihara, H Izawa, T Murohara, M Yokota
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 47(4) 75A-75A 2006年2月  
  • 平敷 安希博, 前田 雅彦, 木村 正哉, 井澤 英夫, 小川 恭弘, 大島 覚, 浅野 展行, 小林 正和, 山田 高資, 村瀬 洋介, 室原 豊明
    Japanese Journal of Interventional Cardiology 21(1) 72-76 2006年2月  
    68歳男.高血圧,高脂血症を指摘されたが放置した.労作性狭心症が出現し,胸痛が持続し救急搬送された.心拍数は55/min,心電図でST上昇,陰性T波を認め,胸部X線でCTR63%で中等度鬱血を認めた.又,緊急心臓カテーテルでKillip II度の心原性プレショック状態の急性下壁心筋梗塞と診断し,緊急冠動脈造影を施行した.LADに対してはPCIを施行した.心電図におけるST上昇部位と灌流域の大きさより右冠動脈に対しPCIを行い,ガイディングワイヤー,ガイディングカテーテルを使用したが,冠動脈造影上,責任病変は動脈硬化主体で,血栓量は多くないと判断し,バルーンカテーテルで前拡張し,良好な拡張を確保した.完全血行再建を目的とする一期的PCIは症例によっては,多枝病変の虚血性疾患に対する方法として有用な可能性があると思われた
  • 小林 光一, 近藤 隆久, 井澤 英夫
    Vascular medicine : journal of vascular medicine / 「Vascular medicine」編集委員会 編 2(1) 58-65 2006年1月  
  • K Obata, K Nagata, M Iwase, M Odashima, T Nagasaka, H Izawa, T Murohara, Y Yamada, M Yokota
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 338(2) 1299-1305 2005年12月  
    The possible role of calcineurin in cardiac hypertrophy induced by calmodulin (CaM) overexpression in the heart was investigated. CaM transgenic (CaM-TG) mice developed marked cardiac hypertrophy and exhibited up-regulation of atrial natriuretic factor (ANF) and P-myosin heavy chain gene expression in the heart during the first 2 weeks after birth. The activity of calcineurin in the heart was also significantly increased in CaM-TG mice compared with wild-type littermates. Treatment of CaM-TG mice with the calcineurin inhibitor FK506 (1 mg/kg per day) prevented the increase in the heart-to-body weight ratio as well as that in cardiomyocyte width. FK506 also inhibited the induction of fetal-type cardiac gene expression in CaM-TG mice. Overexpression of CaM in cultured rat cardiomyocytes activated the ANF gene promoter in a manner sensitive to FK506. Activation of a calcineurin-dependent pathway thus contributes to the development of cardiac hypertrophy induced by CaM overexpression in the heart. (c) 2005 Elsevier Inc. All rights reserved.
  • S Ohshima, S Isobe, H Izawa, M Nanasato, A Ando, A Yamada, K Yamada, TS Kato, K Obata, A Noda, T Nishizawa, K Kato, K Nagata, K Okumura, T Murohara, M Yokota
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 46(11) 2061-2068 2005年12月  
    OBJECTIVES We investigated the relationship between iodine-123-metaiodobenzylguanidine (I-123-MIBG) findings and myocardial contractile reserve in patients with mild to moderate dilated cardiomyopathy (DCM). BACKGROUND Little is known regarding the relationship between cardiac sympathetic nervous function and myocardial contractile reserve in DCM. METHODS Twenty-four DCM patients who showed sinus rhythm underwent echocardiography, biventricular catheterization, and myocardial I-123-MIBG scintigraphy. Left ventricular (LV) pressures were measured using a micromanometer-tipped catheter. The myocardial contractile function (LV dP/dt(max)) was determined at rest and during atrial pacing. The messenger ribonucleic acid (mRNA) expressions of intracellular Ca2+-regulatory proteins were analyzed by real-time quantitative reverse transcription-polymerase chain reaction. Myocardial I-123-MIBG accumulation was quantified as a heart-mediastinum ratio (HMR). RESULTS A significant correlation was observed between the delayed I-123-MIBG HMR and the percentage change in LV dP/dt(max) from the baseline to the peak or critical heart rate (r = 0.64; p &lt; 0.001). The delayed I-123-MIBG HMR was significantly lower in patients showing a worsening change in LV dP/dt(max) than in those showing a favorable change (p &lt; 0.005). The maximum LV dP/dt(max) during pacing and the sarcoplasmic reticulum Ca2+-ATPase (SERCA2) mRNA levels were significantly more reduced in patients with a delayed HMR than in those with a delayed HMR &gt; 1.8 (p &lt; 0.05, respectively). CONCLUSIONS Abnormal myocardial I-123-MIBG accumulation is related to an impaired myocardial contractile reserve and down-regulation of SERCA2 mRNA in DCM. Myocardial I-123-MIBG scintigraphy can be useful in noninvasively evaluating myocardial contractile reserve in patients with mild to moderate DCM.
  • T Kato, A Noda, H Izawa, A Yamada, H Asano, K Obata, Y Murase, S Oshima, T Murohara, M Yokota
    JOURNAL OF CARDIAC FAILURE 11(9) S284-S284 2005年12月  
  • A Hirashiki, H Izawa, H Asano, T Murohara, M Yokota
    JOURNAL OF CARDIAC FAILURE 11(9) S283-S283 2005年12月  
  • H Izawa, T Murohara, K Nagata, S Isobe, H Asano, T Amano, S Ichihara, T Kato, S Ohshima, Y Murase, S Iino, K Obata, A Noda, K Okumura, M Yokota
    CIRCULATION 112(19) 2940-2945 2005年11月  
    Background-Mineralocorticoid receptor antagonism reduces mortality associated with heart failure by mechanisms that remain unclear. The effects of the mineralocorticoid receptor antagonist spironolactone on left ventricular (LV) function and chamber stiffness associated with myocardial fibrosis were investigated in mildly symptomatic patients with idiopathic dilated cardiomyopathy (DCM). Methods and Results-Twenty-five DCM patients with a New York Heart Association functional class of I or II were examined before and after treatment with spironolactone for 12 months. LV pressures and volumes were measured simultaneously, and LV endomyocardial biopsy specimens were obtained. Serum concentrations of the carboxyl-terminal propeptide ( PIP) and carboxyl-terminal telopeptide (CITP) of collagen type I were measured. The patients were divided into 2 groups on the basis of the serum PIP/CITP ratio (&lt;= 35, group A, n = 12; &gt; 35, group B, n = 13), an index of myocardial collagen accumulation. LV diastolic chamber stiffness, the collagen volume fraction, and abundance of collagen type I and III mRNAs in biopsy tissue were greater and the LV early diastolic strain rate (tissue Doppler echocardiography) was smaller in group B than in group A at baseline. These differences and the difference in PIP/CITP were greatly reduced after treatment of patients in group B with spironolactone, with treatment having no effect on these parameters in group A. The collagen volume fraction was significantly correlated with PIP/CITP, LV early diastolic strain rate, and LV diastolic chamber stiffness for all patients before and after treatment with spironolactone. Conclusions-Spironolactone ameliorated LV diastolic dysfunction and reduced chamber stiffness in association with regression of myocardial fibrosis in mildly symptomatic patients with DCM. These effects appeared limited, however, to patients with increased myocardial collagen accumulation.
  • JL Xu, K Nagata, K Obata, S Ichihara, H Izawa, A Noda, T Nagasaka, M Iwase, T Naoe, T Murohara, M Yokota
    HYPERTENSION 46(4) 719-724 2005年10月  
    Long-term administration of vasodilators increases shear stress, which is thought to be important for vascular growth in the heart. Nicorandil, an activator of ATP-sensitive potassium channels with a nitrate-like action, is a potent vasodilator. We have now investigated the effects of nicorandil on vascular growth and gene expression in the failing heart of Dahl salt-sensitive (DS) hypertensive rats. DS rats fed a high-salt diet from 6 weeks of age develop concentric cardiac hypertrophy secondary to hypertension at I I weeks, followed by heart failure at IS weeks. DS rats on such a diet were treated with a nonantihypertensive oral dose of nicorandil (6 mg/kg per day) or vehicle from I I to 18 weeks of age. Treatment of DS rats with nicorandil improved cardiac function and attenuated the development of heart failure. Myocardial capillary and arteriolar densities did not differ between vehicle-treated DS rats and age-matched controls. The abundance of mRNAs for endothelial NO synthase (eNOS), vascular endothelial growth factor (VEGF), the VEGF receptor Flt-1, and basic fibroblast growth factor (bFGF) in the myocardium was markedly reduced in vehicle-treated DS rats compared with controls. Treatment of DS rats with nicorandil greatly increased capillary and arteriolar densities and inhibited the downregulation of eNOS, VEGF, fms-like tyrosin kinase-1. and bFGF gene expression. This, nicorandil stimulates coronary capillary and arteriolar growth and thereby likely suppresses the development of heart failure in DS rats. Nicorandil may prove beneficial for the treatment of hypertensive heart failure as well as of ischemic heart disease.
  • TS Kato, A Noda, H Izawa, S Oshima, Y Murase, H Asano, M Kobayashi, T Yamada, K Hamada, S Iino, M Yokota
    CIRCULATION 112(17) U659-U659 2005年10月  
  • 吉田 幸彦, 坪井 直哉, 青山 豊, 石川 真, 小椋 康弘, 鈴木 博彦, 山下 健太郎, 村松 崇, 七里 守, 三輪田 悟, 平山 治雄, 伊藤 昭男, 岡田 太郎, 山田 功, 村上 善正, 因田 恭也, 井澤 英夫, 近藤 隆久, 室原 豊明, 平井 真理, 外山 淳治
    Journal of Cardiology 46(Suppl.I) 174-174 2005年8月  
  • S Isobe, H Izawa, M Iwase, M Nanasato, M Nonokawa, A Ando, S Ohshima, K Nagata, K Kato, T Nishizawa, T Murohara, M Yokota
    JOURNAL OF NUCLEAR MEDICINE 46(6) 909-916 2005年6月  
    Little is known about the relation between left ventricular (LV) functional reserve in response to exercise and cardiac sympathetic nervous function in patients with nonobstructive hypertrophic cardiomyopathy (HCM). We investigated whether an assessment of cardiac sympathetic nervous function by myocardial I-123-metaiodobenzylguanidine (I-123-MIBG) scintigraphy might provide a sign of an abnormal LV functional reserve in response to exercise-induced P-adrenergic stimulation in patients with HCM. Methods: Thirty HCM patients underwent I-123-MIBG scintigraphy and echocardiography at rest and subsequent biventricular cardiac catheterization at rest and during dynamic exercise. LV pressures were measured using a micromanometer-tipped catheter system. The,early and delayed I-123-MIBG images were quantified as a heart-to-mediastinum ratio (H/M). The plasma levels of brain natriuretic peptide (BNP) and norepinephrine (NE) were also measured. Results: Patients were divided into 2 groups according to the delayed I-123-MIBG H/M: group I consisted of 12 patients with a delayed H/M of &lt;= 1.8 and group II had 18 patients with a delayed H/M of &gt; 1.8. Both the percentage increase from rest to exercise in LV isovolumic contraction (LV dP/dt(max)) and the percentage shortening of LV pressure half-time (T-1/2) as an index of isovolumic relaxation were significantly less in group I than in group II (P &lt; 0.05, respectively). A significant linear correlation was observed between the percentage increase in LV dP/dt(max) and I-123-MIBG H/Ms (early H/M: r = 0.49, P &lt; 0.01; delayed H/M: r = 0.54, P &lt; 0.005, respectively). A significant linear correlation was also observed between the percentage shortening in T1/2 and I-123-MIBG H/Ms (early H/M: r = 0.58, P &lt; 0.001; delayed H/M: r = 0.64, P &lt; 0.0005, respectively). The plasma NE levels were significantly higher in group I than in group If (P &lt; 0.01), whereas the plasma BNP levels were comparable in the 2 HCM groups. Conclusion: beta-Adrenergic enhancement of LV function during exercise may depend on the extent of cardiac sympathetic nervous innervation in HCM patients. Resting myocardial I-123-MIBG scintigraphy can noninvasively evaluate LV functional reserve in response to exercise in patients with nonobstructive HCM.
  • Katou Tomoko, Noda Akiko, Izawa Hideo, Yamada Akira, Obata Koji, Nagata Kozo, Asano Hiroyuki, Murohara Toyoaki, Yokota Mitsuhiro
    Circulation journal : official journal of the Japanese Circulation Society 69 316-316 2005年3月1日  
  • 加藤 倫子, Chan Micheal, Hunt Sharon, 井澤 英夫, 横田 充弘, 室原 豊明
    呼吸と循環 53(3) S20-S21 2005年3月  
  • H Izawa, K Negata, K Obata, T Kato, H Asano, S Ohshima, A Yamada, Y Murase, S Isobe, S Ichihara, Y Inden, K Okumura, T Murohara, M Yokota
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 45(3) 381A-381A 2005年2月  
  • A Hirashiki, H Izawa, F Somura, K Nagata, T Kato, H Asano, S Ohshima, A Yamada, Y Murase, A Node, K Obata, M Maeda, T Murohara, M Yokota
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 45(3) 144A-144A 2005年2月  
  • H Izawa, S Ichihara, K Yasui, F Takatsu, H Hirayama, M Waters, T Sone, A Yamada, T Kato, H Asano, Y Yamada, T Murohara, M Yokota
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 45(3) 189A-189A 2005年2月  
  • A Yamada, A Noda, H Izawa, T Kato, T Murohara, M Yokota
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 45(3) 302A-302A 2005年2月  
  • A Yamada, A Noda, H Izawa, Y Murase, H Asano, T Kato, T Murohara, M Yokota
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 45(3) 129A-130A 2005年2月  
  • Ohshima S, Isobe S, Izawa H, Yamada K, Ando A, Kato K, Nagata K, Murohara T, Yokota M
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 45(3) 262A-262A 2005年2月1日  
  • Isobe S, Izawa H, Iwase M, Ohshima S, Yamada K, Nanasato M, Hirai T, Ando A, Nagata K, Kato K, Murohara T, Yokota M
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 45(3) 261A-261A 2005年2月1日  
  • 井澤 英夫, 小林 光一, 近藤 隆久, 室原 豊明
    Heart View 9(11) 123-127 2005年  
  • 分子心血管病 6 293-297 2005年  
  • Tomoko S. Kato, Akiko Noda, Hideo Izawa, Akira Yamada, Koji Obata, Kohzo Nagata, Mitsunori Iwase, Toyoaki Murohara, Mitsuhiro Yokota
    Circulation 110(25) 3808-3814 2004年12月21日  
    Background-The differentiation of hypertrophic cardiomyopathy (HCM) from hypertensive left ventricular hypertrophy (H-LVH) on the basis of morphological information obtained by conventional echocardiography is occasionally problematic. We investigated whether strain rate (SR) imaging derived from tissue Doppler imaging (TDI) is able to discriminate HCM from H-LVH. Methods and Results-Conventional echocardiography and TDI were performed with 34 patients with LVH and 16 reference subjects. Mean values of systolic strain (εsys), peak systolic SR, and early diastolic SR obtained from 8 left ventricular (LV) segments were calculated. LV pressures were recorded simultaneously in the patients. Patients were diagnosed with HCM (n=20) or H-LVH (n=14) on the basis of conventional echocardiography and endomyocardial biopsy findings. Multivariate analysis revealed that septum/posterior wall thickness ratio (P=0.00013) and εsys (P&lt 0.0001) were each able to discriminate HCM from H-LVH. A εsys cutoff value of - 10.6% discriminated between HCM and H-LVH with a sensitivity of 85.0%, specificity of 100.0%, and predictive accuracy of 91.2%. The combination of the septum/posterior wall thickness ratio and εsys discriminated HCM from H-LVH with a predictive accuracy of 96.1%. The εsys parameter was significantly correlated with pulmonary arterial wedge pressure, LV end-diastolic pressure, the peak positive first derivative of LV pressure, and the time constant of LV pressure decay. Conclusions-SR imaging is able to discriminate HCM from H-LVH, with εsys reflecting myocardial contractile and lusitropic properties.
  • K Yamamoto, T Kondo, S Suzuki, H Izawa, M Kobayashi, N Emi, K Komori, T Naoe, J Takamatsu, T Murohara
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 24(12) E192-E196 2004年12月  
    Objective - Although some patients with limb ischemia have recently undergone therapeutic angiogenesis by cell transplantation, their angiogenic potential has not been well characterized. It is also important to evaluate endothelial progenitor cell (EPC) contents in different stem cell sources to choose the best material for therapeutic angiogenesis. Methods and Results - We quantitated the mRNA expression of EPC-specific molecules (eg, Flk-1, Flt-1, CD133, VE-cadherin, etc) in bone marrow-derived or peripheral blood-derived mononuclear cells obtained from patients with ischemic limbs, using real-time reverse-transcription polymerase chain reaction technique. The mRNA expression level of EPC markers was significantly lower in the patients than in healthy controls, which was consistent with results of flow cytometric analysis. However, the implantation of autologous bone marrow mononuclear cells increased the circulating EPCs in the peripheral blood of patients. We furthermore revealed the different expression pattern of EPC markers in possible sources for stem cell transplantation, including normal bone marrow, peripheral blood obtained from recombinant granulocyte colony - stimulating factor-treated donor, and umbilical cord blood. Conclusions - Patients with peripheral obstructive arterial diseases may have lower angiogenic potential because of decreased expression of EPC specific molecules in their marrow and blood. Therapeutic angiogenesis by transplantation of autologous marrow mononuclear cells increased circulating EPCs in the patients and improved ischemic symptoms.
  • 永田 浩三, 野田 明子, 小畑 孝二, 許 京蘭, 横田 充弘, 加藤 倫子, 山田 晶, 井澤 英夫, 室原 豊明, 市原 佐保子, 岩瀬 三紀
    Circulation journal : official journal of the Japanese Circulation Society 68 908-908 2004年10月20日  
  • 山田 晶, 因田 恭也, 村瀬 洋介, 浅野 展行, 大島 覚, 加藤 倫子, 武藤 真広, 高田 康信, 井澤 英夫, 磯部 智, 近藤 隆久, 永田 浩三, 奥村 健二, 室原 豊明, 野田 明子, 平井 真理, 横田 充弘, 吉川 雅治, 竹中 拡晴, 碓氷 章彦, 土田 裕一
    Circulation journal : official journal of the Japanese Circulation Society 68 914-914 2004年10月20日  
  • 加藤 倫子, 井澤 英夫, 磯部 智, 山田 晶, 村瀬 洋介, 永田 浩三, 大島 覚, 高田 康信, 山田 清康, 浅野 展行, 近藤 隆久, 因田 恭也, 室原 豊明, 泊 史郎, 吉川 雅治, 碓氷 章彦, 〓田 裕一, 成川 充弘
    Circulation journal : official journal of the Japanese Circulation Society 68 919-919 2004年10月20日