研究者業績

井澤 英夫

イザワ ヒデオ  (Hideo Izawa)

基本情報

所属
藤田医科大学 医学部 医学科 教授
学位
医学博士(名古屋大学)

J-GLOBAL ID
200901029584552340
researchmap会員ID
6000001679

学歴

 2

論文

 200
  • Reina Ozaki, Sadako Motoyama, Yukio Ozaki, Masayoshi Sarai, Hideki Kawai, Tevfik F. Ismail, Wakaya Fujiwara, Keiichi Miyajima, Yasuomi Nagahara, Noriya Uchida, Scot Garg, Naoyuki Kawashima, Yudai Niwa, Hidemaro Takatsu, Yu Yoshiki, Masaya Ohta, Takashi Muramatsu, Masahide Harada, Hiroyuki Naruse, Ayaka Matsui, Haruo Kamiya, Akihiko Tobe, Tsai Tsung-Ying, Yasuko Bando, Yoshinobu Onuma, Hiroshi Takahashi, Hideo Izawa, Patrick W. Serruys, Toyoaki Murohara
    International Journal of Cardiology 421 132895-132895 2025年2月  
  • Yu Yoshiki, Yukio Ozaki, Mitsuru Abe, Tevfik F Ismail, Hiroshi Takahashi, Masaharu Akao, Hideki Kawai, Takashi Muramatsu, Masahide Harada, Masaya Ohta, Yosuke Hashimoto, Yuichiro Shiki, Masayuki Koshikawa, Keiichi Miyajima, Hidemaro Takatsu, Yudai Niwa, Naoyuki Kawashima, Reina Ozaki, Naotake Tsuboi, Satoshi Iimuro, Hiroshi Iwata, Ichiro Sakuma, Yoshihisa Nakagawa, Kiyoshi Hibi, Takafumi Hiro, Yoshihiro Fukumoto, Seiji Hokimoto, Katsumi Miyauchi, Hisao Ogawa, Hiroyuki Daida, Hiroaki Shimokawa, Hideo Izawa, Takeshi Kimura, Ryozo Nagai
    Journal of the American Heart Association 14(2) e034627 2025年1月21日  
    BACKGROUND: The effect of worsening renal function and baseline chronic kidney disease (CKD) on outcomes in patients with chronic coronary syndrome in the setting of optimal medical therapy remains unknown. METHODS AND RESULTS: The REAL-CAD (Randomized Evaluation of Aggressive or Moderate Lipid Lowering Therapy With Pitavastatin in Coronary Artery Disease) study is a prospective, multicenter, randomized trial of high-dose (pitavastatin 4 mg/day) or low-dose (pitavastatin 1 mg/day) statin therapy in 12 118 patients with chronic coronary syndrome. The primary end point was a composite of cardiovascular death, nonfatal myocardial infarction, stroke, or unstable angina requiring hospitalization (major adverse cardiac and cerebral events [MACCE]). CKD was defined as an estimated glomerular filtration rate [eGFR] <60 mL/min per 1.73 m2. WRF was defined as a decrease in eGFR ≥20% in the initial year; borderline renal function was an annual decrease of 0%<eGFR<20%, and stable renal function was no decrease. Of 12 118 patients, 4340 had baseline CKD and 7778 did not. The rate of MACCE at 5 years was significantly lower in those without (5.5%) versus with CKD (9.5%) (P<0.0001). After excluding 1247 patients who had MACCE, were censored, or missing eGFR within 1 year, 10 871 patients were included. Of these, 3885 were baseline CKD and the remaining 6986 did not have baseline CKD. Of the 10 871 patients, 577 patients had WRF, 6014 patients showed borderline renal function, and the remaining 4280 patients maintained stable renal function. In patients with CKD, WRF was an independent predictor for MACCE at 4 years as compared with stable renal function (hazard ratio [HR]: 1.67; [95% CI, 1.03-2.73; P=0.039]). In patients without CKD, borderline renal function was a significant predictor for MACCE at 4 years compared with stable renal function (HR: 1.40 [95% CI, 1.03-1.91; P=0.032]). CONCLUSIONS: Baseline CKD was an independent predictor for MACCE in patients with CCS. WRF was a significant predictor for MACCE in patients with CKD. Because borderline renal function was an independent predictor for MACCE even in patients without CKD, mild-to-moderate annual declines of eGFR should be carefully monitored (NCT01042730). REGISTRATION: URL: https://www.clinicaltrials.gov; Unique Identifier: NCT01042730.
  • Yuji Kono, Masahiko Mukaino, Yushi Ozawa, Koji Mizutani, Yuki Senju, Takayuki Ogasawara, Masumi Yamaguchi, Takashi Muramatu, Hideo Izawa, Yohei Otaka
    Heart and vessels 39(10) 918-919 2024年10月  
  • Taro Makino, Yuya Ishihara, Masahide Harada, Yoshihiro Sobue, Eiichi Watanabe, Yukio Ozaki, Hideo Izawa
    International Heart Journal 65(5) 841-848 2024年9月30日  
  • Masataka Yoshinaga, Takashi Muramatsu, Masato Ishikawa, Takuo Toriya, Takashi Uwatoko, Yuji Matsuwaki, Yuko Ukai, Yohei Kobayashi, Katsuyoshi Ito, Hideaki Ota, Hideo Izawa
    Cardiovascular intervention and therapeutics 2024年8月13日  
    Slow-flow or no-reflow phenomenon is a common procedural complication during percutaneous coronary intervention (PCI). Given the presence of fragile plaque or thrombotic materials, we hypothesized that long-time predilatation using a perfusion balloon in conjunction with intracoronary nicorandil administration reduces the risk of slow-flow or no-reflow in patients presenting with acute coronary syndrome (ACS). Subjects were patients presenting with ACS who underwent PCI between April 2020 and April 2022. We retrospectively investigated the incidence of slow-flow or no-reflow during the procedure as well as in-hospital outcomes in comparison between the cases undergoing 3-min predilatation using a perfusion balloon in conjunction with intracoronary nicorandil administration followed by DES implantation (PB group) and those with direct stenting (DS group). Among 439 ACS patients, 36 patients in the PB group and 51 patients in the DS group were examined. Mean age was 70 years and 78.2% was male. Distal protection devices were more frequently used in the DS group than in the PB group (31.3% vs. 11.1%, p = 0.02). The incidence rate of slow-flow or no-reflow was significantly lower in the PB group than in the DS group (2.8% vs. 23.5%; p < 0.01). Six cases (11.7%) in the DS group required intra-aortic balloon pumping (IABP), while none in the PB group required (p < 0.01). In-hospital clinical outcomes did not differ between the two groups. Prolonged perfusion balloon predilatation in conjunction with intracoronary nicorandil administration was safe and feasible. This novel strategy could be an attractive alternative to conventional direct stenting for ACS patients.

MISC

 273
  • Therapeutic Research 23 1769-1774 2002年  
  • 西村 英哉, 安藤 晃禎, 野々川 信, 高田 康信, 清水 敦哉, 飯野 重夫, 因田 恭也, 赤星 誠, 井澤 英夫, 近藤 隆久, 平井 真理, 横田 充弘, 高田 康夫, 七里 守
    65 748 2001年10月20日  
  • 磯部 智, 安藤 晃禎, 野々川 信, 鈴木 徳幸, 高田 康信, 飯野 重夫, 井澤 英夫, 赤星 誠, 因田 恭也, 近藤 隆久, 平井 真理, 横田 充弘, 石木 良治, 七里 守
    Japanese circulation journal 65 764-764 2001年10月20日  
  • 野々川 信, 磯部 智, 安藤 晃禎, 井澤 英夫, 永田 浩三, 曽村 富士, 平井 真理, 加藤 倫子, 横田 充弘
    Japanese circulation journal 65 764-764 2001年10月20日  
  • Y Takeichi, M Yokota, M Iwase, H Izawa, T Nishizawa, R Ishiki, F Somura, K Nagata, S Isobe, A Noda
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 38(2) 335-343 2001年8月  
    Objectives The aim of this study was to clarify the serial changes in left ventricular (LV) end-diastolic pressure (LVEDP) during dynamic exercise in patients with hypertrophic cardiomyopathy (HCM). Background Although HCM is characterized by impaired resting LV diastolic function, serial changes in LVEDP during exercise have not been characterized. Methods We simultaneously measured LV pressure and LV dimensions during symptom-limited supine bicycle exercise in 5 healthy individuals and 20 patients with HCM. Exercise thallium-201 scintigraphic studies were also performed. Results The LVEDP (baseline: 12 +/-5 mm Hg) progressively increased to a maximum value at peak exercise (28 +/-8 mm Hg) in 11 patients with HCM (group I). In the remaining nine patients with HCM (group II), changes in LVEDP during exercise were biphasic, with an initial progressive increase and a subsequent gradual decline up to peak exercise (14 +/-4 mm Hg at baseline, 27 +/-5 mm Hg at the critical heart rate, 16 +/-3 mm Hg at peak exercise). Exorcise-induced changes in LV dimensions and LV peak systolic pressures were similar in both groups. However, the maximum first derivative of LV pressure was greater and the LV pressure half-time was shorter in group II than in group I at a similar peak exercise heart rate. The biphasic changes in LVEDP disappeared by pretreatment with propranolol. The LV hypertrophy scores were higher in group I than in group II. Exercise thallium-201 images showed more severe perfusion defects in group I than in group II patients. Conclusions The biphasic changes in LVEDP seen during exercise may be related to improved coronary microcirculation in response to beta-adrenergic stimulation in patients with mild to moderate HCM. (J Am Coll Cardiol 2001;38:335-43) (C) 2001 by the American College of Cardiology.
  • F Somura, H Izawa, M Iwase, Y Takeichi, R Ishiki, T Nishizawa, A Noda, K Nagata, Y Yamada, M Yokota
    CIRCULATION 104(6) 658-663 2001年8月  
    Background-The relationship between left ventricular (LV) contractile functional reserve and gene expression of Ca2+-handling proteins in patients with hypertrophic cardiomyopathy (HCM) remains to be clarified. Methods and Results-We calculated the maximum first derivative of LV pressure (LV dP/dt(max)) and the LV pressure half-time (T-1/2) during pacing in 14 patients with nonobstructive HCM (LV ejection fraction &gt; 55%) and 7 control subjects. Endomyocardial tissue was obtained, and mRNA levels of sarcoplasmic reticulum Ca2+-ATPase (SERCA2), ryanodine receptor-2, phospholamban, calsequestrin, and Na+/Ca2+, exchanger were quantified by use of a real-time quantitative reverse transcription-polymerase chain reaction method. Group A consisted of 7 HCM patients who showed a progressive rise in the LV dP/dt(max) with increased heart rate. Group B consisted of 7 HCM patients in whom the heart rate-LV dP/dt,,,, relation was biphasic at physiological pacing rates. Both the mean maximal wall thick-ness and the LV hypertrophy score in group B were greater than in group A (20 +/-5 versus 15 +/-3 nun and 7 +/-1 versus 5 +/-2 points, respectively). SERCA2 mRNA levels were significantly lower in group B (SERCA2/GAPDH ratio 0.34 +/-0.15) compared with group A (0.72 +/-0.27) and control subjects (0.85 +/-0.47), whereas the mRNA expression of ryanodine receptor-2, phospholamban. calsequestrin, and Na+/Ca2+ exchanger were similar in all groups. Conclusions-These results suggest that downregulation of SERCA2 mRNA, resulting in altered Ca2+ handling, may contribute to impaired LV contractile reserve in HCM patients with severe hypertrophy, even in the absence of detectable baseline systolic dysfunction.
  • 安藤 晃禎, 野々川 信, 磯部 智, 七里 守, 高田 康夫, 井澤 英夫, 平井 真理, 横田 充弘
    Japanese circulation journal 65 624-624 2001年4月20日  
  • 野々川 信, 安藤 晃禎, 磯部 智, 井澤 英夫, 平井 真理, 七里 守, 高田 康夫, 横田 充弘
    Japanese circulation journal 65 625-625 2001年4月20日  
  • 左 萍, 野田 明子, 加藤 倫子, 西沢 孝夫, 石木 良治, 伊藤 菜美, 曽村 富士, 井澤 英井, 横田 充弘
    Journal of medical ultrasonics = 超音波医学 28(3) J443 2001年4月15日  
  • 岩瀬 三紀, 野田 明子, 古池 保雄, 北市 清幸, 高木 健次, 金澤 寛明, 高木 健三, 井澤 英夫, 西澤 孝夫, 横田 充弘
    Journal of medical ultrasonics = 超音波医学 28(3) J448 2001年4月15日  
  • M Iwase, M Yokota, K Kitaichi, L Wang, K Takagi, T Nagasaka, H Izawa, T Hasegawa
    CRITICAL CARE MEDICINE 29(3) 609-617 2001年3月  
    Objective: In this study, we evaluated the time course of the alterations in left ventricular (LV) dimensions, LV wall thickness, and LV systolic function in rats with endotoxemia by using echocardiography as well as myocardial histopathologic assessments. Our second goal was to examine whether pretreatment with a platelet-activating factor (PAF) antagonist would ameliorate the lipopolysaccharide (LPS)-induced cardiovascular collapse during the early phase. Design:A prospective, controlled, in vivo animal laboratory study. Setting: Research laboratory at a university. Subjects: Male, Wistar rats (8-9 wks old; n = 83), Interventions: In pentobarbitat-anesthetized rats, the right carotid artery was cannulated to measure the arterial blood pressure and to sample blood. The right jugular vein also was catheterized for the administration of drugs. LPS (2 mg/kg) derived from Klebsiella pneumoniae or physiologic saline was administered in the presence or absence of pretreatment with TCV-309, a specific potent PAF antagonist. Echocardiographic studies were performed with an 8- to 13-MHz transducer. Measurements and Main Results:LPS administration immediately induced progressive hypotension, The maximal hypotensive response was observed at 10 mins after LPS infusion with mean arterial pressure decreasing from 119 +/- 2 to 56 +/- 3 mm Hg (p &lt; .001). LV end-diastolic internal dimensions decreased from 6.4 +/- 0.1 to 3.1 +/- 0.1 mm (p &lt; .001) at 30 mins after LPS and remained significantly reduced compared with control rats. LV end-systolic dimensions also decreased dramatically from 3.5 +/- 0.2 to 0.5 +/- 0.1 mm (p &lt;.001) at 30 mins after LPS and remained significantly reduced throughout the experiment. LV fractional shortening increased from 45 +/- 1% to 84 +/- 2% (p &lt; .001) at 30 mins after LPS and remained elevated compared with control rats, LV wall thickness increased strikingly from 15 mins until 2 hrs after LPS infusion. Pathologic studies demonstrated marked congestion of capillaries and mild edema in the LV myocardium. The hematocrit increased after the administration of LPS. LPS markedly increased sympathetic tone as demonstrated by the elevation of plasma concentrations of epinephrine and norepinephrine, There was no elevation of concentrations of nitrite and nitrate, Pretreatment with TCV-309, a specific potent PAF antagonist, reduced LPS-induced hypotension and attenuated LV functional and structural changes. TCV-309 administration reduced the LPS-induced adrenergic activation and hemoconcentration, Conclusions:The hypotension that occurred during the initial phase of LPS-induced shock was accompanied by LV functional and structural alterations. The marked increase in LV wall thick ness can be ascribed to the congestion of capillaries and edema in the LV myocardium. Pretreatment with a PAF antagonist reduced LPS-induced alterations. PAF may play a pivotal role during the initial phase of LPS-induced cardiovascular responses.
  • T Nishizawa, M Iwase, H Kanazawa, T Nagasaka, T Hasegawa, R Ishiki, F Somura, H Izawa, Y Ishikawa, M Yokota
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 37(2) 177A-177A 2001年2月  
  • Y Yamada, S Ichihara, H Izawa, M Tanaka, M Yokota
    JOURNAL OF HUMAN GENETICS 46(8) 436-441 2001年  
    Plasma platelet-activating factor acetylhydrolase (PAF-AH) acts as a key defense against oxidative stress by hydrolyzing PAF and oxidized phospholipids. Deficiency of the activity of this enzyme may thus potentially result in predisposition to myocardial damage. The possible role of the G(994) (Vallele) --&gt; T (F allele) polymorphism of the PAF-AH gene in modulating cardiac function was investigated in 142 Japanese subjects with nonfamilial hypertrophic cardiomyopathy (HCM). Logistic regression analysis adjusted for age, sex, height, and body weight revealed that the frequency of the F allele was significantly higher in HCM patients than in 284 healthy controls. Echocardiographic examination revealed that left ventricular (LV) end-diastolic and end-systolic dimensions were significantly greater in HCM patients with the FF genotype than in those with the FF genotype. Cardiac catheterization revealed that LV end-diastolic pressure was significantly higher, whereas the LV ejection fraction was significantly smaller, for HCM patients with the F allele than for those with the FF genotype. Interstitial fibrosis was significantly more severe in HCM subjects with the FF genotype than in those with the FF genotype. These results suggest that the G(994) --&gt; T (Val(279) --&gt; Phe) polymorphism in the plasma PAF-AH gene may exacerbate cardiac damage in Japanese individuals with nonfamilial HCM, although this polymorphism is unlikely to be a causative factor for this condition.
  • 磯部 智, 安藤 晃禎, 野々川 信, 高田 康信, 飯野 重夫, 吉田 幸彦, 石木 良治, 井澤 英夫, 富田 保志, 赤星 誠, 因田 恭也, 近藤 隆久, 平井 真理, 七里 守, 高田 康夫, 横田 充弘
    Japanese circulation journal 64 899-899 2000年10月20日  
  • 西澤 孝夫, 寺澤 求, 長坂 徹郎, 横田 充弘, 岩瀬 三紀, 野田 明子, 北市 清幸, 石木 良治, 曽村 富士, 井澤 英夫, 永田 浩三
    Japanese circulation journal 64 895-895 2000年10月20日  
  • 岩瀬 三紀, 北市 清幸, 野田 明子, 西澤 孝夫, 寺澤 求, 長坂 徹郎, 横田 充弘, 永田 浩三, 曽村 富士, 石木 良治, 井澤 英夫
    Japanese circulation journal 64 895-895 2000年10月20日  
  • F Somura, R Ishiki, H Izawa, M Terasawa, K Nagata, M Iwase, Y Yamada, M Koide, M Yokota
    CIRCULATION 102(18) 625-625 2000年10月  
  • P Zuo, H Izawa, R Ishiki, A Noda, T Nishizawa, K Shigemura, K Nagata, M Iwase, M Yokota
    AMERICAN HEART JOURNAL 140(2) 329-337 2000年8月  
    Background The impaired adrenergic control of both inotropic and lusitropic reserves has been evaluated in patients with hypertrophic cardiomyopathy (HCM) but nor in those with apical HCM (APH). Objectives We examined the influence of increases in heart rate and adrenergic stimulation on inotropic and lusitropic reserves in HCM and APH with normal resting left ventricular (IV) systolic function. Methods We evaluated LV isovolumic contraction and relaxation during atrial pacing and during supine leg exercise in 7 patients with APH and in 8 patients with HCM. Results Heart rate was significantly correlated with IV isovolumic contraction and relaxation during pacing and exercise in all patients. In all patients with APH, the increase in LV isovolumic contraction was greater during exercise (101%) than pacing alone (27%) for similar increase in heart rate. In 5 patients with HCM, the increase in IV isovolumic contraction was greater during exercise (83%) than pacing alone (24%), whereas in 3 patients with HCM the increase in LV isovolumic contraction was similar between during exercise (25%) and during pacing alone (22%). in all patients with APH, relaxation was shorter during exercise (39%) than pacing alone (16%). Conversely, in patients with HCM relaxation was similarly shortened between during pacing alone (20%) and during exercise (19%). Conclusions The force-frequency and the relaxation-frequency relations were well-preserved in all patients. In patients with HCM, the adrenergic enhancement of force-frequency relation and/or relaxation-frequency relation was impaired. In patients with APH, however, adrenergic control of both force-frequency and relaxation-frequency relations was well-preserved, which may indicate a preserved beta-adrenergic signaling pathway.
  • R Ishiki, H Ishihara, H Izawa, K Nagata, M Hirai, M Yokota
    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY 35(6) 897-905 2000年6月  
    A recent long-term multicenter trial has shown that pimobendan is more effective when administered in low doses. However, no data are available concerning the effect of a low dose of pimobendan on the systolic and diastolic pressure-volume relations in patients with heart failure. Therefore we examined the effects of a single low dose of oral pimobendan, a calcium sensitizer, on systolic and diastolic hemodynamics in patients with cardiomyopathy and congestive heart failure. We measured the left ventricular (LV) pressure-volume relations using a conductance catheter with a micromanometer tip in 10 patients with chronic congestive heart failure resulting from idiopathic cardiomyopathy before and 45 and 90 min after administration of a single oral dose of 2.5 mg of pimobendan. End-systolic elastance was used as an index of LV contractility and was measured during transient occlusion of the inferior vena cava. End-systolic elastance increased significantly by 25% at 45 min (p &lt; 0.05) and by 55% at 90 min (p &lt; 0.01) without an increase in myocardial oxygen consumption. The inotropic effect was accompanied by improved ventriculoarterial coupling. This effect was attenuated in patients with severely impaired myocardial contractility. LV relaxation, assessed by the time constant of isovolumic pressure decay (T-1/2), was significantly shortened at 90 min (from 47.7 +/- 1.9 to 41.2 +/- 1.7 ms; p &lt; 0.01), although it remained unchanged at 45 min. The diastolic pressure-volume relation showed a leftward and downward shift in all patients. These results indicate that low-dose oral pimobendan had favorable short-term inotropic and lusitropic effects in patients with congestive heart failure caused by idiopathic dilated cardiomyopathy, and may thus be a useful alternative to traditional agents. Further study in a large-scale trial is merited.
  • S Isobe, A Ando, M Nanasato, M Nonokawa, H Izawa, M Hirai, K Kato, M Tadokoro, T Ishigaki, M Yokota
    JOURNAL OF NUCLEAR MEDICINE 41(5) 161P-161P 2000年5月  
  • 吉田 幸彦, 因田 恭也, 高田 康信, 下方 敬子, 清水 敦哉, 飯野 重夫, 井澤 英夫, 磯部 智, 赤星 誠, 杉野 幹夫, 近藤 隆久, 平井 真理, 鈴木 智理, 金子 鎮二
    64 786 2000年4月20日  
  • 磯部 智, 安藤 晃禎, 高田 康信, 井澤 英夫, 飯野 重夫, 近藤 隆久, 吉田 幸彦, 因田 恭也, 赤星 誠, 杉野 幹夫, 平井 真理, 横田 充弘, 野々川 信, 七里 守
    Japanese circulation journal 64 771-771 2000年4月20日  
  • 河村 大誠, 外畑 巌, 井澤 英夫, 曽村 富士, 石木 良治, 磯部 智, 吉田 幸彦, 因田 恭也, 赤星 誠, 永田 浩三, 平井 真理, 野田 明子, 岩瀬 三紀, 重村 一成, 西沢 孝夫, 寺澤 求, 横田 充弘
    Japanese circulation journal 64 774-774 2000年4月20日  
  • 石木 良治, 曽村 富士, 河村 大誠, 梅田 久視, 武市 康志, 稲垣 将文, 井澤 英夫, 永田 浩三, 祖父江 俊和, 平井 真理, 横田 充弘, 西澤 孝夫, 野田 明子, 岩瀬 三紀
    Japanese circulation journal 64 220-220 2000年3月1日  
  • 永田 浩三, 石木 良治, 曽村 富士, 井澤 英夫, 平井 真理, 岩瀬 三紀, 西澤 孝夫, 寺澤 求, 横田 充弘
    Japanese circulation journal 64 506-506 2000年3月1日  
  • 河村 大誠, 井澤 英夫, 曽村 富士, 石木 良治, 永田 浩三, 祖父江 俊和, 平井 真理, 横田 充弘, 野田 明子, 岩瀬 三紀
    Japanese circulation journal 64 638-638 2000年3月1日  
  • 岩瀬 三紀, 野田 明子, 北市 清幸, 西澤 孝夫, 横田 充弘, 長坂 徹郎, 井澤 英夫
    Japanese circulation journal 64 372-372 2000年3月1日  
  • 井澤 英夫, 横田 充弘
    現代医学 48(2) 247-252 2000年  
  • Ryoji Ishiki, Hitoshi Ishihara, Hideo Izawa, Kohzo Nagata, Makoto Hirai, Mitsuhiro Yokota
    Journal of Cardiovascular Pharmacology 35(6) 897-905 2000年  
    A recent long-term multicenter trial has shown that pimobendan is more effective when administered in low doses. However, no data are available concerning the effect of a low dose of pimobendan on the systolic and diastolic pressure-volume relations in patients with heart failure. Therefore we examined the effects of a single low dose of oral pimobendan, a calcium sensitizer, on systolic and diastolic hemodynamics in patients with cardiomyopathy and congestive heart failure. We measured the left ventricular (LV) pressure-volume relations using a conductance catheter with a micromanometer tip in 10 patients with chronic congestive heart failure resulting from idiopathic cardiomyopathy before and 45 and 90 min after administration of a single oral dose of 2.5 mg of pimobendan. End-systolic elastance was used as an index of LV contractility and was measured during transient occlusion of the inferior vena cava. End-systolic elastance increased significantly by 25% at 45 min (p &lt 0.05) and by 55% at 90 min (p &lt 0.01) without an increase in myocardial oxygen consumption: The inotropic effect was accompanied by improved ventriculoarterial coupling. This effect was attenuated in patients with severely impaired myocardial contractility. LV relaxation, assessed by the time constant of isovolumic pressure decay (T(1/2)), was significantly shortened at 90 min (from 47.7 ± 1.9 to 41.2 ± 1.7 ms p &lt 0.01), although it remained unchanged at 45 min. The diastolic pressure-volume relation showed a leftward and downward shift in all patients. These results indicate that low-dose oral pimobendan had favorable short-term inotropic and lusitropic effects in patients with congestive heart failure caused by idiopathic dilated cardiomyopathy, and may thus be a useful alternative to traditional agents. Further study in large-scale trial is merited.
  • Y Mitsuhiro, M Inagaki, H Izawa, R Ishiki, K Nagata, M Iwase, Y Yamada, M Koide
    CIRCULATION 100(18) 23-23 1999年11月  
  • 山内 正樹, 吉田 幸彦, 井澤 英夫, 飯野 重雄, 赤星 誠, 因田 恭也, 近藤 隆久, 平井 真理, 横田 充弘, 沢田 健
    63(2) 749 1999年8月20日  
  • 岩瀬 三紀, 野田 明子, 王 莉, 北市 清幸, 長谷川 高明, 古池 保雄, 井澤 英夫, 祖父江 俊和, 長坂 徹郎, 横田 充弘
    Journal of medical ultrasonics = 超音波医学 26(4) 576-576 1999年4月15日  
  • M Inagaki, M Yokota, H Izawa, R Ishiki, K Nagata, M Iwase, Y Yamada, M Koide, T Sobue
    CIRCULATION 99(14) 1822-1830 1999年4月  
    Background-The extent to which force-frequency and relaxation-frequency relations (FFR and RFR, respectively) and exercise-induced adrenergic stimulation affect myocardial inotropic and lusitropic reserves has not been established in patients with left ventricular (LV) hypertrophy (LVH). Methods and Results-We calculated the maximum first derivative of LV pressure (LV dP/dt(max)) and the LV pressure half-time (T-1/2) during pacing, exercise, and isoproterenol infusion in 17 patients with hypertensive WH and 9 control subjects to investigate the influence of increases in heart rate (HR) and adrenergic stimulation on inotropic and lusitropic reserves. Group A consisted of 10 LVH patients who showed a progressive increase in the HR-LV dP/dt(max) relation. Group B consisted of 7 LVH patients in whom the HR-dP/dt(max) relation at physiological pacing rates was biphasic. The LV mass index was larger and the LV ejection fraction was smaller in group B than in group A (244+/-72 g/m(2) versus 172+/-22 g/m(2) and 55 +/- 18% versus 72+/-6%, respectively; both P&lt;0.05). The increase in LV dP/dt(max) was seater during exercise than pacing alone for similar increases in HR in all groups (P&lt;0.05) (group A, 111+/-22% versus 25+/-14%; group B, 105+/-355 versus 14+/-10%; control, 111+/-24% versus 25+/-12%). T-1/2 was shorter (P&lt;0.05) during exercise than with pacing alone in all groups (group A, 41+/-6% versus 11+/-3%; group B, 38+/-9% versus 14+/-4%; control, 44+/-6% versus 12+/-5%). Isoproterenol infusion caused similar increases in LV dP/dt(max) and similar decreases in T-1/2 in all groups. Conclusions-The FFR was biphasic in patients with seven LVH irrespective of LV function but was preserved in patients with less severe LVH and control subjects. Importantly, the RFR and adrenergic control of both inotropic and lusitropic reserves were well preserved in all LVH patients. A biphasic FFR at physiological pacing rates may be one of the earliest markers of the transition from physiological adaptation to the pathological process in LVH patients.
  • 稲垣 将文, 河村 大誠, 曽村 富士, 武市 康志, 石木 良治, 井澤 英夫, 永田 浩三, 祖父江 俊和, 平井 真理, 野田 明子, 岩瀬 三紀, 横田 充弘
    Japanese circulation journal 63(1) 643-643 1999年3月1日  
  • 井澤 英夫, 平井 真理, 石木 良治, 永田 浩三, 寺澤 求, 稲垣 将文, 武市 康志, 曽村 富士, 河村 大誠, 因田 恭也, 祖父江 俊和, 野田 明子, 横田 充弘
    Japanese circulation journal 63(1) 605-605 1999年3月1日  
  • 磯部 智, 安藤 晃禎, 井澤 英夫, 野々川 信, 平井 真理, 横田 充弘, 七里 守
    Japanese circulation journal 63(1) 601-601 1999年3月1日  
  • 石木 良治, 石原 均, 岩瀬 三紀, 祖父江 俊和, 井澤 英夫, 横田 充弘
    臨床薬理 30(1) 139-140 1999年  
  • 神田 裕文, 祖父江 俊和, 石原 均, 加藤 良三, 町井 剛, 井澤 英夫, 横田 充弘
    Japanese circulation journal 61 829-829 1998年3月20日  
  • 稲垣 将文, 岩瀬 三紀, 井澤 英夫, 武市 康志, 藤村 高陽, 市原 佐保子, 石木 良治, 曽村 富士, 祖父江 俊和, 横田 充弘
    Japanese circulation journal 62 181-181 1998年2月28日  
  • 市原 佐保子, 曽村 富士, 武市 康志, 石木 良治, 藤村 高陽, 稲垣 将文, 井澤 英夫, 祖父江 俊和, 岩瀬 三紀, 横田 充弘, 山田 芳司
    Japanese circulation journal 62 372-372 1998年2月28日  
  • 市原 佐保子, 曽村 富士, 武市 康志, 石木 良治, 藤村 高陽, 稲垣 将文, 井澤 英夫, 岩瀬 三紀, 祖父江 俊和, 横田 充弘, 山田 芳司
    Japanese circulation journal 62 593-593 1998年2月28日  
  • 石木 良治, 石原 均, 岩瀬 三紀, 井澤 英夫, 藤村 高陽, 市原 佐保子, 武市 康志, 曽村 富士, 祖父江 俊和, 横田 充弘
    Japanese circulation journal 62 446-446 1998年2月28日  
  • M Inagaki, H Izawa, M Iwase, T Sobue, M Yokota
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 31(2) 322A-322A 1998年2月  
  • H Izawa, M Yokota, Y Takeichi, M Inagaki, K Nagata, M Iwase, T Sobue
    CIRCULATION 96(9) 2959-2968 1997年11月  
    Background Exercise-induced enhancement of the force frequency and relaxation-frequency relations has been studied in conscious animals but not in intact diseased human hearts. Methods and Results We evaluated left ventricular (LV) isovolumic contraction (dP/dt(max)) and relaxation (tau) during atrial pacing and dynamic exercise in 13 patients with nonobstructive hypertrophic cardiomyopathy (HCM) and 7 control subjects to investigate the influence of exercise on the force-frequency and relaxation-frequency relations. Group A consisted of 6 patients in whom the heart rate (HR)-dP/dt(max) relation was markedly enhanced during exercise (88+/-30%) compared with during pacing (34+/-15%). Group B consisted of 7 patients in whom the HR-dP/dt(max) relation showed similar enhancement during exercise (28+/-7%) and atrial pacing (28+/-11%). There was no difference in the HR-tau (derivative method [TD] and pressure half-time method [T-1/2]) relation between pacing and exercise in groups A and B. Both the mean maximal wall thickness and the hypertrophy score in group B were greater than in group A (27+/-5 versus 19+/-2 mm and 7+/-1 versus 5+/-1 points, respectively; both P&lt;.01). There was no difference in the LV peak systolic pressure, end-diastolic pressure, or the plasma level of catecholamines at baseline, at 50 W of exercise, and at peak pacing between groups A and B. The HR-dP/dt(max), relation in the control group was markedly enhanced during exercise (80+/-27%) compared with during pacing (32+/-14%). The HR-tau relation in the control group was enhanced during exercise (TD, 35+/-9%; T-1/2 34+/-8%) compared with during pacing (TD, 12+/-7%; T-1/2 14+/-7%). Conclusions Exercise-induced enhancement of the relaxation-frequency relation was inhibited in all HCM patients, regardless of the degree of LV hypertrophy. The patients without exercise-induced enhancement of the force-frequency relation had more severe LV hypertrophy than the patients with the enhancement, indicating that the adrenergic control of the force-frequency relation may, at least in part, depend on the severity of LV hypertrophy or the stage of HCM.