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1論文
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Computers 15(2) 115-115 2026年2月8日In lung cytology, screeners and pathologists examine many cells in cytological specimens and describe their corresponding imaging findings. To support this process, our previous study proposed an image-finding generation model based on convolutional neural networks and a transformer architecture. However, further improvements are required to enhance the accuracy of these findings. In this study, we developed a cytology-specific image-finding generation model using a vision transformer and open-source large language models. In the proposed method, a vision transformer pretrained on large-scale image datasets and multiple open-source large language models was introduced and connected through an original projection layer. Experimental validation using 1059 cytological images demonstrated that the proposed model achieved favorable scores on language-based evaluation metrics and good classification performance when cells were classified based on the generated findings. These results indicate that a task-specific model is an effective approach for generating imaging findings in lung cytology.
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Respiratory Investigation 64(1) 101335-101335 2026年1月
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Computers 14(11) 489-489 2025年11月9日In the diagnosis of lung cancer, imaging findings of lung nodules are essential for benign and malignant classifications. Although numerous studies have investigated the classification of lung nodules, no method has been proposed for obtaining detailed imaging findings. This study aimed to develop a novel method for generating image findings and classifying benign and malignant nodules in chest computed tomography (CT) images using vision–language models. In this study, we collected chest CT images of 77 patients diagnosed with either benign or malignant tumors at Fujita Health University Hospital. For these images, we cropped the regions of interest around the nodules, and a pulmonologist provided the corresponding image findings. We used vision–language models for image captioning to generate image findings. The findings generated by these two models were grammatically correct, with no deviations in notation, as expected from the image findings. Moreover, the descriptions of benign and malignant characteristics were accurately obtained. The bootstrapping language–image pretraining (BLIP) base model achieved an accuracy of 79.2% in classifying nodules, and the bilingual evaluation understudy-4 score for agreement with physician findings was 0.561. These results suggest that the proposed method may be effective for classifying and generating lung nodule findings.
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Fujita medical journal 11(3) 121-128 2025年8月OBJECTIVES: To develop a comprehensive machine learning model incorporating various clinical factors, including frailty and comorbidities, to predict 30-day readmission and mortality risk in patients with chronic obstructive pulmonary disease (COPD). METHODS: This retrospective cohort study used electronic health records (EHR) from Fujita Health University Hospital (2004-2019) for 1294 patients with COPD and 3499 hospitalization or death events. The EHR contained longitudinal patient data (demographics, diagnoses, test results, clinical records). We developed two eXtreme Gradient Boosting models, the comprehensive Top64 and practical 11-feature models. We compared these with the Comorbidity, Obstruction, Dyspnea, and Previous Exacerbations index (CODEX) model, a widely used tool for predicting hospital readmission or death in patients with COPD. The area under the receiver operating characteristic curve (AUC) with 95% confidence interval (CI), sensitivity, and specificity were used to evaluate the model performance. RESULTS: The Top64 (AUC: 0.769, 95% CI: 0.747-0.791) and practical 11-feature (AUC: 0.746, 95% CI: 0.730-0.762) models performed better than the CODEX model (AUC: 0.587, 95% CI: 0.563-0.611). The Top64 model showed 0.978 sensitivity and 0.341 specificity, and the practical 11-feature model achieved 0.955 sensitivity and 0.361 specificity. The calibration curves showed good agreement between the observed and predicted results for both models. CONCLUSIONS: A machine learning approach based on clinical data readily available from the EHR performed better than existing models in predicting 30-day readmission and mortality risks in patients with COPD. A comprehensive risk prediction tool may enhance individualized care strategies and improve patient outcomes in COPD management.
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Respirology case reports 13(5) e70157 2025年5月Bronchoscopic lung volume reduction (BLVR) with endobronchial valves is an established treatment for selected patients with advanced emphysema. A 74-year-old male patient with chronic obstructive pulmonary disease and severe dyspnea was scheduled to undergo BLVR targeting the right middle lobe bronchus based on high-resolution CT findings, which showed severe emphysematous changes with hyperinflation and fissure completeness of 98% in the right middle lobe. The physician conducted preoperative virtual reality (VR)-assisted planning using the patient's imaging data, enabling comprehensive visualisation of the bronchial tree, airway measurements, and procedural simulation. The Chartis system confirmed a 'no flow' pattern, supporting the absence of collateral ventilation. During the procedure, a size 5.5 valve was placed in the right B4/5 bronchus following VR and intraoperative assessments. The patient remained stable postoperatively without complications. VR enhanced procedural planning by improving airway assessment, optimising valve sizing, and reducing cognitive load, leading to increased efficiency and operator confidence. Further research is warranted to validate the utility of VR in bronchoscopic interventions.
MISC
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BMC PULMONARY MEDICINE 14 14-14 2014年2月 査読有り
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GERIATRICS & GERONTOLOGY INTERNATIONAL 13(4) 986-992 2013年10月 査読有り
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Allergology international : official journal of the Japanese Society of Allergology 62(3) 367-73 2013年9月 査読有りBACKGROUND: Although a challenge test using non-steroidal anti-inflammatory drugs (NSAIDs) is crucial for diagnosis of aspirin-induced asthma (AIA), it also has drawbacks in terms of possible side effects. Therefore, alternative in-vitro diagnostic methods for AIA are awaited. METHODS: Nineteen stable non-AIA patients (9 males and 10 females; mean age, 49.4 ± 4.8 years), and 20 AIA patients (9 males and 11 females; mean age, 51.1 ± 4.8 years) were enrolled in this study. CD11b and CD16 expressions on the peripheral-blood granulocytes after administration of aspirin and different concentrations of PGE2 in vitro were examined using flowcytometry. RESULTS: Aspirin induced a significant increase in CD11b expression on eosinophils (CD16 negative granulocytes) in 19 AIA patients and one non-AIA patient. Increase in CD11b expression on eosinophils by aspirin administration was suppressed by PGE2 in a dose-dependent manner. CONCLUSIONS: The measurement of CD11b expression on peripheral-blood eosinophils showed very high sensitivity and specificity of (-95%) in diagnosing AIA. Although this method requires laboratory facilities for flowcytometry, it may be very useful in diagnosis of AIA without side effects. In addition, PGE2 may be involved in regulation of CD11b expression on eosinophils by aspirin administration.
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European journal of heart failure 15(9) 1003-10 2013年9月 査読有りAIMS: We examined whether the severity of central sleep apnoea (CSA) and the level of C-reactive protein are associated with the prevalence and complexity of arrhythmias, and whether these factors contribute to increased risk of nocturnal sudden death. METHODS AND RESULTS: We prospectively examined 178 patients (age 70 ± 1 years) who were admitted to our hospital due to worsening heart failure. We recorded a simultaneous overnight cardiorespiratory polygraph and Holter ECG. Obstructive sleep apnoea was excluded and patients were dichotomized based on the median value of the central apnoea index (CAI) of 7.5/h. The prevalence and complexity of arrhythmias were compared between daytime (06:00 h to 15:00 h) and night-time (21:00 h to 06:00 h). A multivariate logistic regression analysis revealed that the CAI was associated with prevalence of atrial fibrillation (AF) [odds ratio 1.03, 95% confidence interval (CI) 1.02-2.51)] and sinus pause during the night-time period (1.12, 95% CI 1.08-1.35). The CAI and C-reactive protein were independently associated with non-sustained ventricular tachycardia during both daytime (1.22, 95% CI 1.00-6.92; and 5.82, 2.58-56.1, respectively) and night-time periods (3.57, 95% CI 1.06-13.1; and 10.7, 3.30-44.4, respectively). During a mean follow-up period of 22 months, 30 (17%) patients had cardiovascular deaths and the CSA was an independent predictor (hazard ratio 1.29, 95% CI 1.16-2.32); only 5 (2.8%) of them died due to ventricular tachyarrhythmia, occurring during wakefulness. CONCLUSIONS: We demonstrated that the severity of CSA and C-reactive protein levels are independently associated with the prevalence and complexity of arrhythmias. CSA was associated with increased mortality risk, but it was not related directly to nocturnal death due to ventricular tachyarrhythmia.
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Respirology 18(2) 340-347 2013年2月 査読有り
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気管支学(日本呼吸器内視鏡学会雑誌) 35(2) 188-192 2013年 査読有り背景.骨転移を伴う悪性腫瘍を疑いEBUS-TBNAを施行した,縦隔副甲状腺嚢胞の1例を経験したので報告する.症例. 63歳男性.主訴は誤嚥,嗄声. PET-CTでFDGの集積を認める,上縦隔の嚢胞性病変および肋骨の溶骨性病変を認めた.縦隔病変に対しEBUS-TBNAを施行し,血性の液体成分を採取したが,悪性所見は認めなかった.肋骨病変に対する生検では副甲状腺機能亢進症に伴うbrown腫瘍の可能性が示され,血中副甲状腺ホルモン(intact PTH)は高値であった.縦隔副甲状腺嚢胞を摘出したところ骨病変は縮小した.結論.本症例は異所性副甲状腺嚢胞に肋骨brown腫瘍を伴ったものであり,稀な症例と考えられた.腫瘍性病変に高Ca血症を伴うことはしばしば見られるが,副甲状腺ホルモンの測定により異所性副甲状腺腫瘍を鑑別することが重要と考えられた.
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平成24年度 厚生労働科学研究費補助金 難治性疾患等克服研究事業 免疫アレルギー疾患等予防・治療研究事業 研究報告書(免疫アレルギー疾患分野) 288-292 2013年
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IMMUNOGENETICS 65(1) 17-24 2013年1月 査読有り
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INTERNAL MEDICINE 52(13) 1473-1478 2013年 査読有り
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Respiration; international review of thoracic diseases 86(3) 252-3 2013年 査読有り
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MOLECULAR CARCINOGENESIS 51(5) 400-410 2012年5月 査読有り
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INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY 7(3) 359-369 2012年5月 査読有り
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平成23年度総括・分担研究報告書、厚生労働科学研究・免疫アレルギー疾患等予防・治療研究事業 23-26 2012年
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AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 45(4) 684-691 2011年10月 査読有り
書籍等出版物
2講演・口頭発表等
79共同研究・競争的資金等の研究課題
16-
日本学術振興会 科学研究費助成事業 2025年4月 - 2028年3月
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日本学術振興会 科学研究費助成事業 2023年4月 - 2026年3月
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日本学術振興会 科学研究費助成事業 2023年4月 - 2026年3月
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日本学術振興会 科学研究費助成事業 2022年4月 - 2025年3月
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日本学術振興会 科学研究費助成事業 2021年4月 - 2024年3月
その他教育活動上特記すべき事項
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件名第48回医学教育ワークショップ終了年月日2013/08/18概要「臨床実習学習成果の設定」に参加した。