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  2. Yuichi Hirose

Yuichi Hirose

  (廣瀬 雄一)

Profile Information

Affiliation
School of Medicine Faculty of Medicine, Fujita Health University
Degree
医学博士(慶應義塾大学)
J-GLOBAL ID
200901043674612973
researchmap Member ID
5000066271

Research Areas

 1

Research History

 15
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Education

 1

Committee Memberships

 9
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Papers

 408
  • Kiyonori Kuwahara, Ichiro Nakahara, Shoji Matsumoto, Yoshio Suyama, Jun Morioka, Akiko Hasebe, Jun Tanabe, Sadayoshi Watanabe, Kenichiro Suyama, Yuichi Hirose
    Radiology case reports, 19(5) 1692-1696, May, 2024  
    It is impossible to predict underlying anomalies in acute large vessel occlusion and it could be a problem when performing mechanical thrombectomy (MT). We report a case of MT for occlusion of the fenestrated middle cerebral artery (MCA) M1 segment. A 49-year-old woman presented to our hospital with dysarthria and left hemiparesis. Acute ischemic stroke due to right occluded MCA was diagnosed. During performing emergent MT, a part of the M1 segment was revealed to be slit-shaped by digital subtraction angiography, suggesting a fenestrated MCA. The aspiration catheter could not be advanced through the narrow limb of the fenestration, and the distal thrombus was retrieved using a stent retriever, additionally. Postoperatively, the patient's symptoms improved without complications. When occlusion of the fenestrated MCA is suspected, it is necessary to consider converting the strategy from an aspiration catheter alone to the combined use of a stent retriever.
  • Hikaru Sasaki, Yohei Kitamura, Masahiro Toda, Yuichi Hirose, Kazunari Yoshida
    Brain tumor pathology, Apr 2, 2024  
    Oligodendroglioma, IDH-mutant and 1p/19q-codeleted is known for their relative chemosensitivity and indolent clinical course among diffuse gliomas of adult type. Based on the data from phase 3 clinical trials, the standard of post-surgical care for those tumors is considered to be initial chemoradiotherapy regardless of histopathological grade, particularly with PCV. However, partly due to its renewed definition in late years, prognostic factors in patients with those tumors are not well established. Moreover, the survival rate declines over 15 years, with only a 37% OS rate at 20 years for grade 3 tumors, even with the current standard of care. Given that most of this disease occurs in young or middle-aged adults, further improvements in treatment and management are necessary. Here, we discuss prognostic factors, standard of care and chemotherapy, and future perspectives with neoadjuvant strategy in those tumors.
  • Jun Muto, Ichiro Tateya, Hirofumi Nakatomi, Ichiro Uyama, Yuichi Hirose
    Neurospine, Mar 31, 2024  
  • Yuya Nishiyama, Mitsuhiro Hasegawa, Kazuhide Adachi, Yuichi Hirose
    World Neurosurgery, Mar, 2024  
  • Kei Yamashiro, Motoharu Hayakawa, Kazuhide Adachi, Mitsuhiro Hasegawa, Yuichi Hirose
    AJNR. American journal of neuroradiology, Jan 30, 2024  
    BACKGROUND AND PURPOSE: Tumor embolization through the meningohypophyseal trunk and inferolateral trunk is known to be effective in skull-based tumors; however, microcatheter cannulation into these arteries is difficult, and the number of cases that can be safely embolized is limited. In this study, we present a novel embolization procedure for meningohypophyseal trunk and inferolateral trunk using the distal balloon protection technique and detail its clinical efficacy and complication risks. We developed this procedure to allow safe embolization in patients who cannot be adequately cannulated with microcatheters into these arteries. MATERIALS AND METHODS: Patients who underwent meningohypophyseal trunk or inferolateral trunk embolization using the distal balloon protection technique for skull-based tumors at our institution between 2010 and 2023 were included. In this procedure, the ICA was temporarily occluded with a balloon at the ophthalmic artery bifurcation, the microcatheter was guided to the meningohypophyseal trunk or inferolateral trunk vicinity, and embolic particles were injected into the arteries. The balloon was deflated after the embolic particles, that had refluxed into the ICA, were aspirated. RESULTS: A total of 25 meningohypophyseal trunks and inferolateral trunks were embolized during 21 surgeries. Of these 25 arteries, only nine (36.0%) were successfully cannulated with microcatheters. Nevertheless, effective embolization was achieved in all cases. Permanent complications occurred in only one case (4.8%), in which the central retinal artery was occluded during inferolateral trunk embolization, resulting in a visual field defect. No permanent complications resulting from the embolic cerebral infarction were observed. Of 16 cases that underwent MRI within a week after embolization, however, 11 (68.8%) demonstrated embolic cerebral infarctions. CONCLUSIONS: In patients with skull-based tumors with meningohypophyseal trunk or inferolateal trunk feeders that cannot be catheterized directly, embolization using the distal balloon protection technique for tumor supply can be considered as a salvage technique. ABBREVIATIONS: MHT = meningohypophyseal trunk; ILT = inferolateral trunk; GC = guide catheter; AC = aspiration catheter; FR = flow reverse.
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Misc.

 186
  • 西山悠也, 大場茂生, 安達一英, 安倍雅人, 長谷川光広, 廣瀬雄一
    日本脳腫瘍学会プログラム・抄録集, 36th, 2018  
  • 西山悠也, 長谷川光広, 我那覇司, 我那覇司, 山田勢至, 伊藤亮太, 安倍雅人, 廣瀬雄一
    Brain Tumor Pathology, 35(Supplement), 2018  
  • 西山悠也, 長谷川光広, 我那覇司, 廣瀬雄一
    日本神経内視鏡学会プログラム・抄録集, 25th, 2018  
  • 長谷川光広, 安達一英, 西山悠也, 大場茂生, 早川基治, 廣瀬雄一
    日本脳腫瘍の外科学会プログラム・抄録集, 23rd, 2018  
  • 西山悠也, 我那覇司, 山城慧, 川副雄史, 村山和宏, 長谷川光広, 廣瀬雄一
    日本間脳下垂体腫瘍学会プログラム・抄録集, 28th, 2018  
  • Yuichi Hirose
    Neuro-Oncology, 19 64-64, Nov, 2017  
  • 大場 茂生, 中江 俊介, 西山 悠也, 安達 一英, 長谷川 光広, 佐々木 光, 安倍 雅人, 廣瀬 雄一
    Brain Tumor Pathology, 34(Suppl.) 096-096, May, 2017  
  • 定藤章代, 早川基治, 安達一英, 山城慧, 立山慎一郎, 熊井惟志, 川副雄史, 鈴木健也, 長谷部朗子, 渡邉定克, 中原一郎, 廣瀬雄一
    脳血管内治療(Web), 2(Supplement), 2017  
  • 中江俊介, 加藤武馬, 村山和宏, 佐々木光, 公文将備, 熊井惟志, 西山悠也, 大場茂生, 安倍雅人, 長谷川光広, 倉橋浩樹, 廣瀬雄一
    日本脳腫瘍学会プログラム・抄録集, 35th, 2017  
  • 佐々木光, 金澤徳典, 西山悠也, 中江俊介, 廣瀬雄一, 吉田一成
    日本脳腫瘍の外科学会プログラム・抄録集, 22nd, 2017  
  • 西山悠也, 村山和宏, 我那覇司, 大場茂生, 安達一英, 長谷川光広, 廣瀬雄一
    日本脳腫瘍の外科学会プログラム・抄録集, 22nd, 2017  
  • 中江俊介, 公文将備, 西山悠也, 大場茂生, 佐々木光, 安倍雅人, 長谷川光広, 廣瀬雄一
    日本脳腫瘍の外科学会プログラム・抄録集, 22nd, 2017  
  • 中江俊介, 加藤武馬, 萩原英雄, 村山和宏, 佐々木光, 大場茂生, 公文将備, 西山悠也, 安倍雅人, 長谷川光広, 倉橋浩樹, 廣瀬雄一
    日本臨床分子形態学会総会・学術集会講演プログラム・要旨集, 49th, 2017  
  • 長谷川光広, 西山悠也, 我那覇司, 山城慧, 安達一英, 大場茂生, 早川基治, 廣瀬雄一
    日本脳腫瘍の外科学会プログラム・抄録集, 22nd, 2017  
  • Shigeo Ohba, Andrew Mancini, Joydeep Mukherjee, Tor-Christian Johannessen, Tracy Chow, Matthew Wood, Lindsey Jones, Tali Mazor, Roxanne Marshall, Pavithra Viswanath, Yuichi Hirose, Kyle Walsh, Arie Perry, Robert Bell, Joanna Phillips, Joseph Costello, Sabrina Ronen, Russell Pieper
    NEURO-ONCOLOGY, 18 35-35, Nov, 2016  
  • 金澤 徳典, 藤原 広和, 高橋 秀典, 西山 悠也, 廣瀬 雄一, 吉田 一成, 佐々木 光
    Brain Tumor Pathology, 33(Suppl.) 107-107, May, 2016  
  • Joji Inamasu, Akiyo Sadato, Yuichi Hirose
    STROKE, 47, Feb, 2016  
  • 廣瀬雄一, 大場茂生, 西山悠也, 中江俊介, 安達一英, 長谷川光広
    日本脳腫瘍の外科学会プログラム・抄録集, 21st, 2016  
  • 中江俊介, 村山和宏, 大場茂生, 公文将備, 西山悠也, 長久伸也, 稲桝丈司, 安倍雅人, 長谷川光広, 廣瀬雄一
    日本脳腫瘍学会プログラム・抄録集, 34th, 2016  
  • 西山悠也, 村山和宏, 中江俊介, 大場茂生, 安達一英, 長谷川光広, 阿部雅人, 廣瀬雄一
    日本脳腫瘍学会プログラム・抄録集, 34th, 2016  
  • 大場茂生, 山城慧, 中江俊介, 大見達夫, 西山悠也, 安達一英, 長谷川光広, 佐々木光, 安倍雅人, 廣瀬雄一
    日本脳腫瘍の外科学会プログラム・抄録集, 21st, 2016  
  • 中江俊介, 村山和宏, 公文将備, 西山悠也, 大場茂生, 長久伸也, 稲桝丈司, 安倍雅人, 長谷川光広, 廣瀬雄一
    日本分子脳神経外科学会プログラム・抄録集, 17th, 2016  
  • Joji Inamasu, Motoki Oheda, Takuro Hayashi, Yoko Kato, Yuichi Hirose
    EUROPEAN JOURNAL OF EMERGENCY MEDICINE, 22(3) 170-175, Jun, 2015  Peer-reviewed
    Objective High blood pressure (HBP) is observed frequently in patients with spontaneous intracerebral haemorrhage (SICH). Although HBP at admission has been associated with poor outcomes, most studies from which such conclusions were derived had been carried out decades earlier, when aggressive BP management was not implemented. In our institution, SICH patients showing HBP undergo aggressive BP management by intravenous nicardipine with target systolic BP (SBP) less than 140mmHg. We investigated whether responsiveness to intravenous nicardipine, haematoma expansion rate and activity of daily living 90 days after admission differed by the degree of admission SBP. Patients and methods A retrospective study was carried out by reviewing charts of 120 SICH patients admitted within 6 h of onset who were quadrichotomized on the basis of SBP: <140 mmHg (n=6), 140-184 mmHg (n=49), 185-219 mmHg (n=38) and >= 220 mmHg (n=27). The six patients with SBP less than 140 mmHg were excluded, and demographic and outcome variables of the latter three groups were compared. Whether plasma catecholamine levels differed among the three groups was also investigated. Results Optimal BP management (target SBP<140mmHg) within 2 h of arrival was achieved in 98%, haematoma expansion occurred in 7% and the 90-day mortality rate was 11%. Responsiveness to intravenous nicardipine, haematoma expansion rate and activity of daily living were not significantly different. Furthermore, plasma catecholamine levels did not differ significantly. Conclusion The lack of difference in the demographic and outcome variables in SICH patients managed by aggressive treatment to normalize the BP indicates that the previously reported association between HBP at admission and poor outcomes needs to be re-evaluated. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved.
  • ハセガワ ミツヒロ
    42(5) 35-39, May, 2015  
  • 安藤 瑞穂, 鈴木 敦詞, 植田 佐保子, 垣田 彩子, 四馬田 恵, 高柳 武志, 牧野 真樹, 石原 興平, 廣瀬 雄一, 山中 克郎, 伊藤 光泰
    日本内分泌学会雑誌, 91(1) 377-377, Apr, 2015  
  • 伊藤 圭介, 稲桝 丈司, 森谷 茂太, 熊井 維志, 長谷川 光広, 廣瀬 雄一, 柴田 純平
    日本脳神経外傷学会プログラム・抄録集, 38回 167-167, Mar, 2015  
  • 伊藤 圭介, 森谷 茂太, 熊井 惟志, 川副 裕史, 稲桝 丈司, 廣瀬 雄一
    Neurosurgical Emergency, 19(3) 373-373, Jan, 2015  
  • 山田康博, 加藤庸子, 立山慎一郎, 山城慧, 稲枡丈司, 大枝基樹, 我那覇司, 廣瀬雄一
    日本脳ドック学会総会プログラム・抄録集, 24th, 2015  
  • 中江俊介, 佐々木光, 林佐衣子, 山城慧, 公文将備, 安達一英, 長久伸也, 安倍雅人, 長谷川光広, 廣瀬雄一
    Brain Tumor Pathology, 32(Supplement), 2015  
  • 長谷川光広, 早川基治, 廣瀬雄一
    月刊新医療, 5 36-39, 2015  
  • Saeko Tanaka, Hikaru Sasaki, Tokuhiro Kimura, Kaori Kameyama, Takumi Nakamura, Yohei Kitamura, Tomoru Miwa, Yuichi Hirose, Kazunari Yoshida
    NEURO-ONCOLOGY, 16, Nov, 2014  
  • Joji Inamasu, Teppei Tanaka, Akiyo Sadato, Motoharu Hayakawa, Kazuhide Adachi, Takuro Hayashi, Yoko Kato, Yuichi Hirose
    GERIATRICS & GERONTOLOGY INTERNATIONAL, 14(4) 858-863, Oct, 2014  Peer-reviewed
    AimTherapeutic intervention to repair unruptured aneurysms (UA) has not been strongly recommended for the elderly, because of their limited life expectancy and low annual bleeding rate. However, physically and mentally healthy older adults with seemingly high risk of aneurysmal bleeding might benefit from having their UA repaired. MethodsA single-center retrospective study was carried out. Among 1078 patients admitted for treatment of UA between 2007 and 2011, the number of patients aged 75 years who underwent surgical and endovascular repair of UA was 30 and 31, respectively. The operative and mid-term outcomes were compared between the two groups. For evaluation of the operative outcomes, frequency and types of adverse events that occurred within 30 days of intervention (operative morbidity) were described. For assessment of the mid-term outcomes, activities of daily living (ADL) at 24 months after intervention were evaluated with the modified Rankin Scale (mRS). ResultsThe operative morbidity rate was 6.7% in the open surgery group and 6.5% in the endovascular surgery group, and they did not differ significantly. The frequency of patients with mRS 0-2 at 24 months after intervention was 85.7% in the open surgery group and 82.8% in the endovascular surgery group, and they did not differ significantly. The adverse event rate of patients with middle cerebral artery aneurysms treated endovascularly was high (80%). ConclusionsThe outcomes of individuals aged 75 years who underwent repair of UA were generally favorable in either treatment group, with more than 80% living an independent life at 24 months after intervention. Geriatr Gerontol Int 2014; 14: 858-863.
  • Hikaru Sasaki, Y. Hirose, T. Yazaki, T. Kimura, H. Fujiwara, Y. Kitamura, M. Katayama, M. Toda, T. Ohira, K. Yoshida
    NEURO-ONCOLOGY, 16, Jul, 2014  
  • Yuichi Hirose, Hikaru Sasaki
    NEURO-ONCOLOGY, 16, Jul, 2014  
  • 中江 俊介, 服部 夏樹, 佐々木 光, 西山 悠也, 安達 一英, 長久 伸也, 林 拓郎, 安倍 雅人, 長谷川 光広, 廣瀬 雄一
    Brain Tumor Pathology, 31(Suppl.) 106-106, May, 2014  
  • Yuya Nishiyama, Hikaru Sasaki, Shinya Nagahisa, Kazihide Adachi, Takuro Hayashi, Koichiro Yoshida, Tsukasa Kawase, Natsuki Hattori, Kazuhiro Murayama, Masato Abe, Mitsuhiro Hasegawa, Yuichi Hirose
    NEUROSURGICAL REVIEW, 37(2) 291-299, Apr, 2014  Peer-reviewed
  • 稲桝丈司, 森谷茂太, 大枝基樹, 大見達夫, 山城慧, 林拓郎, 安達一英, 長久伸也, 長谷川光弘, 廣瀬雄一
    日本脳腫瘍の外科学会プログラム・抄録集, 19th, 2014  
  • 中江俊介, 山城慧, 服部夏樹, 佐々木光, 森谷茂太, 我那覇司, 大枝基樹, 西山悠也, 安達一英, 長久伸也, 林拓郎, 安部雅人, 長谷川光広, 廣瀬雄一
    日本脳腫瘍学会プログラム・抄録集, 32nd, 2014  
  • 佐々木光, 西山悠也, 木村徳宏, 木村徳宏, 藤原広和, 廣瀬雄一, 吉田一成
    日本脳腫瘍の外科学会プログラム・抄録集, 19th, 2014  
  • 入江恵子, 入江恵子, 小嶋真弘, 齋藤永宏, 根來眞, 福田敏男, 廣瀬雄一, 中原一郎
    日本血管内治療学会誌, 15(1), 2014  
  • 林拓郎, 林拓郎, 長谷川光弘, 稲桝丈司, 黒島義明, 府賀道康, 中村芳樹, 安達一英, 長久伸也, 廣瀬雄一
    日本脳腫瘍の外科学会プログラム・抄録集, 19th, 2014  
  • Joji Inamasu, Takuro Hayashi, Yoko Kato, Yuichi Hirose
    NEUROREPORT, 25(2) 94-99, Jan, 2014  Peer-reviewed
    Our assumption that blood pressure (BP) in supratentorial hypertensive intracerebral hemorrhage patients does not differ significantly according to the hemispheric laterality has never been verified before. This study was carried out to explore the possibility of hemispheric BP differences and whether this might influence the outcomes. A review of the charts/radiographic images of 281 patients with putaminal/thalamic hemorrhages diagnosed within 6 h of symptom onset was performed. Immediately after arrival, they received a continuous intravenous nicardipine infusion to lower and maintain systolic BP (SBP) between 120 and 160 mmHg. They were quadrichotomized as follows: left putamen (LP, n=89), right putamen (RP, n=69), left thalamus (LT, n=68), and right thalamus (RT, n=55). Two-group or four-group comparisons were made on demographic variables, BPs, and outcomes. Patients with left-sided hemorrhages presented with significantly worse neurologic scores in both hemorrhage categories and tended to sustain larger hematomas than their right-sided counterparts. Significant differences in SBPs between LP and RP (205 +/- 31 vs. 189 +/- 29 mmHg, P<0.01) as well as in diastolic BPs between LT and RT (109 +/- 19 vs. 97 +/- 20 mmHg, P=0.03) were noted. Multivariate regression analysis showed that patients with SBPs of at least 220 mmHg were 2.9 times more likely to harbor left-sided hemorrhages. There were no significant intergroup differences in responsiveness to a continuous intravenous nicardipine infusion or 30-day mortality rates. Although the differences in BPs are unlikely to have influenced outcomes, future trials involving supratentorial hypertensive intracerebral hemorrhages may benefit from considering hemispheric differences in BP and other demographic variables. (C) 2014 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
  • Joji Inamasu, Keiko Sugimoto, Eiichi Watanabe, Yoko Kato, Yuichi Hirose
    Stroke, 44(12) 3550-2, Dec, 2013  Peer-reviewed
    Background and Purpose Insular injuries are known to cause autonomic derangements. Patients with ruptured middle cerebral artery aneurysms frequently develop temporal hematomas (THs) in addition to subarachnoid hemorrhages, and those with TH may sustain autonomic derangements more frequently than those without TH. Hemispheric lateralization in autonomic derangements has been reported in patients with insular ischemic stroke, and this study was conducted to clarify whether such lateralization was also observed in patients with TH resulting from middle cerebral artery aneurysm rupture. Methods A retrospective analysis on the medical records of 79 patients with ruptured middle cerebral artery aneurysms was performed on the basis of lateralization and presence of TH. They were quadrichotomized as left TH+ (LTH+; n=17), right TH+ (n=25), left TH- (n=15), and right TH- (n=22). Comparisons, mainly between LTH+ and right TH+, were made on demographic variables, autonomic/cardiac parameters, plasma catecholamine and glucose levels, and outcomes. Results There were no significant differences in demographic or cardiac parameters between the 2 groups. Systolic blood pressures were lower in LTH+ (13934 versus 174 +/- 47 mm Hg; P=0.05). The LTH+ group also tended to be more bradycardiac (80 +/- 19 versus 101 +/- 22 bpm; P=0.13). The LTH+ group exhibited significantly lower plasma norepinephrine (1008 +/- 975 versus 2549 +/- 2133 pg/mL; P=0.03) and glucose levels (9.3 +/- 1.8 versus 12.2 +/- 4.5 mmol/L; P=0.04). However, in-hospital mortality did not differ significantly (41% versus 44%; P=1.00). Conclusions Lateralization of autonomic derangements observed might not have had a significant effect on the outcomes. Nevertheless, autonomic derangements associated with insular injury should be considered in the management of subarachnoid hemorrhage patients with TH.
  • Saeko Hayashi, Hikaru Sasaki, Tokuhiro Kimura, Takumi Nakamura, Tomoru Miwa, Yuichi Hirose, Kazunari Yoshida
    NEURO-ONCOLOGY, 15 89-90, Nov, 2013  
  • Kazuhide Adachi, Hikaru Sasaki, Shinya Nagahisa, Kouichiro Yoshida, Natsuki Hattori, Yuya Nishiyama, Tsukasa Kawase, Mitsuhiro Hasegawa, Masato Abe, Yuichi Hirose
    NEURO-ONCOLOGY, 15 136-136, Nov, 2013  
  • Joji Inamasu, Takafumi Kaito, Takeya Watabe, Tsukasa Ganaha, Yasuhiro Yamada, Teppei Tanaka, Shuei Imizu, Takuro Hayashi, Motoharu Hayakawa, Yoko Kato, Yuichi Hirose
    JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 22(8) 1350-1354, Nov, 2013  Peer-reviewed
    Background: Malignant hemispheric infarction is a life-threatening condition with a high mortality rate. Decompressive hemicraniectomy (DHC) is frequently a life-saving procedure that has shown the highest grade of evidence for patients 18 to 60 years of age. However, the efficacy of DHC in patients >60 years of age has rarely been investigated. Methods: A retrospective study was conducted in a single academic institution. Surrogates of patients with clinical signs of impending brain herniation despite standard medical therapy were offered the option of DHC regardless of age or the side of the lesion. The clinical data from 18 patients >60 years of age who underwent DHC for malignant hemispheric infarction in our institution were analyzed. Patients were classified into the following 2 groups: 61-70 and >70 years of age, and their demographics and surgical outcomes were compared. The variables compared included the male: female ratio, side of the lesion, type of stroke, site of vascular occlusion, use of thrombolytic therapy, National Institutes of Health Stroke Scale score, stroke onset-to-DHC interval, duration of hospital stay, infectious complications, and 90-day mortality rate. Results: There were no significant intergroup differences in any of the demographic variables evaluated. However, the 30-day mortality rate was significantly higher in the group that was >70 years of age (0% v 60%; P = .01) than in the group that was 61 to 70 years of age. Conclusions: We suggest that the efficacy of DHC in malignant hemispheric stroke patients between 61 and 70 years of age be further investigated in future randomized trials. By contrast, it appears unlikely that patients >70 years of age would benefit from DHC.
  • Takuro Hayashi, Kazuhide Adachi, Shigeo Ohba, Yuichi Hirose
    Journal of neuro-oncology, 115(2) 169-78, Nov, 2013  Peer-reviewed
    The recent progress in chemotherapy for malignant gliomas is attributable to the introduction of the DNA-methylating agent temozolomide (TMZ) however, drug resistance remains a major issue. Previous studies have shown that TMZ induces prolonged arrest of human glioma cells in the G2/M phase of the cell cycle followed by a senescence-like phenomenon or mitotic catastrophe. These findings suggest that the G2 checkpoint is linked to DNA repair mechanisms. We investigated the effect of a cyclin-dependent kinase (Cdk) inhibitor flavopiridol (FP) that inhibits the action of Cdc2, a key protein in the G2 checkpoint pathway, on TMZ-treated glioma cells. Colony formation efficiency revealed that FP potentiated the cytotoxicity of TMZ in glioma cells in a p53-independent manner. This effect was clearly associated with the suppression of key proteins at the G2-M transition, accumulation of the cells exclusively at the G2 phase, and increase in a double-stranded DNA break marker (seen on performing immunoblotting). TMZ-resistant clones showed activation of the G2 checkpoint in response to TMZ, while FP treatment resensitized these clones to TMZ. FP also enhanced the cytotoxicity of TMZ in U87MG-AktER cells. Moreover, administration of TMZ and/or FP to nude mice with xenografted U87MG cells revealed that FP sensitized xenografted U87MG cells to TMZ in these mice. Our findings suggest that TMZ resistance could be promoted by enhanced DNA repair activity in the G2-M transition and that a Cdk inhibitor could suppress this activity, leading to potentiation of TMZ action on glioma cells. © 2013 Springer Science+Business Media New York.
  • 西山 悠也, 村山 和宏, 片田 和広, 廣瀬 雄一
    脳神経外科ジャーナル, 22(10) 798-803, Oct, 2013  
  • Yuichi Hirose, Hikaru Sasaki, Masato Abe, Natsuki Hattori, Kazuhide Adachi, Yuya Nishiyama, Shinya Nagahisa, Takuro Hayashi, Mitsuhiro Hasegawa, Kazunari Yoshida
    BRAIN TUMOR PATHOLOGY, 30(4) 203-208, Oct, 2013  Peer-reviewed
    Management of gliomas depends on histological diagnosis; there are, however, limitations to the systems presently used. Tumors in the same entity can have different clinical courses, especially when they are diagnosed as WHO grade II-III. Previous studies revealed that genetic subgrouping of gliomas provides useful information that could help establishment of treatment procedures on the basis of the genetic background of the tumors. Recently, the authors analyzed the chromosomal copy number aberrations (CNAs) of adult supratentorial gliomas by comparative genomic hybridization using microdissected tissue sections. The tumors were classified into subgroups according to chromosomal CNAs. WHO grade II-III gliomas contained a variety of genetic subgroups that correlated well with the clinical course. Of these, long progression-free survival was observed for tumors with +7q and those with -1p/19q, low-grade tumors of 2 major lineages, and, in our preliminary data, both were closely correlated with mutation of IDH1. Furthermore, in contrast with +7q tumors, the great majority of +7 or +7/-10q groups had wildtype IDH1. Genetic studies suggest that cytogenetic characterization may provide an additional classification system for gliomas, and new criteria could help to establish rational and objective means for analysis of treatment procedures.
  • Shinya Nagahisa, Takeya Watabe, Hikaru Sasaki, Yuya Nishiyama, Takuro Hayashi, Mitsuhiro Hasegawa, Yuichi Hirose
    Neurosurgical review, 36(4) 595-600, Oct, 2013  Peer-reviewed
    Stereotactic biopsy has been validated for tissue sampling of deep-seated lesions that cannot be easily resected via open craniotomy. However, some inherent problems including the inability to directly observe the lesion and difficulty in confirming hemostasis limit its usefulness. To overcome these issues, we used the endoscope in brain tumor biopsy, for not only intraventricular tumors but also intraparenchymal tumors. The rigid scope was used in association with a surgical navigation system for intraparenchymal lesions via a transcortical route. There were no useful anatomical landmarks when the trajectory to the lesions was decided; therefore, surgical navigation system was required for the transcortical procedures. The endoscopic procedure described here was attempted in 21 cases of intraparenchymal lesions between January 2007 and February 2012. A definitive diagnosis was obtained in all cases, and genetic analysis was performed when required. Serious postsurgical hemorrhage or neurological deficits were not observed in any cases. Endoscopic surgery provides a clear view of the target and makes it easier to differentiate tumor tissue from normal brain tissue. Moreover, the endoscope helped to confirm hemostasis during the procedure. Thus, endoscopic biopsy has the potential to contribute toward safe and reliable diagnosis of brain tumors.

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Presentations

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教育内容・方法の工夫（授業評価等を含む）

 2
  • 件名（英語）
    臨床医学への興味を喚起する教育を試みる
    開始年月日（英語）
    2010
    終了年月日（英語）
    2012
    概要（英語）
    Ｍ3「神経系」講義において、手術ビデオの供覧など臨床医学に対する興味を促進した。
  • 件名（英語）
    臨床医学への興味を喚起する教育を試みる
    開始年月日（英語）
    2010
    終了年月日（英語）
    2012
    概要（英語）
    M5臨床実習においてカルテ記載を促進し、疾患の理解を促した。
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