Curriculum Vitaes

Akira Ota

(太田明)

Profile Information

Affiliation: Professor, School of Medicine, Faculty of Medicine, Department of Physiology, Fujita Health University

Degree: (BLANK)
医学

J-GLOBAL ID: 200901044594102075
researchmap Member ID: 1000102458

Research Interests

4

Research Areas

3

Research History

3

Education

4

- 1978

School of Medicine, Nagoya University
- 1978

Faculty of Medicine, Nagoya University
- 1972

Faculty of Science, Kyoto University
- 1972

Faculty of Science, Kyoto University

Misc.

37

Tetrahydrobiopterin biosynthesis in white and brown adipose tissues is enhanced following intraperitoneal administration of bacterial lipopolysaccharide

K Fujiwara, K Mori, YS Kaneko, A Nakashima, A Nagasaka, M Itoh, A Ota

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1670(3) 181-198, Feb, 2004
Interactions between Egr1 and AP1 factors in regulation of tyrosine hydroxylase transcription

Akira Nakashima, Akira Ota, Esther L. Sabban

Molecular Brain Research, 112(1-2) 61-69, Apr 10, 2003
Interactions between Egr1 and AP1 factors in regulation of tyrosine hydroxylase transcription

A Nakashima, A Ota, EL Sabban

MOLECULAR BRAIN RESEARCH, 112(1-2) 61-69, Apr, 2003
Peripheral administration of lipopolysasoharide enhances the expression of guanusive triphosphate cyclohydrolase I mRNA in murine locus cueruleus

Neuroscience, 116(1) 7-12, 2003
Peripheral administration of lipopelysaccharide enhances the expression of guanosine tirphosphote cycluhydrolase I mRNA in murine locus coeruleus

Neuroscience, 1161, 7-12, 2003
Effect of peripheral lipopolysaccharide injection on dopamine content in murine anterior olfactory nucleus

K Mori, YS Kaneko, A Nakashima, K Fujiwara, Nagatsu, I, A Ota

JOURNAL OF NEURAL TRANSMISSION, 110(1) 31-50, Jan, 2003
Peripheral injection of risperidone, an atypical antipsychotic, alters the bodyweight gain of rats

M Ota, K Mori, A Nakashima, YS Kaneko, K Fujiwara, M Itoh, A Nagasaka, A Ota

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 29(11) 980-989, Nov, 2002
The mutation of two amino acid residues in the N-terminus of tyrosine hydroxylase (TH) dramatically enhances the catalytic activity in neuroendocrine atT-20 cells

Akira Nakashima, Yoko S. Kaneko, Keiji Mori, Kentaro Fujiwara, Toshimitsu Tsugu, Takahiro Suzuki, Toshiharu Nagatsu, Akita Ota

Journal of Neurochemistry, 82(1) 202-206, 2002
Determination of tetrahydrobiopterin in murine locus coeruleus by HPLC with fluorescence detection

YS Kaneko, K Mori, A Nakashima, Nagatsu, I, T Nagatsu, A Ota

BRAIN RESEARCH PROTOCOLS, 8(1) 25-31, Aug, 2001
Exon 3 of tyrosine hydroxylase gene: lack of association with Japanese schizophrenic patients

M Ota, A Nakashima, K Ikemoto, S Nojima, M Tanaka, M Okuda, H Koga, K Mori, YS Kaneko, K Fujiwara, H Yamamoto, T Nagatsu, A Ota

MOLECULAR PSYCHIATRY, 6(3) 315-319, May, 2001
Expression of GTP cyclohydrolase I in murine locus ceruleus is enhanced by peripheral administration of lipopolysaccharide

Yoko S. Kaneko, Keiko Ikemoto, Keiji Mori, Akira Nakashima, Ikuko Nagatsu, Akira Ota

Brain Research, 890(2) 203-210, Feb 2, 2001
Positive charge intrinsic to Arg(37)-Arg(38) is critical for dopamine inhibition of the catalytic activity of human tyrosine hydroxylase type 1

A Nakashima, N Hayashi, K Mori, YS Kaneko, T Nagatsu, A Ota

FEBS LETTERS, 465(1) 59-63, Jan, 2000
Expression of human tyrosine hydroxylase type I in Escherichia coli as a protease-cleavable fusion protein

A Nakashima, K Mori, T Nagatsu, A Ota

JOURNAL OF NEURAL TRANSMISSION, 106(9-10) 819-824, 1999
Dopamine inhibition of human tyrosine hydroxylase type I is controlled by the specific portion in the N-terminus of the enzyme.

Journal of Neurochemistry, 72(5) 2145-2153, 1999
Risperidone, an atypical antipsychotic, affects the mRNA expressions of monoamine oxidase type B and vesicular monoamine transporter-2 in rat brain

M Ota, A Nakashima, K Mori, T Hamanaka, A Ota

BIOGENIC AMINES, 15(2) 197-216, 1999
Enzymes related to catecholamine biosynthesis in Tetrahymena pyriformis. Presenu of GTP cyclahydrolase (]G0001[).

Camparative Biochemistry and Physiology, 120B(4) 753-760, 1998
Effect of lipopolysaccharide on the gene expression of the enzyme involved in tetrahydrobiopterin de novo biosynthesis in murine neuroblastoma cell line NIE-115

Neuroscience Letters, 238(1) 2,21-24, 1997
Effects of dopamine on N-terminus-deleted human tyrosine hydroxylase type I expressed in Escherichia coli

Neuroscience Letters, 229(1) 57-60, 1997
Tetrahydrobiopterin biosynthesis enhanced by lipopolysaccharide stimulation in murine neuroblastoma cell line N1E-115

A Ota, S Yoshida, T Nomura, S Matsui, Y Hagino, K Umezawa, S Katoh, T Nagatsu

JOURNAL OF NEUROCHEMISTRY, 67(6) 2540-2548, Dec, 1996
Dissociated release of tetrahydrobiopterin and nitric oxide by lipopolysaccharide from mouse neuroblastoma cells

S Yoshida, A Ota, K Umezawa, T Nagatsu

NEUROSCIENCE LETTERS, 212(2) 135-138, Jul, 1996
Regulation of N-terminus-deleted human tyrosine hydroxylase type 1 by end products of catecholamine biosynthetic pathway

A Ota, S Yoshida, T Nagatsu

JOURNAL OF NEURAL TRANSMISSION, 103(12) 1415-1428, 1996
ALTERATION OF CATECHOLAMINE PHENOTYPE IN TRANSGENIC MICE INFLUENCES EXPRESSION OF ADRENERGIC-RECEPTOR SUBTYPES

K KOBAYASHI, A OTA, A TOGARI, S MORITA, T MIZUGUCHI, H SAWADA, K YAMADA, NAGATSU, I, S MATSUMOTO, K FUJITA, T NAGATSU

JOURNAL OF NEUROCHEMISTRY, 65(2) 492-501, Aug, 1995
DELETION MUTAGENESIS OF HUMAN TYROSINE-HYDROXYLASE TYPE-1 REGULATORY DOMAIN

A OTA, S YOSHIDA, T NAGATSU

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 213(3) 1099-1106, Aug, 1995
MOUSE SEPIAPTERIN REDUCTASE - AN ENZYME INVOLVED IN THE FINAL STEP OF TETRAHYDROBIOPTERIN BIOSYNTHESIS - PRIMARY STRUCTURE DEDUCED FROM THE CDNA SEQUENCE

A OTA, H ICHINOSE, T NAGATSU

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1260(3) 320-322, Feb, 1995
NICOTINE-INDUCED REGULATION OF TYROSINE-HYDROXYLASE ACTIVITY IN ADRENAL-GLAND OF TRANSGENIC MOUSE CARRYING HUMAN TYROSINE-HYDROXYLASE GENE

A OTA, H ICHINOSE, K KOBAYASHI, S MORITA, H SAWADA, T MIZUGUCHI, T NAGATSU

NEUROSCIENCE LETTERS, 166(1) 55-58, Jan, 1994
Distribution of β₁-and adrenoceptor subtypes in various mouse tissues

Neuroscience Letters, 160, 1993
The effect of a heterocyclic amine, 3-amino-1,4-dimethyl-5H-pyrids-[4,3-b]indole(Trp-P-1), on tyrosine hydroxylase mRNA in PC 12h cells

Neuroscience Letters, 154, 1993
Reduction of enzymatic activity of tyrosine hydroxylase by a heterocyclic amine, 3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole(Trp-P-1), was due to reduced affinity to a cofactor biopterine

Neuroscience Letters, 125, 1991
Insulin and IGF-I receptors in neuroblastoma cells : Increased binding produced by glyburide

Neuropeptides, 14, 1989
Insulin-related neurite formation in a neuroblastoma cell line(SH-SYSY)is associated with increased IGF-I receptor mRNA and binding

Molecular Brain Research, 6, 1989
Insulin-related molecules and insulin effects in the sea urchin embryo

Developmental Biology, 130, 1988
Insulin-sensitive tyrosine kinase is increased in livers of adult obese Zncker rats : Conection with prolonged fasting

Endocrinology, 123, 1988
Development of brain insulin receptors

International Journal of Biochemistry, 20, 1988
Insulin-like growth factor (]G0001[) receptors on mouse neuroblastoma cells : Two β subunits are derived from differences in glycosylotion

European Journal of Biochemistry, 174, 1988
Functional insulin-like growth factor (]G0001[) receptors are expressed by neural-derived continuous cell lines

Endocrinology, 122, 1988
Characterization of the altered oligosaccharide composition of the insulin receptor on neural-derived cells

Brain Research, 443, 1988
Insulin-like growth factor (]G0001[) receptors in neuronal and glial cells : Characterization and biological effects in primary culture

Journal of Biological Chemistry, 262, 1987

Professional Memberships

5

Research Projects

5

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