医学部
基本情報
- 所属
- 藤田医科大学 医学部 医学科 放射線医学 教授 (特命教授)
- 学位
- 医学博士(1990年3月 藤田医科大学)
- 連絡先
- htoyama
fujita-hu.ac.jp
- J-GLOBAL ID
- 200901090746938010
- researchmap会員ID
- 1000102544
研究分野
1経歴
1-
2024年9月 - 現在
論文
155-
Cancers 16(9) 2024年4月28日BACKGROUND: Diffusion-weighted images (DWI) obtained by echo-planar imaging (EPI) are frequently degraded by susceptibility artifacts. It has been suggested that DWI obtained by fast advanced spin-echo (FASE) or reconstructed with deep learning reconstruction (DLR) could be useful for image quality improvements. The purpose of this investigation using in vitro and in vivo studies was to determine the influence of sequence difference and of DLR for DWI on image quality, apparent diffusion coefficient (ADC) evaluation, and differentiation of malignant from benign head and neck tumors. METHODS: For the in vitro study, a DWI phantom was scanned by FASE and EPI sequences and reconstructed with and without DLR. Each ADC within the phantom for each DWI was then assessed and correlated for each measured ADC and standard value by Spearman's rank correlation analysis. For the in vivo study, DWIs obtained by EPI and FASE sequences were also obtained for head and neck tumor patients. Signal-to-noise ratio (SNR) and ADC were then determined based on ROI measurements, while SNR of tumors and ADC were compared between all DWI data sets by means of Tukey's Honest Significant Difference test. RESULTS: For the in vitro study, all correlations between measured ADC and standard reference were significant and excellent (0.92 ≤ ρ ≤ 0.99, p < 0.0001). For the in vivo study, the SNR of FASE with DLR was significantly higher than that of FASE without DLR (p = 0.02), while ADC values for benign and malignant tumors showed significant differences between each sequence with and without DLR (p < 0.05). CONCLUSION: In comparison with EPI sequence, FASE sequence and DLR can improve image quality and distortion of DWIs without significantly influencing ADC measurements or differentiation capability of malignant from benign head and neck tumors.
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Magnetic resonance imaging 2024年2月1日PURPOSE: The purpose of this study was to determine the utility of compressed sensing (CS) with deep learning reconstruction (DLR) for improving spatial resolution, image quality and focal liver lesion detection on high-resolution contrast-enhanced T1-weighted imaging (HR-CE-T1WI) obtained by CS with DLR as compared with conventional CE-T1WI with parallel imaging (PI). METHODS: Seventy-seven participants with focal liver lesions underwent conventional CE-T1WI with PI and HR-CE-T1WI, surgical resection, transarterial chemoembolization, and radiofrequency ablation, followed by histopathological or >2-year follow-up examinations in our hospital. Signal-to-noise ratios (SNRs) of liver, spleen and kidney were calculated for each patient, after which each SNR was compared by means of paired t-test. To compare focal lesion detection capabilities of the two methods, a 5-point visual scoring system was adopted for a per lesion basis analysis. Jackknife free-response receiver operating characteristic (JAFROC) analysis was then performed, while sensitivity and false positive rates (/data set) for consensus assessment of the two methods were also compared by using McNemar's test or the signed rank test. RESULTS: Each SNR of HR-CE-T1WI was significantly higher than that of conventional CE-T1WI with PI (p < 0.05). Sensitivities for consensus assessment showed that HR-CE-MRI had significantly higher sensitivity than conventional CE-T1WI with PI (p = 0.004). Moreover, there were significantly fewer FP/cases for HR-CE-T1WI than for conventional CE-T1WI with PI (p = 0.04). CONCLUSION: CS with DLR are useful for improving spatial resolution, image quality and focal liver lesion detection capability of Gd-EOB-DTPA enhanced 3D T1WI without any need for longer breath-holding time.
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European journal of radiology 171 111289-111289 2024年1月6日PURPOSE: The purpose of this in vivo study was to determine the effect of reverse encoding direction (RDC) on apparent diffusion coefficient (ADC) measurements and its efficacy for improving image quality and diagnostic performance for differentiating malignant from benign tumors on head and neck diffusion-weighted imaging (DWI). METHODS: Forty-eight patients with head and neck tumors underwent DWI with and without RDC and pathological examinations. Their tumors were then divided into two groups: malignant (n = 21) and benign (n = 27). To determine the utility of RDC for DWI, the difference in the deformation ratio (DR) between DWI and T2-weighted images of each tumor was determined for each tumor area. To compare ADC measurement accuracy of DWIs with and without RDC for each patient, ADC values for tumors and spinal cord were determined by using ROI measurements. To compare DR and ADC between two methods, Student's t-tests were performed. Then, ADC values were compared between malignant and benign tumors by Student's t-test on each DWI. Finally, sensitivity, specificity and accuracy were compared by means of McNemar's test. RESULTS: DR of DWI with RDC was significantly smaller than that without RDC (p < 0.0001). There were significant differences in ADC between malignant and benign lesions on each DWI (p < 0.05). However, there were no significant difference of diagnostic accuracy between the two DWIs (p > 0.05). CONCLUSION: RDC can improve image quality and distortion of DWI and may have potential for more accurate ADC evaluation and differentiation of malignant from benign head and neck tumors.
MISC
113-
日本サルコイドーシス/肉芽腫性疾患学会雑誌 39(1-2) 59-64 2019年10月我々は心臓サルコイドーシス疑いの74例において,「2016年版心臓サルコイドーシスの診療ガイドライン」における組織診断・臨床診断を真として,FDG-PET/CTの診断精度を検討した.さらにFDG-PET/CTと同時期に心臓造影MRIを施行した33例において,ガドリニウム造影剤を用いた遅延造影(LGE)所見を検討した.全74例中31例が本症の診断基準を満たし,38例が診断基準を満たさず,残り5例は心限局性サ症の疑診例であった.診断基準を満たした31例を真とすると,FDGPET/CTによる感度,特異度,正診率,陽性的中率,陰性的中率は,それぞれ90%,87%,88%,85%,92%であった.心臓造影MRIを同時期に施行した33例において,FDG-PET/CT陽性の20例中16例でLGE陽性,FDG-PET/CT陰性の13例中8例でLGE陽性であった.心サ症疑い患者におけるFDG-PET/CTの診断精度は非常に良好であった.さらに心臓MRIの遅延造影所見を加えることは,本症の活動性や線維化の診断に有用であった.(著者抄録)
書籍等出版物
3-
Springer Nature Singapore Pte Ltd. 2020 2020年1月
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Wolters Kluwer/Lippincott Williams & Wilkins 2010年
講演・口頭発表等
117所属学協会
3共同研究・競争的資金等の研究課題
27-
日本学術振興会 科学研究費助成事業 2024年4月 - 2027年3月
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日本学術振興会 科学研究費助成事業 2023年4月 - 2026年3月
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日本学術振興会 科学研究費助成事業 2023年4月 - 2026年3月
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日本学術振興会 科学研究費助成事業 2022年4月 - 2025年3月
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日本学術振興会 科学研究費助成事業 2021年4月 - 2024年3月
教育内容・方法の工夫(授業評価等を含む)
1-
件名生涯教育研修センター12階、IT学習室のPCシステムを利用した。開始年月日2008終了年月日2013概要基本的診療技能Ⅱ(実習)において、1台/1人のPCシステムを利用し、頭部、胸部、腹部CTの横断解剖の実習を行った。
作成した教科書、教材、参考書
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件名Functional Cerebral SPECT and PET Imaging, 4thedition, Van Heertum RL, Tikofsky RS, Ichise M, eds.終了年月日2010概要Moya-moya disease, 310-311,Wolters Kluwer/Lippincott Williams & Wilkinsを分担執筆した。
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件名Functional Cerebral SPECT and PET Imaging. 4th edition, Van Heertum RL, Tikofsky RS, Ichise M.eds.終了年月日2010概要Herpes encephalitis, 440-441,Wolters Kluwer/Lippincott Williams & Wilkinsを分担執筆した。
教育方法・教育実践に関する発表、講演等
3-
件名第44回日本医学教育学会大会, 横浜終了年月日2012概要若月 徹, 大槻眞嗣, 江﨑誠治, 外山 宏, 田中郁子, 菊川 薫, 鈴木茂孝,諸岡正史, 佐久間隆子, 長田明子, 石原 慎, 中島 昭, 松井俊和,辻 孝雄:藤田式PBL tutorial 第3報 PBLへのピア評価の導入について発表した。
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件名第43回日本医学教育学会大会, 広島終了年月日2011概要鈴木茂孝, 若月 徹, 大槻眞嗣, 江崎誠治, 鴨下淳一, 飯田忠行, 松井俊和,外山 宏, 田中郁子, 菊川 薫, 辻 孝雄:グループ学習での簡易的なピア評価方法の試作について発表した。
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件名第44回日本医学教育学会大会, 広島終了年月日2010概要大槻眞嗣, 松井俊和, 外山 宏, 田中郁子, 菊川 薫, 若月 徹, 江崎誠治,鈴木茂孝, 佐久間隆子, 中島 昭, 長田明子, 辻 孝雄, 小野雄一郎:藤田式PBL tutorial, the second reportについて発表した。
その他教育活動上特記すべき事項
2-
件名第22年藤田保健衛生大学医学教育ワークショップ開始年月日2010/04/12終了年月日2010/04/13概要医学教育ワークショップに参加した。
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件名第32年藤田保健衛生大学医学教育ワークショップ開始年月日2011/12/19終了年月日2011/12/20概要医学教育ワークショップに参加した。