研究者業績
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  2. 楠原 康弘

楠原 康弘

クスハラ ヤスヒロ  (kusuhara yasuhiro)

基本情報

所属
藤田医科大学 医療科学部 臨床検査学科 基礎病態解析 講師
基礎病態分析
学位
博士(医学）
J-GLOBAL ID
200901092473536595
researchmap会員ID
1000102607

研究分野

 1

論文

 17
  • Yasuhiro Kusuhara
    Int J Anal Bio-Sci 8(1) 24-27 2020年3月31日  査読有り筆頭著者
  • Ichino N, Osakabe K, Sugimoto k, Suzuki K, Yamada H, Takai H, Sugiyama H, Yukitake J, Inoue T, Ohashi k, Hata T, Hamajima T, Watarai R, Kimura A, Kusuhara Y, Hamajima N, Nishikawa T, Hashimoto S, Kawabe N, Yoshioka K
    Rinsho Byori 63(1) 32-43 2015年  査読有り
  • 楠原康弘
    Int J Anal Bio-Sci. 2(2) 72-76 2014年5月  査読有り
  • Koji Suzuki, Junichi Ishii, Fumihiko Kitagawa, Atsuhiro Kuno, Yasuhiro Kusuhara, Junichi Ochiai, Naohiro Ichino, Keisuke Osakabe, Keiko Sugimoto, Hiroya Yamada, Yoshinori Ito, Nobuyuki Hamajima, Takashi Inoue
    Journal of Epidemiology 23(3) 163-168 2013年  査読有り
    Background: Several epidemiologic studies have reported an inverse association between serum levels of carotenoids and cardiovascular disease risk. However, no studies have reported an association between serum carotenoids and N-terminal pro-brain-type natriuretic peptide (NT-proBNP) in the general population. Methods: In this cross-sectional study,we investigated whether serum carotenoids were associated with serum NTproBNP in 1056 Japanese subjects (390 men, 666 women) who attended a health examination. Serum levels of carotenoids were separately determined by high-performance liquid chromatography. Serum NT-proBNP level was measured by electrochemiluminescence immunoassay. Results: Serum NT-proBNP was elevated (≥55 pg/ml) in 31.8% of men and 48.2% of women. Multivariate logistic regression analyses adjusted for confounding factors showed a significant association between the highest quartile of serum a-carotene and elevated NT-proBNP in men (odds ratio [OR]= 0.40, 95% CI = 0.19-0.82, P for trend = 0.005) and women (OR = 0.62, 95% CI = 0.39-0.99, P for trend = 0.047). In women, moreover, elevated serum NTproBNP was significantly associated with serum canthaxanthin (OR = 0.57, 95% CI = 0.36-0.90 for highest quartile, P for trend = 0.026) and ß-cryptoxanthin (OR = 0.53, 95% CI = 0.32-0.85 for highest quartile, P for trend = 0.026), after adjusting for potential confounders. Conclusions: Higher levels of serum carotenoids were associated with lower risk of elevated serum NT-proBNP levels after adjusting for possible confounders, which suggests that a diet rich in carotenoids could help prevent cardiac overload in the Japanese population. © 2013 Japan Epidemiological Association.
  • 枝川亜希子, 木村明生, 田中栄次, 土井均, 楠原康弘
    防菌防黴誌 38(10) 661-665 2010年  
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MISC

 6
  • Naohiro Ichino, Keisuke Osakabe, Keiko Sugimoto, Akira Yokoi, Takashi Inoue, Koji Suzuki, Yasuhiro Kusuhara, Nobuyuki Hamajima, Hiroji Takai, Tadayoshi Hata
    JOURNAL OF MEDICAL ULTRASONICS 39(1) 3-9 2012年1月  
    Assessment of plaque formation in the common carotid artery (CCA) is important for stratification of the risk of subsequent stroke. The stiffness parameter beta, which can be assessed using an ultrasonic phase-locked echo-tracking system, was developed to evaluate arterial stiffness. The purpose this study was to examine the relationship of the stiffness parameter beta to intima-media thickness (IMT) and plaque formation. The stiffness parameter beta and mean IMT were measured using an ultrasonic phase-locked echo-tracking system and an automatic IMT measurement system, respectively, and the presence of plaque was assessed by ultrasonography in 347 subjects who took part in a health check-up program for community-dwelling people in Hokkaido. Values of the stiffness parameter beta were significantly higher in subjects with plaque formation than in those without plaque (10.60 +/- A 0.45 vs. 8.88 +/- A 0.23, P < 0.005) in whom IMT was not thickened; however, it was not different in subjects with increased IMT (> 1.0 mm). The percentage of plaque formation was significantly correlated with the value of the stiffness parameter beta. Furthermore, the stiffness parameter beta was significantly correlated with plaque formation after adjustment for several clinical variables (odds ratio 1.113-1.178, P < 0.001). The stiffness parameter beta is associated with plaque formation in the CCA, especially in subjects with a normal IMT. This could potentially be used as a predictor for plaque formation.
  • Koji Suzuki, Takashi Inoue, Shuji Hashimoto, Junichi Ochiai, Yasuhiro Kusuhara, Yoshinori Ito, Nobuyuki Hamajima
    CLINICA CHIMICA ACTA 411(17-18) 1330-1334 2010年9月  
    Background: Several studies have reported that serum concentrations of carotenoids and adiponectin are inversely associated with the risk for cardiovascular disease (CVD). However, no studies have investigated the association between serum concentrations of adiponectin and carotenoids in the general population. Methods: We investigated cross-sectionally whether serum carotenoids are associated with serum high molecular weight (HMW) adiponectin and some inflammatory markers in 437 Japanese subjects (116 men and 321 women) who attended a health examination. Results: In multiple linear regression analysis adjusted for confounding factors, serum beta-carotene concentrations were significantly associated with serum HMW adiponectin concentrations in both sexes (standardized beta coefficient = 0.197, p = 0.036 for men; standardized beta coefficient = 0.146, p = 0.012 for women). Serum alpha-carotene and beta-carotene concentrations were significantly associated with serum C-reactive protein (CRP) concentrations in men. In women, there were significant negative associations between serum carotenoids concentrations and serum interleukin-6 (IL-6) concentrations. Additional adjustment for serum concentrations of IL-6 or CRP did not significantly affect the association between carotenoids and HMW adiponectin in non-smoking men as well as in women. Conclusion: Serum beta-carotene concentrations were positively associated with serum HMW adiponectin concentrations even after adjustment for possible confounding factors including inflammatory markers. (C) 2010 Elsevier B.V. All rights reserved.
  • Akiko Edagawa, Akio Kimura, Takako Kawabuchi-Kurata, Yasuhiro Kusuhara, Panagiotis Karanis
    PARASITOLOGY RESEARCH 105(4) 1109-1117 2009年10月  
    Here, we carried out a survey to determine the prevalence of free-living amoebae (FLA) in tap-water sources from rivers and water treatment plants located in Osaka Prefecture, Japan. A total of 374 raw water samples were collected from 113 sampling points. The samples were filtrated and transferred to non-nutrient agar plates seeded with a heat-killed suspension of Escherichia coli and incubated for 2 to 7 days at 30A degrees C or 42A degrees C. The plates were examined by microscopy to morphologically identify FLA families, and polymerase chain reaction and sequence analysis were then performed to define the species of the detected Naegleria and Acanthamoeba isolates. A total of 257 of 374 samples (68.7%) were positive for FLA by microscopy, and among these there were 800 FLA isolates, including Acanthamoeba and Naegleria species. Sequence analysis identified five Acanthamoeba spp. isolates of the known pathogenic T4 genotype and 43 Naegleria australiensis isolates, a reported pathogen to mice and also of concern as a potential pathogen to humans. Our results suggest a wide distribution of FLA, including potential pathogenic species, in tap-water sources of western Japan.
  • 曽和 順子, 有馬 豪, 鈴木 加余子, 松永 佳世子, 山本 紘子, 楠原 康弘, 岡本 紀久
    日本皮膚科学会雑誌 111(6) 989-989 2001年5月  
  • 前野 芳正, 辻 孝雄, 中澤 秀介, 長嶋 茂雄, 楠原 康弘, 佐々木 潤, 神原 廣二, 谷口 孝喜
    衞生動物 52 125-125 2001年4月4日  
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書籍等出版物

 2

講演・口頭発表等

 6
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所属学協会

 1

Works(作品等)

 6

共同研究・競争的資金等の研究課題

 1

教育内容・方法の工夫（授業評価等を含む）

 1
  • 件名
    -
    終了年月日
    2013/04/01
    概要
    iPadを用いて寄生虫学実習における各種寄生虫卵や原虫の多角的な写真の供覧

作成した教科書、教材、参考書

 2
  • 件名
    医学領域における臨床検査学入門　第2版および３版
    終了年月日
    2009/07/24
    概要
    臨床検査技師国家試験対策用教科書。寄生虫学の項、担当
  • 件名
    医学領域における臨床検査学入門　第2版および３版
    終了年月日
    2013/07/15
    概要
    臨床検査技師国家試験対策用教科書。寄生虫学の項、担当
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