研究者業績

平田 ゆかり

hirata yukari

基本情報

所属
藤田医科大学 医学部 医学科 法医学 助教
学位
学士(保健衛生学)

J-GLOBAL ID
200901066892893143
researchmap会員ID
1000102616

MISC

 8
  • 中留真人, 折井みなみ, 濱島誠, 平田ゆかり, 日比淑江, 布谷美弥, 磯部一郎
    DNA多型 20 209-302 2012年  
  • Masato Nakatome, Minami Orii, Makoto Hamajima, Yukari Hirata, Misato Uemura, Sayaka Hirayama, Ichiro Isobe
    LEGAL MEDICINE 13(4) 205-209 2011年7月  査読有り
    DNA methylation in gene promoter regions influences gene expression. Circadian clock genes play an important role in the formation of a biological clock and aberrant methylation of these genes contributes to several disorders. In this study, we examined forensic autopsy specimens to determine whether DNA methylation status in the promoter regions of nine circadian clock genes (Per1, Per2, Per3, Cry1, Cry2, Bmal1, Clock, Tim, and Ck1e) is related to a change in acquired diathesis and/or causes of death. Methylation-specific PCR and direct sequencing methods revealed that the promoters of Per1, Cry2, Bmal1, Clock, and Ck1e were unmethylated in all the forensic autopsy specimens, while the promoters of Per2, Per3, Cry1, and Tim were partially methylated. Methylation status varied between individuals and between tissues in the same patient. A detailed analysis of methylation patterns in the Cry1 promoter region revealed that the patterns also varied between individuals and the Cry1 promoter had highly methylated patterns in two cases that had been exposed to methamphetamine. These results suggest that the methylation status of clock gene promoters varies between individuals. Methamphetamine use may influence methylation in the Cry1 gene promoter region and disturb circadian rhythmicity. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
  • Masato Nakatome, Minami Orii, Makoto Hamajima, Yukari Hirata, Misato Uemura, Sayaka Hirayama, Ichiro Isobe
    LEGAL MEDICINE 13(4) 205-209 2011年7月  
    DNA methylation in gene promoter regions influences gene expression. Circadian clock genes play an important role in the formation of a biological clock and aberrant methylation of these genes contributes to several disorders. In this study, we examined forensic autopsy specimens to determine whether DNA methylation status in the promoter regions of nine circadian clock genes (Per1, Per2, Per3, Cry1, Cry2, Bmal1, Clock, Tim, and Ck1e) is related to a change in acquired diathesis and/or causes of death. Methylation-specific PCR and direct sequencing methods revealed that the promoters of Per1, Cry2, Bmal1, Clock, and Ck1e were unmethylated in all the forensic autopsy specimens, while the promoters of Per2, Per3, Cry1, and Tim were partially methylated. Methylation status varied between individuals and between tissues in the same patient. A detailed analysis of methylation patterns in the Cry1 promoter region revealed that the patterns also varied between individuals and the Cry1 promoter had highly methylated patterns in two cases that had been exposed to methamphetamine. These results suggest that the methylation status of clock gene promoters varies between individuals. Methamphetamine use may influence methylation in the Cry1 gene promoter region and disturb circadian rhythmicity. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
  • 中留真人, 折井みなみ, 濱島誠, 平田ゆかり, 植村美里, 平山沙也香, 磯部一郎
    DNA多型 19 240-244 2011年  
  • 中留真人, 濱島誠, 平田ゆかり, 磯部一郎, 山本琢磨, 的場梁次
    DNA多型 18 268-271 2010年  

講演・口頭発表等

 36

担当経験のある科目(授業)

 4

教育内容・方法の工夫(授業評価等を含む)

 3
  • 件名
    法医学実習
    開始年月日
    2009
    終了年月日
    2015
    概要
    学生が内容を理解し、安全・スムースに実習を行う指導
  • 件名
    読書ゼミナール
    開始年月日
    2012
    終了年月日
    2017
    概要
    学生が積極的にディスカッションに参加する
  • 件名
    アッセンブリー
    開始年月日
    2009
    終了年月日
    2017
    概要
    学生・教職員が一つの目標に一丸となって取り組む

作成した教科書、教材、参考書

 2
  • 件名
    法医学実習書
    開始年月日
    2009
    終了年月日
    2015
    概要
    学生が内容を理解し、安全・スムースに実習を行うための実習書
  • 件名
    読書ゼミナール参考資料
    開始年月日
    2009
    終了年月日
    2017
    概要
    学生が書籍の内容を深く理解する