Hisahide Takahashi

(髙橋久英)

Profile Information

Affiliation: School of Health Sciences, Faculty of Medical Technology, Fujita Health University

Degree: (BLANK)(Fujita Health University)

J-GLOBAL ID: 200901059120541717
researchmap Member ID: 1000102672

Research Interests

Research Areas

Research History

1982 - 1984

藤田保健衛生大学助教授
1982 - 1984

Fujita Health University, Assistant Professor
1984

- 藤田保健衛生大学教授
1984

- Fujita Health University, Professor
1976 - 1982

名古屋保健衛生大学講師(後、藤田保健衛生大学に改名)

Education

- 1966

School of Agricultural Sciences, Nagoya University
- 1966

Faculty of Agriculture, Nagoya University

Committee Memberships

Awards

1989

嚢胞腎研究財団功労賞(PKR Foundation,U.S.A)

Misc.

嚢胞性腎疾患におけるMAPキナーゼ

発達腎研究会, 10(1) 62-65, 2002
Progressive renal fibrosis in murine polycystic kidney disease: An immunohistochemical observation

H Okada, S Ban, S Nagao, H Takahashi, H Suzuki, EG Neilson

KIDNEY INTERNATIONAL, 58(2) 587-597, Aug, 2000
Effect of probucol in a murine model of slowly progressive polycystic kidney disease

S Nagao, T Yamaguchi, M Kasahara, M Kusaka, J Matsuda, N Ogiso, H Takahashi, JJ Grantham

AMERICAN JOURNAL OF KIDNEY DISEASES, 35(2) 221-226, Feb, 2000
自然発症口唇、口蓋裂CL/Frマウスにおける口唇・口蓋裂発生原因としての遺伝的要因

藤田学園医学会誌, 24(1) 99-102, 2000
新たに育成したコンジェニックBDIX-chiラットの実験動物学的検討

藤田学園医学会誌, 24(2), 175-179, 2000
Progressive renal fibrosis in mirene pocystic kidney disease an immunohistochemical observation.

kidney International, 585, 587-597, 2000
Characterrization of a novel polycystic vidney rat model with accompanying polycystic liver.

Exp. Anim., 49, 51-55, 2000
The study on the role of Myocoptes musculinus (kekuidani) on the skin eruptions of the atopic model mice (NC mice).

Environ Dermatology, 7, 52-62, 2000
Progressive renal fibrosis in mirene pocystic kidney disease an immunohistochemical observation.

kidney International, 585, 587-597, 2000
Characterization of a novel polycystic kidney rat model with accompanying polycystic liver

Makoto Katsuyama, Takeshi Masuyama, Ichiro Komura, Tsutomu Hibino, Hisahide Takahashi

Experimental Animals, 49(1) 51-55, 2000
Generation of a polymorphic marker linked to thymoma susceptibility gene of rat 1 by genetically-directed representational difference analysis

Kyoko HIGO, Toshikazu USHIJIMA, Atsushi OYABU, Chunlin YE, Shigeru YAGYU, Hisahide TAKAHASHI, Mutsushi MATSUYAMA

Exp. Anim., 49(3) 189-195, 2000
The study on the role of Myocoptes musculinus(kekuidani)on the skin eruptions of the atopic model mice(NC).

Environ. Dermatol., 7 52-60, 2000
Characterization of a novel polycystic kidney rat model with accompanying polycystic liver.

Exp. Anim., 49(1) 51-55, 2000
Characterization of a novel polycystic kidney rat model with accompanying polycystic liver

M Katsuyama, T Masuyama, Komura, I, T Hibino, H Takahashi

EXPERIMENTAL ANIMALS, 49(1) 51-55, Jan, 2000
Generation of a polymorphic marker linked to thymoma susceptibility gene of nat 1 by genetically-directed representational difference analysis.

Kyoko HIGO, Toshikazu USHIJIMA, Atsushi OYABU, Chunlin YE, Shigeru YAGYU, Hisahide TAKAHASHI, Mutsushi MATSUYAMA

Exp. Anim., 49(3) 189-195, 2000
Closely linked polymorphic markers for determining the autosomal dominant allele (Cy) in rat polycystic kidney disease

S Nagao, T Ushijima, M Kasahara, T Yamaguchi, M Kusaka, J Matsuda, M Nagao, H Takahashi

BIOCHEMICAL GENETICS, 37(7-8) 227-235, Aug, 1999
Gene therapy for renal anemia in mice with polycystic kidney using an adenovirus vector encoding the human erythropoietin gene

S Osada, Ebihara, I, Y Setoguchi, H Takahashi, Y Tomino, H Koide

KIDNEY INTERNATIONAL, 55(4) 1234-1240, Apr, 1999
Milan Normotensive Rat(MNS)における腎硬化症の進展機序

血圧, 6(6), 564-569, 1999
多発性嚢胞腎症DBA/2FG-pcyマウスにおける塩化アンモニウム負荷の影響

金田繁, 長尾静子, 笠原正男, 高橋久英

藤田学園医学会誌, 23(1) 41-45, 1999

多発性嚢胞腎症D2-pcyマウスに1.0%NH4Cl- 20%しょ糖液を8週齢から1週間摂取させると,飼料摂取量は増加したが,体重,摂水量,尿量は低下し,腎重量は対照レベルを下回る傾向を示した.腎の組織変化の程度ならびに尿素窒素の血中濃度は対照と同レベルであった.尿中アンモニア窒素は著しく増加し,尿pHは対照レベルより更に低下したが,滴定酸及び無機リンの尿中排泄に変化はみられずNH4Cl摂取の嚢胞形成に及ぼす有意な影響は認めなかった
Milan Normotensive Rat(MNS)における腎硬化症の進展機序:ACE阻害薬とA(]G0002[)受容体拮抗薬の腎保護効果

血圧, 6(6) 564-569, 1999
Electron microscopic observation on the parathyroid gland of the cardiomyopathic hamster (UM-X7.1 Syrian hamster)

M Utsumi, K Moriguchi, H Takahashi, C Kinoshita, A Togari, M Mizutani, N Ohno

JOURNAL OF ELECTRON MICROSCOPY, 48(2) 139-145, 1999
Renal carbonic anhydrase activity in DBA/2FG-pcy/pcy mice with inherited polycystic kidney disease.

Shigeru KANETA, Satoshi ISHIZUKI, Masao KASAHARA, Shizuko NAGAO, Hisahide TAKAHASHI

Exp. Anim., 48(3) 161-169, 1999
Alteration of enzymatic activities implicating neuronal degeneration in the spinal cord of the motor neuron degeneration mouse during postnatal development

K Fujita, K Shibayama, M Yamauchi, T Kato, M Ando, H Takahashi, K Iritani, N Yoshimoto, Y Nagata

NEUROCHEMICAL RESEARCH, 23(4) 557-562, Apr, 1998
Increase of glial fibrillary acidic protein fragments in the spinal cord of motor neuron degeneration mutant mouse

K Fujita, M Yamauchi, T Matsui, K Titani, H Takahashi, T Kato, G Isomura, M Ando, Y Nagata

BRAIN RESEARCH, 785(1) 31-40, Feb, 1998
多発性嚢胞腎症DBA/FG-pcyにおける酸性尿の排泄

藤田学園医学会誌, 22(1) 93-99, 1998
多発性嚢胞腎症モデルマウスにおける細胞分裂抑制薬タキソール投与の影響

金田繁, 長尾静子, 笠原正男, 高橋久英

藤田学園医学会誌, 22(1) 87-91, 1998

多発性嚢胞腎症マウスに細胞分裂抑制薬タキソールを週1回腹腔内注射して腎の機能,形態に及ぼす影響を検討した. 1)生後12日目の動物は初回投与150μgで半数が死亡したが,100μgでは体重の増加抑制,脱毛がみられたもののこの投与量に耐え,11週間の投与期間中,多尿及び尿pHの低下が抑制され,嚢胞の拡張遅延がみられた.投与終了後の血清尿素窒素,尿量及び尿中クレアチンに有意差は認められなかった. 2)生後21日目から150μgを9週間投与したが,DMSO投与群と殆ど相異がなく,タキソール投与群の検査では,血清尿素窒素の有意低下がみられたが,腎嚢胞の拡張進展に影響はみられなかった
多発性嚢胞腎症における抗炎症薬と細胞増殖抑制剤の効果

長尾静子, 金田繁, 笠原正男, 小木曽昇, 高橋久英

藤田学園医学会誌, 22(1) 81-85, 1998

1)細胞増殖抑制剤パクリタキセルの構造類似物質であるドセタキセルを,多発性嚢胞腎症(PKD)の進行が比較的緩やかであるpcyマウスに投与したが,PKDの進行を抑制することはできなかった. 2)パクリタキセルと抗ファイブロジェニック効果を有する抗炎症薬メチルプレドニゾロンをpcyマウスに併用投与したところ,高死亡率と低体重と共に,顕著なPKD進行の抑制が認められた. 3)嚢胞発生関連因子に基づいた投薬実験は,嚢胞発生機序の解析に寄与すると考える
多発性嚢胞腎マウスDBA/ZFG-pcyマウスにおける重炭酸ナトリウム負荷の影響

藤田学園医学会誌, 22(2) 9-12, 1998
多発性嚢胞腎(PKDモデル)

病理と臨床, 16(2) 177-184, 1998
Effect of dietary soy protein and genistein on disease progression in mice with polycystic kidney disease

K Tomobe, DJ Philbrick, MR Ogborn, H Takahashi, BJ Holub

AMERICAN JOURNAL OF KIDNEY DISEASES, 31(1) 55-61, Jan, 1998
Renal accumulation and excretion of cyclic adenosine monophosphate in a murine model of slowly progressive polycystic kidney disease

T Yamaguchi, S Nagao, M Kasahara, H Takahashi, JJ Grantham

AMERICAN JOURNAL OF KIDNEY DISEASES, 30(5) 703-709, Nov, 1997
嚢胞腎(自然発症マウス)

小児外科, 22 233-237, 1997
Genetic reguration of slowly progressing maid in fast-twitch muscle of BUF/Mna rats.

Muscle Nerve, 20 1258-1263, 1997
Experimental study on cleft lip and/or palate: Fetuses of A/J mice in uteri of F1 hybrid mothers using ovarian transplantation

K Yoshida, N Natsume, H Kinoshita, N Tsunoda, H Takahashi, T Kawai

CLEFT PALATE-CRANIOFACIAL JOURNAL, 33(4) 291-296, Jul, 1996
Vx2腫瘍を用いた家兎癌性腹膜炎モデルの確立

藤田学園医学会誌, 20(2) 215-218, 1996
Scidマウスの血清補体

藤田学園医学会誌, 20(2) 255-258, 1996
多発性嚢胞腎症マウスにおける1-Ety-Nitrosourea経胎盤投与の影響

藤田学園医学会誌, 20(2) 211-214, 1996
Experimental study on cleft lip and/or palate : fetuses of A/J mice in uteri of F₁ hybrid mothers using ovarian trans-plantation

Cleft. Palate. J., 33 294-296, 1996
The effect of paclitaxel on the progression of polycystic Kidney disease in rodents

Am. J. Kidney Die., 29 435-444, 1996
Genetic mapping of the polycystic kidney gene, pcy, on mouse chromosome 9

S Nagao, T Watanabe, N Ogiso, T Marunouchi, H Takahashi

BIOCHEMICAL GENETICS, 33(11-12) 401-412, Dec, 1995
ALTERED EXTRACELLULAR-MATRIX COMPONENT GENE-EXPRESSION IN MURINE POLYCYSTIC KIDNEY

EBIHARA, I, T NAKAMURA, T TAKAHASHI, M YAMAMOTO, Y TOMINO, S NAGAO, H TAKAHASHI, H KOIDE

RENAL PHYSIOLOGY AND BIOCHEMISTRY, 18(2) 73-80, Mar, 1995
METHYLPREDNISOLONE RETARDS THE PROGRESSION OF INHERITED POLYCYSTIC KIDNEY-DISEASE IN RODENTS

VH GATTONE, BD COWLEY, BD BARASH, S NAGAO, H TAKAHASHI, T YAMAGUCHI, JJ GRANTHAM

AMERICAN JOURNAL OF KIDNEY DISEASES, 25(2) 302-313, Feb, 1995
多発性嚢胞腎病マウス(共著) バイオメデイカルリサーチマニュアル-動物実験法-

株式会社養賢堂発行, VI 100, 1995
Cyst fluid murine model of polycystic kidney disease stimulates fluid secretion, cyclic AMP accumulation and cell proliferation by MDCK cells in vitro.

Am. J. Kidney Dis., 25 471-477, 1995
EARLY DIETARY-PROTEIN RESTRICTION SLOWS DISEASE PROGRESSION AND LENGTHENS SURVIVAL IN MICE WITH POLYCYSTIC KIDNEY-DISEASE

K TOMOBE, D PHILBRICK, HM AUKEMA, WF CLARK, MR OGBORN, A PARBTANI, H TAKAHASHI, BJ HOLUB

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 5(6) 1355-1360, Dec, 1994
NUMBER OF SIMULTANEOUSLY EXPRESSED ENZYME ALTERATIONS CORRELATES WITH PROGRESSION OF N-ETHYL-N-HYDROXYETHYLNITROSAMINE-INDUCED HEPATOCARCINOGENESIS IN RATS

S YAMAGUCHI, K HAKOI, K OZAKI, T KATO, D TIWAWECH, S NAGAO, H TAKAHASHI, K MATSUMOTO, H TSUDA

JAPANESE JOURNAL OF CANCER RESEARCH, 84(12) 1237-1244, Dec, 1993
[6]多発性嚢胞腎炎マウス(共著)(疾患別)モデル動物の作製と新薬開発のための試験・実験法

技術情報協会, 328, 1993
マウス多発性嚢胞腎症における尿細管の上皮細胞特性の消失

藤田学園医学会誌, 17(2) 261-265, 1993
乳幼児型嚢胞腎症マウス,C57BL/6-cpk,の特性

藤田学園医学会誌, 17(2) 255-259, 1993
Dietary sorbose prevevents and improves hyperglycemia in genetically diabetic mice.

J. Nutr., 123,59-63, 1993

Books and Other Publications

多発性嚢胞腎の基礎5.モデル動物の育成と利用・「多発性嚢胞腎－遺伝子からベッドサイドまで－小出輝ら編

南山堂, 2001
疾患モデルと遺伝子解析の現状-多発性嚢胞腎"自然発症疾患モデル動物(コモンディシーズの原因遺伝子ハンテング)"

Molecular Medicine,中山書店,東京, 1999

Professional Memberships

Works

Research Projects

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