Curriculum Vitaes
Profile Information
- Affiliation
- School of Health Sciences, Faculty of Medical Technology, Fujita Health University
- Degree
- (BLANK)(Fujita Health University)
- J-GLOBAL ID
- 200901059120541717
- researchmap Member ID
- 1000102672
Research Interests
6Research Areas
3Research History
8-
1982 - 1984
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1982 - 1984
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1984
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1976 - 1982
Education
2Committee Memberships
4-
1985 - 1993
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1985 - 1993
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1985 - 1988
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1980
Awards
1Misc.
66-
J. Am. Soc. Nephrol, 3,1378-1386, 1993
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Lipids, 27,429-435, 1992
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Experimental and Molecular Pathology, 57,39-46, 1992
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Kidney International, 42,838-842, 1992
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J. Nutr. Biochem, 3,491-495, 1992
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Strain difference in expression of the adult type polycystic kidney disease gene, pcy, in the mouse.Exp. Animal, 40(1), 1991
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J. Am. Soc. Nephrol, 1(7), 1991
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Exp. Animal, 40(4) 557-560, 1991Two murine models of polycystic kidney disease (PKD) in humans are currently available: the infant-type cpk in mice and the adult-type pcy mutation in mice. Our linkage analysis was to determine whether these genes are allelic forms of the same gene, or infant-type and adult-type PKD resulting from homozygous and heterozy-gous mutation, as in the rat Cy gene. We found that the pcy gene in the mice was linked with the d gene on chromosome 9, but the cpk gene was not. A segregation test indicated that the two genes are inherited independently. This indicates that the cpk and pcy genes are not alleles and that the genetic mechanism of PKD pathogenesis in the mouse is different from that in the Cy rat.