研究者業績

千原 猛

チハラ タケシ  (Chihara Takeshi)

基本情報

所属
藤田医科大学 医療科学部 臨床検査学科 准教授
学位
博士(医学)(藤田保健衛生大学)

J-GLOBAL ID
200901075510286403
researchmap会員ID
1000102768

論文

 29
  • Yoshihiro Uekuzu, Takashi Higashiguhi, Akihiko Futamura, Akihiro Ito, Naoharu Mori, Miyo Murai, Hiroshi Ohara, Hiroko Awa, Takeshi Chihara
    BIOLOGICAL & PHARMACEUTICAL BULLETIN 40(3) 278-283 2017年3月  査読有り
    There have been few detailed reports on respiratory depression due to overdoses of opioids in terminal cancer patients. We investigated the situation of treatment with opioid antagonists for respiratory depression that occurred after administration of opioid at optimal doses in terminal cancer patients, to clarify pathological changes as well as causative factors. In 2443 terminal cancer patients receiving opioids, 7 patients (0.3%) received opioid antagonists: 6, morphine (hydrochloride, 5; sulfate, 1); 1, oxycodone. The median dosage of opioids was 13.3 mg/d, as converted to morphine injection. Respiratory depression occurred on this daily dose in 4 patients and after changed dose and route in 3 patients. Opioids were given through the vein in 6 patients and by the enteral route in 1 patient. Concomitant drugs included nonsteroidal anti-inflammatory drugs in 3 patients and zoledronic acid in 2 patients. In morphine-receiving patients, renal functions were significantly worsened at the time of administration of an opioid antagonist than the day before the start of opioid administration. These findings indicate that the proper use of opioids was safe and acceptable in almost all terminal cancer patients. In rare cases, however, a risk toward respiratory depression onset is indicated because morphine and morphine-6-glucuronide become relatively excessive owing to systemic debility due to disease progression, especially respiratory and renal dysfunctions. At the onset of respiratory depression, appropriate administration of an opioid antagonist mitigated the symptoms. Thereafter, opioid switching or continuous administration at reduced dosages of the same opioids prevented the occurrence of serious adverse events.
  • Hiroko Awa, Akihiko Futamura, Takashi Higashiguchi, Akihiro Ito, Naoharu Mori, Miyo Murai, Hiroshi Ohara, Takeshi Chihara, Takaaki Kaneko
    BIOLOGICAL & PHARMACEUTICAL BULLETIN 40(3) 266-271 2017年3月  査読有り
    A functional dietary supplement (FDS) containing Coenzyme Q10, branched-chain amino acids and L-carnitine was administered to tumor-bearing mice, investigating its effects on tumor and muscle tissues. Experiment (A): B16 melanoma cells were implanted subcutaneously into the right side of the abdomen of 8- to 9 -week-old C57BL/6J mice. The mice were divided into two groups: a FDS group that received oral administration of FDS (n=10), and a control group that received oral administration of glucose (n=10). The moribund condition was used as the endpoint, and median survival time was determined. Experiment (B): On day 21 after tumor implantation, tumors, soleus muscle, gastrocnemius muscle, and suprahyoid muscles were collected. Tumor and muscle weight and other aspects were evaluated in each group: FDS group (n=15) and control group (n=15). The median survival time was comparable (21 d in the FDS group vs. 18 d in the control group, p=0.30). However, cumulative food intake was significantly higher in the FDS group than the control group (p=0.011). Metastasis of melanoma to the lung was observed in the control group but not in the FDS group (p=0.043). The weight of the suprahyoid muscles was significantly higher in the FDS group than in the control group (p=0.0045). The weight of the tumor was significantly lower in the FDS group than in the control group (p=0.013). The results possibly suggest oral administration of FDS in tumor-bearing mice enhances the maintenance of suprahyoid muscles, resulting in an extended feeding period and suppression of tumor growth and metastasis.
  • Abbas Orand, Hiroyuki Miyasaka, Kotaro Takeda, Genichi Tanino, Takeshi Chihara, Hidehiko Beppu, Shigeru Sonoda
    BIOCYBERNETICS AND BIOMEDICAL ENGINEERING 37(1) 114-123 2017年  査読有り
    The consistency of torque measurements during repetitive moving arm movements and also during passive wrist movements at two angular velocities of slow (similar to 6 degrees/s) and moderate (similar to 120 degrees/s) was investigated. The designed and developed device was applied to 3 cases, to a spring, to 8 able-bodied subjects and to 2 hemiplegic patients. While the mean of the intra-class correlation coefficient of subjects were 0.65 and 0.75 for slow and moderate angular velocities, those of the hemiplegic patients and the spring respectively ranged between excellent values of 0.93-1 and 0.91-1. The Pearson's product-moment correlation coefficients of the 3 cases for the 2 slow and moderate angular velocities ranged between 0.80 and 1. We could verify that the device can be used in our future researches and it can (1) reliably rotate a moving arm horizontally with angular velocities between 3 and 350 degrees/s constantly in a range of motion between -60 and 60 degrees and (2) simultaneously capture the data of angular displacement, torque, and two electromyogram activities. For the standardization of our future studies with the device, we could verify the stability of the last two repeated passive wrist movements in case of patients. The results of the study with the able-bodied subjects are also important as a reference for our studies with the hemiplegic. (C) 2017 The Authors. Published by Elsevier B.V. on behalf of Nalecz Institute of Biocybemetics and Biomedical Engineering of the Polish Academy of Sciences. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
  • Kenmei Mizutani, Shigeru Sonoda, Hideaki Wakita, Hideto Okazaki, Yoshimitsu Katoh, Takeshi Chihara, Kan Shimpo
    NEUROREPORT 27(9) 659-664 2016年6月  査読有り
    Although it has been suggested that the combination of exercise and bryostatin-1 administration may induce greater functional recovery than exercise alone, the detailed molecular mechanisms are not well known. Here, we examined the relationship between this combination treatment and monoamine dynamics in the cerebral cortex peri-infarction area to promote our understanding of these molecular mechanisms. Experimental cerebral cortex infarctions were produced by photothrombosis in rats. Voluntary exercise was initiated 2 days after surgery. Motor performance was then measured using the rotarod test. Monoamine concentrations in the perilesional cortex were analyzed by high-performance liquid chromatography. In behavioral evaluations, performance in the rotarod test was significantly increased by exercise. Moreover, performance in the rotarod test after the combination of exercise and bryostatin-1 administration was significantly greater than that after exercise alone. In the analysis of monoamines, serotonin (5-HT) concentrations were significantly higher in the groups treated with exercise and bryostatin-1. In addition, 5-HT turnover was significantly lower in the groups treated with exercise and bryostatin-1. Furthermore, the mean latency in the rotarod test showed a significant positive correlation with 5-HT levels. In immunohistochemical analysis, 5-HT immunoreactivity in the dorsal raphe nucleus was shown to be higher in the groups treated with exercise. In the present study, we detected changes in the levels of monoamines associated with the combined treatment of exercise and bryostatin-1 administration in the perilesional cortex. It has been suggested that this combination of therapies may affect 5-HT turnover and serve to increase local 5-HT concentrations in the perilesional area. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.
  • 新保 寛, 千原 猛, 金児孝晃, 別府秀彦
    薬理と臨床 23(3) 97-104 2016年  

MISC

 59

書籍等出版物

 16

講演・口頭発表等

 38

共同研究・競争的資金等の研究課題

 8

教育内容・方法の工夫(授業評価等を含む)

 10
  • 件名
    生化学講義の分担
    開始年月日
    2012/06/05
    終了年月日
    2012/06/26
    概要
    藤田保健衛生大学医療科学部医療経営情報学科1年生の「生化学」の講義を分担
  • 件名
    生理学実習の指導分担
    開始年月日
    2012/09/26
    終了年月日
    2012/11/02
    概要
    藤田保健衛生大学医療科学部臨床検査学科2年生の「生理学実習」の指導分担
  • 件名
    生化学講義の分担
    開始年月日
    2013/06/12
    終了年月日
    2013/06/26
    概要
    藤田保健衛生大学医療科学部医療経営情報学科1年生の「生化学」の講義を分担
  • 件名
    生理学実習の指導分担
    開始年月日
    2013/09/25
    終了年月日
    2013/11/01
    概要
    藤田保健衛生大学医療科学部臨床検査学科2年生の「生理学実習」の指導分担
  • 件名
    形態機能学Ⅲ講義の分担
    開始年月日
    2013/11/25
    終了年月日
    2013/12/09
    概要
    三重県立看護大学看護学部看護学科1年生の「形態機能学Ⅲ」の講義を分担
  • 件名
    生化学講義の分担
    開始年月日
    2016/06/01
    終了年月日
    2016/07/06
    概要
    藤田保健衛生大学医療科学部医療経営情報学科1年生の「生化学」の講義の分担
  • 件名
    生化学講義の分担
    開始年月日
    2014/04/30
    終了年月日
    2014/05/28
    概要
    藤田保健衛生大学医療科学部医療経営情報学科1年生の「生化学」の講義の分担
  • 件名
    生理学実習の指導分担
    開始年月日
    2014/09/24
    終了年月日
    2014/10/30
    概要
    藤田保健衛生大学医療科学部臨床検査学科2年生に「生理学実習」の指導分担
  • 件名
    生化学講義の分担
    開始年月日
    2015/04/15
    終了年月日
    2015/06/24
    概要
    藤田保健衛生大学医療科学部医療経営情報学科1年生の「生化学」の講義の分担
  • 件名
    生理学実習の分担
    開始年月日
    2015/09/24
    終了年月日
    2015/10/30
    概要
    藤田保健衛生大学医療科学部臨床検査学科2年生の「生理学実習」の指導分担

作成した教科書、教材、参考書

 2
  • 件名
    医学領域における臨床検査学入門(藤田保健衛生大学「臨床検査学入門」編集委員会 編著、KTC中央出版)第2版
    終了年月日
    2009/07/24
    概要
    臨床検査技師国家試験対策参考書、臨床検査総論の項を分担執筆
  • 件名
    医学領域における臨床検査学入門(藤田保健衛生大学「臨床検査学入門」編集委員会 編著、KTC中央出版)第3版
    終了年月日
    2013/07/03
    概要
    臨床検査技師国家試験対策参考書、臨床検査総論の項を分担執筆

その他教育活動上特記すべき事項

 2
  • 件名
    平成24年度愛知県高等学校文化連盟自然科学部講習会講師
    終了年月日
    2012/11/10
    概要
    愛知県高等学校自然科学部の教師および学生に、「動物の取り扱い」についての講義および動物実験手技の実習指導
  • 件名
    平成25年度愛知県高等学校文化連盟自然科学部講習会講師
    終了年月日
    2013/10/26
    概要
    愛知県高等学校自然科学部の教師および学生に、「動物の取り扱い」についての講義および動物実験手技の実習指導