kaneko chiyuki

Helicobacter pylori (H. pylori) is a very important pathogenic bacteria associated with many upper gastrointestinal diseases including chronic active gastritis, chronic inactive gastritis, gastric and duodenal peptic ulcer disease, gastric MALT lymphoma, and gastric adenocarcinoma. There are no distinct endoscopic patterns of chronic H. pylori gastritis. The diagnosis of H. pylori gastritis is made by pathologic examination of gastric mucosal biopsies or by the detection of urease in mucosal specimens using the CLO test or urea breath test.  H. pylori infection has been diagnosed based on the histological laboratory procedure and indirectly from a background gastric-mucous-membrane view. Alcian Yellow Touidine Blue staining is available and useful as one of the diagnostic methods.

Background: We here in report a case of uterine cervical cancer with an extremely rare histological variant of clear cell adenocarcinoma.<BR>Case: A 77-year-old female was admitted our hospital because of irregular genital bleeding and presented with a polypoid tumor in the uterine cervix. The touch-smear cytology indicated that neoplastic cells with large and prominent nucleoli showed not only cohesive clusters with mirror ball or rod-like appearances but also small clusters with floweret-like features. Furthermore, amorphous substances appearing pale green were observed at the center of the cluster, indicating that this neoplasm was malignant and was thought to be a clear cell adenocarcinoma. A modified radical hysterectomy was carried out and the final histological diagnosis of this case was clear cell adenocarcinoma in the uterine cervix.<BR>Conclusion: Cytological findings of clear cell adenocarcinomas with a predominantly papillary growth pattern are characterized by 1) amorphous substances (substances in the basement membrane) pale green in color at the center of the cluster and 2) a mirror ball or a rod-like cluster and a floweretlike small cluster. Therefore, in these cases where the cytological characteristics of clear cell adenocarcinoma are observed, it is possible to predict the histological diagnosis of clear cell adenocarcinoma in the uterine cervix.