研究者業績
基本情報
経歴
1-
2023年5月 - 現在
論文
70-
AJNR. American journal of neuroradiology 2024年1月30日BACKGROUND AND PURPOSE: Tumor embolization through the meningohypophyseal trunk and inferolateral trunk is known to be effective in skull-based tumors; however, microcatheter cannulation into these arteries is difficult, and the number of cases that can be safely embolized is limited. In this study, we present a novel embolization procedure for meningohypophyseal trunk and inferolateral trunk using the distal balloon protection technique and detail its clinical efficacy and complication risks. We developed this procedure to allow safe embolization in patients who cannot be adequately cannulated with microcatheters into these arteries. MATERIALS AND METHODS: Patients who underwent meningohypophyseal trunk or inferolateral trunk embolization using the distal balloon protection technique for skull-based tumors at our institution between 2010 and 2023 were included. In this procedure, the ICA was temporarily occluded with a balloon at the ophthalmic artery bifurcation, the microcatheter was guided to the meningohypophyseal trunk or inferolateral trunk vicinity, and embolic particles were injected into the arteries. The balloon was deflated after the embolic particles, that had refluxed into the ICA, were aspirated. RESULTS: A total of 25 meningohypophyseal trunks and inferolateral trunks were embolized during 21 surgeries. Of these 25 arteries, only nine (36.0%) were successfully cannulated with microcatheters. Nevertheless, effective embolization was achieved in all cases. Permanent complications occurred in only one case (4.8%), in which the central retinal artery was occluded during inferolateral trunk embolization, resulting in a visual field defect. No permanent complications resulting from the embolic cerebral infarction were observed. Of 16 cases that underwent MRI within a week after embolization, however, 11 (68.8%) demonstrated embolic cerebral infarctions. CONCLUSIONS: In patients with skull-based tumors with meningohypophyseal trunk or inferolateal trunk feeders that cannot be catheterized directly, embolization using the distal balloon protection technique for tumor supply can be considered as a salvage technique. ABBREVIATIONS: MHT = meningohypophyseal trunk; ILT = inferolateral trunk; GC = guide catheter; AC = aspiration catheter; FR = flow reverse.
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Acta neurochirurgica 166(1) 44-44 2024年1月29日BACKGROUND: In intraventricular surgery using a flexible endoscope, the lesion is usually aspirated via the working channel. However, the surgical view during aspiration is extremely poor because the objective lens is located adjacent to the working channel. METHOD: To address this issue, we developed a novel surgical procedure using an angiographic catheter. In this procedure, the catheter is inserted into the working channel, and the lesion is aspirated through the catheter. Besides, continuous intraventricular irrigation is performed via the gap between the catheter and the working channel. CONCLUSION: This procedure maintains a clear view during surgery and reduces complications.
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Japanese Journal of Stroke 2024年
MISC
290-
JNET: Journal of Neuroendovascular Therapy 9(6) S358-S358 2015年11月
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JNET: Journal of Neuroendovascular Therapy 9(6) S366-S366 2015年11月
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JNET: Journal of Neuroendovascular Therapy 9(6) S425-S425 2015年11月
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JNET: Journal of Neuroendovascular Therapy 9(6) S430-S430 2015年11月
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新医療 42(5) 35-39 2015年5月レンチキュラ方式を用いた3Dディスプレイにより専用眼鏡なしで高品質3D画像を描出することが可能となり、医学教育をはじめ多方面の医療分野への応用が期待される。本システムの脳腫瘍手術教育への応用の概要と今後の展望を紹介する。(著者抄録)
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JNET: Journal of Neuroendovascular Therapy 8(6) 222-222 2014年12月
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JNET: Journal of Neuroendovascular Therapy 8(6) 231-231 2014年12月
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JNET: Journal of Neuroendovascular Therapy 8(6) 299-299 2014年12月
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JNET: Journal of Neuroendovascular Therapy 8(6) 353-353 2014年12月
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JNET: Journal of Neuroendovascular Therapy 8(6) 405-405 2014年12月
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Geriatrics & gerontology international 14(4) 858-63 2014年10月 査読有りAIM: Therapeutic intervention to repair unruptured aneurysms (UA) has not been strongly recommended for the elderly, because of their limited life expectancy and low annual bleeding rate. However, physically and mentally healthy older adults with seemingly high risk of aneurysmal bleeding might benefit from having their UA repaired. METHODS: A single-center retrospective study was carried out. Among 1078 patients admitted for treatment of UA between 2007 and 2011, the number of patients aged ≥ 75 years who underwent surgical and endovascular repair of UA was 30 and 31, respectively. The operative and mid-term outcomes were compared between the two groups. For evaluation of the operative outcomes, frequency and types of adverse events that occurred within 30 days of intervention (operative morbidity) were described. For assessment of the mid-term outcomes, activities of daily living (ADL) at 24 months after intervention were evaluated with the modified Rankin Scale (mRS). RESULTS: The operative morbidity rate was 6.7% in the open surgery group and 6.5% in the endovascular surgery group, and they did not differ significantly. The frequency of patients with mRS 0-2 at 24 months after intervention was 85.7% in the open surgery group and 82.8% in the endovascular surgery group, and they did not differ significantly. The adverse event rate of patients with middle cerebral artery aneurysms treated endovascularly was high (80%). CONCLUSIONS: The outcomes of individuals aged ≥ 75 years who underwent repair of UA were generally favorable in either treatment group, with more than 80% living an independent life at 24 months after intervention.
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脳神経外科ジャーナル 23(9) 710-715 2014年9月脳動脈瘤の発症、成長、破裂は、血流によって引き起こされる力学的刺激が重要な役割を果たすことが指摘されている。力学的刺激には、圧刺激、進展刺激、ずり刺激の3つが挙げられ、その中でも特に壁面せん断応力は内皮細胞に影響を与え、脳動脈瘤を考える際に重要な力学的刺激といわれている。本研究は、これらの力学的刺激を定量的に捉えるために、医用画像や計測データから得られる患者の血管形状に対して数値解析を適用し、患者個別の血行動態の情報を得るとともに予防や診断を生かすことのできる支援システムの構築を目指している。本論文では、血液の流体力学(血行力学)や患者個別のシミュレーションの概説とともに、より生体に近い現象を再現するための末梢血管や血管壁の弾性の影響を考慮したマルチスケール血流-血管壁の数値解析について紹介する。(著者抄録)
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映像情報medical 46(10) 72-77 2014年9月
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CLINICAL NEURORADIOLOGY 24(2) 145-150 2014年6月 査読有りMany epidemiological studies on unruptured cerebral aneurysms have reported that the larger the aneurysm, the higher the risk of rupture. However, many ruptured aneurysms are not large. Electrocardiography (ECG)-gated 3D-computed tomography angiography (4D-CTA) was used to detect pulsation in unruptured cerebral aneurysms. The differences in the clinical course of patients in whom pulsation was or was not detected were then evaluated. Forty-two patients with 62 unruptured cystiform cerebral aneurysms who underwent 4D-CTA and follow-up 3D-CTA more than 120 days later were studied. The tube voltage, tube current, and rotation speed were 120 kV, 270 mA, and 0.35 s/rot., respectively. ECG-gated reconstruction was performed, with the cardiac cycle divided into 20 phases. Patients with heart rates higher than 80 bpm were excluded, so 37 patients with 56 aneurysms were analyzed. Pulsation was detected in 20 of the 56 unruptured aneurysms. Of these 20 aneurysms, 6 showed a change in shape at the time of follow-up. Of the 36 aneurysms in which pulsation was not detected, 2 showed a change in shape at follow-up. There was no significant difference in the follow-up interval between the two groups. The aneurysms in which pulsation was detected were significantly more likely to show a change in shape (P = 0.04), with a higher odds ratio of 7.286. Unruptured aneurysms in which pulsation was detected by 4D-CTA were more likely to show a change in shape at follow-up, suggesting that 4D-CTA may be useful for identifying aneurysms with a higher risk of rupture.
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脳血管攣縮 29 62-65 2014年2月発症72時間以内に入院しclippingまたはcoilingによる再出血予防を行ったクモ膜下出血患者224例を対象に、脳血管攣縮および脳梗塞発症について検討した。WFNS gradeはIが25%、IIが45%、IIIが8%、IVが22%であった。症候性脳血管攣縮は27例、CTで新たな脳梗塞を認めたのは23例で、これら高度攣縮(HVS)の発生率は14.3%であった。HVS発生率はWFNS grade別にみるとIが3.6%、II+IIIが16.0%、IVが22.5%と増加し、術式ではクリッピング術14.0%、コイル塞栓術15.6%と有意差はなかった。症候性脳血管攣縮の退院時転帰は約半数がmRS 0〜2であり、血管内治療を行った群での分布に近く、血管内治療の効果を反映していると考えられた。保存的治療群は血管内治療を行うタイミングを逸した者が多く含まれており、転帰不良の傾向であった。攣縮に対する血管内治療後の症状は、消失27.8%、改善38.9%、不変33.3%であった。
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脳神経外科速報 24(1) 60-64 2014年1月近年画質が向上し、脳動脈~脳動脈瘤の拍動を再現し得る心電同期再構成3D-CTA(4D-CTA)のデータを用いて、脳動脈瘤の弾性に考慮した解析を行った。得られたデータとそれぞれの時相での血流速度を挿入し、WSSやpressureを解析した。この擬似弾性モデルと通常の剛性モデルでのCFD解析結果を比較したところ、pressureにおいて、ブレブ部分で疑似拍動モデルと剛性モデルの間で若干の違いを認めた。さらなる検証が必要であるが、今後、4D-CTAデータがCFDによる脳動脈瘤解析に必要となる可能性がある。(著者抄録)
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脳神経外科ジャーナル 23(1) 29-36 2014年深部髄膜腫は、アプローチの選択に加え、深部静脈、脳神経、脳幹等からの剥離操作が機能予後に直結する。連続293例の髄膜腫手術から深部髄膜腫を抽出しその頻度、局在、脳神経機能温存率、至適アプローチ等に関し後ろ向きに検討した。視機能障害を有する傍鞍部病変36例における視機能改善率は89%、半球間裂アプローチ30例における嗅覚温存率は93%、内耳道内進展を有する聴覚障害9例の改善率は44%であった。重要構造からの剥離操作のいかんが術後の機能予後を大きく左右するため、剥離部位を直視下にできるアプローチの選択とそのための術前の詳細な画像検査、内頸動脈系を含む術前塞栓術、多段階手術、腫瘍活性ならびに境界部の病理所見の理解、Simpson grade IV手術など、考慮すべき点は多い。(著者抄録)
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JOURNAL OF STROKE & CEREBROVASCULAR DISEASES 22(8) 1350-1354 2013年11月Background: Malignant hemispheric infarction is a life-threatening condition with a high mortality rate. Decompressive hemicraniectomy (DHC) is frequently a life-saving procedure that has shown the highest grade of evidence for patients 18 to 60 years of age. However, the efficacy of DHC in patients >60 years of age has rarely been investigated. Methods: A retrospective study was conducted in a single academic institution. Surrogates of patients with clinical signs of impending brain herniation despite standard medical therapy were offered the option of DHC regardless of age or the side of the lesion. The clinical data from 18 patients >60 years of age who underwent DHC for malignant hemispheric infarction in our institution were analyzed. Patients were classified into the following 2 groups: 61-70 and >70 years of age, and their demographics and surgical outcomes were compared. The variables compared included the male: female ratio, side of the lesion, type of stroke, site of vascular occlusion, use of thrombolytic therapy, National Institutes of Health Stroke Scale score, stroke onset-to-DHC interval, duration of hospital stay, infectious complications, and 90-day mortality rate. Results: There were no significant intergroup differences in any of the demographic variables evaluated. However, the 30-day mortality rate was significantly higher in the group that was >70 years of age (0% v 60%; P = .01) than in the group that was 61 to 70 years of age. Conclusions: We suggest that the efficacy of DHC in malignant hemispheric stroke patients between 61 and 70 years of age be further investigated in future randomized trials. By contrast, it appears unlikely that patients >70 years of age would benefit from DHC.
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脳卒中の外科 41(4) 247-252 2013年未破裂または破裂慢性期の広頸動脈瘤に対し、Enterprise stentとcoilを用いて瘤内塞栓術を行った35例36個(男8例、女27例)の成績を報告した。塞栓結果は、complete occlusion 13個、neck remnant 9個、body filling 14個であった。術中破裂はなく、症候性血栓・塞栓性合併症を6例認め、うち4例は一過性であった。症状持続の2例はいずれも脳底動脈先端部動脈瘤で、脳幹に小梗塞を合併したが比較的軽症であった。術後7日以内のMRI拡散強調像で合併症所見を評価したところ、虚血病巣なしが2例(grade A)、小lesion 5個以下が6例(grade B)、小lesion 6個以上が16例(grade C)、大lesionを含むものが8例(grade D)であった。grade D発生率は、動脈瘤サイズで有意差はなく、術前クロピドグレル内服期間では3日未満群(50%)が4日以上群(17%)に、術後抗凝固薬ではアルガトロバン点滴群(38%)がヘパリン点滴群(16%)に比較して高い傾向であった。
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JNET: Journal of Neuroendovascular Therapy 6(5) 181-181 2012年11月
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JNET: Journal of Neuroendovascular Therapy 6(5) 214-214 2012年11月
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JNET: Journal of Neuroendovascular Therapy 6(5) 218-218 2012年11月
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JNET: Journal of Neuroendovascular Therapy 6(5) 223-223 2012年11月
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Journal of Neuroendovascular Therapy 6(5) 425-425 2012年11月
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映像情報Medical 44(8) 96-101 2012年7月
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Annual Review神経 2012 59-67 2012年1月2007年10月から臨床で稼働を開始した320列Area Detector CT(Aquilion ONE:東芝メディカルシステムズ)の最大の特徴は,造影剤をボーラス静注しながら1分程度の連続スキャンを行うことによって,脳神経領域の診断に必要な単純CT,全脳CT灌流画像,全脳Dynamic CTAを一度に得られることである.これまでの研究結果によりその有用性と課題が明らかにされつつあり,320列Area Detector CTは脳神経領域における診断ツールとして重要な役割を担っていると思われる.一方,広範囲の連続撮影によって被曝線量の増加が懸念されるが,現在ではIterative Re-construction(Adaptive Iterative Dose Re-duction 3D;東芝メディカルシステムズ)を用いた被曝線量低減への取り組みもなされている.本稿では,320列Area Detector CTを用いたCT灌流画像,Dynamic CTAの臨床応用について,最近の文献や実際の臨床画像を呈示しながら概説する.(著者抄録)
書籍等出版物
4講演・口頭発表等
34-
第43回日本脳卒中の外科学会学術集会(STROKE2014) 2014年3月13日
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Geriatr Gerontol Int 2013年11月8日
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Congress of Neurological Surgeons 2013 / 63rd Annual Meeting (e-poster) 2013年10月19日
共同研究・競争的資金等の研究課題
2-
日本学術振興会 科学研究費助成事業 2022年4月 - 2026年3月
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日本学術振興会 科学研究費助成事業 2015年4月 - 2017年3月