基本情報
- 所属
- 藤田医科大学 医学部 一般教育 教授
- 学位
- 博士(医学)(1996年1月 名古屋大学)
- J-GLOBAL ID
- 200901092810093374
- researchmap会員ID
- 1000289362
- 外部リンク
1. Education
06/1995 - 06/1997
Louisiana State University
Department of Molecular Biochemistry
Postdoctoral Fellow
New Orleans, USA
04/1991 - 03/1993
Nagoya University School of Medicine
Department of Circulation
Nagoya, Japan
Ph.D. 01/23/1996
04/1987 - 03/1991
St. Luke’s International Hospital
Internal Medicine Residency
Tokyo, Japan
04/1982 – 03/1987
Yamagata University School of Medicine
Yamagata, Japan
M.D. 06/16/1987
2. Professional Experience
04/2020 - Present
Fujita Health University School of Medicine
Professor of Cardiology
07/1999 - 03/2020
Fujita Health University School of Medicine
Professor of Cardiology
Director of Cardiac Arrhythmia Program
07/1997 - 06/1999
Nagoya First Red Cross Hospital
Department of Emergency Medicine
Nagoya, Japan
研究キーワード
4研究分野
1学歴
2-
- 1987年
委員歴
3論文
205-
International heart journal 65(5) 841-848 2024年9月30日Acute heart failure is an important cause of unplanned hospitalizations and poses a significant burden through increased mortality and frequent hospitalizations. Heart failure with preserved ejection fraction (HFpEF) presents as a diverse condition characterized by complex cardiovascular and non-cardiovascular pathology. This study aimed to identify distinct clinical phenotypes in acute decompensated HFpEF (ADHF) using cluster analysis and assess their prognostic significance. We applied a latent class analysis to 1,281 ADHF patients admitted to a single cardiac intensive care unit between 2008 and 2022 with a left ventricular ejection fraction ≥ 50%. We used 83 factors obtained at hospitalization. We evaluated the association between phenogroups and clinical outcomes using either Cox regression model or Fine-Gray competing risk model. We identified 4 phenogroups: Phenogroup 1 (n = 133, 10%) included younger patients with metabolic disorders and a low level of B-type natriuretic peptide (BNP); Phenogroup 2 (n = 346, 27%) had systemic congestion and high BNP levels; Phenogroup 3 (n = 514, 40%) had multiple comorbidities and vascular disorders; Phenogroup 4 (n = 288, 22%) included older patients with bradyarrhythmia and atrial fibrillation. After adjusting for age, sex, and Get with the Guidelines-Heart Failure risk score, Phenogroup 2 had the highest risk of all-cause death and cardiac death. In conclusion, we identified 4 clinically relevant phenogroups of ADHF patients, each associated with different adverse outcomes. Phenotyping may provide a better understanding of the underlying mechanisms involved in the heterogeneity of ADHF and decompensation. Furthermore, it may facilitate the search for phenotype-specific therapeutic strategies.
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Circulation journal : official journal of the Japanese Circulation Society 88(9) 1509-1595 2024年8月23日
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Heart Rhythm O2 5(8) 520-528 2024年8月
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Journal of arrhythmia 40(4) 655-752 2024年8月
MISC
83書籍等出版物
3-
Chapman and Hall 1997年 (ISBN: 0412146118)
主要な所属学協会
9共同研究・競争的資金等の研究課題
10-
日本学術振興会 科学研究費助成事業 2021年4月 - 2024年3月
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日本学術振興会 科学研究費助成事業 2020年4月 - 2023年3月
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日本学術振興会 科学研究費助成事業 2020年4月 - 2023年3月
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日本学術振興会 科学研究費助成事業 基盤研究(C) 2017年4月 - 2020年3月
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日本学術振興会 科学研究費助成事業 2016年4月 - 2019年3月
作成した教科書、教材、参考書
1-
件名―開始年月日2013/06/10概要児玉逸雄, 渡邉英一. 不整脈. 矢﨑義雄, 編. 内科学 第10版. 東京都: 朝倉書店; 2013.p.478-82.