Profile Information
- Affiliation
- Professor (Professor), Cardiology, Fujita Health University Bantane Hospital
- Degree
- MD, Ph.D(Jan, 1996, Nagoya University)
- J-GLOBAL ID
- 200901092810093374
- researchmap Member ID
- 1000289362
- External link
1. Education
06/1995 - 06/1997
Louisiana State University
Department of Molecular Biochemistry
Postdoctoral Fellow
New Orleans, USA
04/1991 - 03/1993
Nagoya University School of Medicine
Department of Circulation
Nagoya, Japan
Ph.D. 01/23/1996
04/1987 - 03/1991
St. Luke’s International Hospital
Internal Medicine Residency
Tokyo, Japan
04/1982 – 03/1987
Yamagata University School of Medicine
Yamagata, Japan
M.D. 06/16/1987
2. Professional Experience
04/2020 - Present
Fujita Health University School of Medicine
Professor of Cardiology
07/1999 - 03/2020
Fujita Health University School of Medicine
Professor of Cardiology
Director of Cardiac Arrhythmia Program
07/1997 - 06/1999
Nagoya First Red Cross Hospital
Department of Emergency Medicine
Nagoya, Japan
Research Interests
4Research Areas
1Education
2Committee Memberships
3Papers
205-
International heart journal, 65(5) 841-848, Sep 30, 2024Acute heart failure is an important cause of unplanned hospitalizations and poses a significant burden through increased mortality and frequent hospitalizations. Heart failure with preserved ejection fraction (HFpEF) presents as a diverse condition characterized by complex cardiovascular and non-cardiovascular pathology. This study aimed to identify distinct clinical phenotypes in acute decompensated HFpEF (ADHF) using cluster analysis and assess their prognostic significance. We applied a latent class analysis to 1,281 ADHF patients admitted to a single cardiac intensive care unit between 2008 and 2022 with a left ventricular ejection fraction ≥ 50%. We used 83 factors obtained at hospitalization. We evaluated the association between phenogroups and clinical outcomes using either Cox regression model or Fine-Gray competing risk model. We identified 4 phenogroups: Phenogroup 1 (n = 133, 10%) included younger patients with metabolic disorders and a low level of B-type natriuretic peptide (BNP); Phenogroup 2 (n = 346, 27%) had systemic congestion and high BNP levels; Phenogroup 3 (n = 514, 40%) had multiple comorbidities and vascular disorders; Phenogroup 4 (n = 288, 22%) included older patients with bradyarrhythmia and atrial fibrillation. After adjusting for age, sex, and Get with the Guidelines-Heart Failure risk score, Phenogroup 2 had the highest risk of all-cause death and cardiac death. In conclusion, we identified 4 clinically relevant phenogroups of ADHF patients, each associated with different adverse outcomes. Phenotyping may provide a better understanding of the underlying mechanisms involved in the heterogeneity of ADHF and decompensation. Furthermore, it may facilitate the search for phenotype-specific therapeutic strategies.
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Circulation journal : official journal of the Japanese Circulation Society, 88(9) 1509-1595, Aug 23, 2024
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Heart Rhythm O2, 5(8) 520-528, Aug, 2024
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Journal of arrhythmia, 40(4) 655-752, Aug, 2024
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日本循環器学会学術集会抄録集, 88回 PJ031-5, Mar, 2024
Misc.
83-
日本循環器学会学術集会抄録集, 83回 OJ24-5, Mar, 2019
Books and Other Publications
3-
Chapman and Hall, 1997 (ISBN: 0412146118)
Major Professional Memberships
9Research Projects
10-
科学研究費助成事業, 日本学術振興会, Apr, 2021 - Mar, 2024
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科学研究費助成事業, 日本学術振興会, Apr, 2020 - Mar, 2023
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科学研究費助成事業, 日本学術振興会, Apr, 2020 - Mar, 2023
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Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020
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Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019
作成した教科書、教材、参考書
1-
件名(英語)―開始年月日(英語)2013/06/10概要(英語)児玉逸雄, 渡邉英一. 不整脈. 矢﨑義雄, 編. 内科学 第10版. 東京都: 朝倉書店; 2013.p.478-82.