Taku Nagai

(永井拓)

Profile Information

Affiliation: Professor, Division of Behavioral Neuropharmacology, International Center for Brain Science (ICBS), Fujita Health University
(Concurrent)Vice Director, International Center for Brain Science (ICBS)
(Concurrent)Professor, Department of Behavioral Neuropharmacology, Graduate School of Medicine
(Concurrent)Vice Director, Open Facility Center

Degree: M.S.(Meijo University)
Ph.D.(Nagoya University)

J-GLOBAL ID: 200901083965882198
researchmap Member ID: 5000081871

Research Interests

Research Areas

Life sciences / Psychiatry /

Research History

Jan, 2020 - Present

Professor, Fujita Health University
Jan, 2010 - Dec, 2019

Nagoya University Hospital Department of Hospital Pharmacy, Nagoya University
Apr, 2006 - Dec, 2009

Designated lecturer, Graduate School of Medicine, Nagoya University
Apr, 2004 - Mar, 2006

Research Associate, Laboratory of Neuropsychopharmacology, Division of Life Sciences, Graduate School of Natural Sciences and Technology, Kanazawa University, Kanazawa, Japan
Apr, 2003 - Mar, 2004

Clinical Pharmacist, Department of Hospital Pharmacy, Nagoya University School of Medicine, Nagoya, Japan

Committee Memberships

Sep, 2021 - Present

幹事, 脳の医学・生物学研究会
Mar, 2019 - Present

広報委員会委員, 日本神経精神薬理学会
Oct, 2016 - Present

委員, 日本神経精神薬理学会倫理委員会委員
Oct, 2016 - Present

委員, 日本神経精神薬理学会先端研究推進基盤構築タスクフォース委員
Apr, 2013 - Dec, 2019

幹事, 地域連携薬剤管理指導研究会

Awards

Sep, 2017

日本神経化学会優秀賞, 日本神経化学会
Oct, 2015

第5回柳田知司賞, 日本依存神経精神科学会
Jun, 2014

Excellence in Reviewing of Neurochemistry International, Neurochemistry International
Jul, 2013

日本薬学会東海支部学術奨励賞, 日本薬学会東海支部
Oct, 2012

第1回日本神経精神薬理学会学術奨励賞, 日本神経精神薬理学会

Papers

195

Phosphoproteomics identifies Rho-Kinase-associated phospho-signaling and autophagy-associated alterations in the medial prefrontal cortex of a schizophrenia-related mouse model

Wenjun Zhu, Rinako Tanaka, Tetsuo Matsuzaki, Tsuyoshi Nakai, Taku Nagai, Toshitaka Nabeshima, Kozo Kaibuchi, Norio Ozaki, Hiroaki Ikesue, Hiroyuki Mizoguchi, Kiyofumi Yamada

Pharmacological Research, 108201-108201, Apr, 2026
Antipsychotic-like effects of the selective Rho-kinase 2 inhibitor KD025 in genetic and pharmacological mouse models of schizophrenia

Rinako Tanaka, Jingzhu Liao, Yue Liu, Wenjun Zhu, Kisa Fukuzawa, Masamichi Kondo, Masahito Sawahata, Daisuke Mori, Akihiro Mouri, Hisayoshi Kubota, Daiki Tachibana, Yohei Kobayashi, Tetsuo Matsuzaki, Taku Nagai, Toshitaka Nabeshima, Kozo Kaibuchi, Norio Ozaki, Hiroyuki Mizoguchi, Kiyofumi Yamada

Molecular Psychiatry, Apr 1, 2026
Acute systemic immune challenge induces cognitive impairments and anhedonia through interferon-induced transmembrane protein 3 in adult male mice

Wenjun Zhu, Akira Sobue, Rinako Tanaka, Kazuhiro Hada, Daisuke Ibi, Yue Liu, Tetsuo Matsuzaki, Taku Nagai, Toshitaka Nabeshima, Kozo Kaibuchi, Norio Ozaki, Hiroyuki Mizoguchi, Hiroaki Ikesue, Kiyofumi Yamada

Behavioural Brain Research, 496 115832-115832, Jan, 2026
Cortical excitatory and inhibitory neuron deficits may underlie the cognitive and social impairments in a mouse model of schizophrenia with exonic Reln deletion

Youyun Zhu, Kanako Kitagawa, Daisuke Mori, Tetsuo Matsuzaki, Taku Nagai, Toshitaka Nabeshima, Sayaka Takemoto-Kimura, Hiroaki Ikesue, Norio Ozaki, Hiroyuki Mizoguchi, Kiyofumi Yamada

European Journal of Pharmacology, Jan, 2026
Twinfilin-1 phosphorylation in reelin signaling regulates actin dynamics and spine development

Geyao Dong, Daisuke Mori, Tetsuo Matsuzaki, Rinako Tanaka, Norimichi Itoh, Takaaki Matsui, Ayato Sato, Yuko Arioka, Hiroki Okumura, Ryota Fukaya, Hiroshi Kuba, Taku Nagai, Toshitaka Nabeshima, Hiroaki Ikesue, Takao Kohno, Mitsuharu Hattori, Kozo Kaibuchi, Norio Ozaki, Hiroyuki Mizoguchi, Kiyofumi Yamada

Pharmacological Research, 221 107986-107986, Nov, 2025

Misc.

248

GABA(B) receptor agonist baclofen improves methamphetamine-induced cognitive deficit in mice

Sawako Arai, Kazuhiro Takuma, Hiroyuki Mizoguchi, Daisuke Ibi, Taku Nagai, Hiroyuki Kamei, Hyoung-Chun Kim, Kiyofumi Yamada

EUROPEAN JOURNAL OF PHARMACOLOGY, 602(1) 101-104, Jan, 2009 Peer-reviewed
Involvement of Pallidotegmental Neurons in Methamphetamine- and MK-801-Induced Impairment of Prepulse Inhibition of the Acoustic Startle Reflex in Mice: Reversal by GABA(B) Receptor Agonist Baclofen

Sawako Arai, Kazuhiro Takuma, Hiroyuki Mizoguchi, Daisuke Ibi, Taku Nagai, Kenji Takahashi, Hiroyuki Kamei, Toshitaka Nabeshima, Kiyofumi Yamada

NEUROPSYCHOPHARMACOLOGY, 33(13) 3164-3175, Dec, 2008 Peer-reviewed
The extensive nitration of neurofilament light chain in the hippocampus is associated with the cognitive impairment induced by amyloid beta in mice

Tursun Alkam, Atsumi Nitta, Hiroyuki Mizoguchi, Akio Itoh, Rina Murai, Taku Nagai, Kiyofumi Yamada, Toshitaka Nabeshima

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 327(1) 137-147, Oct, 2008 Peer-reviewed
Social isolation rearing-induced impairment of the hippocampal neurogenesis is associated with deficits in spatial memory and emotion-related behaviors in juvenile mice

Daisuke Ibi, Kazuhiro Takuma, Hiroyuki Koike, Hiroyuki Mizoguchi, Katsuki Tsuritani, Yusuke Kuwahara, Hiroyuki Kamei, Taku Nagai, Yukio Yoneda, Toshitaka Nabeshima, Kiyofumi Yamada

JOURNAL OF NEUROCHEMISTRY, 105(3) 921-932, May, 2008 Peer-reviewed
Role of tissue plasminogen activator in the sensitization of methamphetamine-induced dopamine release in the nucleus accumbens

Ayumi Fukakusa, Taku Nagai, Hiroyuki Mizoguchi, Noboru Otsuka, Haruhide Kimura, Hiroyuki Kamei, Hyoung-Chun Kim, Toshitaka Nabeshima, Kazuhiro Takuma, Kiyofumi Yamada

JOURNAL OF NEUROCHEMISTRY, 105(2) 436-444, Apr, 2008 Peer-reviewed
Schizophrenic animal models and evaluation of antipsychotics

KOSEKI Takenao, MOURI Akihiro, MURAI Rina, NAGAI Taku, NODA Yukihiro, NABESHIMA Toshitaka

19(1) 31-40, Mar 25, 2008
Effects of GABA receptor agonists on cognitive impairment in animal models of schizophrenia

Sawako Arai, Kazuhiro Takuma, Hiroyuki Mizoguchi, Taku Nagai, Hiroyuki Kamei, Kiyofumi Yamada

JOURNAL OF PHARMACOLOGICAL SCIENCES, 106 231P-231P, 2008
Effect of aripiprazole on phencyclidine-induced impairment of recognition memory in mice

Taku Nagai, Rina Murai, Kanae Matsui, Hiroyuki Kamei, Yukihiro Noda, Hiroshi Furukawa, Toshitaka Nabeshima

JOURNAL OF PHARMACOLOGICAL SCIENCES, 106 233P-233P, 2008
Histone modification in methamphetamine-associated contextual memory

Hiroyuki Mizoguchi, Kazuhiro Takuma, Daisuke Ibi, Eiichi Someya, Taku Nagai, Yan Yijan, Yasuhiko Kanou, Toshitaka Nabeshima, Makoto Sawada, Jun Sato, Kiyofumi Yamada

JOURNAL OF PHARMACOLOGICAL SCIENCES, 106 138P-138P, 2008
Involvement of cholinergic system relate the chronic stress-induced memory impairment in ovariectomized mice

Yoko Funatsu, Kazuhiro Takuma, Yukiko Himeno, Emiko Fukuzaki, Yuko Kitahara, Yuki Hoshina, Hiroyuki Kamei, Hiroyuki Mizoguchi, Taku Nagai', Koji Koike, Masaki Inoue, Kiyofumi Yamada

JOURNAL OF PHARMACOLOGICAL SCIENCES, 106 181P-181P, 2008
A novel molecule "shati" is involved in methamphetamine-induced hyperlocomotion, sensitization, and conditioned place preference

Minae Niwa, Atsumi Nitta, Hiroyuki Mizoguchi, Yasutomo Itoh, Yukihiro Noda, Taku Nagai, Toshitaka Nabeshima

JOURNAL OF PHARMACOLOGICAL SCIENCES, 106 55P-55P, 2008
Perinatal immune activation impairs emotional and cognitive functions in adolescent mice

Taku Nagai, Daisuke Ibi, Hiroyuki Mizoguchi, Toshitaka Nabeshima, Kiyofumi Yamada

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 128 69-69, 2008
Cognitive impairment in a mouse model of viral infection during perinatal stage

Daisuke Ibi, Taku Nagai, Hiroyuki Mizoguchi, Hiroyuki Koike, Kazuhiro Takumo, Kiyofumi Yamada

NEUROSCIENCE RESEARCH, 61 S129-S129, 2008
Induction of tissue plasminogen activator by repeated methamphetamine treatment is associated with the development of sensitization in methamphetamine-induced dopamine release

Ayumi Fukakusa, Taku Nagai, Hiroyuki Mizoguchi, Toshitaka Nabeshima, Kazuhiro Takuma, Kiyofumi Yamada

JOURNAL OF PHARMACOLOGICAL SCIENCES, 106 174P-174P, 2008
組織プラスミノーゲン活性化因子による依存性薬物の報酬効果の制御．

永井拓, 田熊一敞, 鍋島俊隆, 山田清文

日本神経精神薬理学雑誌, 28 1-6, 2008 Peer-reviewed
Basic and Translational Research on Proteinase-Activated Receptors: Regulation of nicotine reward by tPA-plasmin system via proteinase-activated receptor1

Nagai T, Nabeshima, T, Yamada K

J. Pharmacol. Sci., 108 408-414, 2008 Peer-reviewedInvited
学習・記憶とエピジェネティクス

永井拓, 鍋島俊隆

日本薬理学雑誌, 130(6) 521-521, Dec 1, 2007
Activation of post-synaptic dopamine D(1) receptors promotes the release of tissue plasminogen activator in the nucleus accumbens via PKA signaling

Mina Ito, Taku Nagai, Hiroyuki Mizoguchi, Kosuke Sato, Minoru Hayase, Noboru Otsuka, Ayumi Fukakusa, Nozomi Kumagai, Hyoung-Chun Kim, Toshitaka Nabeshima, Kazuhiro Takuma, Kiyofumi Yamada

JOURNAL OF NEUROCHEMISTRY, 103(6) 2589-2596, Dec, 2007 Peer-reviewed
メタンフェタミン誘発性ドパミン遊離の逆耐性形成における組織プラスミノーゲン活性化因子の役割

深草亜由美, 永井拓, 溝口博之, 鍋島俊隆, 田熊一敞, 山田清文

日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology, 27(5), Nov 25, 2007
Ginkgo biloba extract EGb 761 attenuates hippocampal neuronal loss and cognitive dysfunction resulting from chronic restraint stress in ovariectomized rats

K. Takuma, Y. Hoshina, S. Arai, Y. Himeno, A. Matsuo, Y. Funatsu, Y. Kitahara, D. Ibi, M. Hayase, H. Kamei, H. Mizoguchi, T. Nagai, K. Koike, M. Inoue, K. Yamada

NEUROSCIENCE, 149(2) 256-262, Oct, 2007 Peer-reviewed
The survey of the relationship between falling risk and psychotropic medications in inpatients of Nagoya University Hospital

Akira Yoshimi, Yukihiro Noda, Harumi Miyata, Mie Tsuji, Akio Ito, Koji Senzaki, Kazuhiro Ishikawa, Taku Nagai, Takahiro Soma, Yuichi Ueda, Toshitaka Nabeshima, Norio Ozaki

INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY, 22(5) A26-A26, Sep, 2007
Repeated methamphetamine treatment impairs spatial working memory in rats: reversal by clozapine but not haloperidol

Taku Nagai, Kazuhiro Takuma, Misato Dohniwa, Daisuke Ibi, Hiroyuki Mizoguchi, Hiroyuki Kamei, Toshitaka Nabeshima, Kiyofumi Yamada

PSYCHOPHARMACOLOGY, 194(1) 21-32, Sep, 2007 Peer-reviewed
Enduring vulnerability to reinstatement of methamphetamine-seeking behavior in glial cell line-derived neurotrophic factor mutant mice

Yijin Yan, Kiyofumi Yamada, Minae Niwa, Taku Nagai, Atsumi Nitta, Toshitaka Nabeshima

FASEB JOURNAL, 21(9) 1994-2004, Jul, 2007 Peer-reviewed
A novel molecule "Shati" is involved in methamphetamine-induced hyperlocomotion, sensitization, and conditioned place preference

Minae Niwa, Atsumi Nitta, Hiroyuki Mizoguchi, Yasutomo Ito, Yukihiro Noda, Taku Nagai, Toshitaka Nabeshima

JOURNAL OF NEUROSCIENCE, 27(28) 7604-7615, Jul, 2007 Peer-reviewed
Neural circuits containing pallidotegmental GABAergic neurons are involved in the prepulse inhibition of the startle reflex in mice

Kenji Takahashi, Taku Nagai, Hiroyuki Kamei, Kenji Maeda, Takahiro Matsuya, Sawako Arai, Hiroyuki Mizoguchi, Yukio Yoneda, Toshitaka Nabeshima, Kazuhiro Takuma, Kiyofumi Yamada

BIOLOGICAL PSYCHIATRY, 62(2) 148-157, Jul, 2007 Peer-reviewed
Possible involvement of protease-activated receptor-1 in the regulation of morphine-induced dopamine release and hyperlocomotion by the tissue plasminogen activator-plasmin system

Mina Ito, Taku Nagai, Hiroyuki Mizoguchi, Ayumi Fukakusa, Yutaka Nakanishi, Hiroyuki Kamei, Toshitaka Nabeshima, Kazuhiro Takuma, Kiyofumi Yamada

JOURNAL OF NEUROCHEMISTRY, 101(5) 1392-1399, Jun, 2007 Peer-reviewed
Reinforcing effects of morphine are reduced in tissue plasminogen activator-knockout mice

Y. Yan, K. Yamada, H. Mizoguchi, Y. Noda, T. Nagai, A. Nitta, T. Nabeshima

NEUROSCIENCE, 146(1) 50-59, Apr, 2007 Peer-reviewed
17 beta-Estradiol attenuates hippocampal neuronal loss and cognitive dysfunctim induced by chronic restraint stress in ovariectomized rats

K. Takuma, A. Matsuo, Y. Himeno, Y. Hoshina, Y. Ohno, Y. Funatsu, S. Arai, H. Kamei, H. Mizoguchi, T. Nagai, K. Koike, M. Inoue, K. Yamada

NEUROSCIENCE, 146(1) 60-68, Apr, 2007 Peer-reviewed
CD38 is critical for social behaviour by regulating oxytocin secretion

Duo Jin, Hong-Xiang Liu, Hirokazu Hirai, Takashi Torashima, Taku Nagai, Olga Lopatina, Natalia A. Shnayder, Kiyofumi Yamada, Mami Noda, Toshihiro Seike, Kyota Fujita, Shin Takasawa, Shigeru Yokoyama, Keita Koizumi, Yoshitake Shiraishi, Shigenori Tanaka, Minako Hashii, Toru Yoshihara, Kazuhiro Higashida, Mohammad Saharul Islam, Nobuaki Yamada, Kenshi Hayashi, Naoya Noguchi, Ichiro Kato, Hiroshi Okamoto, Akihiro Matsushima, Alla Salmina, Toshio Munesue, Nobuaki Shimizu, Sumiko Mochida, Masahide Asano, Haruhiro Higashida

NATURE, 446(7131) 41-45, Mar, 2007 Peer-reviewed
Dopamine D1 receptors regulate protein synthesis-dependent long-term recognition memory via extracellular signal-regulated kinase 1/2 in the prefrontal cortex

Taku Nagai, Kazuhiro Takuma, Hiroyuki Kamei, Yukio Ito, Noritaka Nakamichi, Daisuke Ibi, Yutaka Nakanishi, Masaaki Murai, Hiroyuki Mizoguchi, Toshitaka Nabeshima, Kiyofumi Yamada

LEARNING & MEMORY, 14(3) 117-125, Mar, 2007 Peer-reviewed
Clozapine prevents a decrease in neurogenesis in mice repeatedly treated with phencyclidine

Kenji Maeda, Haruhiko Sugino, Tsuyoshi Hirose, Hisashi Kitagawa, Taku Nagai, Hiroyuki Mizoguchi, Kazuhiro Takuma, Kiyofumi Yamada

JOURNAL OF PHARMACOLOGICAL SCIENCES, 103(3) 299-308, Mar, 2007 Peer-reviewed
Synergistic effects of adenosine A(2A) antagonist and L-DOPA on rotational behaviors in 6-hydroxydopamine-induced hemi-Parkinsonian mouse model

Takahiro Matsuya, Kazuhiro Takuma, Kosuke Sato, Makoto Asai, Yoshihiro Murakami, Sosuke Miyoshi, Akihiro Noda, Taku Nagai, Hiroyuki Mizoguchi, Shintaro Nishimura, Kiyofumi Yamada

JOURNAL OF PHARMACOLOGICAL SCIENCES, 103(3) 329-332, Mar, 2007 Peer-reviewed
A novel azaindolizinone derivative ZSET1446 (spiro[imidazo[1,2-a]pyridine-3,2-indan]-2(3H)-one) improves methamphetamine-induced impairment of recognition memory in mice by activating extracellular signal-regulated kinase 1/2

Yukio Ito, Kazuhiro Takuma, Hiroyuki Mizoguchi, Taku Nagai, Kiyofumi Yamada

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 320(2) 819-827, Feb, 2007 Peer-reviewed
Development and characterization of a mouse model of postmenopausal memory impairment

Yukiko Himeno, Kazuhiro Takuma, Yuki Hoshina, Sawako Arai, Yuki Ohno, Yoko Funatsu, Taku Nagai, Hiroyuki Mizoguchi, Koji Koike, Masaki Inoue, Kiyofumi Yamada

JOURNAL OF PHARMACOLOGICAL SCIENCES, 103 230P-230P, 2007
Implication of the pallidotegmental neurons in methamphetamine- and MK-801-induced impairment of prepulse inhibition of the startle reflex in mice

Sawako Arai, H. Mizoguchi, T. Nagai, K. Takahashi, H. Kamei, K. Takuma, K. Yamada

NEUROSCIENCE RESEARCH, 58 S122-S122, 2007
Mitochondrial dysfunction and neuronal apoptosis in Alzheimer's disease

Kazuhiro Takuma, Emiko Fukuzaki, Taku Nagai, Hiroyuki Mizoguchi, David M. Stern, Shirley ShiDu Yan, Kiyofumi Yamada

JOURNAL OF PHARMACOLOGICAL SCIENCES, 103 45P-45P, 2007
Role of the tPA-plasmin-PAR1 signaling in nicotine rewards

Mina Ito, Taku Nagai, Noritaka Nakamichi, Hiroyuki Mizoguchi, Hiroyuki Kamei, Toshitaka Nabeshima, Kazuhiro Takuma, Kiyofumi Yamada

JOURNAL OF PHARMACOLOGICAL SCIENCES, 103 226P-226P, 2007
Study on the mechanism of neuropsychological abnormalities induced by drugs of abuse

Taku Nagai

JOURNAL OF PHARMACOLOGICAL SCIENCES, 103 12P-12P, 2007
Role of dopamine D1 receptor/ERK1/2 signal in protein synthesis-dependent long-term recognition memory

Taku Nagai, Hiyoruki Kamei, Hiroyuki Mizoguchi, Noritaka Nakamichi, Toshitaka Nabeshima, Makiko Suzuki, Kazuhiro Takuma, Kiyofumi Yamada

JOURNAL OF PHARMACOLOGICAL SCIENCES, 103 33P-33P, 2007
Minocycline improves the object recognition impairment induced by repeated methamphetamine treatment in mice

Yukio Ito, Kazuhiro Takuma, Hiroyuki Mizoguchi, Taku Nagai, Toshitaka Nabeshima, Kiyofumi Yamada

JOURNAL OF PHARMACOLOGICAL SCIENCES, 103 125P-125P, 2007
Proteomic analysis in the prefrontal cortex of mice after repeated treatment of phencyclidine

Makiko Suzuki, Taku Nagai, Toshitaka Nabeshima

JOURNAL OF PHARMACOLOGICAL SCIENCES, 103 116P-116P, 2007
The rewards of nicotine: Regulation by tissue plasminogen activator-plasmin system through protease activated receptor-1

Taku Nagai, Mina Ito, Noritaka Nakamichi, Hiroyuki Mizoguchi, Hiroyuki Kamei, Ayumi Fukakusa, Toshitaka Nabeshima, Kazuhiro Takuma, Kiyofumi Yamada

JOURNAL OF NEUROSCIENCE, 26(47) 12374-12383, Nov, 2006 Peer-reviewed
Involvement of tissue plasminogen activator-plasmin system in depolarization-evoked dopamine release in the nucleus accumbens of mice

Mina Ito, Taku Nagai, Hiroyuki Kamei, Noritaka Nakamichi, Toshitaka Nabeshima, Kazuhiro Takuma, Kiyofumi Yamada

MOLECULAR PHARMACOLOGY, 70(5) 1720-1725, Nov, 2006 Peer-reviewed
Involvement of hippocampal extracellular signal-regulated kinase 1/2 in spatial working memory in rats

Taku Nagai, Hiroyuki Kamei, Misato Dohniwa, Masanori Takayanagi, Masakazu Suzuki, Takahiro Matsuya, Toshitaka Nabeshima, Kazuhiro Takuma, Kiyofumi Yamada

NEUROREPORT, 17(13) 1453-1457, Sep, 2006 Peer-reviewed
Effects of memantine and donepezil on amyloid beta-induced memory impairment in a delayed-matching to position task in rats (vol 162, pg 191, 2005)

K Yamada, M Takayanagi, H Kamei, T Nagai, M Dohniwa, K Kobayashi, S Yoshida, T Ohhara, K Takuma, T Nabeshima

BEHAVIOURAL BRAIN RESEARCH, 166(2) 296-296, Jan, 2006
Role of hippocampal extracellular signal-regulated kinase (ERK1/2) phosphorylation in spatial working memory

M Dohniwa, T Nagai, M Takayanagi, K Kobayashi, K Takuma, T Nabeshima, K Yamada

JOURNAL OF PHARMACOLOGICAL SCIENCES, 100 205P-205P, 2006
Raloxifene and EGb761 suppress stress-induced memory impairment in ovariectomized rats

Y Hoshina, K Takuma, A Matsuo, Y Himeno, S Arai, H Kamei, T Nagai, K Koike, M Inoue, K Yamada

JOURNAL OF PHARMACOLOGICAL SCIENCES, 100 147P-147P, 2006
Role of serotonin 5-HT2C receptor in aggressive behavior induced by social isolation in mice

Kazuhiro Takuma, Tomoko Tsuji, Hiroyuki Koike, Taku Nagai, Kiyofumi Yamada

JOURNAL OF PHARMACOLOGICAL SCIENCES, 101 90-90, 2006
Neural circuit for the regulation of prepulse inhibition of the startle reflex in mice

Sawako Arai, Taku Nagai, Kewi Takahashi, Hiroyuki Kamei, Kazuhiro Takuma, Kiyofumi Yamada

NEUROSCIENCE RESEARCH, 55 S169-S169, 2006
Neuronal circuits involved in the sensorimotor gating in mice

KJ Takahashi, T Nagai, H Kamei, K Takuma, K Yamada

JOURNAL OF PHARMACOLOGICAL SCIENCES, 100 88P-88P, 2006

Books and Other Publications

「実践行動薬理学」第Ⅱ編第4章報酬機構関連3依存性薬物による精神障害の分子機序.

永井拓, 鍋島俊隆, 山田清文 (Role: Joint author)

金芳堂, 2010

Presentations

ドパミン作動性およびグルタミン酸作動性神経伝達の変調と障害に関する神経精神薬理学的研究

永井拓

第22回日本臨床精神神経薬理学会・第42回日本神経精神薬理学会合同年会, Oct 18, 2012
精神疾患モデル動物を用いた神経精神薬理学的研究

永井拓

第16回日本神経麻酔・集中治療研究会, Apr 13, 2012
周産期免疫異常応答によって惹起される精神発達障害とそのメカニズム

永井拓, 衣斐大祐, 山田真之亮, 山田清文

第85回日本薬理学会年会, Mar 14, 2012
周産期における異常免疫応答と神経発達障害

永井拓

第21回日本臨床精神神経薬理学会・第41回日本神経精神薬理学会合同年会, Oct 27, 2011
プロテアーゼを介した薬物依存形成の神経化学的機序

永井拓

第21回日本臨床精神神経薬理学会・第41回日本神経精神薬理学会合同年会, Oct 27, 2011

Teaching Experience

Professional Memberships

Research Projects

エネルギー代謝制御によるアルツハイマー病の脳-筋連関の機構解明とその予防法の開発

科学研究費助成事業, 日本学術振興会, Apr, 2026 - Mar, 2029

中井剛, 溝口博之, 祖父江顕, 常陸圭介, 永井拓, 土田邦博
パーキンソン病における意思決定障害の分子・神経メカニズム解明と新規治療薬開発

科学研究費助成事業, 日本学術振興会, Apr, 2024 - Mar, 2027

永井拓
Study on the regulation mechanism of neural spine morphology and cognitive function by twinfilin-1

Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Apr, 2023 - Mar, 2026
多階層的解析を基盤とした薬物依存症の解明

脳とこころの研究推進プログラム（精神・神経疾患メカニズム解明プロジェクト）, AMED, 2021 - 2024
Study on development of novel antipsychotics based on reverse translational research

Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2023

Nagai Taku

Industrial Property Rights

特願2010-147017 統合失調症マーカー及びその利用

Other

研究シーズ

統合失調症マーカー及びその利用, 尾崎紀夫, 永井拓, 吉見陽, 山田真之亮.「国立大学法人名古屋大学, 特許番号6252949, 出願番号特願 2014-542025, 管理番号 C20130185JP#P01, 出願日2013.10.3., 特許取得2017.12.8.

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