Phosphoproteomics identifies Rho-Kinase-associated phospho-signaling and autophagy-associated alterations in the medial prefrontal cortex of a schizophrenia-related mouse model

Wenjun Zhu, Rinako Tanaka, Tetsuo Matsuzaki, Tsuyoshi Nakai, Taku Nagai, Toshitaka Nabeshima, Kozo Kaibuchi, Norio Ozaki, Hiroaki Ikesue, Hiroyuki Mizoguchi, Kiyofumi Yamada

Pharmacological Research 108201-108201 2026年4月
Antipsychotic-like effects of the selective Rho-kinase 2 inhibitor KD025 in genetic and pharmacological mouse models of schizophrenia

Rinako Tanaka, Jingzhu Liao, Yue Liu, Wenjun Zhu, Kisa Fukuzawa, Masamichi Kondo, Masahito Sawahata, Daisuke Mori, Akihiro Mouri, Hisayoshi Kubota, Daiki Tachibana, Yohei Kobayashi, Tetsuo Matsuzaki, Taku Nagai, Toshitaka Nabeshima, Kozo Kaibuchi, Norio Ozaki, Hiroyuki Mizoguchi, Kiyofumi Yamada

Molecular Psychiatry 2026年4月1日
Acute systemic immune challenge induces cognitive impairments and anhedonia through interferon-induced transmembrane protein 3 in adult male mice

Wenjun Zhu, Akira Sobue, Rinako Tanaka, Kazuhiro Hada, Daisuke Ibi, Yue Liu, Tetsuo Matsuzaki, Taku Nagai, Toshitaka Nabeshima, Kozo Kaibuchi, Norio Ozaki, Hiroyuki Mizoguchi, Hiroaki Ikesue, Kiyofumi Yamada

Behavioural Brain Research 496 115832-115832 2026年1月
Cortical excitatory and inhibitory neuron deficits may underlie the cognitive and social impairments in a mouse model of schizophrenia with exonic Reln deletion

Youyun Zhu, Kanako Kitagawa, Daisuke Mori, Tetsuo Matsuzaki, Taku Nagai, Toshitaka Nabeshima, Sayaka Takemoto-Kimura, Hiroaki Ikesue, Norio Ozaki, Hiroyuki Mizoguchi, Kiyofumi Yamada

European Journal of Pharmacology 2026年1月
Twinfilin-1 phosphorylation in reelin signaling regulates actin dynamics and spine development

Geyao Dong, Daisuke Mori, Tetsuo Matsuzaki, Rinako Tanaka, Norimichi Itoh, Takaaki Matsui, Ayato Sato, Yuko Arioka, Hiroki Okumura, Ryota Fukaya, Hiroshi Kuba, Taku Nagai, Toshitaka Nabeshima, Hiroaki Ikesue, Takao Kohno, Mitsuharu Hattori, Kozo Kaibuchi, Norio Ozaki, Hiroyuki Mizoguchi, Kiyofumi Yamada

Pharmacological Research 221 107986-107986 2025年11月

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GABA(B) receptor agonist baclofen improves methamphetamine-induced cognitive deficit in mice

Sawako Arai, Kazuhiro Takuma, Hiroyuki Mizoguchi, Daisuke Ibi, Taku Nagai, Hiroyuki Kamei, Hyoung-Chun Kim, Kiyofumi Yamada

EUROPEAN JOURNAL OF PHARMACOLOGY 602(1) 101-104 2009年1月査読有り
Involvement of Pallidotegmental Neurons in Methamphetamine- and MK-801-Induced Impairment of Prepulse Inhibition of the Acoustic Startle Reflex in Mice: Reversal by GABA(B) Receptor Agonist Baclofen

Sawako Arai, Kazuhiro Takuma, Hiroyuki Mizoguchi, Daisuke Ibi, Taku Nagai, Kenji Takahashi, Hiroyuki Kamei, Toshitaka Nabeshima, Kiyofumi Yamada

NEUROPSYCHOPHARMACOLOGY 33(13) 3164-3175 2008年12月査読有り
The extensive nitration of neurofilament light chain in the hippocampus is associated with the cognitive impairment induced by amyloid beta in mice

Tursun Alkam, Atsumi Nitta, Hiroyuki Mizoguchi, Akio Itoh, Rina Murai, Taku Nagai, Kiyofumi Yamada, Toshitaka Nabeshima

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 327(1) 137-147 2008年10月査読有り
Social isolation rearing-induced impairment of the hippocampal neurogenesis is associated with deficits in spatial memory and emotion-related behaviors in juvenile mice

Daisuke Ibi, Kazuhiro Takuma, Hiroyuki Koike, Hiroyuki Mizoguchi, Katsuki Tsuritani, Yusuke Kuwahara, Hiroyuki Kamei, Taku Nagai, Yukio Yoneda, Toshitaka Nabeshima, Kiyofumi Yamada

JOURNAL OF NEUROCHEMISTRY 105(3) 921-932 2008年5月査読有り
Role of tissue plasminogen activator in the sensitization of methamphetamine-induced dopamine release in the nucleus accumbens

Ayumi Fukakusa, Taku Nagai, Hiroyuki Mizoguchi, Noboru Otsuka, Haruhide Kimura, Hiroyuki Kamei, Hyoung-Chun Kim, Toshitaka Nabeshima, Kazuhiro Takuma, Kiyofumi Yamada

JOURNAL OF NEUROCHEMISTRY 105(2) 436-444 2008年4月査読有り
難治性統合失調症の動物モデルと治療薬開発

古関竹直, 毛利彰宏, 村井里菜, 永井拓, 野田幸裕, 鍋島俊隆

脳と精神の医学 = Brain science and mental disorders 19(1) 31-40 2008年3月25日
Effects of GABA receptor agonists on cognitive impairment in animal models of schizophrenia

Sawako Arai, Kazuhiro Takuma, Hiroyuki Mizoguchi, Taku Nagai, Hiroyuki Kamei, Kiyofumi Yamada

JOURNAL OF PHARMACOLOGICAL SCIENCES 106 231P-231P 2008年
Effect of aripiprazole on phencyclidine-induced impairment of recognition memory in mice

Taku Nagai, Rina Murai, Kanae Matsui, Hiroyuki Kamei, Yukihiro Noda, Hiroshi Furukawa, Toshitaka Nabeshima

JOURNAL OF PHARMACOLOGICAL SCIENCES 106 233P-233P 2008年
Histone modification in methamphetamine-associated contextual memory

Hiroyuki Mizoguchi, Kazuhiro Takuma, Daisuke Ibi, Eiichi Someya, Taku Nagai, Yan Yijan, Yasuhiko Kanou, Toshitaka Nabeshima, Makoto Sawada, Jun Sato, Kiyofumi Yamada

JOURNAL OF PHARMACOLOGICAL SCIENCES 106 138P-138P 2008年
Involvement of cholinergic system relate the chronic stress-induced memory impairment in ovariectomized mice

Yoko Funatsu, Kazuhiro Takuma, Yukiko Himeno, Emiko Fukuzaki, Yuko Kitahara, Yuki Hoshina, Hiroyuki Kamei, Hiroyuki Mizoguchi, Taku Nagai', Koji Koike, Masaki Inoue, Kiyofumi Yamada

JOURNAL OF PHARMACOLOGICAL SCIENCES 106 181P-181P 2008年
A novel molecule "shati" is involved in methamphetamine-induced hyperlocomotion, sensitization, and conditioned place preference

Minae Niwa, Atsumi Nitta, Hiroyuki Mizoguchi, Yasutomo Itoh, Yukihiro Noda, Taku Nagai, Toshitaka Nabeshima

JOURNAL OF PHARMACOLOGICAL SCIENCES 106 55P-55P 2008年
Perinatal immune activation impairs emotional and cognitive functions in adolescent mice

Taku Nagai, Daisuke Ibi, Hiroyuki Mizoguchi, Toshitaka Nabeshima, Kiyofumi Yamada

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 128 69-69 2008年
Cognitive impairment in a mouse model of viral infection during perinatal stage

Daisuke Ibi, Taku Nagai, Hiroyuki Mizoguchi, Hiroyuki Koike, Kazuhiro Takumo, Kiyofumi Yamada

NEUROSCIENCE RESEARCH 61 S129-S129 2008年
Induction of tissue plasminogen activator by repeated methamphetamine treatment is associated with the development of sensitization in methamphetamine-induced dopamine release

Ayumi Fukakusa, Taku Nagai, Hiroyuki Mizoguchi, Toshitaka Nabeshima, Kazuhiro Takuma, Kiyofumi Yamada

JOURNAL OF PHARMACOLOGICAL SCIENCES 106 174P-174P 2008年
組織プラスミノーゲン活性化因子による依存性薬物の報酬効果の制御．

永井拓, 田熊一敞, 鍋島俊隆, 山田清文

日本神経精神薬理学雑誌 28 1-6 2008年査読有り
Basic and Translational Research on Proteinase-Activated Receptors: Regulation of nicotine reward by tPA-plasmin system via proteinase-activated receptor1

Nagai T, Nabeshima, T, Yamada K

J. Pharmacol. Sci. 108 408-414 2008年査読有り招待有り
学習・記憶とエピジェネティクス

永井拓, 鍋島俊隆

日本薬理学雑誌 130(6) 521-521 2007年12月1日
Activation of post-synaptic dopamine D(1) receptors promotes the release of tissue plasminogen activator in the nucleus accumbens via PKA signaling

Mina Ito, Taku Nagai, Hiroyuki Mizoguchi, Kosuke Sato, Minoru Hayase, Noboru Otsuka, Ayumi Fukakusa, Nozomi Kumagai, Hyoung-Chun Kim, Toshitaka Nabeshima, Kazuhiro Takuma, Kiyofumi Yamada

JOURNAL OF NEUROCHEMISTRY 103(6) 2589-2596 2007年12月査読有り
メタンフェタミン誘発性ドパミン遊離の逆耐性形成における組織プラスミノーゲン活性化因子の役割

深草亜由美, 永井拓, 溝口博之, 鍋島俊隆, 田熊一敞, 山田清文

日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology 27(5) 2007年11月25日
Ginkgo biloba extract EGb 761 attenuates hippocampal neuronal loss and cognitive dysfunction resulting from chronic restraint stress in ovariectomized rats

K. Takuma, Y. Hoshina, S. Arai, Y. Himeno, A. Matsuo, Y. Funatsu, Y. Kitahara, D. Ibi, M. Hayase, H. Kamei, H. Mizoguchi, T. Nagai, K. Koike, M. Inoue, K. Yamada

NEUROSCIENCE 149(2) 256-262 2007年10月査読有り
The survey of the relationship between falling risk and psychotropic medications in inpatients of Nagoya University Hospital

Akira Yoshimi, Yukihiro Noda, Harumi Miyata, Mie Tsuji, Akio Ito, Koji Senzaki, Kazuhiro Ishikawa, Taku Nagai, Takahiro Soma, Yuichi Ueda, Toshitaka Nabeshima, Norio Ozaki

INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY 22(5) A26-A26 2007年9月
Repeated methamphetamine treatment impairs spatial working memory in rats: reversal by clozapine but not haloperidol

Taku Nagai, Kazuhiro Takuma, Misato Dohniwa, Daisuke Ibi, Hiroyuki Mizoguchi, Hiroyuki Kamei, Toshitaka Nabeshima, Kiyofumi Yamada

PSYCHOPHARMACOLOGY 194(1) 21-32 2007年9月査読有り
Enduring vulnerability to reinstatement of methamphetamine-seeking behavior in glial cell line-derived neurotrophic factor mutant mice

Yijin Yan, Kiyofumi Yamada, Minae Niwa, Taku Nagai, Atsumi Nitta, Toshitaka Nabeshima

FASEB JOURNAL 21(9) 1994-2004 2007年7月査読有り
A novel molecule "Shati" is involved in methamphetamine-induced hyperlocomotion, sensitization, and conditioned place preference

Minae Niwa, Atsumi Nitta, Hiroyuki Mizoguchi, Yasutomo Ito, Yukihiro Noda, Taku Nagai, Toshitaka Nabeshima

JOURNAL OF NEUROSCIENCE 27(28) 7604-7615 2007年7月査読有り
Neural circuits containing pallidotegmental GABAergic neurons are involved in the prepulse inhibition of the startle reflex in mice

Kenji Takahashi, Taku Nagai, Hiroyuki Kamei, Kenji Maeda, Takahiro Matsuya, Sawako Arai, Hiroyuki Mizoguchi, Yukio Yoneda, Toshitaka Nabeshima, Kazuhiro Takuma, Kiyofumi Yamada

BIOLOGICAL PSYCHIATRY 62(2) 148-157 2007年7月査読有り
Possible involvement of protease-activated receptor-1 in the regulation of morphine-induced dopamine release and hyperlocomotion by the tissue plasminogen activator-plasmin system

Mina Ito, Taku Nagai, Hiroyuki Mizoguchi, Ayumi Fukakusa, Yutaka Nakanishi, Hiroyuki Kamei, Toshitaka Nabeshima, Kazuhiro Takuma, Kiyofumi Yamada

JOURNAL OF NEUROCHEMISTRY 101(5) 1392-1399 2007年6月査読有り
Reinforcing effects of morphine are reduced in tissue plasminogen activator-knockout mice

Y. Yan, K. Yamada, H. Mizoguchi, Y. Noda, T. Nagai, A. Nitta, T. Nabeshima

NEUROSCIENCE 146(1) 50-59 2007年4月査読有り
17 beta-Estradiol attenuates hippocampal neuronal loss and cognitive dysfunctim induced by chronic restraint stress in ovariectomized rats

K. Takuma, A. Matsuo, Y. Himeno, Y. Hoshina, Y. Ohno, Y. Funatsu, S. Arai, H. Kamei, H. Mizoguchi, T. Nagai, K. Koike, M. Inoue, K. Yamada

NEUROSCIENCE 146(1) 60-68 2007年4月査読有り
CD38 is critical for social behaviour by regulating oxytocin secretion

Duo Jin, Hong-Xiang Liu, Hirokazu Hirai, Takashi Torashima, Taku Nagai, Olga Lopatina, Natalia A. Shnayder, Kiyofumi Yamada, Mami Noda, Toshihiro Seike, Kyota Fujita, Shin Takasawa, Shigeru Yokoyama, Keita Koizumi, Yoshitake Shiraishi, Shigenori Tanaka, Minako Hashii, Toru Yoshihara, Kazuhiro Higashida, Mohammad Saharul Islam, Nobuaki Yamada, Kenshi Hayashi, Naoya Noguchi, Ichiro Kato, Hiroshi Okamoto, Akihiro Matsushima, Alla Salmina, Toshio Munesue, Nobuaki Shimizu, Sumiko Mochida, Masahide Asano, Haruhiro Higashida

NATURE 446(7131) 41-45 2007年3月査読有り
Dopamine D1 receptors regulate protein synthesis-dependent long-term recognition memory via extracellular signal-regulated kinase 1/2 in the prefrontal cortex

Taku Nagai, Kazuhiro Takuma, Hiroyuki Kamei, Yukio Ito, Noritaka Nakamichi, Daisuke Ibi, Yutaka Nakanishi, Masaaki Murai, Hiroyuki Mizoguchi, Toshitaka Nabeshima, Kiyofumi Yamada

LEARNING & MEMORY 14(3) 117-125 2007年3月査読有り
Clozapine prevents a decrease in neurogenesis in mice repeatedly treated with phencyclidine

Kenji Maeda, Haruhiko Sugino, Tsuyoshi Hirose, Hisashi Kitagawa, Taku Nagai, Hiroyuki Mizoguchi, Kazuhiro Takuma, Kiyofumi Yamada

JOURNAL OF PHARMACOLOGICAL SCIENCES 103(3) 299-308 2007年3月査読有り
Synergistic effects of adenosine A(2A) antagonist and L-DOPA on rotational behaviors in 6-hydroxydopamine-induced hemi-Parkinsonian mouse model

Takahiro Matsuya, Kazuhiro Takuma, Kosuke Sato, Makoto Asai, Yoshihiro Murakami, Sosuke Miyoshi, Akihiro Noda, Taku Nagai, Hiroyuki Mizoguchi, Shintaro Nishimura, Kiyofumi Yamada

JOURNAL OF PHARMACOLOGICAL SCIENCES 103(3) 329-332 2007年3月査読有り
A novel azaindolizinone derivative ZSET1446 (spiro[imidazo[1,2-a]pyridine-3,2-indan]-2(3H)-one) improves methamphetamine-induced impairment of recognition memory in mice by activating extracellular signal-regulated kinase 1/2

Yukio Ito, Kazuhiro Takuma, Hiroyuki Mizoguchi, Taku Nagai, Kiyofumi Yamada

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 320(2) 819-827 2007年2月査読有り
Development and characterization of a mouse model of postmenopausal memory impairment

Yukiko Himeno, Kazuhiro Takuma, Yuki Hoshina, Sawako Arai, Yuki Ohno, Yoko Funatsu, Taku Nagai, Hiroyuki Mizoguchi, Koji Koike, Masaki Inoue, Kiyofumi Yamada

JOURNAL OF PHARMACOLOGICAL SCIENCES 103 230P-230P 2007年
Implication of the pallidotegmental neurons in methamphetamine- and MK-801-induced impairment of prepulse inhibition of the startle reflex in mice

Sawako Arai, H. Mizoguchi, T. Nagai, K. Takahashi, H. Kamei, K. Takuma, K. Yamada

NEUROSCIENCE RESEARCH 58 S122-S122 2007年
Mitochondrial dysfunction and neuronal apoptosis in Alzheimer's disease

Kazuhiro Takuma, Emiko Fukuzaki, Taku Nagai, Hiroyuki Mizoguchi, David M. Stern, Shirley ShiDu Yan, Kiyofumi Yamada

JOURNAL OF PHARMACOLOGICAL SCIENCES 103 45P-45P 2007年
Role of the tPA-plasmin-PAR1 signaling in nicotine rewards

Mina Ito, Taku Nagai, Noritaka Nakamichi, Hiroyuki Mizoguchi, Hiroyuki Kamei, Toshitaka Nabeshima, Kazuhiro Takuma, Kiyofumi Yamada

JOURNAL OF PHARMACOLOGICAL SCIENCES 103 226P-226P 2007年
Study on the mechanism of neuropsychological abnormalities induced by drugs of abuse

Taku Nagai

JOURNAL OF PHARMACOLOGICAL SCIENCES 103 12P-12P 2007年
Role of dopamine D1 receptor/ERK1/2 signal in protein synthesis-dependent long-term recognition memory

Taku Nagai, Hiyoruki Kamei, Hiroyuki Mizoguchi, Noritaka Nakamichi, Toshitaka Nabeshima, Makiko Suzuki, Kazuhiro Takuma, Kiyofumi Yamada

JOURNAL OF PHARMACOLOGICAL SCIENCES 103 33P-33P 2007年
Minocycline improves the object recognition impairment induced by repeated methamphetamine treatment in mice

Yukio Ito, Kazuhiro Takuma, Hiroyuki Mizoguchi, Taku Nagai, Toshitaka Nabeshima, Kiyofumi Yamada

JOURNAL OF PHARMACOLOGICAL SCIENCES 103 125P-125P 2007年
Proteomic analysis in the prefrontal cortex of mice after repeated treatment of phencyclidine

Makiko Suzuki, Taku Nagai, Toshitaka Nabeshima

JOURNAL OF PHARMACOLOGICAL SCIENCES 103 116P-116P 2007年
The rewards of nicotine: Regulation by tissue plasminogen activator-plasmin system through protease activated receptor-1

Taku Nagai, Mina Ito, Noritaka Nakamichi, Hiroyuki Mizoguchi, Hiroyuki Kamei, Ayumi Fukakusa, Toshitaka Nabeshima, Kazuhiro Takuma, Kiyofumi Yamada

JOURNAL OF NEUROSCIENCE 26(47) 12374-12383 2006年11月査読有り
Involvement of tissue plasminogen activator-plasmin system in depolarization-evoked dopamine release in the nucleus accumbens of mice

Mina Ito, Taku Nagai, Hiroyuki Kamei, Noritaka Nakamichi, Toshitaka Nabeshima, Kazuhiro Takuma, Kiyofumi Yamada

MOLECULAR PHARMACOLOGY 70(5) 1720-1725 2006年11月査読有り
Involvement of hippocampal extracellular signal-regulated kinase 1/2 in spatial working memory in rats

Taku Nagai, Hiroyuki Kamei, Misato Dohniwa, Masanori Takayanagi, Masakazu Suzuki, Takahiro Matsuya, Toshitaka Nabeshima, Kazuhiro Takuma, Kiyofumi Yamada

NEUROREPORT 17(13) 1453-1457 2006年9月査読有り
Effects of memantine and donepezil on amyloid beta-induced memory impairment in a delayed-matching to position task in rats (vol 162, pg 191, 2005)

K Yamada, M Takayanagi, H Kamei, T Nagai, M Dohniwa, K Kobayashi, S Yoshida, T Ohhara, K Takuma, T Nabeshima

BEHAVIOURAL BRAIN RESEARCH 166(2) 296-296 2006年1月
Role of hippocampal extracellular signal-regulated kinase (ERK1/2) phosphorylation in spatial working memory

M Dohniwa, T Nagai, M Takayanagi, K Kobayashi, K Takuma, T Nabeshima, K Yamada

JOURNAL OF PHARMACOLOGICAL SCIENCES 100 205P-205P 2006年
Raloxifene and EGb761 suppress stress-induced memory impairment in ovariectomized rats

Y Hoshina, K Takuma, A Matsuo, Y Himeno, S Arai, H Kamei, T Nagai, K Koike, M Inoue, K Yamada

JOURNAL OF PHARMACOLOGICAL SCIENCES 100 147P-147P 2006年
Role of serotonin 5-HT2C receptor in aggressive behavior induced by social isolation in mice

Kazuhiro Takuma, Tomoko Tsuji, Hiroyuki Koike, Taku Nagai, Kiyofumi Yamada

JOURNAL OF PHARMACOLOGICAL SCIENCES 101 90-90 2006年
Neural circuit for the regulation of prepulse inhibition of the startle reflex in mice

Sawako Arai, Taku Nagai, Kewi Takahashi, Hiroyuki Kamei, Kazuhiro Takuma, Kiyofumi Yamada

NEUROSCIENCE RESEARCH 55 S169-S169 2006年
Neuronal circuits involved in the sensorimotor gating in mice

KJ Takahashi, T Nagai, H Kamei, K Takuma, K Yamada

JOURNAL OF PHARMACOLOGICAL SCIENCES 100 88P-88P 2006年