Curriculum Vitaes

sonoda shigeru

  (園田 茂)

Profile Information

Affiliation
Professor, Department of Rehabilitation Medicine II, School of Medicine, Fujita Health University
Degree
DMSc(Keio University)

J-GLOBAL ID
200901019328012929
researchmap Member ID
1000228177

Physiatrist since 1985
President, Fujita Health University Nanakuri Memorial Hospital since 2003

Education

 1

Papers

 205
  • Emi Mizuno, Takayuki Ogasawara, Masahiko Mukaino, Masumi Yamaguchi, Shingo Tsukada, Shigeru Sonoda, Yohei Otaka
    JMIR formative research, 8 e51546, May 29, 2024  
    BACKGROUND: Motor impairments not only lead to a significant reduction in patient activity levels but also trigger a further deterioration in motor function due to deconditioning, which is an issue that is particularly pronounced during hospitalization. This deconditioning can be countered by sustaining appropriate activity levels. Activities that occur outside of scheduled programs, often overlooked, are critical in this context. Wearable technology, such as smart clothing, provides a means to monitor these activities. OBJECTIVE: This study aimed to observe activity levels in patients who had strokes during the subacute phase, focusing on both scheduled training sessions and other nontraining times in an inpatient rehabilitation environment. A smart clothing system is used to simultaneously measure heart rate and acceleration, offering insights into both the amount and intensity of the physical activity. METHODS: In this preliminary cohort study, 11 individuals undergoing subacute stroke rehabilitation were enrolled. The 48-hour continuous measurement system, deployed at admission and reassessed 4 weeks later, monitored accelerometry data for physical activity (quantified with a moving SD of acceleration [MSDA]) and heart rate for intensity (quantified with percent heart rate reserve). The measurements were performed using a wearable activity monitoring system, the hitoe (NTT Corporation and Toray Industries, Inc) system comprising a measuring garment (wear or strap) with integrated electrodes, a data transmitter, and a smartphone. The Functional Independence Measure was used to assess the patients' daily activity levels. This study explored factors such as differences in activity during training and nontraining periods, correlations with activities of daily living (ADLs) and age, and changes observed after 4 weeks. RESULTS: A significant increase was found in the daily total MSDA after the 4-week program, with the average percent heart rate reserve remaining consistent. Physical activity during training positively correlated with ADL levels both at admission (ρ=0.86, P<.001) and 4 weeks post admission (ρ=0.96, P<.001), whereas the correlation between age and MSDA was not significant during training periods at admission (ρ=-0.41, P=.21) or 4 weeks post admission (ρ=-0.25, P=.45). Conversely, nontraining activity showed a negative correlation with age, with significant negative correlations with age at admission (ρ=-0.82, P=.002) and 4 weeks post admission (ρ=-0.73, P=.01). CONCLUSIONS: Inpatient rehabilitation activity levels were positively correlated with ADL levels. Further analysis revealed a strong positive correlation between scheduled training activities and ADL levels, whereas nontraining activities showed no such correlation. Instead, a negative correlation between nontraining activities and age was observed. These observations suggest the importance of providing activity opportunities for older patients, while it may also suggest the need for adjusting the activity amount to accommodate the potentially limited fitness levels of this demographic. Future studies with larger patient groups are warranted to validate and further elucidate these findings.
  • Kenji Kawakami, Hiroyuki Miyasaka, Yuichi Hioki, Ayako Furumoto, Shigeru Sonoda
    International journal of rehabilitation research. Internationale Zeitschrift fur Rehabilitationsforschung. Revue internationale de recherches de readaptation, Apr 9, 2024  
    Practicing walking in a safety suspension device allows patients to move freely and without excessive reliance on a therapist, which requires correcting errors and may facilitate motor learning. This opens the possibility that patients with subacute stroke may improve their walking ability more rapidly. Therefore, we tested the hypothesis that overground gait training in a safety suspension device will result in achieving faster supervision-level walking than gait training without the suspension device. Twenty-seven patients with stroke admitted to the rehabilitation ward with functional ambulation categories (FAC) score of 2 at admission were randomly allocated to safety suspension-device group (SS group) or conventional assisted-gait training group (control group). In addition to regular physical therapy, each group underwent additional gait training for 60 min a day, 5 days a week for 4 weeks. We counted the days until reaching a FAC score of 3 and assessed the probability using Cox regression models. The median days required to reach a FAC score of 3 were 7 days for the SS group and 17.5 days for the control group, which was significantly different between the groups (P < 0.05). The SS group had a higher probability of reaching a FAC score of 3 after adjusting for age and admission motor impairment (hazard ratio = 3.61, 95% confidence interval = 1.40-9.33, P < 0.01). The gait training with a safety suspension device accelerates reaching the supervision-level walking during inpatient rehabilitation. We speculate that a safety suspension device facilitated learning by allowing errors to be experienced and correct in a safe environment.
  • Yoko Inamoto, Masahiko Mukaino, Sayuri Imaeda, Manami Sawada, Kumi Satoji, Ayako Nagai, Satoshi Hirano, Hideto Okazaki, Eiichi Saitoh, Shigeru Sonoda, Yohei Otaka
    JMIR formative research, 7 e42219, Feb 8, 2023  
    BACKGROUND: There is an extensive library of language tests, each with excellent psychometric properties; however, many of the tests available take considerable administration time, possibly bearing psychological strain on patients. The Short and Tailored Evaluation of Language Ability (STELA) is a simplified, tablet-based language ability assessment system developed to address this issue, with a reduced number of items and automated testing process. OBJECTIVE: The aim of this paper is to assess the administration time, internal consistency, and validity of the STELA. METHODS: The STELA consists of a tablet app, a microphone, and an input keypad for clinician's use. The system is designed to assess language ability with 52 questions grouped into 2 comprehension modalities (auditory comprehension and reading comprehension) and 3 expression modalities (naming and sentence formation, repetition, and reading aloud). Performance in each modality was scored as the correct answer rate (0-100), and overall performance expressed as the sum of modality scores (out of 500 points). RESULTS: The time taken to complete the STELA was significantly less than the time for the WAB (mean 16.2, SD 9.4 vs mean 149.3, SD 64.1 minutes; P<.001). The STELA's total score was strongly correlated with the WAB Aphasia Quotient (r=0.93, P<.001), supporting the former's concurrent validity concerning the WAB, which is a gold-standard aphasia assessment. Strong correlations were also observed at the subscale level; STELA auditory comprehension versus WAB auditory comprehension (r=0.75, P<.001), STELA repetition versus WAB repetition (r=0.96, P<.001), STELA naming and sentence formation versus WAB naming and word finding (r=0.81, P<.001), and the sum of STELA reading comprehension or reading aloud versus WAB reading (r=0.82, P<.001). Cronbach α obtained for each modality was .862 for auditory comprehension, .872 for reading comprehension, .902 for naming and sentence formation, .787 for repetition, and .892 for reading aloud. Global Cronbach α was .961. The average of the values of item-total correlation to each subscale was 0.61 (SD 0.17). CONCLUSIONS: Our study confirmed significant time reduction in the assessment of language ability and provided evidence for good internal consistency and validity of the STELA tablet-based aphasia assessment system.
  • Yu Takahashi, Hideaki Wakita, Takuma Ishihara, Hideto Okazaki, Akihiro Ito, Mitsunaga Iwata, Shigeru Sonoda, Yohei Doi
    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 29(1) 95-97, Jan, 2023  
    Healthcare-associated COVID-19 among vulnerable patients leads to disproportionate morbidity and mortality. Early pharmacologic intervention may reduce negative sequelae and improve survival in such settings. This study aimed to describe outcome of patients with healthcare-associated COVID-19 who received early short-course remdesivir therapy. We reviewed the characteristics and outcome of hospitalized patients who developed COVID-19 during an outbreak that involved two wards at a non-acute care hospital in Japan and received short-course remdesivir. Forty-nine patients were diagnosed with COVID-19, 34 on a comprehensive inpatient rehabilitation ward and 15 on a combined palliative care and internal medicine ward. Forty-seven were symptomatic and 46 of them received remdesivir. The median age was 75, and the median Charlson comorbidity index was 6 among those who received it. Forty-one patients had received one or two doses of mRNA vaccines, while none had received a third dose. Most patients received 3 days of remdesivir. Of the patients followed up to 14 and 28 days from onset, 41/44 (95.3%) and 35/41(85.4%) were alive, respectively. Six deaths occurred by 28 days in the palliative care/internal medicine ward and two of them were possibly related to COVID-19. Among those who survived, the performance status was unchanged between the time of onset and at 28 days.
  • Ken Tomida, Kei Ohtsuka, Toshio Teranishi, Hiroki Ogawa, Misaki Takai, Akira Suzuki, Kenji Kawakami, Shigeru Sonoda
    Fujita medical journal, 8(4) 121-126, Nov, 2022  
    OBJECTIVES: In stroke patients, the assessment of gait ability over time is important. For quantitative gait assessment using measuring devices, the walking speed condition for measurement is generally based on the patient's preferred walking speed or the maximum walking speed at the time of measurement. However, because walking speed often increases during the convalescent stage, understanding the effects of change in walking speed on gait when comparing the course of recovery is necessary. Although several previous studies have reported the effects of change in walking speed on gait in stroke patients, the time-distance parameters described in these reports may not be generalizable because of the small case numbers. Therefore, we measured treadmill gait at the preferred walking speed (PWS) and 1.3 times the PWS (130% PWS) in 43 post-stroke hemiplegic patients and analyzed the effects of change in walking speed on time-distance parameters. METHODS: Forty-three patients with hemiplegia after a first stroke, who were able to walk on a treadmill under supervision, were recruited as subjects. Using a three-dimensional motion analysis system, treadmill gait was assessed under two conditions: PWS and 130% PWS. The primary outcome measures were the time-distance parameters, which were compared between the PWS and 130% PWS conditions. RESULTS: Cadence, stride length, and step length of the affected and unaffected lower limbs increased significantly at 130% PWS compared with at PWS. In terms of actual time, single stance time and initial and terminal double stance time in both affected and unaffected limbs decreased significantly at 130% PWS. In terms of relative time (% of the gait cycle), compared with PWS, relative single stance time increased significantly, whereas relative initial and terminal double stance times decreased significantly at 130% PWS in both the affected and unaffected limbs. CONCLUSIONS: This study on treadmill gait in patients with hemiplegia after a first stroke confirmed the effects of change in walking speed on time-distance parameters. Our results will help in the interpretation of time-distance parameters measured under different walking speed conditions.

Misc.

 432
  • Kikuo Ota, Eiichi Saitoh, Mikoto Baba, Shigeru Sonoda
    JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 20(3) 183-187, May, 2011  Peer-reviewed
    This retrospective clinical investigation was conducted to evaluate the usefulness of the Secretion Severity Rating Scale (Secretion Scale) in predicting the risk of pneumonia in acute-phase fasting stroke patients. Videoendoscopic (VE) evaluation of swallowing was performed in 72 consecutive stroke patients with a nonoral status. The patients were classified into 2 groups based on the Secretion Scale: the pharyngeal residual group (n = 38; Secretion Scale level 0,8 [11.1%]; level 1,30 [41.7%]) and the laryngeal residual group (n = 34: Secretion Scale level 2, 13 [18.1%]; level 3, 21 [29.2%]). The higher the Secretion Scale score, the more severe the swallowing dysfunction. The results of the evaluation were compared with the frequency of aspiration as well as with the incidence of pneumonia in the period from VE examination to discharge. In addition, the incidence of pneumonia was compared in the aspiration-positive and aspiration-negative groups. After VE evaluation, 4 patients (10.5%) in the pharyngeal residual group developed pneumonia versus 12 (35.3%) in the laryngeal residual group; the incidence of pneumonia was significantly higher in the laryngeal residual group (P &lt; .05; Fisher&apos;s exact test). Our data indicate that the Secretion Scale can be a useful risk-management tool for predicting pneumonia in acute-phase fasting stroke patients.
  • Yoshihiko Yabunaka, Izumi Kondo, Shigeru Sonoda, Eiichi Saitoh, Yukari Tsuruta, Mayumi Konaka, Takamasa Konaka, Satomi Kawarada
    AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION, 90(2) 128-136, Feb, 2011  Peer-reviewed
    Yabunaka Y, Kondo I, Sonoda S, Saitoh E, Tsuruta Y, Konaka M, Konaka T, Kawarada S: Evaluating the effect of intensive intervention in children with cerebral palsy using a hypothetical matched control group: A preliminary study. Am J Phys Med Rehabil 2011;90:128Y136 Objective: To evaluate the effect of intensive intervention in children with cerebral palsy using a hypothetical matched control group based on motor growth curves. Design: For pretest-posttest design using a hypothetical control group, a convenient sample of 39 children with cerebral palsy who received intensive intervention without surgical treatment was assigned to the experimental group. The hypothetical matched control group was created based on motor growth curves. Gains in Gross Motor Function Measure-66 score after intensive treatment in the experimental group were compared with scores in the hypothetical matched control group using a mixed design for repeated-measures two-way analysis of variance. Results: Gross motor function development in the experimental group was significantly accelerated compared with the hypothetical matched control group. Conclusions: In this preliminary study, using a hypothetical control group, the effectiveness of intensive intervention in children with cerebral palsy has been demonstrated. Although it is desirable to have a baseline phase to make sure whether gross motor function in the hypothetical control group changes in a similar way to that in the experimental group before an intervention phase, the hypothetical control group design is well worth considering as a research design option in the field of cerebral palsy research.
  • Sayaka Okamoto, Shigeru Sonoda, Genichi Tanino, Ken Tomida, Hideto Okazaki, Izumi Kondo
    AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION, 90(2) 106-111, Feb, 2011  Peer-reviewed
    Okamoto S, Sonoda S, Tanino G, Tomida K, Okazaki H, Kondo I: Change in thigh muscle cross-sectional area through administration of an anabolic steroid during routine stroke rehabilitation in hemiplegic patients. Am J Phys Med Rehabil 2011;90:106Y111. Objective: The aim of this study was to clarify the effect of administration of an anabolic steroid (AS) without the addition of specific training in stroke patients by measuring the cross-sectional area (CSA) of the thigh. Design: Twenty-six hemiplegic stroke patients during subacute rehabilitation were randomly assigned to a metenolone enanthate (ME) administration group or a control group (CT group). In the ME group, ME (100 mg) was injected intramuscularly weekly for 6 wks in the ME group. The CSA of the bilateral thigh muscles was measured using computed tomography. Motor subscore of the Functional Independence Measure (FIM-M) was assessed before the experimental period. Results: At the end of 6 wks, the CSA increase in the ME group (13.4%, affected side; 14.5%, unaffected side) was significantly larger than that in the CT group (3.3%, affected side; 5.2%, unaffected side). Correlation coefficients between the initial FIM-M score and the CSA increase at 6 wks were -0.754 for the affected side and -0.567 for the unaffected side in the ME group and 0.199 for the affected side and 0.431 for the unaffected side in the CT group. Conclusions: ME administration is effective for improving muscle CSA and, thus, muscle strengthening in stroke rehabilitation. The CSA increase in the ME group was most prominent in patients with a low initial FIM-M score.
  • 別府 秀彦, 渡邊 治夫, 川井 薫, 新保 寛, 土井 直子, 中野 達徳, 松本 美富士, 園田 茂
    生物試料分析, 34(1) 99-99, Jan, 2011  
  • 千原 猛, 新保 寛, 金児孝晃, 別府秀彦, 戸松亜希子, 東口髙志, 園田 茂
    日本食品科学工学会誌, 58(3) 131-135, 2011  
  • 永田千里, 藤井 航, 坂口貴代美, 尾崎研一郎, 園田 茂
    障害者歯科, 32 39-43, 2011  
  • 加藤啓之, 宮坂裕之, 安井千恵子, 植松 瞳, 近藤和泉, 園田 茂
    OTジャーナル, 45 60-64, 2011  Peer-reviewed
  • 岡本さやか, 園田 茂, 谷野元一, 冨田 憲, 岡崎英人, 近藤和泉
    総合リハビリテーション, 20 89-92, 2011  Peer-reviewed
  • Yukina Kawahara, Shigeru Sonoda, Yuko Okuyama, Nami Nobotachi, Geniti Tanino, Makoto Watanabe, Rie Sakamoto, Toshio Teranishi
    Rigakuryoho Kagaku, 26(2) 297-302, Jan 1, 2011  Peer-reviewed
    [Purpose] In 2006, the upper limit of exercise time was increased from 6 to 9 units in our convalescent rehabilitation ward. We investigated the effect of this increase in training amount in relation to ADL. [Subjects] Subjects were discharged stroke patients of a convalescent rehabilitation ward: 122 who performed 5~6 exercise units in 2005, and 41 who performed 7~9 exercise units from April to September in 2008. [Method] We compared the total scores of the FIM motor items (FIM-M), the increase in FIM-M ((FIM-M: discharge score - admission score), FIM efficiency ((FIM-M/length of stay), and the discharge-to-home rate (Home%) between the two groups. [Results] The group who performed 7~9 exercise units had significantly higher ∂FIM-M, FIM efficiency and Home% than the group who performed 5~6 units. [Conclusion] We consider that the training increase effectively improved ADL.
  • Tokunaga M, Watanabe S, Nakanishi R, Yamanaga H, Sannomiya K, Hirata Y, Yamaga M, Terasaki T, Hashimoto Y, Sonoda S
    Jpn J Compr Rehabil Sci, 3 11-17, 2011  Peer-reviewed
  • Wada Y, Kondo I, Sonoda S, Yamada K, Narukawa A, Kawakami K, Nonoyama S, Miyasaka H, Teranishi T, Nagai S, Takeshima N
    Jpn J Compr Rehabil Sci, 2 71-76, 2011  Peer-reviewed
    Wada Y, Kondo I, Sonoda S, Yamada K, Narukawa A, Kawakami K, Nonoyama S, Miyasaka H, Teranishi T, Nagai S, Takeshima N: Mirror therapy for severely affected ankle joints of stroke patients. Jpn J Compr Rehabil Sci 2011; 2: 71-76.<br>Objective: This study investigated the improvement in dorsiflexion of severely affected ankle joints of first-stroke patients after mirror therapy.<br>Methods: Nine first-stroke patients participated in this study. A mirror was placed to reflect the non-paralyzed lower limb. A set of 50 dorsiflexion movements of the ankle joint was performed 4 times a day for 7 days. Foot functions of the Stroke Impairment Assessment Set (SIAS-F) and the foot-floor angle at active dorsiflexion were measured every 7 days starting from 14 days before initiation of the mirror therapy training to 7 days after, for a total of 5 times.<br>Results: SIAS-F did not differ among the cases before mirror therapy training. After the mirror therapy training, 5 of the 9 patients showed SIAS-F improvement. Significant differences were found between the scores at the beginning and at the end of the mirror therapy training, and between the scores at the beginning and 7 days after training. The mean foot-floor angle changed from 0 degrees at the beginning of training to 3.0 degrees at the end of training and 1.2 degrees 7 days after the training; however, these values did not differ significantly.<br>Conclusion: Significant improvement in dorsiflexion of the ankle joint, as measured by SIAS-F, was achieved with mirror therapy.
  • Kawarada S, Kondo I, Sonoda S, Yokoyama E, Tazawa Y, Yabunaka Y
    Jpn J Compr Rehabil Sci, 2 82-88, 2011  Peer-reviewed
  • Nagai S, Sonoda S, Miyai I, Kakehi A, Goto S, Takayama Y, Ota T, Itoh I, Yamamoto S, Takizawa Y, Kaku K, Inoue Y, Ishikawa M
    Jpn J Compr Rehabil Sci, 2 77-81, 2011  Peer-reviewed
  • Ota K, Saitoh E, Kagaya H, Sonoda S, Shibata S
    Jpn J Compr Rehabil Sci, 2 36-41, 2011  Peer-reviewed
  • Miyasaka H, Kondo I, Kato H, Takahashi C, Uematsu H, Yasui C, Tani A, Miyata M, Wada N, Teranishi T, Wada Y, Sonoda S
    Jpn J Compr Rehabil Sci, 2 24-30, 2011  Peer-reviewed
    Miyasaka H, Kondo I, Kato H, Takahashi C, Uematsu H, Yasui C, Tani A, Miyata M, Wada N, Teranishi T, Wada Y, Sonoda S. Assessment of the content validity of Functional Skills Measure after Paralysis with nominal group discussion and revision of its content. Jpn J Compr Rehabil Sci 2011; 2: 24-30<br>Purpose: The purposes of this study were to assess the content validity of Functional Skills Measure after Paralysis (FSMAP) and to revise its content to make it appropriate for use in the clinical setting.<br>Methods: Eight occupational therapists (OTs) participated in the questionnaire study. Nominal Group Technique (NGT) was used to measure the content validity. Before using the NGT, we set an 80% agreement as the criterion for consent. If the agreement for an item did not reach this level and the item’s content validity was not high enough, we revised its content. We repeated the same assessment for the revised FSMAP by using a questionnaire.<br>Results: In the first assessment, 8 out of 15 items (including the subitems and descriptions) did not reach the predetermined agreement level. In the second assessment, 1 out of 15 items did not reach the agreement level. We finished the assessment process because we judged that the content validity of FSMAP reached a satisfactory level after the revision of this item.<br>Discussion: We think that FSMAP should be revised to make it appropriate for use in the clinical setting after assessing its content validity.
  • Yosuke Wada, Izumi Kondo, Shigeru Sonoda, Hiroyuki Miyasaka, Toshio Teranishi, Shota Nagai, Eiichi Saitoh
    AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION, 89(8) 683-687, Aug, 2010  Peer-reviewed
    The purpose of this study was to determine whether high-speed treadmill training improved the gait velocity of patients whose maximum walking speed was assumed to have reached a plateau level. The subjects included seven patients with hemiplegia after stroke. The high-speed treadmill training was performed as the maximum gait velocity of each patient was presumed to have reached a plateau level. The patients walked 20% faster than their maximum gait velocity of the day for 5 days (phase I). Then they walked 20% slower than maximum gait velocity of the day for 5 days, and they repeated the fast treadmill walking for further 5 days (phase II). Before phase I, mean maximum gait velocity of the day was 0.84 m/sec before phase I, 1.08 m/sec after phase I, and 1.24 m/sec after phase II. These results demonstrated that training at a speed 20% faster than the maximum gait velocity of the day on the treadmill for 5 days could further increase a patient&apos;s gait velocity.
  • 澤 俊二, 園田 茂, 伊佐地 隆, 大仲 功一, 安岡 利一, 山川 百合子, 金田 嘉清, 才藤 栄一, 大田 仁史
    The Japanese Journal of Rehabilitation Medicine, 47(Suppl.) S162-S162, Apr, 2010  
  • Kenmei Mizutani, Shigeru Sonoda, Nobuhiro Hayashi, Akihiko Takasaki, Hidehiko Beppu, Eiichi Saitoh, Kan Shimpo
    AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION, 89(2) 107-114, Feb, 2010  Peer-reviewed
    Objective: To investigate the relation between protein expression changes in the cerebellum and improvement of motor coordination in rats with cerebral infarction. Design: The rat group with treadmill training (n = 10) were compared with the rat group without treadmill training (n = 10) after 2.5 hrs of transient middle cerebral artery occlusion.. Motor performance measured by the rotarod test and alteration of protein expression using two-dimensional electrophoresis based on proteomics in the cerebellum were examined. Results: In behavioral evaluation, the mean latency until falling from the rotating rod in the group with treadmill training was significantly longer (P &lt; 0.01) than that in the group without treadmill training 24 days after surgery. As for protein expression, it was revealed by proteome analysis and Western blotting that the expression of the two protein spots, 25-kDa synaptosomal-associated protein and glial fibrillary acidic protein, were significantly enhanced in the cerebellum of rats with treadmill training than that in rats without a treadmill training. Conclusions: The 25-kDa synaptosomal-associated protein and glial fibrillary acidic protein may be related to the underlying mechanisms of improvement of motor coordination and exercise-induced angiogenesis, that is, remodeling of synaptic connections and proliferation of astroglial cells, respectively.
  • 別府秀彦, 松本美富士, 藤野槌美, 菊池基雄, 井谷功典, 角藤年昭, 東口高志, 鈴木康司, 千原 猛, 山口久美子, 園田 茂, 新保 寛
    日本食品新素材研究会誌, 13 43-54, 2010  Peer-reviewed
  • 國分実伸, 谷野元一, 中根純一, 鈴木 享, 園田 茂
    理学療法ジャーナル, 44 973-979, 2010  
  • 岡崎英人, 園田 茂, 宮坂裕之, 前田博士, 平野 哲
    臨床リハビリテーション, 19 1037-1042, 2010  
  • 園田 茂
    Medical Practice, 27 1717-1720, 2010  
  • NOBOTACHI Nami, SONODA Shigeru, OKUYAMA Yuko, KAWAHARA Yukina, WATANABE Makoto, TERANISI Toshio, SAKAMOTO Rie
    Jpn. J. Stroke, 32(4) 340-345, 2010  Peer-reviewed
    Background and Purpose: The relationship between increased exercise and improvement in motor paralysis in stroke patients was examined in relation to changes in the medical insurance system concerning rehabilitation.<br>Methods: Subjects were 122 stroke patients (6-session group) who performed 5 or 6 exercise sessions while the maximum number of exercise sessions permitted by medical insurance was 6 sessions (2 hours) and 45 patients (9-session group) who performed 7, 8, or 9 exercise sessions while the upper limit was 9 session. They underwent subacute rehabilitation in the Kaifukuki rehabilitation ward. Five motor items of the Stroke Impairment Assessment Set (SIAS) were evaluated on admission and at discharge and were compared between the two groups. We also performed a stratified analysis by degree of paralysis on admission.<br>Results: SIAS motor scores were higher in the 9-session group than in the 6-unit group before stratification. When we restricted the analysis to patients with moderate lower extremity paralysis or mild upper extremity paralysis on admission, SIAS motor scores at discharge and the increase in these scores were higher in the 9-unit group than in the 6-unit group.<br>Conclusions: Increasing the number of exercise sessions from 6 to 9 sessions per day improved motor paralysis.
  • The Japanese journal of occupational therapy, 44(6) 489-494, 2010  Peer-reviewed
  • 園田 茂, 伊藤陽子
    リハビリナース, 3 396-405, 2010  
  • 園田 茂
    リハビリテーション医学, 47 347-349, 2010  
  • 近藤和泉, 才藤栄一, 園田 茂
    綜合臨床, 59(増刊) 717-720, 2010  
  • Yuko Okuyama, Shigeru Sonoda, Shota Nagai, Genichi Tanino, Namin Nobotachi, Rie Sakamoto, Yayoi Yanohara, Mari Kikuchi, Yukina Kawahara
    Rigakuryoho Kagaku, 25(2) 275-280, 2010  Peer-reviewed
    Purpose: We examined the perception held in clinical practice, that the greater the number of exercise units the better the outcome in a retrospective survey which investigated the relationship between Activities of Daily Living (ADL) outcome and the number of exercise units performed in exercise limited to 2 hours, with the objective of obtaining basic data for studies of the effects of exercise limits of 3 hours. Subjects: The subjects were 362 patients who were admitted and discharged from the Recovery Stage Rehabilitation Ward of the Fujita Health University Nanakuri Sanatorium in 2005. [Method] We examined the total number of occupational and physical therapy exercise units during the hospital stay and calculated the daily average, analyzed the discharge to home rate and investigated their correlation with the Motor Items Score of the Functional Independence Measure (FIM-M) and the return to home rate. Results: Total exercise units was negatively correlated with FIM-M at admission and discharge from the ward, and gain in FIM-M showed a positive correlation. The group which performed on average 5-6 units per day did not show better results compared to those performing less, but they had a higher return to home rate. Conclusion: Performing the upper limit of exercise (6 units) did not always lead to a high ADL outcome. When investigating the relationship between exercise dose and outcome, the effects of restrictions of exercise dose and lifestyle when not at exercise should also be considered.
  • 別府秀彦, 井上 孝, 金児孝晃, 川井 薫, 田口義浩, 藤田孝輝, 鈴木康司, 木村麻美, 柳澤昌実, 山口久美子, 土井直子, 三木潤子, 石井嘉時, 園田 茂, 新保 寛
    機能食品と薬理栄養, 6 147-156, 2010  Peer-reviewed
  • WADA Yosuke, SONODA Shigeru, NAGAI Shota, KOKUBU Minobu, OKUYAMA Yuko, KAWAKITA Minako, TERANISHI Toshio, KONDO Izumi
    Jpn. J. Stroke, 32(2) 138-145, 2010  Peer-reviewed
    Background and Purpose: This study compared the usefulness of different durations and intensities of rehabilitation training based on changes in activities of daily living (ADL) observed 18 months after discharge of stroke patients who had participated in the FIT (full-time integrated treatment) program.<br>Methods: 1) Subjects in the traditional rehabilitation system (Pre-FIT group) included 49 patients (mean age: 63.3±10.9 years old) who received standard training 5 days a week, 2). Subjects in the FIT program (FIT group) included 81 patients (mean age: 61.1±12.8 years old) who received short-term intensive training 7 days a week. The ADL of these patients was assessed by Functional Independence Measure (FIM). We used mainly the motor subscore of FIM (FIM-M) to analyze the course of changes in the ADL level.<br>Results: The average hospital stay in the FIT group was significantly shorter than that in the Pre-FIT group (Pre-FIT group: 91.8±27.9 days, FIT group: 78.2±41.8 days). Average score of FIM-M in the Pre-FIT group 18 months after discharge (64.0±23.4) was significantly smaller than that in the FIT group (71.8±19.3). The FIM-M score decreased significantly after discharge in both groups (Pre-FIT group: -4.7, FIT group: -3.8).<br>Conclusions: The advantage of the FIT group over Pre-FIT group in ADL gain was maintained even 18 month after discharge. A further study will be required to determine the optimal duration and intensity of training in the FIT program.
  • 宮坂裕之, 近藤和泉, 安井千恵子, 加藤啓之, 植松 瞳, 谷 明奈, 宮田幹子, 寺西利生, 和田陽介, 園田 茂
    総合リハビリテーション, 38 65-71, 2010  Peer-reviewed
  • Shota Nagai, Yuko Okuyama, Shigeru Sonoda, Osamu Nitta, Nami Nobotachi, Rie Sakamoto, Toshio Teranishi, Yoshikiyo Kanada
    Rigakuryoho Kagaku, 25(1) 1-6, 2010  Peer-reviewed
    [Purpose] In this study, in order to establish the clinical path for Activities of Daily Living (ADL) training, and utilizing Functional Independence Measure (FIM) we estimated the predictable goals (independence levels) of individual items of ADL and the time it would take to achieve them. [Subjects] The subjects were 1,479 hospitalized stroke patients admitted to a rehabilitation ward in the recovery period. [Method] Based on the totals of the FIM motor item scores on admission (FIMM), the patients were divided into 9 groups, and for each group, for each of the individual items of FIMM, we calculated the percentage of patients achieving independence, and analyzed the times needed to achieve independence. [Results] The degree of disability in ADL on admission shows characteristics of achievement of independence and time to achieve independence [Conclusion] These results suggest that knowing a combination of these could serve as an index for ADL training of hospitalized hemiplegic stroke patients in rehabilitation wards in the recovery period.
  • Takeshi Chihara, Kan Shimpo, Takaaki Kaneko, Hidehiko Beppu, Kenmei Mizutani, Takashi Higashiguchi, Shigeru Sonoda
    ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 11(5) 1301-1304, 2010  Peer-reviewed
    The scavenging capacity of reactive oxygen species, such as hydroxyl radicals, is reported not to decrease in boiled garlic (an odorless garlic preparation). We therefore examined the modifying effect of boiled garlic powder (BGP) on 1,2-dimethylhydrazine-induced mucin-depleted foci (MDF) and aberrant crypt foci (ACF), preneoplastic lesions, in the rat colorectum. Male F344 rats (5 weeks old) were fed a basal diet, or experimental diets containing 5% or 1% BGP for 5 weeks. One week later, all rats were injected s.c. with DMH (40 mg/kg, once weekly for 2 weeks). At 10 weeks of age, all the rats were sacrificed, and the colorectum was evaluated for MDF and ACF. In rats given DMH and the 5% or 1% BGP diets (Groups 2 and 3), the numbers of MDF decreased significantly in a dose-dependent manner, compared with the DMH and basal diet value (Group 1) (p &lt; 0.01). The numbers of ACF in Group 2, but not Group 3, showed a non-significant tendency to decrease. Next, the effects of BGP on the formation of DMH-induced O-6-methylguanine (O-6-MeG) DNA adducts in rats were studied. Male F344 rats (5 weeks old) were fed the basal diet, or 10% BGP diet for 5 weeks. All rats were injected i.p. once with 40 mg/kg DMH at the end of week 5. The animals were sacrificed 6 hours after DMH injection to analyze the O-6-MeG DNA adducts in the colorectal mucosa. Dietary administration of BGP significantly inhibited the O-6-MeG DNA adduct levels in the colorectal mucosa, compared with the controls (p &lt; 0.01). These results suggested that BGP may exert chemopreventive effects against colon carcinogenesis at least in the initiation stage.
  • Beppu H, Matsumoto Y, Fujino T, Itani Y, Sumitho T, Higashiguchi T, Chihara T, Tamai I, Shigeru S, Shimpo K
    J Anal Bio-Sci, 33 441-450, 2010  Peer-reviewed
  • Takahashi H, Bungo Y, Mikuni K, Beppu H, Ozaki S, Shimpo K, Itani Y, Sonoda S
    J Appl Glycosci, 57(3) 193-197, 2010  Peer-reviewed
    Coenzyme Q10 (CoQ10) is a well-known antioxidant agent that has low solubility in water and poor absorption in humans. CoQ10-cyclodextrin (CD) complex powders containing 20-24% (w/w) CoQ10 were prepared to investigate the effects of different CDs on three properties of CoQ10: aqueous solubility, heat of fusion, and absorption in humans. The aqueous solubility of CoQ10 was increased by α-CD and dextrin, while β-CD, γ-CD and β-Iso® formed an insoluble complex with CoQ10. β-CD, γ-CD and β-Iso® improved the thermal property of CoQ10, as determined by differential scanning calorimetry. That is, β-CD, γ-CD and β-Iso® most likely formed complexes with CoQ10, as the CoQ10 endothermic peak obtained by differential scanning calorimetry greatly decreased in the presence of these compounds. For the absorption studies, 20 healthy female volunteers were divided randomly into four groups and orally administered either CoQ10, the CoQ10-β-CD complex, CoQ10-γ-CD complex or CoQ10-β-Iso® complex containing 0.30 g CoQ10 under fasting conditions. The concentration of CoQ10 in plasma before and 2, 4, 6, 8 and 24 h after sample administration was measured by HPLC analysis, and the plasma concentration of exogenous CoQ10 was calculated as the plasma concentration of CoQ10 before administration subtracted from the value after administration. The area under the plasma exogenous CoQ10 concentration/time-course curve from 0 to 8 h of the three complex groups was significantly higher than that of the CoQ10 group, indicating that β-CD, γ-CD and β-Iso® accelerate the absorption of CoQ10 in humans.
  • Teranishi T, Kondo I, Sonoda S, Kagaya H, Wada Y, Miyasaka H, Tanino G, Narita W, Sakurai H, Okada M, Saitoh E
    Jpn J Compr Rehabil Sci, 1 11-16, 2010  Peer-reviewed
    Teranishi T, Kondo I, Sonoda S, Kagaya H, Wada Y, Miyasaka H, Tanino G, Narita W, Sakurai H, Okada M, Saitoh E. A discriminative measure for static postural control ability to prevent in-hospital falls: Reliability and validity of the Standing Test for Imbalance and Disequilibrium (SIDE). Jpn J Compr Rehabil Sci 2010; 1: 11-16<br>Purposes: To determine the reliability, validity, and clinical significance of the Standing Test for Imbalance and Disequilibrium (SIDE), a discriminative measure of standing balance, before using it to prevent falls in clinical settings.<br>Methods: In all, 30 patients (18 men and 12 women) with a mean (standard deviation) age of 57.4 (16.97) years (range, 25-85 years) who were admitted to the &ldquo;Kaifukuki&rdquo; rehabilitation ward voluntarily participated in this study. In the reliability study, 2 physiotherapists independently classified the level of static postural control ability by using SIDE. Functional balance control ability was simultaneously evaluated using the Berg Balance Scale (BBS). Cohen's &kappa; statistic was used to determine the inter-rater reliability, and the Spearman rank-correlation coefficient between the BBS score and SIDE level was used to determine the criterion-related validity.<br> Results: Inter-rater reliability of SIDE showed excellent reproducibility (Cohen's &kappa; statistic = 0.76). Criterion-related validity was very high between SIDE levels and BBS scores (Spearman rank-correlation coefficient = 0.93; p < 0.01).<br>Conclusion: SIDE can be used to efficiently and accurately classify balance control ability across individuals and has remarkable concurrent validity in balance evaluation compared to BBS.
  • 渡邉 誠, 園田 茂
    Monthly book medical rehabilitation, (112) 25-29, Nov, 2009  
  • 前田 博士, 園田 茂, 近藤 和泉, 鈴木 亨, 岡崎 英人, 岡本 さやか, 水野 志保, 名護 健, 沢田 光思郎, 平野 哲, 成田 渉, 寺西 利生, 奥山 夕子, 登立 奈美, 才藤 栄一
    The Japanese Journal of Rehabilitation Medicine, 46(Suppl.) S185-S185, May, 2009  
  • 澤 俊二, 園田 茂, 伊佐地 隆, 大仲 功一, 安岡 利一, 山川 百合子, 金田 嘉清, 才藤 栄一, 大田 仁史
    The Japanese Journal of Rehabilitation Medicine, 46(Suppl.) S337-S337, May, 2009  
  • 園田 茂, 岡本 さやか, 岡崎 英人
    Monthly book medical rehabilitation, (102) 18-23, Feb, 2009  
  • 新保 寛, 金児孝晃, 千原 猛, 別府秀彦, 新里昌功, 若松一雅, 園田 茂
    医学と生物学, 153 218-223, 2009  Peer-reviewed
  • 園田 茂, 宮井一郎, 永井将太, 山本伸一, 瀧澤泰樹, 伊藤 功, 今井稔也, 加来克幸, 後藤伸介, 高山優子, 筧 淳夫, 井上由起子, 石川 誠
    総合リハビリテーション, 37 453-460, 2009  Peer-reviewed
  • 岡本さやか, 園田 茂
    Current Therapy, 27 73-74, 2009  
  • 別府秀彦, 松本美富士, 渡邊治夫, 園田 茂, 近藤和泉, 中野達徳, 鈴木康司, 東口高志, 武重榮子, 水谷謙明, 土井直子, 新保 寛
    日本食品新素材研究会誌, 12 59-64, 2009  Peer-reviewed
  • 渡邊 進, 中川洋一, 上田 厚, 澤口由貴子, 木下牧子, 横山久代, 塩見 努, 岡田耕平, 三宮克彦, 園田 茂, 石川 誠
    臨床看護, 35 313-323, 2009  
  • 奥山夕子, 園田 茂
    PTジャーナル, 43 673-678, 2009  
  • 宮坂裕之, 近藤和泉, 河野光伸, 安井千恵子, 加藤啓之, 植松 瞳, 谷 明奈, 宮田幹子, 村岡慶裕, 園田 茂
    総合リハビリテーション, 37 945-950, 2009  Peer-reviewed

Presentations

 48

Research Projects

 18