Curriculum Vitaes

sonoda shigeru

  (園田 茂)

Profile Information

Affiliation
Professor, Department of Rehabilitation Medicine II, School of Medicine, Fujita Health University
Degree
DMSc(Keio University)

J-GLOBAL ID
200901019328012929
researchmap Member ID
1000228177

Physiatrist since 1985
President, Fujita Health University Nanakuri Memorial Hospital since 2003

Education

 1

Papers

 205
  • Emi Mizuno, Takayuki Ogasawara, Masahiko Mukaino, Masumi Yamaguchi, Shingo Tsukada, Shigeru Sonoda, Yohei Otaka
    JMIR formative research, 8 e51546, May 29, 2024  
    BACKGROUND: Motor impairments not only lead to a significant reduction in patient activity levels but also trigger a further deterioration in motor function due to deconditioning, which is an issue that is particularly pronounced during hospitalization. This deconditioning can be countered by sustaining appropriate activity levels. Activities that occur outside of scheduled programs, often overlooked, are critical in this context. Wearable technology, such as smart clothing, provides a means to monitor these activities. OBJECTIVE: This study aimed to observe activity levels in patients who had strokes during the subacute phase, focusing on both scheduled training sessions and other nontraining times in an inpatient rehabilitation environment. A smart clothing system is used to simultaneously measure heart rate and acceleration, offering insights into both the amount and intensity of the physical activity. METHODS: In this preliminary cohort study, 11 individuals undergoing subacute stroke rehabilitation were enrolled. The 48-hour continuous measurement system, deployed at admission and reassessed 4 weeks later, monitored accelerometry data for physical activity (quantified with a moving SD of acceleration [MSDA]) and heart rate for intensity (quantified with percent heart rate reserve). The measurements were performed using a wearable activity monitoring system, the hitoe (NTT Corporation and Toray Industries, Inc) system comprising a measuring garment (wear or strap) with integrated electrodes, a data transmitter, and a smartphone. The Functional Independence Measure was used to assess the patients' daily activity levels. This study explored factors such as differences in activity during training and nontraining periods, correlations with activities of daily living (ADLs) and age, and changes observed after 4 weeks. RESULTS: A significant increase was found in the daily total MSDA after the 4-week program, with the average percent heart rate reserve remaining consistent. Physical activity during training positively correlated with ADL levels both at admission (ρ=0.86, P<.001) and 4 weeks post admission (ρ=0.96, P<.001), whereas the correlation between age and MSDA was not significant during training periods at admission (ρ=-0.41, P=.21) or 4 weeks post admission (ρ=-0.25, P=.45). Conversely, nontraining activity showed a negative correlation with age, with significant negative correlations with age at admission (ρ=-0.82, P=.002) and 4 weeks post admission (ρ=-0.73, P=.01). CONCLUSIONS: Inpatient rehabilitation activity levels were positively correlated with ADL levels. Further analysis revealed a strong positive correlation between scheduled training activities and ADL levels, whereas nontraining activities showed no such correlation. Instead, a negative correlation between nontraining activities and age was observed. These observations suggest the importance of providing activity opportunities for older patients, while it may also suggest the need for adjusting the activity amount to accommodate the potentially limited fitness levels of this demographic. Future studies with larger patient groups are warranted to validate and further elucidate these findings.
  • Kenji Kawakami, Hiroyuki Miyasaka, Yuichi Hioki, Ayako Furumoto, Shigeru Sonoda
    International journal of rehabilitation research. Internationale Zeitschrift fur Rehabilitationsforschung. Revue internationale de recherches de readaptation, Apr 9, 2024  
    Practicing walking in a safety suspension device allows patients to move freely and without excessive reliance on a therapist, which requires correcting errors and may facilitate motor learning. This opens the possibility that patients with subacute stroke may improve their walking ability more rapidly. Therefore, we tested the hypothesis that overground gait training in a safety suspension device will result in achieving faster supervision-level walking than gait training without the suspension device. Twenty-seven patients with stroke admitted to the rehabilitation ward with functional ambulation categories (FAC) score of 2 at admission were randomly allocated to safety suspension-device group (SS group) or conventional assisted-gait training group (control group). In addition to regular physical therapy, each group underwent additional gait training for 60 min a day, 5 days a week for 4 weeks. We counted the days until reaching a FAC score of 3 and assessed the probability using Cox regression models. The median days required to reach a FAC score of 3 were 7 days for the SS group and 17.5 days for the control group, which was significantly different between the groups (P < 0.05). The SS group had a higher probability of reaching a FAC score of 3 after adjusting for age and admission motor impairment (hazard ratio = 3.61, 95% confidence interval = 1.40-9.33, P < 0.01). The gait training with a safety suspension device accelerates reaching the supervision-level walking during inpatient rehabilitation. We speculate that a safety suspension device facilitated learning by allowing errors to be experienced and correct in a safe environment.
  • Yoko Inamoto, Masahiko Mukaino, Sayuri Imaeda, Manami Sawada, Kumi Satoji, Ayako Nagai, Satoshi Hirano, Hideto Okazaki, Eiichi Saitoh, Shigeru Sonoda, Yohei Otaka
    JMIR formative research, 7 e42219, Feb 8, 2023  
    BACKGROUND: There is an extensive library of language tests, each with excellent psychometric properties; however, many of the tests available take considerable administration time, possibly bearing psychological strain on patients. The Short and Tailored Evaluation of Language Ability (STELA) is a simplified, tablet-based language ability assessment system developed to address this issue, with a reduced number of items and automated testing process. OBJECTIVE: The aim of this paper is to assess the administration time, internal consistency, and validity of the STELA. METHODS: The STELA consists of a tablet app, a microphone, and an input keypad for clinician's use. The system is designed to assess language ability with 52 questions grouped into 2 comprehension modalities (auditory comprehension and reading comprehension) and 3 expression modalities (naming and sentence formation, repetition, and reading aloud). Performance in each modality was scored as the correct answer rate (0-100), and overall performance expressed as the sum of modality scores (out of 500 points). RESULTS: The time taken to complete the STELA was significantly less than the time for the WAB (mean 16.2, SD 9.4 vs mean 149.3, SD 64.1 minutes; P<.001). The STELA's total score was strongly correlated with the WAB Aphasia Quotient (r=0.93, P<.001), supporting the former's concurrent validity concerning the WAB, which is a gold-standard aphasia assessment. Strong correlations were also observed at the subscale level; STELA auditory comprehension versus WAB auditory comprehension (r=0.75, P<.001), STELA repetition versus WAB repetition (r=0.96, P<.001), STELA naming and sentence formation versus WAB naming and word finding (r=0.81, P<.001), and the sum of STELA reading comprehension or reading aloud versus WAB reading (r=0.82, P<.001). Cronbach α obtained for each modality was .862 for auditory comprehension, .872 for reading comprehension, .902 for naming and sentence formation, .787 for repetition, and .892 for reading aloud. Global Cronbach α was .961. The average of the values of item-total correlation to each subscale was 0.61 (SD 0.17). CONCLUSIONS: Our study confirmed significant time reduction in the assessment of language ability and provided evidence for good internal consistency and validity of the STELA tablet-based aphasia assessment system.
  • Yu Takahashi, Hideaki Wakita, Takuma Ishihara, Hideto Okazaki, Akihiro Ito, Mitsunaga Iwata, Shigeru Sonoda, Yohei Doi
    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 29(1) 95-97, Jan, 2023  
    Healthcare-associated COVID-19 among vulnerable patients leads to disproportionate morbidity and mortality. Early pharmacologic intervention may reduce negative sequelae and improve survival in such settings. This study aimed to describe outcome of patients with healthcare-associated COVID-19 who received early short-course remdesivir therapy. We reviewed the characteristics and outcome of hospitalized patients who developed COVID-19 during an outbreak that involved two wards at a non-acute care hospital in Japan and received short-course remdesivir. Forty-nine patients were diagnosed with COVID-19, 34 on a comprehensive inpatient rehabilitation ward and 15 on a combined palliative care and internal medicine ward. Forty-seven were symptomatic and 46 of them received remdesivir. The median age was 75, and the median Charlson comorbidity index was 6 among those who received it. Forty-one patients had received one or two doses of mRNA vaccines, while none had received a third dose. Most patients received 3 days of remdesivir. Of the patients followed up to 14 and 28 days from onset, 41/44 (95.3%) and 35/41(85.4%) were alive, respectively. Six deaths occurred by 28 days in the palliative care/internal medicine ward and two of them were possibly related to COVID-19. Among those who survived, the performance status was unchanged between the time of onset and at 28 days.
  • Ken Tomida, Kei Ohtsuka, Toshio Teranishi, Hiroki Ogawa, Misaki Takai, Akira Suzuki, Kenji Kawakami, Shigeru Sonoda
    Fujita medical journal, 8(4) 121-126, Nov, 2022  
    OBJECTIVES: In stroke patients, the assessment of gait ability over time is important. For quantitative gait assessment using measuring devices, the walking speed condition for measurement is generally based on the patient's preferred walking speed or the maximum walking speed at the time of measurement. However, because walking speed often increases during the convalescent stage, understanding the effects of change in walking speed on gait when comparing the course of recovery is necessary. Although several previous studies have reported the effects of change in walking speed on gait in stroke patients, the time-distance parameters described in these reports may not be generalizable because of the small case numbers. Therefore, we measured treadmill gait at the preferred walking speed (PWS) and 1.3 times the PWS (130% PWS) in 43 post-stroke hemiplegic patients and analyzed the effects of change in walking speed on time-distance parameters. METHODS: Forty-three patients with hemiplegia after a first stroke, who were able to walk on a treadmill under supervision, were recruited as subjects. Using a three-dimensional motion analysis system, treadmill gait was assessed under two conditions: PWS and 130% PWS. The primary outcome measures were the time-distance parameters, which were compared between the PWS and 130% PWS conditions. RESULTS: Cadence, stride length, and step length of the affected and unaffected lower limbs increased significantly at 130% PWS compared with at PWS. In terms of actual time, single stance time and initial and terminal double stance time in both affected and unaffected limbs decreased significantly at 130% PWS. In terms of relative time (% of the gait cycle), compared with PWS, relative single stance time increased significantly, whereas relative initial and terminal double stance times decreased significantly at 130% PWS in both the affected and unaffected limbs. CONCLUSIONS: This study on treadmill gait in patients with hemiplegia after a first stroke confirmed the effects of change in walking speed on time-distance parameters. Our results will help in the interpretation of time-distance parameters measured under different walking speed conditions.

Misc.

 432
  • 澤 俊二, 千田 直人, 鈴木 めぐみ, 杉山 智, 山田 将之, 百田 貴洋, 酒野 直樹, 壹岐 英正, 片山 脩, 宮下 大典, 熊谷 純久, 園田 茂, 金田 嘉清, 才藤 栄一, 大田 仁史, 磯 博康
    The Japanese Journal of Rehabilitation Medicine, 51(Suppl.) S441-S441, May, 2014  
  • 平野 哲, 才藤 栄一, 園田 茂, 石原 健, 大塚 圭, 田辺 茂雄, 加藤 正樹, 伊藤 慎英, 谷野 元一, 山田 純也, 鴻巣 仁司
    The Japanese Journal of Rehabilitation Medicine, 51(Suppl.) S462-S462, May, 2014  
  • 別府 秀彦, 岡崎 英人, 玉井 育子, 水谷 謙明, 尾関 保則, 井谷 功典, 富田 豊, 宮坂 裕之, 谷野 元一, Abbas Orand, 千原 猛, 新保 寛, 園田 茂
    生物試料分析, 37(1) 77-77, Feb, 2014  
  • 堀和朗, 谷野元一, 高橋亮吾, 加賀谷斉, 尾崎健一, 園田茂
    日本ニューロリハビリテーション学会学術集会プログラム・抄録集, 5th 55, Feb 1, 2014  
  • 土山和大, 谷野元一, 堀和朗, 加賀谷斉, 尾崎健一, 園田茂
    日本ニューロリハビリテーション学会学術集会プログラム・抄録集, 5th 55, Feb 1, 2014  
  • Kenmei Mizutani, Shigeru Sonoda, Hideaki Wakita, Yoshimitsu Katoh, Kan Shimpo
    NEUROLOGICAL SCIENCES, 35(1) 53-59, Jan, 2014  Peer-reviewed
    Recently, it has become widely known that rehabilitative training after stroke brings about some improvement of paralysis and disability; however, not much is known about the relationship between paralysis recovery and the participation of plasticity-related molecules. Hence, the localization and level of expression of several proteins in the cerebral cortex of rat groups with/without voluntary exercise using a running wheel after photo thrombotic infarction were examined in this study. In behavioral evaluation, the mean latency until falling from a rotating rod in the group with voluntary exercise at 6 days after infarction was significantly longer than that in the group without exercise. Immunohistochemical localization of c-Fos protein after behavioral test occurred in the area surrounding the infarction core in the exercise group. In protein expression analysis, protein kinase C (PKC), growth-associated protein 43 (GAP43) and phosphorylated at serine 41 GAP43 (p-GAP43) were significantly increased after voluntary exercise compared with those in rats without exercise. Expression of PKC immunoreactivity was observed in layer III of the perilesional cortex in rats with exercise, and the intracellular localization in the pyramidal neurons was mainly translocated to the plasma membrane. The expression and localization of these proteins may be related to the underlying mechanisms of exercise-induced paralysis recovery, that is, neuronal plasticity and remodeling of cortical connections through the phosphorylation of GAP43 by interaction with PKC. In the present study, the participation of at least some of the modulators associated with the improvement of motor deficit adjacent to the brain lesion might have been detected.
  • Abbas Orand, Hiroyuki Miyasaka, Yutaka Tomita, Genichi Tanino, Shigeru Sonoda
    SOMATOSENSORY AND MOTOR RESEARCH, 31(2) 72-77, 2014  Peer-reviewed
    Wavelet transform energy analyses of the mean and standard error of the electromyogram (EMG) and electroencephalogram (EEG) of eight subjects were investigated in passive movement mirror therapies with no delay (in-phase) and with delay (out-of-phase) situations in two frequency bands of 7.81-15.62 and 15.62-31.25 Hz. It was found that the energy levels of EEG at electrode C4 in the in-phase situation were lower than those in out-of-phase situations, while the energy levels of flexor and extensor forearm muscle groups were larger. With two exceptions, this pattern could be seen in all other subjects. The difference between the in-phase (D0) and out-of-phase situations (D025 and D05) for the frequency range of 15.62-31.25 Hz was found to be significant at a significance level of 0.05 (paired t-test analysis). The respective elevation and decline of EEG and EGM with regard to the increase of the delay may indicate the necessity for synchronization of passive movement and mirror therapy.
  • Abbas Orand, Sayaka Okamoto, Yutaka Tomita, Hiroyuki Miyasaka, Genichi Tanino, Shigeru Sonoda
    BIOMEDICAL ENGINEERING ONLINE, 12 104, Oct, 2013  Peer-reviewed
    Background: To apply advanced methods of communication, sensing, and instrumentation technologies to make a system that can help patients suffering from hemispatial neglect caused by higher cortical function disorder. Method: By using several sensors and actuators, the objective was to construct a tailor-made system for each patient. The input part of the system consists of sensors, an interface and transmitters. The output part consists of a receiver, logical arithmetic, an output interface and actuators. The information from the input part is sent to the output part in a wireless manner allowing the mobility of the input and output parts. Results: The system and its functionality were realized. Voice alarming and neck muscle stimuli were applied to two patients. We could verify the applicability of the system to remind the patients to put on their wheelchair's brake and raise its footrest before attempting to stand for transferring to their beds. Conclusion: The designed and constructed multi-input/output system can be used effectively to alarm the patients.
  • Naoki Takayanagi, Hidehiko Beppu, Kenmei Mizutani, Yutaka Tomita, Shizuko Nagao, Shoichi Suzuki, Abbas Orand, Hisahide Takahashi, Shigeru Sonoda
    JOURNAL OF NEUROSCIENCE METHODS, 219(1) 162-168, Sep, 2013  Peer-reviewed
    Background: Although different gait analysis methods such as Walking Track Analysis exist, they cannot be used to demonstrate the physical condition of mice with specific gait disorder characteristic. Therefore, we developed a new method for the gait analysis of such mice to accurately assess hind limb angle based on the pelvic axis. New method: We established and verified a gait analysis method capable of pelvic axis-based limb angle measurement by video-recording the gait of a control mice group (C57BL/6J(B6)) and three ataxic mice (ataxic B6-wob/t, Parkinson's disease model (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treated (MPTP)), and cerebellum hypoplasia (cytosine-beta-D-arabinofuranoside treated)) from the ventral side. Results: The assessed hind limb angles of B6-wob/t and MPTP-treated mice were significantly wider than B6 mice (p&lt;0.01). Moreover, we could draw separating lines with slopes of minus one that could separate the data of each group in-the scatter plot of the normalized hind limb step width and angle. Comparison with existing methods: We found no significance when we applied the already existing nose-tail method for the analysis of the hind limb angles of B6 and B6-woblt mice. In the nose-tail method, since the whole body axis of the trunk varies while the trunk of the mouse is laterally bent changing the hind limb angle, B6 and B6-wob/t mice could not be differentiated. However, the two mice groups could be differentiated by the pelvic axis-based gait analysis method. Conclusion: The pelvic axis-based gait analysis method is promising and valid for mice with gait disorder. (C) 2013 Elsevier B.V. All rights reserved.
  • 尾崎 幸恵, 園田 茂, 富田 豊, 大橋 綾乃, 宮坂 裕之, 尾崎 健一, 加賀谷 斉, 岡本 さやか
    The Japanese Journal of Rehabilitation Medicine, 50(Suppl.) S257-S257, May, 2013  
  • 澤 俊二, 園田 茂, 伊佐地 隆, 大仲 功, 安岡 利一, 山川 百合子, 金田 嘉清, 才藤 栄一, 大田 仁史
    The Japanese Journal of Rehabilitation Medicine, 50(Suppl.) S398-S398, May, 2013  
  • 尾関保則, 加賀谷斉, 藤井航, 前島伸一郎, 岡本さやか, 田中貴志, 園田茂
    日本摂食嚥下リハビリテーション学会学術大会抄録集(Web), 19th SO1-4-1-9 (WEB ONLY), 2013  
  • 尾崎 幸恵, 園田 茂, 岡本 さやか, 富田 豊, 宮坂 裕之, 大橋 綾乃, 尾崎 健一, 加賀谷 斉
    The Japanese Journal of Rehabilitation Medicine, 50(1) 56-56, Jan, 2013  
  • 藤村健太, 渡邉誠, 佐々木祥, 奥山夕子, 園田茂
    日本作業療法学会抄録集(CD-ROM), 47th ROMBUNNO.P060-RE, 2013  
  • 亀井恵, 宮坂裕之, 中川裕規, 田中絵梨, 横井亜耶, 佐藤裕美, 清水洋毅, 藤村健太, 中原亜美, 園田茂
    回復期リハビリテーション病棟協会研究大会プログラム・抄録集, 21st 148, 2013  
  • 徳永 誠, 渡邊 進, 中西亮二, 山永裕明, 米満弘之, 川野眞一, 箕田修治, 鬼木泰博, 寺崎修司, 平田好文, 山鹿眞紀夫, 橋本洋一郎, 園田 茂
    臨床リハビリテーション, 22 208-213, 2013  Peer-reviewed
  • HIRANO Satoshi, SAITOH Eiichi, SONODA Shigeru, OTSUKA Kei, ITOH Norihide, KATO Masaki, TANABE Shigeo, KONOSU Hitoshi, UNO Akihito, TAKEMITSU Tomohiko
    Bulletin of the Japanese Society of Prosthetic and Orthotic Education, Research and Development, 29(2) 90-97, 2013  
    Japan is entering the era of the unprecedented super-aged society. We will have many elderly and disabled people. In this situation, the emergence of rehabilitation robotics is highly anticipated. Fujita Health University is developing five kinds of rehabilitation robots ; (1) WPAL is a new gait-assist robot which reconstructs practical walking in paraplegics. (2) Independent Gait Assist is designed to assist patients with hemiplegia or lower extremity monoplegia to walk safely and comfortably. (3) Gait Exercise Assist is the robot which provides new and effective gait exercise for stroke patients with hemiplegia. (4) Balance Exercise Assist produces new balance exercises which have a lot of merits from the viewpoint of motor-learning. (5) Transfer Care Assist is aimed at reducing the physical load of caregivers, assisting the transfer and toileting of patients. Rehabilitation robots are just being realized.
  • 宇佐見千恵子, 宮坂裕之, 植松 瞳, 近藤和泉, 富田 豊, 園田 茂
    脳卒中, 35 174-179, 2013  Peer-reviewed
  • Teranishi T, Kondo I, Tanino G, Miyasaka H, Sakurai H, Kaga J, Suzuki Y, Matsushima A, Kawakita M, Sonoda S
    Jpn J Compr Rehabil Sci, 4 7-13, 2013  Peer-reviewed
  • Beppu H, Mizutani K, Takayanagi N, Shinzato M, Sonoda S, Takahashi H
    Keitai Kino, 11 92-100, 2013  Peer-reviewed
  • Chihara T, Shimpo K, Kaneko T, Tomatsu A, Beppu H, Higashiguchi T, Sonoda S
    J Anal Bio-Sci, 36 186-192, 2013  Peer-reviewed
  • Shinzato M, Beppu H, Mizutani K, Sonoda S, Katafuchi T, Ifuku M, Hanada M, Takayanagi N, Yamaguchi K, Nakagawa H, Watanabe Y
    Keitai Kino, 12 10-18, 2013  Peer-reviewed
  • Takeshi Chihara, Kan Shimpo, Hidehiko Beppu, Akiko Tomatsu, Takaaki Kaneko, Miyuki Tanaka, Muneo Yamada, Fumiaki Abe, Shigeru Sonoda
    Asian Pacific Journal of Cancer Prevention, 14(7) 4435-4440, 2013  Peer-reviewed
    Aloe vera gel supercritical CO2 extract (AVGE) has been shown to contain five phytosterols, reduce visceral fat accumulation, and influence the metabolism of glucose and lipids in animal model experiments. Recent epidemiologic studies have shown that obesity is an established risk factor for several cancers including colorectal cancer. Therefore, we examined the effects of AVGE on intestinal polyp formation in Apc-deficient Min mice fed a high-fat diet. Male Min mice were divided into normal diet (ND), high fat diet (HFD), low dose AVGE (HFD+LAVGE) and high dose AVGE (HFD+HAVGE) groups. The ND group received AIN-93G diet and the latter 3 groups were given modified high-fat AIN-93G diet (HFD) for 7 weeks. AVGE was suspended in 0.5% carboxymethyl cellulose (CMC) and administered orally to mice in HFD+LAVGE and HFD+HAVGE groups every day (except on Sunday) for 7 weeks at a dose of 3.75 and 12.5 mg/kg body weight, respectively. ND and HFD groups received 0.5% CMC alone. Between weeks 4 and 7, body weights in the HFD and HFD+LAVGE groups were reduced more than those in the ND group. However, body weights were not reduced in the HFD+HAVGE group. Mice were sacrificed at the end of the experiment and their intestines were scored for polyps. No significant differences were observed in either the incidence and multiplicity of intestinal polyps (≤0.5 mm in a diameter) among the three groups fed HFD. However, when intestinal polyps were categorized by their size into 0.5-1.4, 1.5-2.4, or ≥2.5 mm, the incidence and multiplicity of large polyps (≥2.5 mm) in the intestine in the HFD+HAVGE group were significantly lower than those in the HFD group. We measured plasma lipid (triglycerides and total cholesterol) and adipocytokine [interleukin-6 and high molecular weight (HMW) adiponectin] levels as possible indicators of mechanisms of inhibition. The results showed that HMW adiponectin levels in the HFD group were significantly lower than those in the ND group. However, the levels in the HFD+HAVGE group were significantly higher than those in the HFD group. These results indicate that HAVGE reduced large-sized intestinal polyps and ameliorated reduction in plasma HMW adiponectin levels in Min mice fed HFD.
  • Okazaki H, Beppu H, Mizutani K, Sonoda S
    Jpn J Compr Rehabil Sci, 4 84-87, 2013  Peer-reviewed
  • 田中絵梨, 園田茂, 成田渉, 宮坂裕之, 中川裕規, 川上さつき, 林美帆, 亀井恵, 横井亜耶, 清水洋毅, 藤村健太, 中原亜美
    日本高次脳機能障害学会学術総会プログラム・講演抄録, 36th 188, Oct 17, 2012  
  • 伴野 千尋, 松森 美致世, 川上 健司, 田中 和加奈, 柴田 奈津紀, 岡本 美波, 小西 美緒, 園田 茂
    三重県理学療法学会, 23回 20-21, May, 2012  
  • 栗田 紗江, 大橋 綾乃, 高橋 亮吾, 土山 和大, 谷野 元一, 尾崎 幸恵, 加賀谷 斉, 尾崎 健一, 富田 豊, 園田 茂
    三重県理学療法学会, 23回 48-49, May, 2012  
  • 尾崎 幸恵, 富田 豊, 園田 茂, 大橋 綾乃, 宮坂 裕之, 尾崎 健一, 加賀谷 斉, 岡崎 英人, 岡本 さやか
    The Japanese Journal of Rehabilitation Medicine, 49(Suppl.) S249-S249, May, 2012  
  • 澤 俊二, 園田 茂, 伊佐地 隆, 大仲 功一, 安岡 利一, 山川 百合子, 金田 嘉清, 才藤 栄一, 大田 仁史
    The Japanese Journal of Rehabilitation Medicine, 49(Suppl.) S200-S200, May, 2012  
  • 永井将太, 園田 茂, 宮井一郎, 筧 淳夫, 後藤伸介, 高山優子, 太田利夫, 伊藤 功, 山本伸一, 瀧澤泰樹, 加来克幸, 井上由起子, 石川 誠
    Japanese Journal of Comprehensive Rehabilitation Science, 2 77-81, 2012  
  • 加藤啓之, 宮坂裕之, 安井千恵子, 中西千佳子, 近藤和泉, 園田 茂
    OTジャーナル, 46 286-291, 2012  Peer-reviewed
  • Ken Tomida, Shigeru Sonoda, Genichi Tanino, Sayaka Okamoto, Shota Nagai, Yousuke Wada, Toshio Teranishi
    Rigakuryoho Kagaku, 27(1) 1-5, 2012  Peer-reviewed
    [Purpose] We administered anabolic steroids (AS) to hemiplegic stroke patients and investigated the effect of the AS treatment in combination with general physical and occupational therapy focusing on gait and activities of daily living. [Subjects] The subjects were 19, initial onset, hemiplegic stroke patients who were in the recovery rehabilitation ward of our hospital. [Method] The subjects were randomly assigned to an AS treatment group (AS group) and a control group which did not receive AS. We measured isokinetic knee extension torque as the lower limb strength of the affected side. The intervention period was 6 weeks, and we compared the progress of lower limb strength of the two groups. [Results] In the study of all cases, no significant difference was found between the two groups in rate of muscle strength increase. However, for the cases with only slight paralysis, the muscle strength of the AS group had increased significantly compared to the control group after 6 weeks. [Conclusion] The results suggest administration of AS augments lower limb muscle strength of the affected side of hemiplegic stroke patients with slight paralysis.
  • 園田 茂
    The Bone, 26 33-37, 2012  
  • 西山貴子, 園田 茂
    臨床リハビリテーション, 21 157-162, 2012  
  • SAITOH Eiichi, YOKOTA Motomi, HIRANO Asuka, OHTSUKA Kei, SONODA Shigeru
    Bulletin of the Japanese Society of Prosthetic and Orthotic Education, Research and Development, 28(2) 87-92, 2012  
  • 園田 茂
    総合リハビリテーション, 40 1073-1076, 2012  
  • 谷野美奈, 渡邊豊明, 坂本利恵, 宮坂裕之, 澤 俊二, 園田 茂
    OTジャーナル, 46 1577-1581, 2012  Peer-reviewed
  • 渡邉 誠, 奥山夕子, 登立奈美, 川原由紀奈, 木下恵子, 佐々木祥, 辻有佳子, 園田 茂
    脳卒中, 34 383-390, 2012  Peer-reviewed
  • 尾崎幸恵, 園田 茂, 岡崎英人, 平野 哲, 岡本さやか
    臨床リハビリテーション, 21 1235-1238, 2012  Peer-reviewed
  • Tokunaga M, Watanabe S, Nakanishi R, Yamanaga H, Kawasaki M, Hirata Y, Yamaga M, Terasaki T, Hashimoto Y, Sonoda S
    Jpn J Compr Rehabil Sci, 3 26-31, 2012  Peer-reviewed
  • Tokunaga M, Yonemura M, Inoue R, Sannomiya K, Nakashima Y, Watanabe S, Nakanishi R, Yamanaga H, Yonemitsu H, Sonoda S
    Jpn J Compr Rehabil Sci, 3 32-36, 2012  Peer-reviewed
  • Tokunaga M, Sannomiya K, Watanabe S, Nakanishi R, Yamanaga H, Yonemitsu H, Terasaki T, Mita S, Kawano S, Hirata Y, Yamaga M, Hashimoto Y, Sonoda S
    Jpn J Compr Rehabil Sci, 3 51-58, 2012  Peer-reviewed
  • Takahashi H, Kishino E, Mikuni K, Kiuchi Y, Beppu H, Okazaki H, Shimpo K, Sonoda S
    J Appl Glycosci, 59 97-103, 2012  Peer-reviewed
  • Takaaki Kaneko, Kan Shimpo, Takeshi Chihara, Hidehiko Beppu, Akiko Tomatsu, Masanori Shinzato, Takamasa Yanagida, Tsutomu Ieike, Shigeru Sonoda, Akihiko Futamura, Akihiro Ito, Takashi Higashiguchi
    ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 13(5) 1983-1988, 2012  Peer-reviewed
    High temperature- and pressure-treated garlic (HTPG) has been shown to have enhanced antioxidative activity and polyphenol contents. Previously, we reported that HTPG inhibited 1,2-dimethylhydrazine-induced mucin depleted foci (premalignant lesions) and O-6-methylguanine DNA adduct formation in the rat colorectum. In the present study, we investigated the modifying effects of HTPG on N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG)-induced pyloric stomach and small intestinal carcinogenesis in mice. Male C57BL/6 mice were given ENNG (100 mg/l) in drinking water for the first 4 weeks, then a basal diet or diet containing 2% or 5% HTPG for 30 weeks. The incidence and multiplicity of pyloric stomach and small intestinal (duodenal and jejunal) tumors in the 2% HTPG group (but not in the 5% HTPG group) were significantly lower than those in the control group. Cell proliferation of normal-appearing duodenal mucosa was assessed by MIB-5 immunohistochemistry and shown to be significantly lower with 2% HTPG (but again not 5% HTPG) than in controls. These results in dicate that HTPG, at 2% in the diet, inhibited ENNG-induced pyloric stomach and small intestinal (especially duodenal) tumorigenesis in mice, associated with suppression of cell proliferation.
  • 林美帆, 宮坂裕之, 中川裕規, 川上さつき, 田中絵梨, 清水洋毅, 藤村健太, 富田豊, 園田茂
    リハビリテーション・ケア合同研究大会, 2011 157, Oct 27, 2011  
  • Kenmei Mizutani, Shigeru Sonoda, Keiki Yamada, Hidehiko Beppu, Kan Shimpo
    BRAIN RESEARCH, 1416 61-68, Oct, 2011  Peer-reviewed
    Identification of functional molecules in the brain related to improvement of the degree of paralysis or increase of activities will contribute to establishing a new treatment strategy for stroke rehabilitation. Hence, protein expression changes in the cerebral cortex of rat groups with/without voluntary exercise using a running wheel after cerebral infarction were examined in this study. Motor performance measured by the accelerated rotarod test and alteration of protein expression using antibody microarray analysis comprised 725 different antibodies in the cerebral cortex adjacent to infarction area were examined. In behavioral evaluation, the mean latency until falling from the rotating rod in the group with voluntary exercise for five days was significantly longer than that in the group without voluntary exercise. In protein expression profile, fifteen proteins showed significant quantitative changes after voluntary exercise for five days compared to rats without exercise. Up-regulated proteins were involved in protein phosphorylation, stress response, cell structure and motility, DNA replication and neurogenesis (11 proteins). In contrast, down-regulated proteins were related to apoptosis, cell adhesion and proteolysis (4 proteins). Additional protein expression analysis showed that both growth-associated protein 43 (GAP43) and phosphorylated serine41 GAP43 (pSer41-GAP43) were significantly increased. These protein expression changes may be related to the underlying mechanisms of exercise-induced paralysis recovery, that is, neurite formation, and remodeling of synaptic connections may be through the interaction of NGF, calmodulin, PKC and GAP43. In the present study at least some of the participation of modulators associated with the improvement of paralysis might be detected. (C) 2011 Elsevier B.V. All rights reserved.
  • Toshio Teranishi, Izumi Kondo, Shigeru Sonoda, Yosuke Wada, Hiroyuki Miyasaka, Genichi Tanino, Wataru Narita, Hiroaki Sakurai, Makoto Okada, Eiichi Saitoh
    GAIT & POSTURE, 34(3) 295-299, Jul, 2011  Peer-reviewed
    The standing test for imbalance and disequilibrium (SIDE) is a discriminative measure developed for the purpose of identifying balance deficits that may cause falls. The purpose of the present study was to determine the validity of the sequence of postures used in SIDE. Subjects comprised 30 men with a mean (+/- standard deviation) age of 21.9 +/- 3.11 years (range 19-32 years) and 30 women with a mean age of 20.7 +/- 1.24 years (range 19-23 years). Center of pressure (COP) was measured using a stabilometer recording for 30 s with a 20-Hz sampling frequency. The measurement postures that were similar to postures adopted in the SIDE were: standing with feet 20 cm apart: standing with legs close and the insides of both feet touching; two tandem standing positions (with the dominant foot forward and with the non-dominant foot forward); and two single-leg standing positions (on the dominant foot and on the non-dominant foot). We calculated total path length and envelopment area of sway from the COP data. Statistical differences in means were determined using the Tukey-Kramer multiple comparison test. Results indicate that the orders of total path length and envelopment areas of sway in each posture were consistent with the item order of SIDE. Significant differences existed between the means of total path length and envelopment areas of sway in each posture (p &lt;0.05), with the exception of both tandem standing positions and both one-leg standing positions. The item order of SIDE appears to show concurrent validity in terms of the amount of body sway in the adopted postures. (C) 2011 Elsevier B.V. All rights reserved.
  • Ichiro Miyai, Shigeru Sonoda, Shota Nagai, Yuko Takayama, Yukiko Inoue, Atsuo Kakehi, Masaki Kurihara, Makoto Ishikawa
    NEUROREHABILITATION AND NEURAL REPAIR, 25(6) 540-547, Jul, 2011  Peer-reviewed
    Background. A new interdisciplinary postacute rehabilitation unit, the Kaifukuki (convalescent) rehabilitation ward (KRW), has been incorporated into the Japanese medical insurance system since 2000. More than 57 000 beds (45 beds per 100 000 population) are currently available nationwide. The maximal coverage for therapy sessions increased from 2 to 3 hours per day, 7 days a week, in 2006. Objective. To investigate how changes in policy affected rehabilitation outcomes of KRWs in a retrospective cohort study of 87 917 patients over 10 years. Results. The mean (standard deviation) age of the patients was 73.0 (13.8) years, and 55.4% were women. Diagnoses included stroke (47.9%); orthopedic diseases, including hip fracture (35.2%); and traumatic brain and spinal cord injury (5.4 %). Onset-admission interval (OAI) was 31.5 (18.6) days, length of stay was 75.9 (46.1) days, and 69.1% were discharged home. Daily therapy time was 79.4 (34.5) minutes. Admission/discharge scores of the Barthel Index and the Functional Independence Measure were 49.3 (31.0)/70.4 (31.9) and 75.3 (31.2)/91.7 (31.8), respectively. Year-by-year comparison revealed that older age, greater initial disability, and shorter OAI were coupled with a higher dose of rehabilitative interventions and a higher rate of home discharge. Longitudinal data from a cohort of hospitals implied a small but significant dose-dependent effect of hours of therapy on rehabilitation outcome after stroke. Conclusions. Although the organization of KRWs is in flux as the system of hospitals grows, results over the past 8 years suggest that changes in national insurance policies are affecting the quantity and organization of rehabilitation interventions and improvement in patient outcomes.

Presentations

 48

Research Projects

 18