Curriculum Vitaes
Profile Information
- Affiliation
- Associate Professor, School of Medicine, Fujita Health University(Concurrent)Director, Office for Medical ICT Planning and Promotion
- Degree
- Ph.D.(NAIST)
- J-GLOBAL ID
- 201001070039507320
- Researcher ID
- B-6061-2015
- researchmap Member ID
- 6000022342
- External link
強化学習の神経機構について、コンピュータ上で脳をつくることで理解しようと取り組んでいます。特に神経生物学実験の経験を生かして生物学的に妥当な詳細なモデルを構築することで、強化学習がどのようにして脳で実装されているのかを研究しています。また、様々な研究機関と共同研究を行い脳神経活動データや臨床からの医療データに対してデータサイエンスの手法を用いて解析をすることで、脳の理解や医学への貢献に取り組んでいます。
Research Interests
8Research Areas
4Research History
9-
Apr, 2020 - Apr, 2025
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May, 2017 - Mar, 2020
Education
2-
Apr, 2005 - Mar, 2010
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Apr, 2001 - Mar, 2005
Committee Memberships
7-
Aug, 2023 - Present
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Jan, 2020 - Mar, 2023
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Nov, 2021 - Nov, 2022
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2020 - 2021
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2020 - 2021
Awards
1Papers
26-
International Journal of Molecular Sciences, 25(21) 11365-11365, Oct 22, 2024 Peer-reviewedWhen exposed to X-rays, scintillators emit visible luminescence. X-ray-mediated optogenetics employs scintillators for remotely activating light-sensitive proteins in biological tissue through X-ray irradiation. This approach offers advantages over traditional optogenetics, allowing for deeper tissue penetration and wireless control. Here, we assessed the short-term safety and efficacy of candidate scintillator materials for neuronal control. Our analyses revealed that lead-free halide scintillators, such as Cs3Cu2I5, exhibited significant cytotoxicity within 24 h and induced neuroinflammatory effects when injected into the mouse brain. In contrast, cerium-doped gadolinium aluminum gallium garnet (Ce:GAGG) nanoparticles showed no detectable cytotoxicity within the same period, and injection into the mouse brain did not lead to observable neuroinflammation over four weeks. Electrophysiological recordings in the cerebral cortex of awake mice showed that X-ray-induced radioluminescence from Ce:GAGG nanoparticles reliably activated 45% of the neuronal population surrounding the implanted particles, a significantly higher activation rate than europium-doped GAGG (Eu:GAGG) microparticles, which activated only 10% of neurons. Furthermore, we established the cell-type specificity of this technique by using Ce:GAGG nanoparticles to selectively stimulate midbrain dopamine neurons. This technique was applied to freely behaving mice, allowing for wireless modulation of place preference behavior mediated by midbrain dopamine neurons. These findings highlight the unique suitability of Ce:GAGG nanoparticles for X-ray-mediated optogenetics. The deep tissue penetration, short-term safety, wireless neuronal control, and cell-type specificity of this system offer exciting possibilities for diverse neuroscience applications and therapeutic interventions.
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Neurobiology of Aging, 142 8-16, Oct, 2024 Peer-reviewed
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Neural mechanisms underlying uninstructed orofacial movements during reward-based learning behaviorsCurrent Biology, Aug, 2023 Peer-reviewedLead author
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Nature Communications, 13(1), Dec, 2022The original version of this Article contained an error in Figure 3d. The label ‘ChRmine-eYFP’ was incorrectly shown in orange font instead of green font. This error has been corrected in the HTML and PDF versions of the Article.
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Frontiers in Psychiatry, 13, Dec 1, 2022 Lead authorCorresponding author
Misc.
10-
電子情報通信学会技術研究報告, 118(322(NC2018 22-27)(Web)) 1 (WEB ONLY), Nov 15, 2018
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2014 CONFERENCE ON LASERS AND ELECTRO-OPTICS (CLEO), 2014The development of fast and robust chemical delivery systems is important step for nanomedicine. We demonstrate on-demand, sub-second, controlled release of a neuromodulator by applying femtosecond laser pulse trains to robust, liposome structures.
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IEICE technical report, 109(53) 103-110, May 25, 2009
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IPSJ SIG technical reports, 2009(16) 1-8, May 18, 2009The striatum, the input nucleus of the basal ganglia, receives glutamate input from the cortex and dopamine input from the substantia nigra. Recently, several studies reported contradictory results on the dependence of the striatal synaptic plasticity on the timing of cortical input, dopamine input, and the spike output. To clarify the mechanisms behind spike timing-dependent plasticity of striatal synapses, we investigated the spike timing-dependence of intracellular calcium concentration by constructing a striatal neuron model with a realistic morphology. Our simulation predicted that the calcium transient is maximal when cortical spike input and dopamine input preceded the postsynaptic spike. The gain of the calcium transient is enhanced during the "up-state" of striatal cells.
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IPSJ SIG technical reports, 2007(60) 55-62, Jun 14, 2007The plasticity of cortico-striatal synapses is regulated by dopamine, glutamate and post-synaptic activation. We built an intracellular signaling cascade model in order to examine the dynamic mechanisms of cortico-striatal synaptic plasticity. According to our simulation results, bidirectional synaptic plasticity was reproduced well and molecular mechanisms of striatal synaptic plasticity was clarified. We conclude that PKA and DARPP-32 are essen tial for Ca-and DA-dependent cortico-striatal synaptic plasticity. Especially, the activation of CK1-Cdk5-D75 pathway is important for Ca-dependent LTD and the activation of PP2A-D75 pathway is important for Ca-dependent LTP.
Books and Other Publications
2-
Springer, Sep 3, 2009 (ISBN: 9783642042737, 3642042732)
Teaching Experience
12-
2022 - PresentアセンブリIII (藤田医科大学)
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2022 - Present医学統計学 (藤田医科大学)
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2021 - PresentNeuroscience Course (Fujita Health University)
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2021 - Present読書ゼミナール (藤田医科大学)
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2021 - Present基礎データサイエンス (藤田医科大学)
Professional Memberships
4Research Projects
6-
科学研究費助成事業, 日本学術振興会, Apr, 2024 - Mar, 2028
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科学研究費助成事業, 日本学術振興会, Jun, 2024 - Mar, 2027
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科学研究費助成事業 基盤研究(C), 日本学術振興会, Apr, 2020 - Mar, 2024
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Japanese Neural Network Society, Feb, 2020
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Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Jul, 2014 - Mar, 2019