Curriculum Vitaes

Takashi Nakano

  (中野 高志)

Profile Information

Affiliation
Associate Professor, School of Medicine, Fujita Health University
(Concurrent)Director, Office for Medical ICT Planning and Promotion
Degree
Ph.D.(NAIST)

J-GLOBAL ID
201001070039507320
Researcher ID
B-6061-2015
researchmap Member ID
6000022342

External link

強化学習の神経機構について、コンピュータ上で脳をつくることで理解しようと取り組んでいます。特に神経生物学実験の経験を生かして生物学的に妥当な詳細なモデルを構築することで、強化学習がどのようにして脳で実装されているのかを研究しています。また、様々な研究機関と共同研究を行い脳神経活動データや臨床からの医療データに対してデータサイエンスの手法を用いて解析をすることで、脳の理解や医学への貢献に取り組んでいます。


Papers

 26
  • Mercedes Hildebrandt, Masanori Koshimizu, Yasuki Asada, Kansai Fukumitsu, Mahito Ohkuma, Na Sang, Takashi Nakano, Toshiaki Kunikata, Kai Okazaki, Noriaki Kawaguchi, Takayuki Yanagida, Linyuan Lian, Jianbing Zhang, Takayuki Yamashita
    International Journal of Molecular Sciences, 25(21) 11365-11365, Oct 22, 2024  Peer-reviewed
    When exposed to X-rays, scintillators emit visible luminescence. X-ray-mediated optogenetics employs scintillators for remotely activating light-sensitive proteins in biological tissue through X-ray irradiation. This approach offers advantages over traditional optogenetics, allowing for deeper tissue penetration and wireless control. Here, we assessed the short-term safety and efficacy of candidate scintillator materials for neuronal control. Our analyses revealed that lead-free halide scintillators, such as Cs3Cu2I5, exhibited significant cytotoxicity within 24 h and induced neuroinflammatory effects when injected into the mouse brain. In contrast, cerium-doped gadolinium aluminum gallium garnet (Ce:GAGG) nanoparticles showed no detectable cytotoxicity within the same period, and injection into the mouse brain did not lead to observable neuroinflammation over four weeks. Electrophysiological recordings in the cerebral cortex of awake mice showed that X-ray-induced radioluminescence from Ce:GAGG nanoparticles reliably activated 45% of the neuronal population surrounding the implanted particles, a significantly higher activation rate than europium-doped GAGG (Eu:GAGG) microparticles, which activated only 10% of neurons. Furthermore, we established the cell-type specificity of this technique by using Ce:GAGG nanoparticles to selectively stimulate midbrain dopamine neurons. This technique was applied to freely behaving mice, allowing for wireless modulation of place preference behavior mediated by midbrain dopamine neurons. These findings highlight the unique suitability of Ce:GAGG nanoparticles for X-ray-mediated optogenetics. The deep tissue penetration, short-term safety, wireless neuronal control, and cell-type specificity of this system offer exciting possibilities for diverse neuroscience applications and therapeutic interventions.
  • Hiroyuki Ohta, Takashi Nozawa, Takashi Nakano, Yuji Morimoto, Toshiaki Ishizuka
    Neurobiology of Aging, 142 8-16, Oct, 2024  Peer-reviewed
  • Wan-Ru Li, Takashi Nakano, Kohta Mizutani, Takanori Matsubara, Masahiro Kawatani, Yasutaka Mukai, Teruko Danjo, Hikaru Ito, Hidenori Aizawa, Akihiro Yamanaka, Carl C.H. Petersen, Junichiro Yoshimoto, Takayuki Yamashita
    Current Biology, Aug, 2023  Peer-reviewedLead author
  • Takanori Matsubara, Takayuki Yanagida, Noriaki Kawaguchi, Takashi Nakano, Junichiro Yoshimoto, Maiko Sezaki, Hitoshi Takizawa, Satoshi P. Tsunoda, Shin ichiro Horigane, Shuhei Ueda, Sayaka Takemoto-Kimura, Hideki Kandori, Akihiro Yamanaka, Takayuki Yamashita
    Nature Communications, 13(1), Dec, 2022  
    The original version of this Article contained an error in Figure 3d. The label ‘ChRmine-eYFP’ was incorrectly shown in orange font instead of green font. This error has been corrected in the HTML and PDF versions of the Article.
  • Takashi Nakano, Masahiro Takamura, Takahiro A. Kato, Shin-ichi Kano
    Frontiers in Psychiatry, 13, Dec 1, 2022  Lead authorCorresponding author

Misc.

 10
  • 中野高志, 中野高志, 高村真広, 西村春輝, 町澤まろ, 市川奈穂, 吉野敦雄, 岡田剛, 岡本泰昌, 岡本泰昌, 山脇成人, 山田真希子, 須原哲也, 吉本潤一郎
    日本神経化学会大会抄録集(Web), 65th, 2022  
  • 高村真広, 高村真広, 中野高志, 中野高志, 西村春輝, 西村春輝, 町澤まろ, 市川奈穂, 吉野敦雄, 吉野敦雄, 岡田剛, 岡本泰昌, 岡本泰昌, 山脇成人, 山田真希子, 山田真希子, 須原哲也, 吉本潤一郎, 吉本潤一郎
    日本神経化学会大会抄録集(Web), 65th, 2022  
  • 中野高志, 中野高志, 高村真広, 西村春輝, 町澤まろ, 市川奈穂, 岡本泰昌, 山脇成人, 山田真希子, 須原哲也, 吉本潤一郎, 吉本潤一郎
    人工知能学会全国大会(Web), 36th, 2022  
  • 松原崇紀, 柳田健之, 河口範明, 中野高志, 瀬崎真衣子, 滝澤仁, 山中章弘, 山下貴之, 山下貴之
    日本生理学雑誌(Web), 83(2), 2021  
  • 酒井翠, 高村真広, 岡田剛, 岡本泰昌, 山脇成人, 丸野由希, 中野高志, 吉本潤一郎
    電子情報通信学会技術研究報告, 118(322(NC2018 22-27)(Web)) 1 (WEB ONLY), Nov 15, 2018  
  • 酒井翠, 中野高志, 丸野由希, 岡田剛, 高村真広, 岡本泰昌, 山脇成人, 吉本潤一郎
    情報処理学会関西支部支部大会講演論文集(CD-ROM), 2018 3p, 2018  
  • Takashi Nakano, Catherine Chin, David Mo Aung Myint, Eng Wui Tan, Peter John Hale, John N. J. Reynolds, Jeff Wickens, Keshav M. Dani
    2014 CONFERENCE ON LASERS AND ELECTRO-OPTICS (CLEO), 2014  
    The development of fast and robust chemical delivery systems is important step for nanomedicine. We demonstrate on-demand, sub-second, controlled release of a neuromodulator by applying femtosecond laser pulse trains to robust, liposome structures.
  • IEICE technical report, 109(53) 103-110, May 25, 2009  
  • Takashi Nakano, Junichiro Yoshimoto, Jeff Wickens, Kenji Doya
    IPSJ SIG technical reports, 2009(16) 1-8, May 18, 2009  
    The striatum, the input nucleus of the basal ganglia, receives glutamate input from the cortex and dopamine input from the substantia nigra. Recently, several studies reported contradictory results on the dependence of the striatal synaptic plasticity on the timing of cortical input, dopamine input, and the spike output. To clarify the mechanisms behind spike timing-dependent plasticity of striatal synapses, we investigated the spike timing-dependence of intracellular calcium concentration by constructing a striatal neuron model with a realistic morphology. Our simulation predicted that the calcium transient is maximal when cortical spike input and dopamine input preceded the postsynaptic spike. The gain of the calcium transient is enhanced during the "up-state" of striatal cells.
  • NAKANO TAKASHI, DOI TOMOKAZU, YOSHIMOTO JUNICHIRO, DOYA KENJI
    IPSJ SIG technical reports, 2007(60) 55-62, Jun 14, 2007  
    The plasticity of cortico-striatal synapses is regulated by dopamine, glutamate and post-synaptic activation. We built an intracellular signaling cascade model in order to examine the dynamic mechanisms of cortico-striatal synaptic plasticity. According to our simulation results, bidirectional synaptic plasticity was reproduced well and molecular mechanisms of striatal synaptic plasticity was clarified. We conclude that PKA and DARPP-32 are essen tial for Ca-and DA-dependent cortico-striatal synaptic plasticity. Especially, the activation of CK1-Cdk5-D75 pathway is important for Ca-dependent LTD and the activation of PP2A-D75 pathway is important for Ca-dependent LTP.

Books and Other Publications

 2

Teaching Experience

 12

Research Projects

 6

Other

 1
  • ① レーザーとリポソームを用いた薬物投与法 *本研究シーズに関する産学共同研究の問い合わせは藤田医科大学産学連携推進センター(fuji-san@fujita-hu.ac.jp)まで